Published in Nat Immunol on February 26, 2012
Managing diabetes with nanomedicine: challenges and opportunities. Nat Rev Drug Discov (2014) 1.39
Adoptive transfer of immunomodulatory M2 macrophages prevents type 1 diabetes in NOD mice. Diabetes (2012) 1.25
Defining the transcriptional and cellular landscape of type 1 diabetes in the NOD mouse. PLoS One (2013) 1.21
Noninvasive mapping of pancreatic inflammation in recent-onset type-1 diabetes patients. Proc Natl Acad Sci U S A (2015) 1.00
The role of the complement system in metabolic organs and metabolic diseases. Semin Immunol (2013) 0.95
Advancing biomedical imaging. Proc Natl Acad Sci U S A (2015) 0.91
Epigenetic modulation of type-1 diabetes via a dual effect on pancreatic macrophages and β cells. Elife (2014) 0.91
Monocytes and macrophages as nanomedicinal targets for improved diagnosis and treatment of disease. Expert Rev Mol Diagn (2013) 0.88
Antigen recognition in the islets changes with progression of autoimmune islet infiltration. J Immunol (2014) 0.87
CD8+ dendritic cell-mediated tolerance of autoreactive CD4+ T cells is deficient in NOD mice and can be corrected by blocking CD40L. J Leukoc Biol (2013) 0.84
Limitations of IL-2 and rapamycin in immunotherapy of type 1 diabetes. Diabetes (2013) 0.84
GLP-1R-targeting magnetic nanoparticles for pancreatic islet imaging. Diabetes (2014) 0.83
Insulinoma-released exosomes activate autoreactive marginal zone-like B cells that expand endogenously in prediabetic NOD mice. Eur J Immunol (2013) 0.83
DCIR2+ cDC2 DCs and Zbtb32 Restore CD4+ T-Cell Tolerance and Inhibit Diabetes. Diabetes (2015) 0.82
Targeting GLP-1 receptors for repeated magnetic resonance imaging differentiates graded losses of pancreatic beta cells in mice. Diabetologia (2014) 0.82
Bioluminescence imaging reveals dynamics of beta cell loss in the non-obese diabetic (NOD) mouse model. PLoS One (2013) 0.81
The kinetics of plasmacytoid dendritic cell accumulation in the pancreas of the NOD mouse during the early phases of insulitis. PLoS One (2013) 0.81
Nardilysin-dependent proteolysis of cell-associated VTCN1 (B7-H4) marks type 1 diabetes development. Diabetes (2014) 0.80
Anti-serpin antibody-mediated regulation of proteases in autoimmune diabetes. J Biol Chem (2012) 0.79
The unique neonatal NK cells: a critical component required for neonatal autoimmune disease induction by maternal autoantibody. Front Immunol (2014) 0.79
Pathology: Cause and effect. Nature (2012) 0.79
RGS4 inhibits angiotensin II signaling and macrophage localization during renal reperfusion injury independent of vasospasm. Kidney Int (2014) 0.78
Type 1 diabetes genetic susceptibility and dendritic cell function: potential targets for treatment. J Leukoc Biol (2016) 0.78
Nanosized contrast agents to noninvasively detect kidney inflammation by magnetic resonance imaging. Adv Chronic Kidney Dis (2013) 0.78
Identification of Orch3, a locus controlling dominant resistance to autoimmune orchitis, as kinesin family member 1C. PLoS Genet (2012) 0.77
Interleukin-2-mediated inhibition of dendritic cell development correlates with decreased CD135 expression and increased monocyte/macrophage precursors. Immunology (2014) 0.77
Expression profiling pre-diabetic mice to uncover drugs with clinical application to type 1 diabetes. Clin Transl Immunology (2015) 0.75
Rapid, high efficiency isolation of pancreatic ß-cells. Sci Rep (2015) 0.75
Autoimmunity: Fortune tellers. Nat Rev Immunol (2012) 0.75
Solving the plot: early events are the key to diabetes intervention. Nat Immunol (2012) 0.75
Cutting Edge: Origins, Recruitment, and Regulation of CD11c(+) Cells in Inflamed Islets of Autoimmune Diabetes Mice. J Immunol (2017) 0.75
Imaging the emergence and natural progression of spontaneous autoimmune diabetes. Proc Natl Acad Sci U S A (2017) 0.75
GenePattern 2.0. Nat Genet (2006) 29.07
Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol (2009) 25.96
Monocyte and macrophage heterogeneity. Nat Rev Immunol (2005) 24.36
Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med (2000) 19.81
Development of monocytes, macrophages, and dendritic cells. Science (2010) 12.86
Identification of splenic reservoir monocytes and their deployment to inflammatory sites. Science (2009) 10.47
The Immunological Genome Project: networks of gene expression in immune cells. Nat Immunol (2008) 7.23
Following a diabetogenic T cell from genesis through pathogenesis. Cell (1993) 6.46
Identification of Tim4 as a phosphatidylserine receptor. Nature (2007) 6.06
Genetics, pathogenesis and clinical interventions in type 1 diabetes. Nature (2010) 5.16
beta-Cell death during progression to diabetes. Nature (2001) 4.61
Early expression of antiinsulin autoantibodies of humans and the NOD mouse: evidence for early determination of subsequent diabetes. Proc Natl Acad Sci U S A (2000) 3.89
Pancreatic islet autoantibodies as predictors of type 1 diabetes in the Diabetes Prevention Trial-Type 1. Diabetes Care (2009) 2.91
CRIg: a macrophage complement receptor required for phagocytosis of circulating pathogens. Cell (2006) 2.89
Immunohistochemical characterization of monocytes-macrophages and dendritic cells involved in the initiation of the insulitis and beta-cell destruction in NOD mice. Diabetes (1994) 2.17
C-peptide as a measure of the secretion and hepatic extraction of insulin. Pitfalls and limitations. Diabetes (1984) 2.12
Natural killer cells distinguish innocuous and destructive forms of pancreatic islet autoimmunity. Proc Natl Acad Sci U S A (2004) 1.96
Noninvasive imaging of pancreatic islet inflammation in type 1A diabetes patients. J Clin Invest (2010) 1.93
The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors. Proc Natl Acad Sci U S A (2008) 1.85
MHC-linked protection from diabetes dissociated from clonal deletion of T cells. Science (1990) 1.70
Imaging inflammation of the pancreatic islets in type 1 diabetes. Proc Natl Acad Sci U S A (2004) 1.51
VSIG4, a B7 family-related protein, is a negative regulator of T cell activation. J Clin Invest (2006) 1.51
A role of macrophage complement receptor CRIg in immune clearance and inflammation. Mol Immunol (2008) 1.27
A novel inhibitor of the alternative pathway of complement reverses inflammation and bone destruction in experimental arthritis. J Exp Med (2007) 1.22
Insulin autoantibodies are associated with islet inflammation but not always related to diabetes progression in NOD congenic mice. Diabetes (2003) 1.15
Noninvasive imaging of pancreatic inflammation and its reversal in type 1 diabetes. J Clin Invest (2005) 1.14
Cellular and molecular changes accompanying the progression from insulitis to diabetes. Eur J Immunol (1999) 1.12
Complement receptor of the Ig superfamily enhances complement-mediated phagocytosis in a subpopulation of tissue resident macrophages. J Immunol (2008) 0.97
Pancreatic islet blood perfusion in the nonobese diabetic mouse: diabetes-prone female mice exhibit a higher blood flow compared with male mice in the prediabetic phase. Endocrinology (1998) 0.96
Adhesion molecules and microvascular changes in the nonobese diabetic (NOD) mouse pancreas. An NO-inhibitor (L-NAME) is unable to block adhesion inflammation-induced activation. Autoimmunity (1998) 0.94
Th1 and Th2 cytokines exert regulatory effects upon islet microvascular areas in the NOD mouse. J Cell Biochem (2002) 0.94
Down-regulation of Z39Ig on macrophages by IFN-gamma in patients with chronic HBV infection. Clin Immunol (2010) 0.91
Greater permeability of the neonatal lung. Postnatal changes in surface charge and biochemistry of porcine pulmonary capillary endothelium. J Thorac Cardiovasc Surg (1991) 0.89
Inhibition of the alternative pathway of complement activation reduces inflammation in experimental autoimmune uveoretinitis. Eur J Immunol (2010) 0.87
A novel inhibitor of the alternative pathway of complement attenuates intestinal ischemia/reperfusion-induced injury. J Surg Res (2009) 0.86
Expansion of a unique macrophage subset in rheumatoid arthritis synovial lining layer. Clin Exp Immunol (2008) 0.85
Induction of T cells suppression by dendritic cells transfected with VSIG4 recombinant adenovirus. Immunol Lett (2009) 0.85
MR lymphography: study of a high-efficiency lymphotrophic agent. Radiology (1994) 0.85
Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers. Nat Med (2008) 14.47
Restoration of p53 function leads to tumour regression in vivo. Nature (2007) 12.62
Projection of an immunological self shadow within the thymus by the aire protein. Science (2002) 12.15
The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. J Exp Med (2007) 11.51
Identification of splenic reservoir monocytes and their deployment to inflammatory sites. Science (2009) 10.47
Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med (2009) 9.71
Looking and listening to light: the evolution of whole-body photonic imaging. Nat Biotechnol (2005) 9.57
FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell (2006) 9.24
Noninvasive detection of clinically occult lymph-node metastases in prostate cancer. N Engl J Med (2003) 9.09
Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity (2010) 8.90
Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata. J Clin Invest (2007) 8.65
Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell (2012) 7.36
The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells. J Exp Med (2008) 6.07
Fluorescence imaging with near-infrared light: new technological advances that enable in vivo molecular imaging. Eur Radiol (2002) 6.06
Codon-optimized Gaussia luciferase cDNA for mammalian gene expression in culture and in vivo. Mol Ther (2005) 6.04
Gut immune maturation depends on colonization with a host-specific microbiota. Cell (2012) 5.91
Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse. Proc Natl Acad Sci U S A (2006) 5.90
Mast cells: a cellular link between autoantibodies and inflammatory arthritis. Science (2002) 5.82
Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature. Immunity (2007) 5.67
Fluorescence molecular tomography resolves protease activity in vivo. Nat Med (2002) 5.53
The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies. Cancer Cell (2006) 5.34
Arthritis critically dependent on innate immune system players. Immunity (2002) 5.31
Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell (2002) 5.11
The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha. Cell (2010) 5.11
Cytokine requirements for acute and Basal homeostatic proliferation of naive and memory CD8+ T cells. J Exp Med (2002) 5.09
Stability of the regulatory T cell lineage in vivo. Science (2010) 4.89
The cellular mechanism of Aire control of T cell tolerance. Immunity (2005) 4.74
Myocardial infarction accelerates atherosclerosis. Nature (2012) 4.48
Aire. Annu Rev Immunol (2009) 4.43
PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells. Nature (2012) 4.31
Chip-NMR biosensor for detection and molecular analysis of cells. Nat Med (2008) 4.29
Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo. Circulation (2007) 4.20
Local proliferation dominates lesional macrophage accumulation in atherosclerosis. Nat Med (2013) 4.14
Magnetic relaxation switches capable of sensing molecular interactions. Nat Biotechnol (2002) 4.13
Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo. Proc Natl Acad Sci U S A (2004) 4.12
Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy. Nat Med (2012) 4.11
Foxp3+ regulatory T cells: differentiation, specification, subphenotypes. Nat Immunol (2009) 4.07
A spatially and temporally restricted mouse model of soft tissue sarcoma. Nat Med (2007) 3.96
Therapeutic siRNA silencing in inflammatory monocytes in mice. Nat Biotechnol (2011) 3.95
Tetrazine-based cycloadditions: application to pretargeted live cell imaging. Bioconjug Chem (2008) 3.93
Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation. Immunity (2006) 3.92
Nanoparticle PET-CT imaging of macrophages in inflammatory atherosclerosis. Circulation (2007) 3.85
Fast and sensitive pretargeted labeling of cancer cells through a tetrazine/trans-cyclooctene cycloaddition. Angew Chem Int Ed Engl (2009) 3.63
Noninvasive vascular cell adhesion molecule-1 imaging identifies inflammatory activation of cells in atherosclerosis. Circulation (2006) 3.57
CD4+CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion. J Exp Med (2004) 3.57
Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic mice. Proc Natl Acad Sci U S A (2011) 3.55
Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease. Circulation (2007) 3.51
Adaptation of TCR repertoires to self-peptides in regulatory and nonregulatory CD4+ T cells. J Immunol (2007) 3.47
Molecular imaging in drug discovery and development. Nat Rev Drug Discov (2003) 3.44
Monocyte accumulation in mouse atherogenesis is progressive and proportional to extent of disease. Proc Natl Acad Sci U S A (2006) 3.38
Multifunctional magnetic nanoparticles for targeted imaging and therapy. Adv Drug Deliv Rev (2008) 3.34
A secreted luciferase for ex vivo monitoring of in vivo processes. Nat Methods (2008) 3.31
Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells. Immunity (2008) 3.25
How antibodies to a ubiquitous cytoplasmic enzyme may provoke joint-specific autoimmune disease. Nat Immunol (2002) 3.20
Intravital imaging. Cell (2011) 3.18
Antigen persistence is required throughout the expansion phase of a CD4(+) T cell response. J Exp Med (2005) 3.14
A special population of regulatory T cells potentiates muscle repair. Cell (2013) 3.09
A comprehensive review of interventions in the NOD mouse and implications for translation. Immunity (2005) 3.07
Critical roles for interleukin 1 and tumor necrosis factor alpha in antibody-induced arthritis. J Exp Med (2002) 2.98
Physiological beta cell death triggers priming of self-reactive T cells by dendritic cells in a type-1 diabetes model. J Exp Med (2003) 2.94
Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis. J Exp Med (2012) 2.92
Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells. J Exp Med (2004) 2.92
Multivalent effects of RGD peptides obtained by nanoparticle display. J Med Chem (2006) 2.91
MicroRNA-21 knockdown disrupts glioma growth in vivo and displays synergistic cytotoxicity with neural precursor cell delivered S-TRAIL in human gliomas. Cancer Res (2007) 2.90
Impaired infarct healing in atherosclerotic mice with Ly-6C(hi) monocytosis. J Am Coll Cardiol (2010) 2.90
Near-infrared fluorescence: application to in vivo molecular imaging. Curr Opin Chem Biol (2009) 2.89
Cre-mediated cell ablation contests mast cell contribution in models of antibody- and T cell-mediated autoimmunity. Immunity (2011) 2.87
An X-ray computed tomography imaging agent based on long-circulating bismuth sulphide nanoparticles. Nat Mater (2006) 2.84
Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire. J Exp Med (2007) 2.84
Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells. Proc Natl Acad Sci U S A (2006) 2.83
Ultrasensitive clinical enumeration of rare cells ex vivo using a micro-hall detector. Sci Transl Med (2012) 2.82