Published in J Cell Sci on February 17, 2012
Phase geometries of two-dimensional excitable waves govern self-organized morphodynamics of amoeboid cells. Proc Natl Acad Sci U S A (2013) 1.05
Millisecond spatiotemporal dynamics of FRET biosensors by the pair correlation function and the phasor approach to FLIM. Proc Natl Acad Sci U S A (2012) 1.00
Self-organization of protrusions and polarity during eukaryotic chemotaxis. Curr Opin Cell Biol (2014) 0.94
Fluctuation-based imaging of nuclear Rac1 activation by protein oligomerisation. Sci Rep (2014) 0.83
Using fluctuation analysis to establish causal relations between cellular events without experimental perturbation. Biophys J (2014) 0.81
ERK reinforces actin polymerization to power persistent edge protrusion during motility. Sci Signal (2015) 0.80
The small GTPase HRas shapes local PI3K signals through positive feedback and regulates persistent membrane extension in migrating fibroblasts. Mol Biol Cell (2013) 0.80
Modeling self-organized spatio-temporal patterns of PIP₃ and PTEN during spontaneous cell polarization. Phys Biol (2014) 0.79
Relocation of CLIC1 promotes tumor cell invasion and colonization of fibrin. Mol Cancer Res (2014) 0.79
Envisioning migration: mathematics in both experimental analysis and modeling of cell behavior. Curr Opin Cell Biol (2013) 0.78
Visualization of phosphatidic acid fluctuations in the plasma membrane of living cells. PLoS One (2014) 0.78
Distinct predictive performance of Rac1 and Cdc42 in cell migration. Sci Rep (2015) 0.78
Two New FRET Imaging Measures: Linearly Proportional to and Highly Contrasting the Fraction of Active Molecules. PLoS One (2016) 0.75
Spatial analysis of Cdc42 activity reveals a role for plasma membrane-associated Cdc42 in centrosome regulation. Mol Biol Cell (2017) 0.75
Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat Immunol (2004) 5.71
Activation of rac and cdc42 video imaged by fluorescent resonance energy transfer-based single-molecule probes in the membrane of living cells. Mol Cell Biol (2002) 4.50
Activity of Rho-family GTPases during cell division as visualized with FRET-based probes. J Cell Biol (2003) 3.85
Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis. Science (2008) 3.38
Selective inhibition of NF-kappa B blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo. Nat Med (2004) 2.94
Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction. J Exp Med (2005) 2.90
Dynamics of the Ras/ERK MAPK cascade as monitored by fluorescent probes. J Biol Chem (2006) 2.73
Localized RhoA activation as a requirement for the induction of membrane ruffling. Mol Biol Cell (2005) 2.58
Development of an optimized backbone of FRET biosensors for kinases and GTPases. Mol Biol Cell (2011) 2.28
Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-A1, with off-track and vascular endothelial growth factor receptor type 2. Genes Dev (2004) 2.22
The Rho-mDia1 pathway regulates cell polarity and focal adhesion turnover in migrating cells through mobilizing Apc and c-Src. Mol Cell Biol (2006) 2.11
Roles played by a subset of integrin signaling molecules in cadherin-based cell-cell adhesion. J Cell Biol (2004) 2.02
E-selectin receptors on human leukocytes. Blood (2008) 1.99
Regulation of osteoclast differentiation and function by the CaMK-CREB pathway. Nat Med (2006) 1.93
Defective microtubule-dependent podosome organization in osteoclasts leads to increased bone density in Pyk2(-/-) mice. J Cell Biol (2007) 1.92
Cell type-specific regulation of RhoA activity during cytokinesis. J Biol Chem (2004) 1.76
IkappaBzeta regulates T(H)17 development by cooperating with ROR nuclear receptors. Nature (2010) 1.76
Lateral propagation of EGF signaling after local stimulation is dependent on receptor density. Dev Cell (2002) 1.74
Coactivation of Rac1 and Cdc42 at lamellipodia and membrane ruffles induced by epidermal growth factor. Mol Biol Cell (2003) 1.72
SH3BP1, an exocyst-associated RhoGAP, inactivates Rac1 at the front to drive cell motility. Mol Cell (2011) 1.70
Stochastic ERK activation induced by noise and cell-to-cell propagation regulates cell density-dependent proliferation. Mol Cell (2013) 1.62
Ras binding opens c-Raf to expose the docking site for mitogen-activated protein kinase kinase. EMBO Rep (2005) 1.62
A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis. J Biol Chem (2004) 1.56
Processive phosphorylation of ERK MAP kinase in mammalian cells. Proc Natl Acad Sci U S A (2011) 1.55
Visualization of small GTPase activity with fluorescence resonance energy transfer-based biosensors. Nat Protoc (2009) 1.53
Local phosphatidylinositol 3,4,5-trisphosphate accumulation recruits Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite outgrowth in nerve growth factor-stimulated PC12 cells. Mol Biol Cell (2005) 1.48
Site mapping and characterization of O-glycan structures on alpha-dystroglycan isolated from rabbit skeletal muscle. J Biol Chem (2010) 1.43
Spatio-temporal regulation of Rac1 and Cdc42 activity during nerve growth factor-induced neurite outgrowth in PC12 cells. J Biol Chem (2003) 1.41
Mechanism of the spatio-temporal regulation of Ras and Rap1. EMBO J (2003) 1.40
Imaging of Rab5 activity identifies essential regulators for phagosome maturation. Nature (2008) 1.39
Suppression of RhoG activity is mediated by a syndecan 4-synectin-RhoGDI1 complex and is reversed by PKCalpha in a Rac1 activation pathway. J Cell Biol (2009) 1.36
Glycomic analyses of mouse models of congenital muscular dystrophy. J Biol Chem (2011) 1.32
A clathrin-dependent pathway leads to KRas signaling on late endosomes en route to lysosomes. J Cell Biol (2009) 1.30
Palmitoylated Ras proteins traffic through recycling endosomes to the plasma membrane during exocytosis. J Cell Biol (2010) 1.30
Signaling pathway via TNF-alpha/NF-kappaB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis. Am J Physiol Gastrointest Liver Physiol (2009) 1.27
Involvement of the c-Src-Crk-C3G-Rap1 signaling in the nectin-induced activation of Cdc42 and formation of adherens junctions. J Biol Chem (2004) 1.26
An essential role for the SHIP2-dependent negative feedback loop in neuritogenesis of nerve growth factor-stimulated PC12 cells. J Cell Biol (2007) 1.25
Rap1-PDZ-GEF1 interacts with a neurotrophin receptor at late endosomes, leading to sustained activation of Rap1 and ERK and neurite outgrowth. J Cell Biol (2007) 1.23
Monitoring spatio-temporal regulation of Ras and Rho GTPase with GFP-based FRET probes. Methods (2005) 1.21
Regulation of protein glycosylation and sorting by the Golgi matrix proteins GRASP55/65. Nat Commun (2013) 1.20
Sphingosine 1-phosphate induces membrane ruffling and increases motility of human umbilical vein endothelial cells via vascular endothelial growth factor receptor and CrkII. J Biol Chem (2002) 1.19
Inhibition of RANKL-induced osteoclastogenesis by (-)-DHMEQ, a novel NF-kappaB inhibitor, through downregulation of NFATc1. J Bone Miner Res (2004) 1.19
Analysis of the spatiotemporal activation of rho GTPases using Raichu probes. Methods Enzymol (2006) 1.18
Akt-PDK1 complex mediates epidermal growth factor-induced membrane protrusion through Ral activation. Mol Biol Cell (2006) 1.15
IDAWG: Metabolic incorporation of stable isotope labels for quantitative glycomics of cultured cells. J Proteome Res (2009) 1.15
Novel function of Chat in controlling cell adhesion via Cas-Crk-C3G-pathway-mediated Rap1 activation. J Cell Sci (2002) 1.14
Targeted glycoproteomic identification of biomarkers for human breast carcinoma. J Proteome Res (2008) 1.14
Spatiotemporal regulation of small GTPases as revealed by probes based on the principle of Förster Resonance Energy Transfer (FRET): Implications for signaling and pharmacology. Annu Rev Pharmacol Toxicol (2011) 1.12
Identification of N-glycosylated proteins from the central nervous system of Drosophila melanogaster. Glycobiology (2007) 1.12
Phosphorylation and activation of the Rac1 and Cdc42 GEF Asef in A431 cells stimulated by EGF. J Cell Sci (2008) 1.10
Multiple decisive phosphorylation sites for the negative feedback regulation of SOS1 via ERK. J Biol Chem (2010) 1.09
Adaptor protein Crk is required for ephrin-B1-induced membrane ruffling and focal complex assembly of human aortic endothelial cells. Mol Biol Cell (2002) 1.09
The pivotal role of the alternative NF-kappaB pathway in maintenance of basal bone homeostasis and osteoclastogenesis. J Bone Miner Res (2010) 1.09
Revolving movement of a dynamic cluster of actin filaments during mitosis. J Cell Biol (2010) 1.08
R-Ras regulates exocytosis by Rgl2/Rlf-mediated activation of RalA on endosomes. Mol Biol Cell (2007) 1.07
Rapid turnover rate of phosphoinositides at the front of migrating MDCK cells. Mol Biol Cell (2008) 1.06
Visualization of growth signal transduction cascades in living cells with genetically encoded probes based on Förster resonance energy transfer. Philos Trans R Soc Lond B Biol Sci (2008) 1.05
In vivo fluorescence resonance energy transfer imaging reveals differential activation of Rho-family GTPases in glioblastoma cell invasion. J Cell Sci (2012) 1.05
Inefficient enhancement of viral infectivity and CD4 downregulation by human immunodeficiency virus type 1 Nef from Japanese long-term nonprogressors. J Virol (2002) 1.05
Amelioration of bone loss in collagen-induced arthritis by neutralizing anti-RANKL monoclonal antibody. Biochem Biophys Res Commun (2006) 1.03
Live imaging of protein kinase activities in transgenic mice expressing FRET biosensors. Cell Struct Funct (2012) 1.03
Fluorescence (Förster) resonance energy transfer imaging of oncogene activity in living cells. Cancer Sci (2006) 1.03
Delayed-onset muscle injury and its modification by wheat gluten hydrolysate. Nutrition (2009) 1.03
Spatiotemporal activation of Rac1 for engulfment of apoptotic cells. Proc Natl Acad Sci U S A (2008) 1.03
A quantitative model of ERK MAP kinase phosphorylation in crowded media. Sci Rep (2013) 1.03
FRET imaging in nerve growth cones reveals a high level of RhoA activity within the peripheral domain. Brain Res Mol Brain Res (2005) 1.02
Fluorescence resonance energy transfer imaging of cell signaling from in vitro to in vivo: basis of biosensor construction, live imaging, and image processing. Dev Growth Differ (2013) 1.02
Quantification of local morphodynamics and local GTPase activity by edge evolution tracking. PLoS Comput Biol (2008) 1.01
A tumor necrosis factor receptor loop peptide mimic inhibits bone destruction to the same extent as anti-tumor necrosis factor monoclonal antibody in murine collagen-induced arthritis. Arthritis Rheum (2007) 1.01
RalA activation at nascent lamellipodia of epidermal growth factor-stimulated Cos7 cells and migrating Madin-Darby canine kidney cells. Mol Biol Cell (2004) 1.00
GTP hydrolysis by the Rho family GTPase TC10 promotes exocytic vesicle fusion. Dev Cell (2006) 1.00
The scaffold protein Shoc2/SUR-8 accelerates the interaction of Ras and Raf. J Biol Chem (2010) 0.99
Suppression of NF-kappaB increases bone formation and ameliorates osteopenia in ovariectomized mice. Endocrinology (2010) 0.98
Regulation of glycan structures in murine embryonic stem cells: combined transcript profiling of glycan-related genes and glycan structural analysis. J Biol Chem (2012) 0.97
Stable expression of FRET biosensors: a new light in cancer research. Cancer Sci (2012) 0.96
STAT3 noncell-autonomously controls planar cell polarity during zebrafish convergence and extension. J Cell Biol (2004) 0.95
Purification and characterization of Heteroscorpine-1 (HS-1) toxin from Heterometrus laoticus scorpion venom. Toxicon (2006) 0.95
Syndecan 4 regulates FGFR1 signaling in endothelial cells by directing macropinocytosis. Sci Signal (2012) 0.94
Stimulation of bone formation in cortical bone of mice treated with a receptor activator of nuclear factor-κB ligand (RANKL)-binding peptide that possesses osteoclastogenesis inhibitory activity. J Biol Chem (2013) 0.94
A novel role of nectins in inhibition of the E-cadherin-induced activation of Rac and formation of cell-cell adherens junctions. Mol Biol Cell (2003) 0.94
Processing of the NF-kappa B2 precursor p100 to p52 is critical for RANKL-induced osteoclast differentiation. J Bone Miner Res (2010) 0.93
Suppression of Rac1 activity at the apical membrane of MDCK cells is essential for cyst structure maintenance. EMBO Rep (2012) 0.93
The amino-terminal B-Raf-specific region mediates calcium-dependent homo- and hetero-dimerization of Raf. EMBO J (2006) 0.93
Heterogeneity of phosphatidic acid levels and distribution at the plasma membrane in living cells as visualized by a Föster resonance energy transfer (FRET) biosensor. J Biol Chem (2010) 0.93
A mutation in a ganglioside biosynthetic enzyme, ST3GAL5, results in salt & pepper syndrome, a neurocutaneous disorder with altered glycolipid and glycoprotein glycosylation. Hum Mol Genet (2013) 0.93