Published in EMBO J on September 23, 2004
Control of developmental regulators by Polycomb in human embryonic stem cells. Cell (2006) 28.21
Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes Dev (2006) 14.36
Mechanisms of polycomb gene silencing: knowns and unknowns. Nat Rev Mol Cell Biol (2009) 9.29
The polycomb group protein Suz12 is required for embryonic stem cell differentiation. Mol Cell Biol (2007) 8.57
Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer. Science (2008) 7.59
Control of the embryonic stem cell state. Cell (2011) 6.89
Genome-wide identification of polycomb-associated RNAs by RIP-seq. Mol Cell (2010) 6.88
EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. Mol Cell (2008) 6.86
The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells. Genes Dev (2007) 6.77
Suz12 binds to silenced regions of the genome in a cell-type-specific manner. Genome Res (2006) 6.75
Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. Genes Dev (2007) 6.71
Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells. Cell (2009) 5.26
Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms. Mol Cell (2008) 4.44
JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells. Nature (2010) 4.35
Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer. Cell Stem Cell (2010) 4.18
Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing. EMBO J (2006) 4.16
H2AZ is enriched at polycomb complex target genes in ES cells and is necessary for lineage commitment. Cell (2008) 3.90
Polycomb repressive complex 2 is dispensable for maintenance of embryonic stem cell pluripotency. Stem Cells (2008) 3.81
Occupying chromatin: Polycomb mechanisms for getting to genomic targets, stopping transcriptional traffic, and staying put. Mol Cell (2013) 3.50
Control of differentiation in a self-renewing mammalian tissue by the histone demethylase JMJD3. Genes Dev (2008) 3.32
Deconstructing repression: evolving models of co-repressor action. Nat Rev Genet (2010) 3.29
Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2. Genes Dev (2008) 3.10
Insights into GATA-1-mediated gene activation versus repression via genome-wide chromatin occupancy analysis. Mol Cell (2009) 3.05
Epigenetic modifications in pluripotent and differentiated cells. Nat Biotechnol (2010) 3.02
Cell type-specific DNA methylation patterns in the human breast. Proc Natl Acad Sci U S A (2008) 2.99
Transcriptional regulation by Polycomb group proteins. Nat Struct Mol Biol (2013) 2.96
Ezh2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation in vivo. Mol Cell Biol (2008) 2.93
A double take on bivalent promoters. Genes Dev (2013) 2.79
RYBP-PRC1 complexes mediate H2A ubiquitylation at polycomb target sites independently of PRC2 and H3K27me3. Cell (2012) 2.77
Polycomb complex 2 is required for E-cadherin repression by the Snail1 transcription factor. Mol Cell Biol (2008) 2.57
Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators. Nat Cell Biol (2010) 2.55
Regulation of stem cell pluripotency and differentiation involves a mutual regulatory circuit of the NANOG, OCT4, and SOX2 pluripotency transcription factors with polycomb repressive complexes and stem cell microRNAs. Stem Cells Dev (2009) 2.40
Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes. Nucleic Acids Res (2010) 2.37
Polycomb group complexes--many combinations, many functions. Trends Cell Biol (2009) 2.36
AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes. Cancer Cell (2014) 2.33
esBAF facilitates pluripotency by conditioning the genome for LIF/STAT3 signalling and by regulating polycomb function. Nat Cell Biol (2011) 2.29
CTCF regulates allelic expression of Igf2 by orchestrating a promoter-polycomb repressive complex 2 intrachromosomal loop. Mol Cell Biol (2008) 2.24
Variant PRC1 complex-dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation. Cell (2014) 2.20
Topologically associating domains are stable units of replication-timing regulation. Nature (2014) 2.17
Histone lysine demethylases as targets for anticancer therapy. Nat Rev Drug Discov (2013) 2.16
Role of hPHF1 in H3K27 methylation and Hox gene silencing. Mol Cell Biol (2007) 2.10
NuRD-mediated deacetylation of H3K27 facilitates recruitment of Polycomb Repressive Complex 2 to direct gene repression. EMBO J (2011) 2.09
Antagonism between DNA and H3K27 methylation at the imprinted Rasgrf1 locus. PLoS Genet (2008) 2.08
Statistical analysis of the genomic distribution and correlation of regulatory elements in the ENCODE regions. Genome Res (2007) 2.03
Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus. EMBO J (2007) 1.99
Chromatin modifiers and remodellers: regulators of cellular differentiation. Nat Rev Genet (2013) 1.98
Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2). Proc Natl Acad Sci U S A (2010) 1.96
Nucleosome binding and histone methyltransferase activity of Drosophila PRC2. EMBO Rep (2005) 1.95
miR-101 is down-regulated in glioblastoma resulting in EZH2-induced proliferation, migration, and angiogenesis. Oncotarget (2010) 1.92
Erk1/2 activity promotes chromatin features and RNAPII phosphorylation at developmental promoters in mouse ESCs. Cell (2014) 1.85
Subunit contributions to histone methyltransferase activities of fly and worm polycomb group complexes. Mol Cell Biol (2005) 1.78
A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia. Genes Dev (2012) 1.75
The histone variant macroH2A is an epigenetic regulator of key developmental genes. Nat Struct Mol Biol (2009) 1.75
Polycomb-like 2 associates with PRC2 and regulates transcriptional networks during mouse embryonic stem cell self-renewal and differentiation. Cell Stem Cell (2010) 1.74
Ubiquitin E3 ligase Ring1b/Rnf2 of polycomb repressive complex 1 contributes to stable maintenance of mouse embryonic stem cells. PLoS One (2008) 1.72
Retinoblastoma tumor suppressor protein-dependent methylation of histone H3 lysine 27 is associated with irreversible cell cycle exit. J Cell Biol (2007) 1.72
Roles of the Polycomb group proteins in stem cells and cancer. Cell Death Dis (2011) 1.70
Derepression of Polycomb targets during pancreatic organogenesis allows insulin-producing beta-cells to adopt a neural gene activity program. Genome Res (2010) 1.68
UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic development. PLoS Genet (2012) 1.67
PRC2 directly methylates GATA4 and represses its transcriptional activity. Genes Dev (2012) 1.66
Distinct histone modifications in stem cell lines and tissue lineages from the early mouse embryo. Proc Natl Acad Sci U S A (2010) 1.64
Kdm2b maintains murine embryonic stem cell status by recruiting PRC1 complex to CpG islands of developmental genes. Nat Cell Biol (2013) 1.61
The placenta: transcriptional, epigenetic, and physiological integration during development. J Clin Invest (2010) 1.61
The N terminus of Drosophila ESC binds directly to histone H3 and is required for E(Z)-dependent trimethylation of H3 lysine 27. Mol Cell Biol (2007) 1.60
PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies. Nature (2014) 1.60
Dominant alleles identify SET domain residues required for histone methyltransferase of Polycomb repressive complex 2. J Biol Chem (2008) 1.58
Polycomb repressive complex 2 (PRC2) restricts hematopoietic stem cell activity. PLoS Biol (2008) 1.53
Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation. Nat Struct Mol Biol (2012) 1.52
Epithelial cell adhesion molecule regulation is associated with the maintenance of the undifferentiated phenotype of human embryonic stem cells. J Biol Chem (2010) 1.52
Chromatin regulatory mechanisms in pluripotency. Annu Rev Cell Dev Biol (2010) 1.51
O-GlcNAc cycling: emerging roles in development and epigenetics. Semin Cell Dev Biol (2010) 1.50
Jarid1b targets genes regulating development and is involved in neural differentiation. EMBO J (2011) 1.50
Bivalent histone modifications in early embryogenesis. Curr Opin Cell Biol (2012) 1.48
The Polycomb complex PRC2 supports aberrant self-renewal in a mouse model of MLL-AF9;Nras(G12D) acute myeloid leukemia. Oncogene (2012) 1.46
The Polycomb group protein EZH2 impairs DNA repair in breast epithelial cells. Neoplasia (2005) 1.42
Epigenetic control of embryonic stem cell fate. J Exp Med (2010) 1.40
PRC2 complexes with JARID2, MTF2, and esPRC2p48 in ES cells to modulate ES cell pluripotency and somatic cell reprogramming. Stem Cells (2011) 1.37
Stable CpG hypomethylation of adipogenic promoters in freshly isolated, cultured, and differentiated mesenchymal stem cells from adipose tissue. Mol Biol Cell (2006) 1.36
Tracking the intermediate stages of epithelial-mesenchymal transition in epithelial stem cells and cancer. Cell Cycle (2011) 1.34
Histone h1 depletion impairs embryonic stem cell differentiation. PLoS Genet (2012) 1.32
Partially redundant functions of two SET-domain polycomb-group proteins in controlling initiation of seed development in Arabidopsis. Proc Natl Acad Sci U S A (2006) 1.32
Huntingtin facilitates polycomb repressive complex 2. Hum Mol Genet (2009) 1.32
Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity. Nat Struct Mol Biol (2012) 1.30
The role of the polycomb complex in silencing alpha-globin gene expression in nonerythroid cells. Blood (2008) 1.28
EZH2: biology, disease, and structure-based drug discovery. Acta Pharmacol Sin (2013) 1.27
Epigenomic reorganization of the clustered Hox genes in embryonic stem cells induced by retinoic acid. J Biol Chem (2010) 1.26
REST-mediated recruitment of polycomb repressor complexes in mammalian cells. PLoS Genet (2012) 1.26
Epigenetic regulation in pluripotent stem cells: a key to breaking the epigenetic barrier. Philos Trans R Soc Lond B Biol Sci (2013) 1.26
The roles of EZH2 in cell lineage commitment. Am J Transl Res (2011) 1.24
EZH2 methyltransferase and H3K27 methylation in breast cancer. Int J Biol Sci (2011) 1.23
Quantitative mass spectrometry of histones H3.2 and H3.3 in Suz12-deficient mouse embryonic stem cells reveals distinct, dynamic post-translational modifications at Lys-27 and Lys-36. Mol Cell Proteomics (2010) 1.23
Choline deficiency alters global histone methylation and epigenetic marking at the Re1 site of the calbindin 1 gene. FASEB J (2009) 1.21
MicroRNA-128 coordinately targets Polycomb Repressor Complexes in glioma stem cells. Neuro Oncol (2013) 1.20
EZH2: not EZHY (easy) to deal. Mol Cancer Res (2014) 1.20
Transcriptional silencing by polycomb-group proteins. Cold Spring Harb Perspect Biol (2014) 1.19
Epigenetic plasticity: a central regulator of epithelial-to-mesenchymal transition in cancer. Oncotarget (2014) 1.19
Recruitment and biological consequences of histone modification of H3K27me3 and H3K9me3. ILAR J (2012) 1.19
The JARID2-PRC2 duality. Genes Dev (2010) 1.18
Yin Yang 1 extends the Myc-related transcription factors network in embryonic stem cells. Nucleic Acids Res (2011) 1.16
Drosophila ESC-like can substitute for ESC and becomes required for Polycomb silencing if ESC is absent. Dev Biol (2007) 1.16
Translating the histone code. Science (2001) 56.77
Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science (2002) 24.31
The polycomb group protein EZH2 is involved in progression of prostate cancer. Nature (2002) 18.30
EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells. Proc Natl Acad Sci U S A (2003) 13.68
Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev (2002) 13.08
Histone methyltransferase activity of a Drosophila Polycomb group repressor complex. Cell (2002) 13.05
Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites. Cell (2002) 12.28
Partitioning and plasticity of repressive histone methylation states in mammalian chromatin. Mol Cell (2003) 11.33
EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer. EMBO J (2003) 9.55
The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3. Curr Opin Genet Dev (2004) 7.89
Stable suppression of tumorigenicity by virus-mediated RNA interference. Cancer Cell (2002) 7.88
The polycomb-group gene Ezh2 is required for early mouse development. Mol Cell Biol (2001) 7.20
E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis. Genes Dev (2001) 6.13
Epigenetic dynamics of imprinted X inactivation during early mouse development. Science (2003) 5.80
Use of chromatin immunoprecipitation to clone novel E2F target promoters. Mol Cell Biol (2001) 5.61
Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3. Mol Cell (2004) 5.06
Related chromosome binding sites for zeste, suppressors of zeste and Polycomb group proteins in Drosophila and their dependence on Enhancer of zeste function. EMBO J (1993) 4.26
Ten different Polycomb group genes are required for spatial control of the abdA and AbdB homeotic products. Development (1992) 3.47
Genetic analysis of the enhancer of zeste locus and its role in gene regulation in Drosophila melanogaster. Genetics (1990) 3.27
The eed mutation disrupts anterior mesoderm production in mice. Development (1995) 3.17
Su(z)12, a novel Drosophila Polycomb group gene that is conserved in vertebrates and plants. Development (2001) 3.06
Polycomb repression: from cellular memory to cellular proliferation and cancer. Biochim Biophys Acta (2002) 2.96
Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development. Development (2003) 2.91
The Polycomb-group gene eed is required for normal morphogenetic movements during gastrulation in the mouse embryo. Development (1998) 2.90
Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors. Proc Natl Acad Sci U S A (2001) 2.54
The Polycomb group--no longer an exclusive club? Curr Opin Genet Dev (2001) 2.05
Polycomb group proteins in cell cycle progression and cancer. Cell Cycle (2004) 1.94
Functional analysis of mouse Polycomb group genes. Cell Mol Life Sci (1998) 1.86
Polycomb group suppressor of zeste 12 links heterochromatin protein 1alpha and enhancer of zeste 2. J Biol Chem (2003) 1.45
Purification of histone methyltransferases from HeLa cells. Methods Enzymol (2004) 1.30
Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes Dev (2006) 14.36
EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer. EMBO J (2003) 9.55
The polycomb group protein Suz12 is required for embryonic stem cell differentiation. Mol Cell Biol (2007) 8.57
UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development. Nature (2007) 8.32
TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity. Nature (2011) 8.31
The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells. Genes Dev (2007) 6.77
A model for transmission of the H3K27me3 epigenetic mark. Nat Cell Biol (2008) 5.55
Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease. Genes Dev (2008) 5.25
H3K79 methylation profiles define murine and human MLL-AF4 leukemias. Cancer Cell (2008) 5.23
The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3. Nature (2006) 4.74
Polycomb group proteins: navigators of lineage pathways led astray in cancer. Nat Rev Cancer (2009) 4.40
JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells. Nature (2010) 4.35
RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3. Cell (2007) 4.34
E2F target genes: unraveling the biology. Trends Biochem Sci (2004) 3.49
Molecular mechanisms and potential functions of histone demethylases. Nat Rev Mol Cell Biol (2012) 3.40
The E2F family: specific functions and overlapping interests. EMBO J (2004) 3.33
BLUEPRINT to decode the epigenetic signature written in blood. Nat Biotechnol (2012) 3.24
Role of the polycomb repressive complex 2 in acute promyelocytic leukemia. Cancer Cell (2007) 3.16
Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2. Genes Dev (2008) 3.10
Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development. Mol Cell Biol (2002) 3.10
The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence. Genes Dev (2009) 3.04
Loss of Geminin induces rereplication in the presence of functional p53. J Cell Biol (2004) 2.97
Transcriptional regulation by Polycomb group proteins. Nat Struct Mol Biol (2013) 2.96
The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation. Cell (2005) 2.85
A functional link between the histone demethylase PHF8 and the transcription factor ZNF711 in X-linked mental retardation. Mol Cell (2010) 2.77
The histone methyltransferase SET8 is required for S-phase progression. J Cell Biol (2007) 2.74
Members of the heat-shock protein 70 family promote cancer cell growth by distinct mechanisms. Genes Dev (2005) 2.67
Polycomb complexes act redundantly to repress genomic repeats and genes. Genes Dev (2010) 2.63
Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity. Mol Cell Biol (2004) 2.61
Polycomb complex 2 is required for E-cadherin repression by the Snail1 transcription factor. Mol Cell Biol (2008) 2.57
Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas. Cancer Cell (2013) 2.50
The emerging functions of histone demethylases. Curr Opin Genet Dev (2008) 2.47
Polycomb group protein-mediated repression of transcription. Trends Biochem Sci (2010) 2.37
Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes. Nucleic Acids Res (2010) 2.37
Histone demethylases in development and disease. Trends Cell Biol (2010) 2.25
DNA methylation: TET proteins-guardians of CpG islands? EMBO Rep (2011) 2.23
Histone lysine demethylases as targets for anticancer therapy. Nat Rev Drug Discov (2013) 2.16
E2F7, a novel E2F featuring DP-independent repression of a subset of E2F-regulated genes. EMBO J (2003) 2.14
Nucleophosmin is required for DNA integrity and p19Arf protein stability. Mol Cell Biol (2005) 2.10
Antagonism between DNA and H3K27 methylation at the imprinted Rasgrf1 locus. PLoS Genet (2008) 2.08
Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus. EMBO J (2007) 1.99
HMGA2 induces pituitary tumorigenesis by enhancing E2F1 activity. Cancer Cell (2006) 1.96
Polycomb group proteins in cell cycle progression and cancer. Cell Cycle (2004) 1.94
Histone methyltransferases in cancer. Semin Cell Dev Biol (2009) 1.93
Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis. EMBO J (2004) 1.88
Fbxl10/Kdm2b recruits polycomb repressive complex 1 to CpG islands and regulates H2A ubiquitylation. Mol Cell (2013) 1.86
Polycomb group protein displacement and gene activation through MSK-dependent H3K27me3S28 phosphorylation. Mol Cell (2010) 1.84
Identification of target genes of the p16INK4A-pRB-E2F pathway. J Biol Chem (2003) 1.83
Tet proteins connect the O-linked N-acetylglucosamine transferase Ogt to chromatin in embryonic stem cells. Mol Cell (2013) 1.78
Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription. Nucleic Acids Res (2005) 1.61
Deregulated E2F activity induces hyperplasia and senescence-like features in the mouse pituitary gland. Mol Cell Biol (2005) 1.61
ATAD2 is a novel cofactor for MYC, overexpressed and amplified in aggressive tumors. Cancer Res (2009) 1.60
Cyclin G recruits PP2A to dephosphorylate Mdm2. Mol Cell (2002) 1.57
NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint. Nat Cell Biol (2009) 1.55
Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation. Nat Struct Mol Biol (2012) 1.52
E2F1 is crucial for E2F-dependent apoptosis. EMBO Rep (2005) 1.51
Jarid1b targets genes regulating development and is involved in neural differentiation. EMBO J (2011) 1.50
Retinoic acid expression associates with enhanced IL-22 production by γδ T cells and innate lymphoid cells and attenuation of intestinal inflammation. J Exp Med (2013) 1.47
A novel repressive E2F6 complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner. J Biol Chem (2004) 1.46
Tet2 facilitates the derepression of myeloid target genes during CEBPα-induced transdifferentiation of pre-B cells. Mol Cell (2012) 1.43
Epigenetic control of embryonic stem cell fate. J Exp Med (2010) 1.40
Genome-wide profiling identifies a DNA methylation signature that associates with TET2 mutations in diffuse large B-cell lymphoma. Haematologica (2013) 1.40
The histone demethylase PHF8 governs retinoic acid response in acute promyelocytic leukemia. Cancer Cell (2013) 1.38
SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation. J Cell Biol (2011) 1.34
The histone methyltransferase and putative oncoprotein MMSET is overexpressed in a large variety of human tumors. Clin Cancer Res (2011) 1.26
89Zr-bevacizumab PET of early antiangiogenic tumor response to treatment with HSP90 inhibitor NVP-AUY922. J Nucl Med (2010) 1.23
Quantitative mass spectrometry of histones H3.2 and H3.3 in Suz12-deficient mouse embryonic stem cells reveals distinct, dynamic post-translational modifications at Lys-27 and Lys-36. Mol Cell Proteomics (2010) 1.23
Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation. Nat Cell Biol (2013) 1.16
A role for the transcription factor HEY1 in glioblastoma. J Cell Mol Med (2008) 1.16
PU.1 target genes undergo Tet2-coupled demethylation and DNMT3b-mediated methylation in monocyte-to-osteoclast differentiation. Genome Biol (2013) 1.13
Suppression of the p53- or pRB-mediated G1 checkpoint is required for E2F-induced S-phase entry. Nat Genet (2002) 1.13
Reduced hepatic tumor incidence in cyclin G1-deficient mice. Hepatology (2003) 1.12
NPAT expression is regulated by E2F and is essential for cell cycle progression. Mol Cell Biol (2003) 1.12
Middle-down hybrid chromatography/tandem mass spectrometry workflow for characterization of combinatorial post-translational modifications in histones. Proteomics (2014) 1.11
The histone demethylase Jarid1b ensures faithful mouse development by protecting developmental genes from aberrant H3K4me3. PLoS Genet (2013) 1.09
The role of p53 and pRB in apoptosis and cancer. Curr Opin Genet Dev (2002) 1.09
The demethylase JMJD2C localizes to H3K4me3-positive transcription start sites and is dispensable for embryonic development. Mol Cell Biol (2014) 1.07
Utx is required for proper induction of ectoderm and mesoderm during differentiation of embryonic stem cells. PLoS One (2013) 1.07
CHD5 is required for neurogenesis and has a dual role in facilitating gene expression and polycomb gene repression. Dev Cell (2013) 1.06
Inhibitors of histone demethylases. Bioorg Med Chem (2011) 1.06
Molecular mechanisms in gliomagenesis. Adv Cancer Res (2005) 1.04
The negative role of cyclin G in ATM-dependent p53 activation. Oncogene (2004) 1.03
The polycomb repressive complex 2 is a potential target of SUMO modifications. PLoS One (2008) 0.99
The novel oral Hsp90 inhibitor NVP-HSP990 exhibits potent and broad-spectrum antitumor activities in vitro and in vivo. Mol Cancer Ther (2012) 0.98
Inhibition of GSK3B bypass drug resistance of p53-null colon carcinomas by enabling necroptosis in response to chemotherapy. Clin Cancer Res (2013) 0.98
Precision mapping of coexisting modifications in histone H3 tails from embryonic stem cells by ETD-MS/MS. Anal Chem (2013) 0.96
Conditional E2F1 activation in transgenic mice causes testicular atrophy and dysplasia mimicking human CIS. Oncogene (2005) 0.96