Published in Endocrinology on April 06, 2006
Glucolipotoxicity: fuel excess and beta-cell dysfunction. Endocr Rev (2007) 4.91
Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis. J Lipid Res (2008) 4.09
Cellular and molecular mechanisms of liver injury. Gastroenterology (2008) 3.02
Initiation and execution of lipotoxic ER stress in pancreatic beta-cells. J Cell Sci (2008) 2.99
Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease. Semin Liver Dis (2008) 2.89
Obesity, insulin resistance and free fatty acids. Curr Opin Endocrinol Diabetes Obes (2011) 2.67
Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents. J Clin Invest (2008) 2.58
Eukaryotic initiation factor 2 phosphorylation and translational control in metabolism. Adv Nutr (2012) 2.27
Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondria. J Biol Chem (2009) 2.21
Endoplasmic reticulum stress and type 2 diabetes. Annu Rev Biochem (2012) 2.10
Endoplasmic reticulum stress and pancreatic β-cell death. Trends Endocrinol Metab (2011) 2.01
Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stress. Proc Natl Acad Sci U S A (2009) 1.84
Glucolipotoxicity of the pancreatic beta cell. Biochim Biophys Acta (2009) 1.69
Palmitate activates autophagy in INS-1E β-cells and in isolated rat and human pancreatic islets. PLoS One (2012) 1.66
Beta-cell failure as a complication of diabetes. Rev Endocr Metab Disord (2008) 1.60
Glucagon-like peptide-1 agonists protect pancreatic beta-cells from lipotoxic endoplasmic reticulum stress through upregulation of BiP and JunB. Diabetes (2009) 1.50
Cytokine-induced beta-cell death is independent of endoplasmic reticulum stress signaling. Diabetes (2008) 1.46
Endoplasmic reticulum stress in beta-cells and development of diabetes. Curr Opin Pharmacol (2009) 1.41
The binary switch that controls the life and death decisions of ER stressed β cells. Curr Opin Cell Biol (2010) 1.41
Carboxypeptidase E mediates palmitate-induced beta-cell ER stress and apoptosis. Proc Natl Acad Sci U S A (2008) 1.39
Ubiquitin fold modifier 1 (UFM1) and its target UFBP1 protect pancreatic beta cells from ER stress-induced apoptosis. PLoS One (2011) 1.38
Endoplasmic reticulum stress: its role in disease and novel prospects for therapy. Scientifica (Cairo) (2012) 1.37
Reduced endoplasmic reticulum luminal calcium links saturated fatty acid-mediated endoplasmic reticulum stress and cell death in liver cells. Mol Cell Biochem (2009) 1.35
Sodium phenylbutyrate, a drug with known capacity to reduce endoplasmic reticulum stress, partially alleviates lipid-induced insulin resistance and beta-cell dysfunction in humans. Diabetes (2011) 1.29
Fatty acids suppress autophagic turnover in β-cells. J Biol Chem (2011) 1.27
Intersection of the unfolded protein response and hepatic lipid metabolism. Cell Mol Life Sci (2009) 1.24
Inhibition of stearoyl-CoA desaturase 1 expression induces CHOP-dependent cell death in human cancer cells. PLoS One (2010) 1.24
Glucose amplifies fatty acid-induced endoplasmic reticulum stress in pancreatic beta-cells via activation of mTORC1. PLoS One (2009) 1.20
Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells. Diabetes (2009) 1.18
Death protein 5 and p53-upregulated modulator of apoptosis mediate the endoplasmic reticulum stress-mitochondrial dialog triggering lipotoxic rodent and human β-cell apoptosis. Diabetes (2012) 1.16
The endoplasmic reticulum stress response and diabetic kidney disease. Am J Physiol Renal Physiol (2011) 1.16
Effect of pioglitazone treatment on endoplasmic reticulum stress response in human adipose and in palmitate-induced stress in human liver and adipose cell lines. Am J Physiol Endocrinol Metab (2008) 1.15
Lack of TXNIP protects against mitochondria-mediated apoptosis but not against fatty acid-induced ER stress-mediated beta-cell death. Diabetes (2009) 1.14
The non-coding RNA gadd7 is a regulator of lipid-induced oxidative and endoplasmic reticulum stress. J Biol Chem (2009) 1.13
Lipid metabolism, apoptosis and cancer therapy. Int J Mol Sci (2015) 1.11
Efficacy of metreleptin in obese patients with type 2 diabetes: cellular and molecular pathways underlying leptin tolerance. Diabetes (2011) 1.10
Protein-folding homeostasis in the endoplasmic reticulum and nutritional regulation. Cold Spring Harb Perspect Biol (2012) 1.06
Roles of ceramide and sphingolipids in pancreatic β-cell function and dysfunction. Islets (2012) 1.02
Endoplasmic reticulum stress response in an INS-1 pancreatic beta-cell line with inducible expression of a folding-deficient proinsulin. BMC Cell Biol (2010) 1.00
Synergistic effect of cAMP and palmitate in promoting altered mitochondrial function and cell death in HepG2 cells. Exp Cell Res (2009) 1.00
The binary switch between life and death of endoplasmic reticulum-stressed beta cells. Curr Opin Endocrinol Diabetes Obes (2010) 0.99
Obesity induces hypothalamic endoplasmic reticulum stress and impairs proopiomelanocortin (POMC) post-translational processing. J Biol Chem (2013) 0.99
Cellular inhibitor of apoptosis protein-1 (cIAP1) plays a critical role in β-cell survival under endoplasmic reticulum stress: promoting ubiquitination and degradation of C/EBP homologous protein (CHOP). J Biol Chem (2012) 0.98
MyD88-dependent interplay between myeloid and endothelial cells in the initiation and progression of obesity-associated inflammatory diseases. J Exp Med (2014) 0.98
Endoplasmic reticulum stress in the β-cell pathogenesis of type 2 diabetes. Exp Diabetes Res (2011) 0.98
A role for aberrant protein palmitoylation in FFA-induced ER stress and β-cell death. Am J Physiol Endocrinol Metab (2012) 0.98
Cultured hypothalamic neurons are resistant to inflammation and insulin resistance induced by saturated fatty acids. Am J Physiol Endocrinol Metab (2010) 0.97
MicroRNA 375 mediates palmitate-induced enteric neuronal damage and high-fat diet-induced delayed intestinal transit in mice. Gastroenterology (2013) 0.97
Apoptosis induced by t10,c12-conjugated linoleic acid is mediated by an atypical endoplasmic reticulum stress response. J Lipid Res (2008) 0.97
Tribbles 3 mediates endoplasmic reticulum stress-induced insulin resistance in skeletal muscle. Nat Commun (2013) 0.97
The multi-level action of fatty acids on adiponectin production by fat cells. PLoS One (2011) 0.96
Lipotoxic lethal and sublethal stress signaling in hepatocytes: relevance to NASH pathogenesis. J Lipid Res (2016) 0.95
Coordinate changes in histone modifications, mRNA levels, and metabolite profiles in clonal INS-1 832/13 β-cells accompany functional adaptations to lipotoxicity. J Biol Chem (2013) 0.95
Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis. Arterioscler Thromb Vasc Biol (2012) 0.95
Role of fibroblast growth factor 21 in the early stage of NASH induced by methionine- and choline-deficient diet. Biochim Biophys Acta (2015) 0.95
Distinct gene expression profiles characterize cellular responses to palmitate and oleate. J Lipid Res (2010) 0.94
Susceptibility of pancreatic beta cells to fatty acids is regulated by LXR/PPARalpha-dependent stearoyl-coenzyme A desaturase. PLoS One (2009) 0.93
Nifedipine protects INS-1 β-cell from high glucose-induced ER stress and apoptosis. Int J Mol Sci (2011) 0.92
Protective effects of dipeptidyl peptidase-4 (DPP-4) inhibitor against increased β cell apoptosis induced by dietary sucrose and linoleic acid in mice with diabetes. J Biol Chem (2011) 0.91
Dimethyl sulfoxide reduces hepatocellular lipid accumulation through autophagy induction. Autophagy (2012) 0.91
Phosphatidylethanolamines modified by γ-ketoaldehyde (γKA) induce endoplasmic reticulum stress and endothelial activation. J Biol Chem (2011) 0.91
Hyperglycemia magnifies Schwann cell dysfunction and cell death triggered by PA-induced lipotoxicity. Brain Res (2010) 0.91
Pancreatic α Cells are Resistant to Metabolic Stress-induced Apoptosis in Type 2 Diabetes. EBioMedicine (2015) 0.90
Lipotoxicity is glucose-dependent in INS-1E cells but not in human islets and MIN6 cells. Lipids Health Dis (2011) 0.89
Activation of the unfolded protein response pathway causes ceramide accumulation in yeast and INS-1E insulinoma cells. J Lipid Res (2011) 0.89
DNAJB3/HSP-40 cochaperone is downregulated in obese humans and is restored by physical exercise. PLoS One (2013) 0.89
The apoptosis inhibitor ARC alleviates the ER stress response to promote β-cell survival. Diabetes (2012) 0.89
Alteration of endoplasmic reticulum lipid rafts contributes to lipotoxicity in pancreatic β-cells. J Biol Chem (2013) 0.88
Unsaturated FAs prevent palmitate-induced LOX-1 induction via inhibition of ER stress in macrophages. J Lipid Res (2010) 0.88
Inhibition of HMGB1 release via salvianolic acid B-mediated SIRT1 up-regulation protects rats against non-alcoholic fatty liver disease. Sci Rep (2015) 0.88
Palmitic and linoleic acids induce ER stress and apoptosis in hepatoma cells. Lipids Health Dis (2012) 0.87
Guards and culprits in the endoplasmic reticulum: glucolipotoxicity and β-cell failure in type II diabetes. Exp Diabetes Res (2011) 0.87
A switch from life to death in endoplasmic reticulum stressed β-cells. Diabetes Obes Metab (2010) 0.86
Reduced levels of SCD1 accentuate palmitate-induced stress in insulin-producing β-cells. Lipids Health Dis (2010) 0.85
Gating of the mitochondrial permeability transition pore by long chain fatty acyl analogs in vivo. J Biol Chem (2009) 0.85
Cathepsin B contributes to autophagy-related 7 (Atg7)-induced nod-like receptor 3 (NLRP3)-dependent proinflammatory response and aggravates lipotoxicity in rat insulinoma cell line. J Biol Chem (2013) 0.85
Grape seed proanthocyanidins ameliorate pancreatic beta-cell dysfunction and death in low-dose streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic rats partially by regulating endoplasmic reticulum stress. Nutr Metab (Lond) (2013) 0.85
(-)-Epicatechin mitigates high-fructose-associated insulin resistance by modulating redox signaling and endoplasmic reticulum stress. Free Radic Biol Med (2014) 0.84
Structural requirements for the cytoprotective actions of mono-unsaturated fatty acids in the pancreatic beta-cell line, BRIN-BD11. Br J Pharmacol (2008) 0.84
Free fatty acids induce ER stress and block antiviral activity of interferon alpha against hepatitis C virus in cell culture. Virol J (2012) 0.84
Triglyceride-rich lipoprotein modulates endothelial vascular cell adhesion molecule (VCAM)-1 expression via differential regulation of endoplasmic reticulum stress. PLoS One (2013) 0.84
Valproate pretreatment protects pancreatic β-cells from palmitate-induced ER stress and apoptosis by inhibiting glycogen synthase kinase-3β. J Biomed Sci (2014) 0.83
Liraglutide Improves the Survival of INS-1 Cells by Promoting Macroautophagy. Int J Endocrinol Metab (2013) 0.83
2-Hydroxyoleic acid induces ER stress and autophagy in various human glioma cell lines. PLoS One (2012) 0.83
Palmitic acid and ergosta-7,22-dien-3-ol contribute to the apoptotic effect and cell cycle arrest of an extract from Marthasterias glacialis L. in neuroblastoma cells. Mar Drugs (2013) 0.83
Endoplasmic reticulum proteostasis in hepatic steatosis. Nat Rev Endocrinol (2016) 0.82
Palmitic acid-induced neuron cell cycle G2/M arrest and endoplasmic reticular stress through protein palmitoylation in SH-SY5Y human neuroblastoma cells. Int J Mol Sci (2014) 0.82
The role of ER stress in lipid metabolism and lipotoxicity. J Lipid Res (2016) 0.81
Npas4 is a novel activity-regulated cytoprotective factor in pancreatic β-cells. Diabetes (2013) 0.81
Dietary oleic acid increases m2 macrophages in the mesenteric adipose tissue. PLoS One (2013) 0.81
Saturated fatty acids regulate retinoic acid signalling and suppress tumorigenesis by targeting fatty acid-binding protein 5. Nat Commun (2015) 0.80
Tumor progression and the different faces of the PERK kinase. Oncogene (2015) 0.80
Clic4, a novel protein that sensitizes β-cells to apoptosis. Mol Metab (2015) 0.80
A Missense Mutation in PPP1R15B Causes a Syndrome Including Diabetes, Short Stature, and Microcephaly. Diabetes (2015) 0.79
Changes in mitochondrial carriers exhibit stress-specific signatures in INS-1Eβ-cells exposed to glucose versus fatty acids. PLoS One (2013) 0.79
JunB protects β-cells from lipotoxicity via the XBP1-AKT pathway. Cell Death Differ (2014) 0.79
Role of the unfolded protein response in β cell compensation and failure during diabetes. J Diabetes Res (2014) 0.79
Endoplasmic Reticulum Stress in the Diabetic Kidney, the Good, the Bad and the Ugly. J Clin Med (2015) 0.79
Fatty acid elongase 7 catalyzes lipidome remodeling essential for human cytomegalovirus replication. Cell Rep (2015) 0.78
Sar1p N-terminal helix initiates membrane curvature and completes the fission of a COPII vesicle. Cell (2005) 3.96
Detection and HER2 expression of circulating tumor cells: prospective monitoring in breast cancer patients treated in the neoadjuvant GeparQuattro trial. Clin Cancer Res (2010) 2.66
Cranio-lenticulo-sutural dysplasia is caused by a SEC23A mutation leading to abnormal endoplasmic-reticulum-to-Golgi trafficking. Nat Genet (2006) 2.39
Endoplasmic reticulum stress: signaling the unfolded protein response. Physiology (Bethesda) (2007) 2.32
The genetic basis of a craniofacial disease provides insight into COPII coat assembly. Dev Cell (2007) 2.26
Rapid transformation of white adipocytes into fat-oxidizing machines. Proc Natl Acad Sci U S A (2004) 2.03
Adipogenic capacity and the susceptibility to type 2 diabetes and metabolic syndrome. Proc Natl Acad Sci U S A (2008) 1.89
Ubiquitinated-protein aggregates form in pancreatic beta-cells during diabetes-induced oxidative stress and are regulated by autophagy. Diabetes (2007) 1.77
Severe block in processing of proinsulin to insulin accompanied by elevation of des-64,65 proinsulin intermediates in islets of mice lacking prohormone convertase 1/3. Proc Natl Acad Sci U S A (2002) 1.73
From the Cover: STIM1-induced precortical and cortical subdomains of the endoplasmic reticulum. Proc Natl Acad Sci U S A (2009) 1.71
Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic beta-cells. Am J Physiol Endocrinol Metab (2008) 1.68
Sequence characteristics of functional siRNAs. RNA (2005) 1.59
Pancreatic β-cells depend on basal expression of active ATF6α-p50 for cell survival even under nonstress conditions. Am J Physiol Cell Physiol (2011) 1.58
Uncoupled packaging of amyloid precursor protein and presenilin 1 into coat protein complex II vesicles. J Biol Chem (2004) 1.52
Fat storage in adipocytes requires inactivation of leptin's paracrine activity: implications for treatment of human obesity. Proc Natl Acad Sci U S A (2005) 1.52
A glucagon-like peptide-1 analog reverses the molecular pathology and cardiac dysfunction of a mouse model of obesity. Circulation (2012) 1.39
Countercurrent distribution of two distinct SNARE complexes mediating transport within the Golgi stack. Mol Biol Cell (2004) 1.39
Metabolic mechanisms of failure of intraportally transplanted pancreatic beta-cells in rats: role of lipotoxicity and prevention by leptin. Diabetes (2007) 1.26
GRP78, but Not Protein-disulfide Isomerase, Partially Reverses Hyperglycemia-induced Inhibition of Insulin Synthesis and Secretion in Pancreatic {beta}-Cells. J Biol Chem (2008) 1.22
Mitofusin-2 independent juxtaposition of endoplasmic reticulum and mitochondria: an ultrastructural study. PLoS One (2012) 1.20
i-SNAREs: inhibitory SNAREs that fine-tune the specificity of membrane fusion. J Cell Biol (2003) 1.14
Differential use of endoplasmic reticulum membrane for phagocytosis in J774 macrophages. Proc Natl Acad Sci U S A (2005) 1.12
Induction of cortical endoplasmic reticulum by dimerization of a coatomer-binding peptide anchored to endoplasmic reticulum membranes. Proc Natl Acad Sci U S A (2010) 1.04
Emerging roles for the ubiquitin-proteasome system and autophagy in pancreatic beta-cells. Am J Physiol Endocrinol Metab (2008) 1.04
Constitutively active calcineurin induces cardiac endoplasmic reticulum stress and protects against apoptosis that is mediated by alpha-crystallin-B. Proc Natl Acad Sci U S A (2010) 1.03
Endoplasmic reticulum stress response in an INS-1 pancreatic beta-cell line with inducible expression of a folding-deficient proinsulin. BMC Cell Biol (2010) 1.00
Computational models for predicting substrates or inhibitors of P-glycoprotein. Drug Discov Today (2011) 0.98
OASIS/CREB3L1 induces expression of genes involved in extracellular matrix production but not classical endoplasmic reticulum stress response genes in pancreatic beta-cells. Endocrinology (2010) 0.97
Oleanolic acid enhances insulin secretion in pancreatic beta-cells. FEBS Lett (2008) 0.97
Ultrafast and sensitive room temperature NH3 gas sensors based on chemically reduced graphene oxide. Nanotechnology (2013) 0.93
Combined leptin actions on adipose tissue and hypothalamus are required to deplete adipocyte fat in lean rats: implications for obesity treatment. J Biol Chem (2006) 0.92
ADMET evaluation in drug discovery. 12. Development of binary classification models for prediction of hERG potassium channel blockage. Mol Pharm (2012) 0.91
The [corrected] SEC23-SEC31 [corrected] interface plays critical role for export of procollagen from the endoplasmic reticulum. J Biol Chem (2012) 0.91
Action of protein disulfide isomerase on proinsulin exit from endoplasmic reticulum of pancreatic β-cells. J Biol Chem (2011) 0.91
Dynamic transport of SNARE proteins in the Golgi apparatus. Proc Natl Acad Sci U S A (2005) 0.89
Theoretical studies on the susceptibility of oseltamivir against variants of 2009 A/H1N1 influenza neuraminidase. J Chem Inf Model (2012) 0.87
SDF2L1 interacts with the ER-associated degradation machinery and retards the degradation of mutant proinsulin in pancreatic β-cells. J Cell Sci (2013) 0.85
Clinical and prognostic significance of lost or decreased PDCD5 expression in human epithelial ovarian carcinomas. Oncol Rep (2010) 0.85
Mammalian Erv46 localizes to the endoplasmic reticulum-Golgi intermediate compartment and to cis-Golgi cisternae. Proc Natl Acad Sci U S A (2003) 0.85
Discovery of Rho-kinase inhibitors by docking-based virtual screening. Mol Biosyst (2013) 0.84
p24 family type 1 transmembrane proteins are required for insulin biosynthesis and secretion in pancreatic beta-cells. FEBS Lett (2010) 0.82
Investigation of design space for freeze-drying: use of modeling for primary drying segment of a freeze-drying cycle. AAPS PharmSciTech (2011) 0.81
Discovery and optimization of triazine derivatives as ROCK1 inhibitors: molecular docking, molecular dynamics simulations and free energy calculations. Mol Biosyst (2013) 0.80
A novel mutation of RPGR gene in an X-linked Chinese family with retinitis pigmentosa. Mol Genet Metab (2010) 0.79
OASIS/CREB3L1 is induced by endoplasmic reticulum stress in human glioma cell lines and contributes to the unfolded protein response, extracellular matrix production and cell migration. PLoS One (2013) 0.79
Magnetic-field-induced diameter-selective synthesis of single-walled carbon nanotubes. Nanoscale (2012) 0.78
IRE1 inhibition perturbs the unfolded protein response in a pancreatic β-cell line expressing mutant proinsulin, but does not sensitize the cells to apoptosis. BMC Cell Biol (2014) 0.78
Highly efficient adenoviral transduction of pancreatic islets using a microfluidic device. Lab Chip (2016) 0.77
Pyrimidine benzamide-based thrombopoietin receptor agonists. Bioorg Med Chem Lett (2007) 0.77
Detection of circulating tumor cells by RT-PCR significantly associated with poor prognosis in breast cancer. Breast Cancer Res Treat (2011) 0.77
Endoplasmic reticulum redox state is not perturbed by pharmacological or pathological endoplasmic reticulum stress in live pancreatic β-cells. PLoS One (2012) 0.76
The mechanism of proton translocation in respiratory complex I from molecular dynamics. J Recept Signal Transduct Res (2014) 0.76
Diverse roles for the p24 family of proteins in eukaryotic cells. Biomol Concepts (2012) 0.76
A rule-based algorithm for automatic bond type perception. J Cheminform (2012) 0.75
Human papilloma virus in oropharyngeal cancers (Re: ANZ J. Surg. 2011; 81: 581-3). ANZ J Surg (2012) 0.75
Depression of reactivity by the collision energy in the single barrier H + CD4 -> HD + CD3 reaction. Proc Natl Acad Sci U S A (2010) 0.75
Binding of activating transcription factor 6 to the A5/Core of the rat insulin II gene promoter does not mediate its transcriptional repression. J Mol Endocrinol (2011) 0.75
RhoA/ROCK pathway inhibition by fasudil suppresses the vasculogenic mimicry of U2OS osteosarcoma cells in vitro. Anticancer Drugs (2017) 0.75
Rapid solid-phase microwave synthesis of highly photoluminescent nitrogen-doped carbon dots for Fe(3+) detection and cellular bioimaging. Nanotechnology (2016) 0.75
Hydrophilic and blue fluorescent N-doped carbon dots from tartaric acid and various alkylol amines under microwave irradiation. Nanoscale (2015) 0.75
Effects of thioacetamide on pancreatic islet B-cell function. Endocrine (2004) 0.75
Development of a force field for zeolitic imidazolate framework-8 with structural flexibility. J Chem Phys (2012) 0.75
Controlled synthesis of different metal oxide nanostructures by direct current arc discharge. J Nanosci Nanotechnol (2013) 0.75
Self-templated free-radical polymerization to form tactic chains in confined environment. J Phys Chem B (2013) 0.75
Three-dimensional conductive networks based on stacked SiO2@graphene frameworks for enhanced gas sensing. Nanoscale (2016) 0.75
Insight into the structural requirements of narlaprevir-type inhibitors of NS3/NS4A protease based on HQSAR and molecular field analyses. Comb Chem High Throughput Screen (2012) 0.75
A novel strategy to identify drugs that interfere with endosomal lipids. Chimia (Aarau) (2011) 0.75