A genome-wide association study identifies rs2000999 as a strong genetic determinant of circulating haptoglobin levels.

PubWeight™: 0.89‹?›

🔗 View Article (PMC 3293812)

Published in PLoS One on March 05, 2012

Authors

Philippe Froguel1, Ndeye Coumba Ndiaye, Amélie Bonnefond, Nabila Bouatia-Naji, Aurélie Dechaume, Gérard Siest, Bernard Herbeth, Mario Falchi, Leonardo Bottolo, Rosa-Maria Guéant-Rodriguez, Cécile Lecoeur, Michel R Langlois, Yann Labrune, Aimo Ruokonen, Said El Shamieh, Maria G Stathopoulou, Anita Morandi, Claudio Maffeis, David Meyre, Joris R Delanghe, Peter Jacobson, Lars Sjöström, Lena M S Carlsson, Andrew Walley, Paul Elliott, Marjo-Riita Jarvelin, George V Dedoussis, Sophie Visvikis-Siest

Author Affiliations

1: Centre National de la Recherche Scientifique (CNRS) 8199 - Institute of Biology, Pasteur Institute, Lille 2 University, Lille, France.

Articles cited by this

PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet (2007) 209.92

Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem (1972) 95.79

Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21

Acute-phase proteins and other systemic responses to inflammation. N Engl J Med (1999) 18.25

Programs for Pedigree Analysis: MENDEL, FISHER, and dGENE. Genet Epidemiol (1988) 13.73

Use of multiple biomarkers to improve the prediction of death from cardiovascular causes. N Engl J Med (2008) 7.33

Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study. JAMA (2003) 6.60

The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease. JAMA (2005) 6.49

Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr (2004) 6.31

Extensions to pedigree analysis. III. Variance components by the scoring method. Ann Hum Genet (1976) 5.86

Novel and conventional biomarkers for prediction of incident cardiovascular events in the community. JAMA (2009) 5.52

A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk. Nat Genet (2008) 5.49

Coronary risk factors measured in childhood and young adult life are associated with coronary artery calcification in young adults: the Muscatine Study. J Am Coll Cardiol (1996) 4.92

Body Mass Index variations: centiles from birth to 87 years. Eur J Clin Nutr (1991) 4.60

A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels. Science (2008) 4.38

Biological and clinical significance of haptoglobin polymorphism in humans. Clin Chem (1996) 4.02

Haptoglobin: the evolutionary product of duplication, unequal crossing over, and point mutation. Adv Hum Genet (1982) 2.42

Nucleotide sequence of the haptoglobin and haptoglobin-related gene pair. The haptoglobin-related gene contains a retrovirus-like element. J Biol Chem (1985) 2.00

Genetically determined heterogeneity in hemoglobin scavenging and susceptibility to diabetic cardiovascular disease. Circ Res (2003) 1.99

Haptoglobin, inflammation and disease. Trans R Soc Trop Med Hyg (2008) 1.94

Genotyping of the common haptoglobin Hp 1/2 polymorphism based on PCR. Clin Chem (2002) 1.90

Ecological and individual predictors of birthweight in a northern Finland birth cohort 1986. Paediatr Perinat Epidemiol (1997) 1.85

Consensus of a group of professional societies and diagnostic companies on guidelines for interim reference ranges for 14 proteins in serum based on the standardization against the IFCC/BCR/CAP Reference Material (CRM 470). International Federation of Clinical Chemistry. Community Bureau of Reference of the Commission of the European Communities. College of American Pathologists. Eur J Clin Chem Clin Biochem (1996) 1.75

Haptoglobin genotype- and diabetes-dependent differences in iron-mediated oxidative stress in vitro and in vivo. Circ Res (2005) 1.71

Haptoglobin phenotype and vascular complications in patients with diabetes. N Engl J Med (2000) 1.23

The STANISLAS Cohort: a 10-year follow-up of supposed healthy families. Gene-environment interactions, reference values and evaluation of biomarkers in prevention of cardiovascular diseases. Clin Chem Lab Med (2008) 1.19

ALK7 expression is specific for adipose tissue, reduced in obesity and correlates to factors implicated in metabolic disease. Biochem Biophys Res Commun (2009) 1.19

Haptoglobin polymorphism, iron metabolism and mortality in HIV infection. AIDS (1998) 1.14

The haptoglobin-gene deletion responsible for anhaptoglobinemia. Am J Hum Genet (1998) 1.11

A multivariate analysis of family data. Am J Epidemiol (1981) 1.11

Modeling of environmental effects in genome-wide association studies identifies SLC2A2 and HP as novel loci influencing serum cholesterol levels. PLoS Genet (2010) 1.10

Inflammatory markers, lipoprotein components and risk of major cardiovascular events in 65,005 men and women in the Apolipoprotein MOrtality RISk study (AMORIS). Atherosclerosis (2010) 1.08

Associations between haptoglobin polymorphism, lipids, lipoproteins and inflammatory variables. Atherosclerosis (1999) 0.99

Analysis of haptoglobin and hemoglobin-haptoglobin interactions with the Neisseria meningitidis TonB-dependent receptor HpuAB by flow cytometry. Infect Immun (2004) 0.96

Haptoglobin polymorphism and infection. Adv Clin Chem (2010) 0.95

The Gene-Diet Attica investigation on childhood obesity (GENDAI): overview of the study design. Clin Chem Lab Med (2007) 0.92

Iron, haptoglobin phenotype, and HIV-1 viral load: a cross-sectional study among pregnant Zimbabwean women. J Acquir Immune Defic Syndr (2003) 0.90

Haptoglobin binds apolipoprotein E and influences cholesterol esterification in the cerebrospinal fluid. J Neurochem (2009) 0.88

Haptoglobin inhibits lecithin-cholesterol acyltransferase in human ovarian follicular fluid. Mol Reprod Dev (2001) 0.88

Analysis of the affinity of each haptoglobin polymer for hemoglobin by two-dimensional affinity electrophoresis. Clin Chim Acta (1997) 0.87

The haptoglobin 2-2 genotype is associated with carotid atherosclerosis in 64-year old women with established diabetes. Clin Chim Acta (2010) 0.87

Haptoglobin and risk of myocardial infarction, stroke, and congestive heart failure in 342,125 men and women in the Apolipoprotein MOrtality RISk study (AMORIS). Ann Med (2009) 0.85

Haptoglobin phenotype appears to affect the pathogenesis of American trypanosomiasis. Ann Trop Med Parasitol (2006) 0.85

Biochemical and bioimaging markers for risk assessment and diagnosis in major cardiovascular diseases: a road to integration of complementary diagnostic tools. J Intern Med (2007) 0.85

Reference distributions for the positive acute phase serum proteins, alpha1-acid glycoprotein (orosomucoid), alpha1-antitrypsin, and haptoglobin: a practical, simple, and clinically relevant approach in a large cohort. J Clin Lab Anal (2000) 0.85

[Decrease of haptoglobin serum level in patients with chronic viral hepatitis C]. Gastroenterol Clin Biol (1993) 0.84

Routine hematologic clinical tests as prognostic markers in patients with acute coronary syndromes. Am Heart J (2008) 0.84

Effect of haptoglobin phenotypes on growth of Streptococcus pyogenes. Clin Chem Lab Med (1998) 0.80

Haptoglobin polymorphism and chronic hepatitis C. J Hepatol (1996) 0.78

Hypohaptoglobinaemia as a biochemical and epidemiological marker of falciparum malaria. J Assoc Physicians India (1999) 0.78

The haptoglobin phenotype is associated with the Epstein-Barr virus antibody titer. Clin Chem Lab Med (2009) 0.77

[Results of the treatment of patients with recurrence of pulmonary tuberculosis with different types of haptoglobin]. Probl Tuberk (1995) 0.77

Association between Cys282Tyr missense mutation and haptoglobin phenotype polymorphism in patients with chronic hepatitis C. Eur J Gastroenterol Hepatol (2001) 0.77

Articles by these authors

A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39

A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature (2007) 35.08

Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21

A fine-scale map of recombination rates and hotspots across the human genome. Science (2005) 26.82

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35

Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01

Effects of bariatric surgery on mortality in Swedish obese subjects. N Engl J Med (2007) 18.45

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89

Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27

Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94

Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet (2007) 13.62

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25

Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44

Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat Genet (2008) 12.32

Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Nat Genet (2008) 12.07

Variants in MTNR1B influence fasting glucose levels. Nat Genet (2008) 10.85

Repeatability of published microarray gene expression analyses. Nat Genet (2008) 8.24

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94

Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia. Am J Hum Genet (2008) 7.33

Bariatric surgery and long-term cardiovascular events. JAMA (2012) 7.11

Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study. Lancet Neurol (2008) 6.76

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet (2010) 6.66

Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. Nat Genet (2009) 6.39

A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. Nat Genet (2009) 6.31

Bariatric surgery and prevention of type 2 diabetes in Swedish obese subjects. N Engl J Med (2012) 6.19

Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides. Nat Genet (2008) 6.06

Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet (2009) 5.81

Effect of lower sodium intake on health: systematic review and meta-analyses. BMJ (2013) 5.78

Aircraft noise and cardiovascular disease near Heathrow airport in London: small area study. BMJ (2013) 5.74

Common genetic variation near MC4R is associated with waist circumference and insulin resistance. Nat Genet (2008) 5.55

A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk. Nat Genet (2008) 5.49

Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. Nat Genet (2009) 5.43

Human metabolic phenotype diversity and its association with diet and blood pressure. Nature (2008) 5.41

Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia. N Engl J Med (2005) 5.38

XENical in the prevention of diabetes in obese subjects (XENDOS) study: a randomized study of orlistat as an adjunct to lifestyle changes for the prevention of type 2 diabetes in obese patients. Diabetes Care (2004) 5.34

Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease. JAMA (2009) 5.32

Salt intakes around the world: implications for public health. Int J Epidemiol (2009) 5.05

A genome-wide association study identifies protein quantitative trait loci (pQTLs). PLoS Genet (2008) 4.75

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet (2012) 4.73

GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. Science (2013) 4.71

Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes. Am J Hum Genet (2008) 4.69

Size matters: just how big is BIG?: Quantifying realistic sample size requirements for human genome epidemiology. Int J Epidemiol (2008) 4.53

Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes. Nat Genet (2005) 4.44

A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels. Science (2008) 4.38

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet (2012) 4.37

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet (2014) 4.13

Genome-wide association study identifies five loci associated with lung function. Nat Genet (2009) 4.10

Genetic variants influencing circulating lipid levels and risk of coronary artery disease. Arterioscler Thromb Vasc Biol (2010) 4.08

Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes (2010) 4.07

Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. PLoS Med (2011) 3.94

Interpreting posterior relative risk estimates in disease-mapping studies. Environ Health Perspect (2004) 3.81

Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI. Diabetes (2008) 3.76