Published in J Biol Chem on January 05, 2010
Raf family kinases: old dogs have learned new tricks. Genes Cancer (2011) 1.72
Disorders of dysregulated signal traffic through the RAS-MAPK pathway: phenotypic spectrum and molecular mechanisms. Ann N Y Acad Sci (2010) 1.54
Desmoglein-1/Erbin interaction suppresses ERK activation to support epidermal differentiation. J Clin Invest (2013) 1.11
A quantitative model of ERK MAP kinase phosphorylation in crowded media. Sci Rep (2013) 1.03
Shoc2 is targeted to late endosomes and required for Erk1/2 activation in EGF-stimulated cells. PLoS One (2012) 0.95
Erbin is a negative modulator of cardiac hypertrophy. Proc Natl Acad Sci U S A (2014) 0.86
Functional Integration of the Conserved Domains of Shoc2 Scaffold. PLoS One (2013) 0.86
Quantitative in vivo fluorescence cross-correlation analyses highlight the importance of competitive effects in the regulation of protein-protein interactions. Mol Cell Biol (2014) 0.82
HUWE1 is a molecular link controlling RAF-1 activity supported by the Shoc2 scaffold. Mol Cell Biol (2014) 0.81
Desmoglein-1, differentiation, and disease. J Clin Invest (2013) 0.81
FHL2 switches MITF from activator to repressor of Erbin expression during cardiac hypertrophy. Int J Cardiol (2015) 0.79
Transcriptional hallmarks of Noonan syndrome and Noonan-like syndrome with loose anagen hair. Hum Mutat (2012) 0.79
The Function of Embryonic Stem Cell-expressed RAS (E-RAS), a Unique RAS Family Member, Correlates with Its Additional Motifs and Its Structural Properties. J Biol Chem (2015) 0.76
Quantitative analysis of recombination between YFP and CFP genes of FRET biosensors introduced by lentiviral or retroviral gene transfer. Sci Rep (2015) 0.76
Research Resource: Androgen Receptor Activity Is Regulated Through the Mobilization of Cell Surface Receptor Networks. Mol Endocrinol (2015) 0.76
Shoc2/Sur8 protein regulates neurite outgrowth. PLoS One (2014) 0.75
The function of Shoc2: A scaffold and beyond. Commun Integr Biol (2016) 0.75
ras genes. Annu Rev Biochem (1987) 22.59
ras oncogenes in human cancer: a review. Cancer Res (1989) 22.03
Mammalian MAP kinase signalling cascades. Nature (2001) 18.89
Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr Rev (2001) 14.02
Small GTP-binding proteins. Physiol Rev (2001) 9.52
Coordinating ERK/MAPK signalling through scaffolds and inhibitors. Nat Rev Mol Cell Biol (2005) 7.07
Using process diagrams for the graphical representation of biological networks. Nat Biotechnol (2005) 5.75
Signal transduction through MAP kinase cascades. Adv Cancer Res (1998) 5.65
Regulation of MAP kinase signaling modules by scaffold proteins in mammals. Annu Rev Cell Dev Biol (2003) 5.38
Monitoring protein conformations and interactions by fluorescence resonance energy transfer between mutants of green fluorescent protein. Methods Enzymol (2000) 4.87
Spatio-temporal images of growth-factor-induced activation of Ras and Rap1. Nature (2001) 4.83
Function and regulation of ras. Annu Rev Biochem (1993) 4.69
The MAP kinase cascade is essential for diverse signal transduction pathways. Trends Biochem Sci (1993) 4.62
Using engineered scaffold interactions to reshape MAP kinase pathway signaling dynamics. Science (2008) 4.37
Prediction and validation of the distinct dynamics of transient and sustained ERK activation. Nat Cell Biol (2005) 4.13
Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties. Proc Natl Acad Sci U S A (2000) 3.95
Recent progress in characterization of protein kinase cascades for phosphorylation of ribosomal protein S6. Biochim Biophys Acta (1991) 3.39
Next generation simulation tools: the Systems Biology Workbench and BioSPICE integration. OMICS (2003) 3.38
Directed evolution of a monomeric, bright and photostable version of Clavularia cyan fluorescent protein: structural characterization and applications in fluorescence imaging. Biochem J (2006) 3.20
Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras. Oncogene (1997) 2.99
Dynamics of the Ras/ERK MAPK cascade as monitored by fluorescent probes. J Biol Chem (2006) 2.73
Using GFP in FRET-based applications. Trends Cell Biol (1999) 2.55
Refractory nature of normal human diploid fibroblasts with respect to oncogene-mediated transformation. Proc Natl Acad Sci U S A (2003) 2.25
Scaffold proteins and immune-cell signalling. Nat Rev Immunol (2009) 1.84
Assessing the balance between protein-protein interactions and enzyme-substrate interactions in the channeling of intermediates between polyketide synthase modules. J Am Chem Soc (2001) 1.75
A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity. Mol Cell (2006) 1.68
The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf. Genes Dev (2000) 1.60
SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans. Cell (1998) 1.51
SOS phosphorylation and disassociation of the Grb2-SOS complex by the ERK and JNK signaling pathways. J Biol Chem (1996) 1.48
Characterization of an improved donor fluorescent protein for Forster resonance energy transfer microscopy. J Biomed Opt (2008) 1.43
Mechanism of the spatio-temporal regulation of Ras and Rap1. EMBO J (2003) 1.40
soc-2 encodes a leucine-rich repeat protein implicated in fibroblast growth factor receptor signaling. Proc Natl Acad Sci U S A (1998) 1.39
Erbin inhibits RAF activation by disrupting the sur-8-Ras-Raf complex. J Biol Chem (2005) 1.28
An essential role for the SHIP2-dependent negative feedback loop in neuritogenesis of nerve growth factor-stimulated PC12 cells. J Cell Biol (2007) 1.25
On the origin of intracellular compartmentation and organized metabolic systems. Mol Cell Biochem (2004) 1.23
Critical contribution of linker proteins to Raf kinase activation. J Biol Chem (2001) 1.15
Interactions between Ras proteins and their effectors. Curr Opin Biotechnol (1996) 1.11
Visualization of growth signal transduction cascades in living cells with genetically encoded probes based on Förster resonance energy transfer. Philos Trans R Soc Lond B Biol Sci (2008) 1.05
Fluorescence (Förster) resonance energy transfer imaging of oncogene activity in living cells. Cancer Sci (2006) 1.03
Structural basis for channelling mechanism of a fatty acid beta-oxidation multienzyme complex. EMBO J (2004) 0.94
The DHR1 domain of DOCK180 binds to SNX5 and regulates cation-independent mannose 6-phosphate receptor transport. Mol Biol Cell (2008) 0.89
Multiple high-throughput analyses monitor the response of E. coli to perturbations. Science (2007) 5.87
Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat Immunol (2004) 5.71
Activation of rac and cdc42 video imaged by fluorescent resonance energy transfer-based single-molecule probes in the membrane of living cells. Mol Cell Biol (2002) 4.50
Activity of Rho-family GTPases during cell division as visualized with FRET-based probes. J Cell Biol (2003) 3.85
PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex. Genes Dev (2008) 3.49
Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis. Science (2008) 3.38
Endophilin BAR domain drives membrane curvature by two newly identified structure-based mechanisms. EMBO J (2006) 2.98
Selective inhibition of NF-kappa B blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo. Nat Med (2004) 2.94
Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction. J Exp Med (2005) 2.90
Dynamics of the Ras/ERK MAPK cascade as monitored by fluorescent probes. J Biol Chem (2006) 2.73
Localized RhoA activation as a requirement for the induction of membrane ruffling. Mol Biol Cell (2005) 2.58
Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis. Nat Cell Biol (2006) 2.57
Development of an optimized backbone of FRET biosensors for kinases and GTPases. Mol Biol Cell (2011) 2.28
Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-A1, with off-track and vascular endothelial growth factor receptor type 2. Genes Dev (2004) 2.22
The Rho-mDia1 pathway regulates cell polarity and focal adhesion turnover in migrating cells through mobilizing Apc and c-Src. Mol Cell Biol (2006) 2.11
Roles played by a subset of integrin signaling molecules in cadherin-based cell-cell adhesion. J Cell Biol (2004) 2.02
E-selectin receptors on human leukocytes. Blood (2008) 1.99
Regulation of osteoclast differentiation and function by the CaMK-CREB pathway. Nat Med (2006) 1.93
Defective microtubule-dependent podosome organization in osteoclasts leads to increased bone density in Pyk2(-/-) mice. J Cell Biol (2007) 1.92
Role for human immunodeficiency virus type 1 membrane cholesterol in viral internalization. J Virol (2002) 1.81
Cell type-specific regulation of RhoA activity during cytokinesis. J Biol Chem (2004) 1.76
IkappaBzeta regulates T(H)17 development by cooperating with ROR nuclear receptors. Nature (2010) 1.76
Lateral propagation of EGF signaling after local stimulation is dependent on receptor density. Dev Cell (2002) 1.74
Coactivation of Rac1 and Cdc42 at lamellipodia and membrane ruffles induced by epidermal growth factor. Mol Biol Cell (2003) 1.72
SH3BP1, an exocyst-associated RhoGAP, inactivates Rac1 at the front to drive cell motility. Mol Cell (2011) 1.70
Stochastic ERK activation induced by noise and cell-to-cell propagation regulates cell density-dependent proliferation. Mol Cell (2013) 1.62
Ras binding opens c-Raf to expose the docking site for mitogen-activated protein kinase kinase. EMBO Rep (2005) 1.62
MAGI-1 is required for Rap1 activation upon cell-cell contact and for enhancement of vascular endothelial cadherin-mediated cell adhesion. Mol Biol Cell (2005) 1.59
A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis. J Biol Chem (2004) 1.56
Processive phosphorylation of ERK MAP kinase in mammalian cells. Proc Natl Acad Sci U S A (2011) 1.55
Visualization of small GTPase activity with fluorescence resonance energy transfer-based biosensors. Nat Protoc (2009) 1.53
Local phosphatidylinositol 3,4,5-trisphosphate accumulation recruits Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite outgrowth in nerve growth factor-stimulated PC12 cells. Mol Biol Cell (2005) 1.48
Induced metamorphosis in crustacean y-larvae: towards a solution to a 100-year-old riddle. BMC Biol (2008) 1.48
Site mapping and characterization of O-glycan structures on alpha-dystroglycan isolated from rabbit skeletal muscle. J Biol Chem (2010) 1.43
Spatio-temporal regulation of Rac1 and Cdc42 activity during nerve growth factor-induced neurite outgrowth in PC12 cells. J Biol Chem (2003) 1.41
Mechanism of the spatio-temporal regulation of Ras and Rap1. EMBO J (2003) 1.40
Imaging of Rab5 activity identifies essential regulators for phagosome maturation. Nature (2008) 1.39
Suppression of RhoG activity is mediated by a syndecan 4-synectin-RhoGDI1 complex and is reversed by PKCalpha in a Rac1 activation pathway. J Cell Biol (2009) 1.36
Glycomic analyses of mouse models of congenital muscular dystrophy. J Biol Chem (2011) 1.32
A clathrin-dependent pathway leads to KRas signaling on late endosomes en route to lysosomes. J Cell Biol (2009) 1.30
Palmitoylated Ras proteins traffic through recycling endosomes to the plasma membrane during exocytosis. J Cell Biol (2010) 1.30
Signaling pathway via TNF-alpha/NF-kappaB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis. Am J Physiol Gastrointest Liver Physiol (2009) 1.27
Involvement of the c-Src-Crk-C3G-Rap1 signaling in the nectin-induced activation of Cdc42 and formation of adherens junctions. J Biol Chem (2004) 1.26
An essential role for the SHIP2-dependent negative feedback loop in neuritogenesis of nerve growth factor-stimulated PC12 cells. J Cell Biol (2007) 1.25
EphA4-mediated Rho activation via Vsm-RhoGEF expressed specifically in vascular smooth muscle cells. Circ Res (2003) 1.23
Rap1-PDZ-GEF1 interacts with a neurotrophin receptor at late endosomes, leading to sustained activation of Rap1 and ERK and neurite outgrowth. J Cell Biol (2007) 1.23
Monitoring spatio-temporal regulation of Ras and Rho GTPase with GFP-based FRET probes. Methods (2005) 1.21
Regulation of protein glycosylation and sorting by the Golgi matrix proteins GRASP55/65. Nat Commun (2013) 1.20
Sphingosine 1-phosphate induces membrane ruffling and increases motility of human umbilical vein endothelial cells via vascular endothelial growth factor receptor and CrkII. J Biol Chem (2002) 1.19
Identification of Fer tyrosine kinase localized on microtubules as a platelet endothelial cell adhesion molecule-1 phosphorylating kinase in vascular endothelial cells. Mol Biol Cell (2003) 1.19
Inhibition of RANKL-induced osteoclastogenesis by (-)-DHMEQ, a novel NF-kappaB inhibitor, through downregulation of NFATc1. J Bone Miner Res (2004) 1.19
Analysis of the spatiotemporal activation of rho GTPases using Raichu probes. Methods Enzymol (2006) 1.18
Akt-PDK1 complex mediates epidermal growth factor-induced membrane protrusion through Ral activation. Mol Biol Cell (2006) 1.15
IDAWG: Metabolic incorporation of stable isotope labels for quantitative glycomics of cultured cells. J Proteome Res (2009) 1.15
Isolation of iodide-oxidizing bacteria from iodide-rich natural gas brines and seawaters. Microb Ecol (2005) 1.14
Novel function of Chat in controlling cell adhesion via Cas-Crk-C3G-pathway-mediated Rap1 activation. J Cell Sci (2002) 1.14
Oligomerization and pore formation of a sphingomyelin-specific toxin, lysenin. J Biol Chem (2003) 1.14
Targeted glycoproteomic identification of biomarkers for human breast carcinoma. J Proteome Res (2008) 1.14
Spatiotemporal regulation of small GTPases as revealed by probes based on the principle of Förster Resonance Energy Transfer (FRET): Implications for signaling and pharmacology. Annu Rev Pharmacol Toxicol (2011) 1.12
Identification of N-glycosylated proteins from the central nervous system of Drosophila melanogaster. Glycobiology (2007) 1.12
Phosphorylation and activation of the Rac1 and Cdc42 GEF Asef in A431 cells stimulated by EGF. J Cell Sci (2008) 1.10
Multiple decisive phosphorylation sites for the negative feedback regulation of SOS1 via ERK. J Biol Chem (2010) 1.09
Adaptor protein Crk is required for ephrin-B1-induced membrane ruffling and focal complex assembly of human aortic endothelial cells. Mol Biol Cell (2002) 1.09
The pivotal role of the alternative NF-kappaB pathway in maintenance of basal bone homeostasis and osteoclastogenesis. J Bone Miner Res (2010) 1.09
Revolving movement of a dynamic cluster of actin filaments during mitosis. J Cell Biol (2010) 1.08
R-Ras regulates exocytosis by Rgl2/Rlf-mediated activation of RalA on endosomes. Mol Biol Cell (2007) 1.07
Rapid turnover rate of phosphoinositides at the front of migrating MDCK cells. Mol Biol Cell (2008) 1.06
Visualization of growth signal transduction cascades in living cells with genetically encoded probes based on Förster resonance energy transfer. Philos Trans R Soc Lond B Biol Sci (2008) 1.05
Inefficient enhancement of viral infectivity and CD4 downregulation by human immunodeficiency virus type 1 Nef from Japanese long-term nonprogressors. J Virol (2002) 1.05
In vivo fluorescence resonance energy transfer imaging reveals differential activation of Rho-family GTPases in glioblastoma cell invasion. J Cell Sci (2012) 1.05
Local activation of Rap1 contributes to directional vascular endothelial cell migration accompanied by extension of microtubules on which RAPL, a Rap1-associating molecule, localizes. J Biol Chem (2004) 1.05
Interaction of FoxO1 and TSC2 induces insulin resistance through activation of the mammalian target of rapamycin/p70 S6K pathway. J Biol Chem (2006) 1.04
Amelioration of bone loss in collagen-induced arthritis by neutralizing anti-RANKL monoclonal antibody. Biochem Biophys Res Commun (2006) 1.03
Fluorescence (Förster) resonance energy transfer imaging of oncogene activity in living cells. Cancer Sci (2006) 1.03
Live imaging of protein kinase activities in transgenic mice expressing FRET biosensors. Cell Struct Funct (2012) 1.03
Delayed-onset muscle injury and its modification by wheat gluten hydrolysate. Nutrition (2009) 1.03
Spatiotemporal activation of Rac1 for engulfment of apoptotic cells. Proc Natl Acad Sci U S A (2008) 1.03