A role for aberrant protein palmitoylation in FFA-induced ER stress and β-cell death.

PubWeight™: 0.98‹?› | Rank: Top 15%

🔗 View Article (PMC 3378068)

Published in Am J Physiol Endocrinol Metab on March 20, 2012

Authors

Aaron C Baldwin1, Christopher D Green, L Karl Olson, Michael A Moxley, John A Corbett

Author Affiliations

1: Medical College of Wisconsin, 8701 Watertown Plank Rd., Milwaukee, WI 53226, USA.

Articles citing this

Upregulation of phagocyte-like NADPH oxidase by cytokines in pancreatic beta-cells: attenuation of oxidative and nitrosative stress by 2-bromopalmitate. Biochem Pharmacol (2012) 0.93

Lost in translation: endoplasmic reticulum stress and the decline of β-cell health in diabetes mellitus. Diabetes Obes Metab (2013) 0.91

Metformin attenuates palmitate-induced endoplasmic reticulum stress, serine phosphorylation of IRS-1 and apoptosis in rat insulinoma cells. PLoS One (2014) 0.87

Fatty acid-mediated endoplasmic reticulum stress in vivo: differential response to the infusion of Soybean and Lard Oil in rats. Metabolism (2013) 0.87

Lipotoxicity in the pancreatic beta cell: not just survival and function, but proliferation as well? Curr Diab Rep (2014) 0.86

PGC-1α Promoter Methylation in Parkinson's Disease. PLoS One (2015) 0.85

Palmitic acid-induced neuron cell cycle G2/M arrest and endoplasmic reticular stress through protein palmitoylation in SH-SY5Y human neuroblastoma cells. Int J Mol Sci (2014) 0.82

The role of ER stress in lipid metabolism and lipotoxicity. J Lipid Res (2016) 0.81

High glucose exposure promotes activation of protein phosphatase 2A in rodent islets and INS-1 832/13 β-cells by increasing the posttranslational carboxylmethylation of its catalytic subunit. Endocrinology (2013) 0.80

Palmitate induces mRNA translation and increases ER protein load in islet β-cells via activation of the mammalian target of rapamycin pathway. Diabetes (2014) 0.80

Free Fatty acids and their metabolism affect function and survival of podocytes. Front Endocrinol (Lausanne) (2014) 0.79

Glut4 palmitoylation at Cys223 plays a critical role in Glut4 membrane trafficking. Biochem Biophys Res Commun (2015) 0.79

TCF2 attenuates FFA-induced damage in islet β-cells by regulating production of insulin and ROS. Int J Mol Sci (2014) 0.79

Where, How, and When: Positioning Posttranslational Modification Within Type 1 Diabetes Pathogenesis. Curr Diab Rep (2016) 0.79

Xanthohumol improved cognitive flexibility in young mice. Behav Brain Res (2014) 0.78

Endoplasmic reticulum stress in obesity and obesity-related disorders: An expanded view. Metabolism (2016) 0.76

Role of Inflammatory Signaling in the Differential Effects of Saturated and Poly-unsaturated Fatty Acids on Peripheral Circadian Clocks. EBioMedicine (2016) 0.75

Palmitate-induced ER stress increases trastuzumab sensitivity in HER2/neu-positive breast cancer cells. BMC Cancer (2016) 0.75

Articles cited by this

Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract (2009) 25.83

Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. JAMA (2003) 25.44

Biochemistry and molecular cell biology of diabetic complications. Nature (2001) 25.43

Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. Genes Dev (1999) 13.24

Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell (2010) 10.96

Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes. J Clin Invest (2002) 6.48

Palmitoylation: policing protein stability and traffic. Nat Rev Mol Cell Biol (2007) 6.15

Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword? Antioxid Redox Signal (2007) 5.17

Mechanisms of fatty acid-induced inhibition of glucose uptake. J Clin Invest (1994) 5.12

Glucolipotoxicity: fuel excess and beta-cell dysfunction. Endocr Rev (2007) 4.91

Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes. Proc Natl Acad Sci U S A (1998) 4.72

Palmitoylation of intracellular signaling proteins: regulation and function. Annu Rev Biochem (2004) 4.34

Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications. Diabetes (1995) 4.33

Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes. Diabetologia (2007) 4.30

Lipotoxicity: when tissues overeat. Curr Opin Lipidol (2003) 4.20

How obesity causes diabetes: not a tall tale. Science (2005) 3.89

Neutral red uptake assay for the estimation of cell viability/cytotoxicity. Nat Protoc (2008) 3.76

Palmitoylation of ligands, receptors, and intracellular signaling molecules. Sci STKE (2006) 3.56

Toxicity determined in vitro by morphological alterations and neutral red absorption. Toxicol Lett (1985) 3.50

Palmitate-induced apoptosis can occur through a ceramide-independent pathway. J Biol Chem (2001) 3.40

Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis. Endocrinology (2006) 3.12

Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress. Endocrinology (2004) 3.03

Initiation and execution of lipotoxic ER stress in pancreatic beta-cells. J Cell Sci (2008) 2.99

Diabetes and mitochondrial function: role of hyperglycemia and oxidative stress. Toxicol Appl Pharmacol (2006) 2.80

Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death. Endocrinology (2003) 2.76

The palmitoylation machinery is a spatially organizing system for peripheral membrane proteins. Cell (2010) 2.72

Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function. Diabetes (2003) 2.62

Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression. J Biol Chem (1998) 2.59

The on-off story of protein palmitoylation. Trends Cell Biol (2003) 2.58

Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated. Diabetes (2002) 2.58

The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients. Diabetologia (2007) 2.48

Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function. Nat Neurosci (2006) 2.19

Receptor palmitoylation and ubiquitination regulate anthrax toxin endocytosis. J Cell Biol (2006) 2.15

Palmitoylation-dependent protein sorting. J Cell Biol (2007) 2.14

Diabetes associated cell stress and dysfunction: role of mitochondrial and non-mitochondrial ROS production and activity. J Physiol (2007) 2.13

Protein lipidation. FEBS J (2007) 2.10

ER stress and SREBP-1 activation are implicated in beta-cell glucolipotoxicity. J Cell Sci (2005) 2.07

Inhibition of carnitine palmitoyltransferase I augments sphingolipid synthesis and palmitate-induced apoptosis. J Biol Chem (1997) 1.98

Specific inhibition of mitochondrial fatty acid oxidation by 2-bromopalmitate and its coenzyme A and carnitine esters. Biochem J (1972) 1.97

Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants. Proc Natl Acad Sci U S A (1999) 1.94

Modulation of neuronal protein trafficking and function by palmitoylation. Curr Opin Neurobiol (2005) 1.80

Biochemical characterization of a palmitoyl acyltransferase activity that palmitoylates myristoylated proteins. J Biol Chem (1995) 1.79

Lipotoxicity of the pancreatic beta-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids. Diabetes (2001) 1.70

Glucolipotoxicity of the pancreatic beta cell. Biochim Biophys Acta (2009) 1.69

Autoacylation of G protein alpha subunits. J Biol Chem (1996) 1.64

Inhibition of Foxo1 protects pancreatic islet beta-cells against fatty acid and endoplasmic reticulum stress-induced apoptosis. Diabetes (2008) 1.61

On the mechanism of protein palmitoylation. EMBO Rep (2004) 1.52

A subcellular fractionation approach for studying insulin release mechanisms and calcium metabolism in islets of Langerhans. Methods Enzymol (1983) 1.48

Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes. Diabetologia (2010) 1.48

Free fatty acids induce a proinflammatory response in islets via the abundantly expressed interleukin-1 receptor I. Endocrinology (2009) 1.47

Increased fatty acid desaturation and enhanced expression of stearoyl coenzyme A desaturase protects pancreatic beta-cells from lipoapoptosis. Diabetes (2005) 1.46

Interleukin-1 stimulates beta-cell necrosis and release of the immunological adjuvant HMGB1. PLoS Med (2005) 1.45

Differential regulation of the endoplasmic reticulum stress response in pancreatic beta-cells exposed to long-chain saturated and monounsaturated fatty acids. J Endocrinol (2008) 1.41

Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: possible role of oxidative stress. Metabolism (2002) 1.40

Mitochondrial dysfunction is involved in apoptosis induced by serum withdrawal and fatty acids in the beta-cell line INS-1. Endocrinology (2003) 1.32

Free fatty acid-induced reduction in glucose-stimulated insulin secretion: evidence for a role of oxidative stress in vitro and in vivo. Diabetes (2007) 1.26

2-Bromopalmitoyl-CoA and 2-bromopalmitate: promiscuous inhibitors of membrane-bound enzymes. Biochim Biophys Acta (1992) 1.22

Glucose amplifies fatty acid-induced endoplasmic reticulum stress in pancreatic beta-cells via activation of mTORC1. PLoS One (2009) 1.20

Life and death decisions of the pancreatic beta-cell: the role of fatty acids. Clin Sci (Lond) (2007) 1.16

Analysis of DHHC acyltransferases implies overlapping substrate specificity and a two-step reaction mechanism. Traffic (2009) 1.14

Mono-unsaturated fatty acids protect against beta-cell apoptosis induced by saturated fatty acids, serum withdrawal or cytokine exposure. FEBS Lett (2004) 1.13

Chemical chaperones protect from effects of apoptosis-inducing mutation in carbonic anhydrase IV identified in retinitis pigmentosa 17. Proc Natl Acad Sci U S A (2004) 1.13

Evidence against the involvement of oxidative stress in fatty acid inhibition of insulin secretion. Diabetes (2004) 1.12

Reduced endoplasmic reticulum (ER)-to-Golgi protein trafficking contributes to ER stress in lipotoxic mouse beta cells by promoting protein overload. Diabetologia (2009) 1.11

The fat controller: roles of palmitoylation in intracellular protein trafficking and targeting to membrane microdomains (Review). Mol Membr Biol (2008) 1.07

Purification of a protein palmitoyltransferase that acts on H-Ras protein and on a C-terminal N-Ras peptide. J Biol Chem (1996) 1.06

Gene and protein kinase expression profiling of reactive oxygen species-associated lipotoxicity in the pancreatic beta-cell line MIN6. Diabetes (2004) 1.05

Plasma membrane and nuclear localization of G protein coupled receptor kinase 6A. Mol Biol Cell (2007) 1.04

Fatty acid-induced defects in insulin signalling, in myotubes derived from children, are related to ceramide production from palmitate rather than the accumulation of intramyocellular lipid. J Cell Physiol (2007) 1.04

Glucolipotoxicity alters lipid partitioning and causes mitochondrial dysfunction, cholesterol, and ceramide deposition and reactive oxygen species production in INS832/13 ss-cells. Endocrinology (2010) 1.03

Homogeneous insulin and C-Peptide sensors for rapid assessment of insulin and C-peptide secretion by the islets. Diabetes (2010) 1.03

Structural determinants influencing the reaction of cysteine-containing peptides with palmitoyl-coenzyme A and other thioesters. Biochim Biophys Acta (2001) 1.03

Palmitoylation of rhodopsin with S-protein acyltransferase: enzyme catalyzed reaction versus autocatalytic acylation. Biochim Biophys Acta (1998) 1.00

One-step cellular caspase-3/7 assay. Biotechniques (2003) 1.00

Effect of -bromo-palmitate on the oxidation of palmitic acid by rat liver cells. J Biol Chem (1971) 0.96

Palmitate potentiation of glucose-induced insulin release: a study using 2-bromopalmitate. Metabolism (2003) 0.96

Structure-activity studies of cerulenin analogues as protein palmitoylation inhibitors. J Med Chem (1999) 0.95

Peroxisome proliferator-activated receptor alpha-retinoid X receptor agonists induce beta-cell protection against palmitate toxicity. FEBS J (2007) 0.91

Differential regulation of the ER stress response by long-chain fatty acids in the pancreatic beta-cell. Biochem Soc Trans (2008) 0.91

Effect of 2-fluoropalmitate, cerulenin and tunicamycin on the palmitoylation and intracellular translocation of myelin proteolipid protein. Neurochem Res (2002) 0.90

Purification of protein fatty acyltransferase and determination of its distribution and topology. J Biol Chem (1990) 0.85

Inhibitory effects of cerulenin on protein palmitoylation and insulin internalization in rat adipocytes. Biochim Biophys Acta (1995) 0.84

Metabolism of serum-free fatty acids. Fed Proc (1960) 0.76

Articles by these authors

Oct4 expression in adult human stem cells: evidence in support of the stem cell theory of carcinogenesis. Carcinogenesis (2004) 3.66

Histone demethylase UTX-1 regulates C. elegans life span by targeting the insulin/IGF-1 signaling pathway. Cell Metab (2011) 2.22

Regulation of hepatic fatty acid elongase and desaturase expression in diabetes and obesity. J Lipid Res (2006) 1.88

Induction of natural killer cell responses by ectromelia virus controls infection. J Virol (2007) 1.62

The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity. Immunity (2013) 1.49

Interleukin-1 stimulates beta-cell necrosis and release of the immunological adjuvant HMGB1. PLoS Med (2005) 1.45

Insulin secretion by bioactive anthocyanins and anthocyanidins present in fruits. J Agric Food Chem (2005) 1.45

Amelioration of obesity and glucose intolerance in high-fat-fed C57BL/6 mice by anthocyanins and ursolic acid in Cornelian cherry (Cornus mas). J Agric Food Chem (2006) 1.42

Surfactant composition and function in patients with ABCA3 mutations. Pediatr Res (2006) 1.37

Interleukin-1 plus gamma-interferon-induced pancreatic beta-cell dysfunction is mediated by beta-cell nitric oxide production. Diabetes (2002) 1.36

Distinct stress responses of two functional laccases in Cryptococcus neoformans are revealed in the absence of the thiol-specific antioxidant Tsa1. Eukaryot Cell (2005) 1.32

The role of reactive oxygen species and proinflammatory cytokines in type 1 diabetes pathogenesis. Ann N Y Acad Sci (2013) 1.30

The role of nitric oxide and the unfolded protein response in cytokine-induced beta-cell death. Diabetes (2007) 1.28

Glucose regulation of insulin gene expression requires the recruitment of p300 by the beta-cell-specific transcription factor Pdx-1. Mol Endocrinol (2004) 1.25

Posttranslational, translational, and transcriptional responses to nitric oxide stress in Cryptococcus neoformans: implications for virulence. Eukaryot Cell (2006) 1.21

The role and regulation of COX-2 during viral infection. Viral Immunol (2003) 1.20

Isolation of islets of Langerhans from rodent pancreas. Methods Mol Med (2003) 1.14

Systematic prediction of pharmacodynamic drug-drug interactions through protein-protein-interaction network. PLoS Comput Biol (2013) 1.13

Genetic and pharmacologic evidence that calcium-independent phospholipase A2beta regulates virus-induced inducible nitric-oxide synthase expression by macrophages. J Biol Chem (2005) 1.12

Role of fatty acid elongases in determination of de novo synthesized monounsaturated fatty acid species. J Lipid Res (2010) 1.12

Modulation of palmitate-induced endoplasmic reticulum stress and apoptosis in pancreatic β-cells by stearoyl-CoA desaturase and Elovl6. Am J Physiol Endocrinol Metab (2011) 1.08

Coagulation-mediated hypoxia and neutrophil-dependent hepatic injury in rats given lipopolysaccharide and ranitidine. J Pharmacol Exp Ther (2005) 1.06

Role of hepatic fibrin in idiosyncrasy-like liver injury from lipopolysaccharide-ranitidine coexposure in rats. Hepatology (2004) 1.06

Facilitative glucose transporter 9 expression affects glucose sensing in pancreatic beta-cells. Endocrinology (2009) 1.05

PPARgamma ligands induce ER stress in pancreatic beta-cells: ER stress activation results in attenuation of cytokine signaling. Am J Physiol Endocrinol Metab (2004) 1.04

The CDK domain of p21 is a suppressor of IL-1beta-mediated inflammation in activated macrophages. Eur J Immunol (2009) 1.04

Homogeneous insulin and C-Peptide sensors for rapid assessment of insulin and C-peptide secretion by the islets. Diabetes (2010) 1.03

Novel role for calcium-independent phospholipase A(2) in the macrophage antiviral response of inducible nitric-oxide synthase expression. J Biol Chem (2002) 1.03

Soraphen A, an inhibitor of acetyl CoA carboxylase activity, interferes with fatty acid elongation. Biochem Pharmacol (2010) 1.03

Ketamine enhances human neural stem cell proliferation and induces neuronal apoptosis via reactive oxygen species-mediated mitochondrial pathway. Anesth Analg (2013) 1.03

IRE1-dependent activation of AMPK in response to nitric oxide. Mol Cell Biol (2011) 1.00

Midlife gene expressions identify modulators of aging through dietary interventions. Proc Natl Acad Sci U S A (2012) 1.00

ERK activation is required for double-stranded RNA- and virus-induced interleukin-1 expression by macrophages. J Biol Chem (2003) 1.00

Role of MAPK in the regulation of double-stranded RNA- and encephalomyocarditis virus-induced cyclooxygenase-2 expression by macrophages. J Immunol (2006) 0.99

Differential alterations in sympathetic neurotransmission in mesenteric arteries and veins in DOCA-salt hypertensive rats. Auton Neurosci (2003) 0.99

Role of cyclooxygenase-2 in cytokine-induced beta-cell dysfunction and damage by isolated rat and human islets. J Biol Chem (2004) 0.99

Repair of nitric oxide-damaged DNA in beta-cells requires JNK-dependent GADD45alpha expression. J Biol Chem (2009) 0.98

Systems biology in aging: linking the old and the young. Curr Genomics (2012) 0.97

Regulation of cyclooxygenase-2 expression by macrophages in response to double-stranded RNA and viral infection. J Immunol (2003) 0.96

The three-dimensional structural basis of type II hyperprolinemia. J Mol Biol (2012) 0.96

AMP-activated protein kinase attenuates nitric oxide-induced beta-cell death. J Biol Chem (2009) 0.94

Nitric oxides mediates a shift from early necrosis to late apoptosis in cytokine-treated β-cells that is associated with irreversible DNA damage. Am J Physiol Endocrinol Metab (2009) 0.94

Activation of autophagy through modulation of 5'-AMP-activated protein kinase protects pancreatic beta-cells from high glucose. Biochem J (2010) 0.93

CoCiter: an efficient tool to infer gene function by assessing the significance of literature co-citation. PLoS One (2013) 0.93

Role for c-Jun N-terminal kinase in beta-cell recovery from nitric oxide-mediated damage. Endocrinology (2003) 0.91

Do β-cells generate peroxynitrite in response to cytokine treatment? J Biol Chem (2013) 0.91

Elevated insulin secretion from liver X receptor-activated pancreatic beta-cells involves increased de novo lipid synthesis and triacylglyceride turnover. Endocrinology (2009) 0.91

FoxO1 and SIRT1 regulate beta-cell responses to nitric oxide. J Biol Chem (2011) 0.90

Glucose-induced activation of glucose uptake in cells from the inner and outer blood-retinal barrier. Invest Ophthalmol Vis Sci (2002) 0.90

Flavin redox switching of protein functions. Antioxid Redox Signal (2010) 0.90

Zinc induces ERK-dependent cell death through a specific Ras isoform. Apoptosis (2006) 0.90

Ketamine induces toxicity in human neurons differentiated from embryonic stem cells via mitochondrial apoptosis pathway. Curr Drug Saf (2012) 0.90

Glucose-modulated tyrosine nitration in beta cells: targets and consequences. Arch Biochem Biophys (2009) 0.89

Coordinate regulation of DNA damage and type I interferon responses imposes an antiviral state that attenuates mouse gammaherpesvirus type 68 replication in primary macrophages. J Virol (2012) 0.89

Enhanced rat islet function and survival in vitro using a biomimetic self-assembled nanomatrix gel. Tissue Eng Part A (2010) 0.89

Encephalomyocarditis virus induces PKR-independent mitogen-activated protein kinase activation in macrophages. J Virol (2005) 0.89

Differential responses of pancreatic β-cells to ROS and RNS. Am J Physiol Endocrinol Metab (2013) 0.87

Calcium-independent phospholipase A2 mediates CREB phosphorylation in double-stranded RNA-stimulated endothelial cells. J Lipid Res (2003) 0.87

Stress-associated H3K4 methylation accumulates during postnatal development and aging of rhesus macaque brain. Aging Cell (2012) 0.87

Epigenomics and the regulation of aging. Epigenomics (2013) 0.87

Elevated glucose attenuates human insulin gene promoter activity in INS-1 pancreatic beta-cells via reduced nuclear factor binding to the A5/core and Z element. Mol Endocrinol (2005) 0.86

MafA expression and insulin promoter activity are induced by nicotinamide and related compounds in INS-1 pancreatic beta-cells. Diabetes (2006) 0.85

Inducible HSP70 regulates superoxide dismutase-2 and mitochondrial oxidative stress in the endothelial cells from developing lungs. Am J Physiol Lung Cell Mol Physiol (2013) 0.85

PGJ2-stimulated beta-cell apoptosis is associated with prolonged UPR activation. Am J Physiol Endocrinol Metab (2006) 0.84

Effect of nitric oxide on naphthoquinone toxicity in endothelial cells: role of bioenergetic dysfunction and poly (ADP-ribose) polymerase activation. Biochemistry (2013) 0.84

Nitric oxide induces ataxia telangiectasia mutated (ATM) protein-dependent γH2AX protein formation in pancreatic β cells. J Biol Chem (2014) 0.83

Reduction in ATP levels triggers immunoproteasome activation by the 11S (PA28) regulator during early antiviral response mediated by IFNβ in mouse pancreatic β-cells. PLoS One (2013) 0.82

Role of interferon regulatory factor-1 in double-stranded RNA-induced iNOS expression by mouse islets. J Biol Chem (2001) 0.82

PPARgamma is not required for the inhibitory actions of PGJ2 on cytokine signaling in pancreatic beta-cells. Am J Physiol Endocrinol Metab (2003) 0.82

Beyond the schools of psychology 2: a digital analysis of psychological review, 1904-1923. J Hist Behav Sci (2014) 0.81

Phosphatidylinositol 3-kinase regulates macrophage responses to double-stranded RNA and encephalomyocarditis virus. J Innate Immun (2009) 0.81

Redox-mediated enrichment of self-renewing adult human pancreatic cells that possess endocrine differentiation potential. Pancreas (2004) 0.81

Primary naive and interleukin-2-activated natural killer cells do not support efficient ectromelia virus replication. J Gen Virol (2008) 0.81

Luminol-based chemiluminescent signals: clinical and non-clinical application and future uses. Appl Biochem Biotechnol (2014) 0.81

Inhibition of IFN-gamma -induced STAT1 activation by 15- deoxy-Delta 12,14-prostaglandin J2. Am J Physiol Endocrinol Metab (2003) 0.81

The Evolution of The American Journal of Psychology 1, 1887-1903: A Network Investigation. Am J Psychol (2015) 0.80

Src family kinases participate in the regulation of encephalomyocarditis virus-induced cyclooxygenase-2 expression by macrophages. J Gen Virol (2010) 0.80

Ccr5 regulates inflammatory gene expression in response to encephalomyocarditis virus infection. Am J Pathol (2011) 0.80

Cytokine-mediated β-cell damage in PARP-1-deficient islets. Am J Physiol Endocrinol Metab (2012) 0.79

Improved MIN6 β-cell function on self-assembled peptide amphiphile nanomatrix inscribed with extracellular matrix-derived cell adhesive ligands. Macromol Biosci (2013) 0.79

Selective mtDNA mutation accumulation results in beta-cell apoptosis and diabetes development. Am J Physiol Endocrinol Metab (2009) 0.79

Evaluating diabetes and hypertension disease causality using mouse phenotypes. BMC Syst Biol (2010) 0.78

Characterization of gap junctional intercellular communication in immortalized human pancreatic ductal epithelial cells with stem cell characteristics. Pancreas (2003) 0.78

Immunoproteasome Activation During Early Antiviral Response in Mouse Pancreatic β-cells: New Insights into Auto-antigen Generation in Type I Diabetes? J Clin Cell Immunol (2013) 0.78

Chemically chaperoning the actions of insulin. Trends Endocrinol Metab (2006) 0.78

Digital models vs plaster models using alginate and alginate substitute materials. Angle Orthod (2010) 0.78

Transcriptome and network changes in climbers at extreme altitudes. PLoS One (2012) 0.77

Sustained NF-κB activation and inhibition in β-cells have minimal effects on function and islet transplant outcomes. PLoS One (2013) 0.76

Incretin hormones and insulin sensitivity. Trends Endocrinol Metab (2005) 0.76

Amyloid and the macrophage: it's all about local production of IL-1β. Diabetes (2014) 0.76

Reply to Gurgul-Convey and Lenzen: Cytokines, nitric oxide, and β-cells. J Biol Chem (2015) 0.75

The success of orthodontic satellite practices. Angle Orthod (2007) 0.75

Extracellular acidification parallels insulin secretion in INS-1 and HIT-T15 beta-cell lines. Biochem Biophys Res Commun (2002) 0.75

Multispecies networks: visualizing the psychological research of the Committee for Research in Problems of Sex. Isis (2015) 0.75

BRIDGE OVER TROUBLED WATERS? THE MOST "CENTRAL" MEMBERS OF PSYCHOLOGY AND PHILOSOPHY ASSOCIATIONS CA. 1900. J Hist Behav Sci (2016) 0.75

An exploratory digital analysis of the early years of G. Stanley Hall's American Journal of Psychology and Pedagogical Seminary. Hist Psychol (2013) 0.75