Published in Genes Dev on March 19, 2012
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Haploinsufficiency screen highlights two distinct groups of ribosomal protein genes essential for embryonic stem cell fate. Proc Natl Acad Sci U S A (2015) 0.78
Inactivation of Eed impedes MLL-AF9-mediated leukemogenesis through Cdkn2a-dependent and Cdkn2a-independent mechanisms in a murine model. Exp Hematol (2015) 0.78
Mechanisms of epigenetic regulation of leukemia onset and progression. Adv Immunol (2013) 0.77
Inhibition of EZH2 expression is associated with the proliferation, apoptosis, and migration of SW620 colorectal cancer cells in vitro. Exp Biol Med (Maywood) (2014) 0.77
Depletion of the chromatin remodeler CHD4 sensitizes AML blasts to genotoxic agents and reduces tumor formation. Blood (2015) 0.77
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Loss of Ezh2 cooperates with Jak2V617F in the development of myelofibrosis in a mouse model of myeloproliferative neoplasm. Blood (2016) 0.76
Inhibition of EZH2 expression is associated with the proliferation, apoptosis and migration of SW620 colorectal cancer cells in vitro. Exp Biol Med (Maywood) (2015) 0.76
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Downregulation of Enhancer of Zeste Homolog 2 (EZH2) is essential for the Induction of Autophagy and Apoptosis in Colorectal Cancer Cells. Genes (Basel) (2016) 0.76
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Dnmt3a regulates T-cell development and suppresses T-ALL transformation. Leukemia (2017) 0.75
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Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity. EMBO J (2004) 7.32
EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. Mol Cell (2008) 6.86
Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes. Nat Genet (2010) 4.90
The murine polycomb group protein Eed is required for global histone H3 lysine-27 methylation. Curr Biol (2005) 4.52
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Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation. Blood (2010) 4.02
Polycomb group protein ezh2 controls actin polymerization and cell signaling. Cell (2005) 3.01
Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia. Nat Med (2012) 2.86
Polycomb group proteins set the stage for early lineage commitment. Cell Stem Cell (2010) 2.83
Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A. Blood (2011) 2.47
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RNA-seq analysis of 2 closely related leukemia clones that differ in their self-renewal capacity. Blood (2010) 1.17
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The Polycomb-group gene eed regulates thymocyte differentiation and suppresses the development of carcinogen-induced T-cell lymphomas. Oncogene (2002) 0.99
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A comprehensive map of the mTOR signaling network. Mol Syst Biol (2010) 1.59
Genomewide location analysis of Candida albicans Upc2p, a regulator of sterol metabolism and azole drug resistance. Eukaryot Cell (2008) 1.56
Tandem autologous-allogeneic nonmyeloablative sibling transplantation in relapsed follicular lymphoma leads to impressive progression-free survival with minimal toxicity. Biol Blood Marrow Transplant (2011) 1.55
An RNAi screen identifies Msi2 and Prox1 as having opposite roles in the regulation of hematopoietic stem cell activity. Cell Stem Cell (2010) 1.52
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Identification of a conserved RNA motif essential for She2p recognition and mRNA localization to the yeast bud. Mol Cell Biol (2005) 1.46
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The MHC class I peptide repertoire is molded by the transcriptome. J Exp Med (2008) 1.31
Deregulated expression of HOXB4 enhances the primitive growth activity of human hematopoietic cells. Blood (2002) 1.30
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The methyltransferase G9a regulates HoxA9-dependent transcription in AML. Genes Dev (2014) 1.23
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Tumor suppressor and deubiquitinase BAP1 promotes DNA double-strand break repair. Proc Natl Acad Sci U S A (2013) 1.21
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RNA-seq analysis of 2 closely related leukemia clones that differ in their self-renewal capacity. Blood (2010) 1.17
An anticlastogenic function for the Polycomb Group gene Bmi1. Proc Natl Acad Sci U S A (2011) 1.17
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The competitive nature of HOXB4-transduced HSC is limited by PBX1: the generation of ultra-competitive stem cells retaining full differentiation potential. Immunity (2003) 1.14
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Oncogenic interaction between BCR-ABL and NUP98-HOXA9 demonstrated by the use of an in vitro purging culture system. Blood (2002) 1.11
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Identification of cooperative genes for NUP98-HOXA9 in myeloid leukemogenesis using a mouse model. Blood (2004) 1.09
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Growth factor independence 1 protects hematopoietic stem cells against apoptosis but also prevents the development of a myeloproliferative-like disease. Stem Cells (2011) 1.07
Polycomb group genes: keeping stem cell activity in balance. PLoS Biol (2008) 1.05
Essential role of BRG, the ATPase subunit of BAF chromatin remodeling complexes, in leukemia maintenance. Blood (2014) 1.04
The signaling protein Wnt4 enhances thymopoiesis and expands multipotent hematopoietic progenitors through beta-catenin-independent signaling. Immunity (2008) 1.04
E4F1: a novel candidate factor for mediating BMI1 function in primitive hematopoietic cells. Genes Dev (2006) 1.04
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