Published in J Gerontol A Biol Sci Med Sci on March 26, 2012
The hallmarks of aging. Cell (2013) 14.29
Small molecule SIRT1 activators for the treatment of aging and age-related diseases. Trends Pharmacol Sci (2014) 2.37
Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction. Aging Cell (2014) 2.35
Resveratrol supplementation does not improve metabolic function in nonobese women with normal glucose tolerance. Cell Metab (2012) 1.93
Interventions to Slow Aging in Humans: Are We Ready? Aging Cell (2015) 1.46
The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet. Cell Rep (2014) 1.42
Effects of resveratrol and SIRT1 on PGC-1α activity and mitochondrial biogenesis: a reevaluation. PLoS Biol (2013) 1.40
Drugs that modulate aging: the promising yet difficult path ahead. Transl Res (2013) 1.38
Resveratrol and clinical trials: the crossroad from in vitro studies to human evidence. Curr Pharm Des (2013) 1.22
Resveratrol potentiates rapamycin to prevent hyperinsulinemia and obesity in male mice on high fat diet. Cell Death Dis (2013) 1.02
Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer. Aging Cell (2016) 0.98
Energetic interventions for healthspan and resiliency with aging. Exp Gerontol (2016) 0.92
Sex Differences in Lifespan. Cell Metab (2016) 0.90
NF-κB pathway activators as potential ageing biomarkers: targets for new therapeutic strategies. Immun Ageing (2013) 0.89
Dietary antiaging phytochemicals and mechanisms associated with prolonged survival. J Nutr Biochem (2014) 0.88
Systemic regulation of mammalian ageing and longevity by brain sirtuins. Nat Commun (2014) 0.87
Exercise training, but not resveratrol, improves metabolic and inflammatory status in skeletal muscle of aged men. J Physiol (2014) 0.87
Curcumin and neurodegenerative diseases. Biofactors (2013) 0.86
Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice. Cell Metab (2016) 0.85
Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects. Nat Commun (2017) 0.83
Mitochondrial function in hypoxic ischemic injury and influence of aging. Prog Neurobiol (2016) 0.83
Green tea polyphenols extend the lifespan of male drosophila melanogaster while impairing reproductive fitness. J Med Food (2014) 0.82
Effect of curcumin on lifespan, activity pattern, oxidative stress, and apoptosis in the brains of transgenic Drosophila model of Parkinson's disease. Biomed Res Int (2014) 0.80
Resveratrol encapsulated in novel fusogenic liposomes activates Nrf2 and attenuates oxidative stress in cerebromicrovascular endothelial cells from aged rats. J Gerontol A Biol Sci Med Sci (2014) 0.80
10-Hydroxy-2-decenoic Acid, the Major Lipid Component of Royal Jelly, Extends the Lifespan of Caenorhabditis elegans through Dietary Restriction and Target of Rapamycin Signaling. J Aging Res (2015) 0.79
Caloric restriction: beneficial effects on brain aging and Alzheimer's disease. Mamm Genome (2016) 0.78
Involvement of arterial baroreflex in the protective effect of dietary restriction against stroke. J Cereb Blood Flow Metab (2013) 0.78
Alive and well? Exploring disease by studying lifespan. Curr Opin Genet Dev (2014) 0.77
Resveratrol Decreases TXNIP mRNA and Protein Nuclear Expressions With an Arterial Function Improvement in Old Mice. J Gerontol A Biol Sci Med Sci (2015) 0.77
NIA's intervention testing program at 10 years of age. Age (Dordr) (2015) 0.77
Resveratrol preserves the function of human platelets stored for transfusion. Br J Haematol (2015) 0.77
Curcumin Mimics the Neurocognitive and Anti-Inflammatory Effects of Caloric Restriction in a Mouse Model of Midlife Obesity. PLoS One (2015) 0.76
New findings rejuvenate age-old drug development field. Nat Med (2013) 0.76
Independent chemical regulation of health and senescent spans in Drosophila. Invertebr Reprod Dev (2014) 0.75
Green tea polyphenols require the mitochondrial iron transporter, mitoferrin, for lifespan extension in Drosophila melanogaster. Arch Insect Biochem Physiol (2016) 0.75
Sirtuin activation as a therapeutic approach against inborn errors of metabolism. J Inherit Metab Dis (2016) 0.75
Nutrition and energetics in rodent longevity research. Exp Gerontol (2016) 0.75
Finding Ponce de Leon's Pill: Challenges in Screening for Anti-Aging Molecules. F1000Res (2016) 0.75
Resveratrol improves health and survival of mice on a high-calorie diet. Nature (2006) 20.91
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature (2009) 19.56
Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov (2006) 11.77
Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature (2004) 10.36
Extended longevity in mice lacking the insulin receptor in adipose tissue. Science (2003) 8.53
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab (2008) 6.22
Flavonoids as antioxidants. J Nat Prod (2000) 6.02
Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci (2010) 5.54
In search of Methuselah: estimating the upper limits to human longevity. Science (1990) 3.99
Multiple biological activities of curcumin: a short review. Life Sci (2006) 3.96
The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci (2001) 3.92
Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate. Curr Biol (2006) 3.88
Phase I clinical trial of oral curcumin: biomarkers of systemic activity and compliance. Clin Cancer Res (2004) 3.51
Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans. Mech Ageing Dev (2007) 2.75
Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice. Aging Cell (2008) 2.65
An Aging Interventions Testing Program: study design and interim report. Aging Cell (2007) 2.54
Extending life: scientific prospects and political obstacles. Milbank Q (2002) 2.51
Green tea and its polyphenolic catechins: medicinal uses in cancer and noncancer applications. Life Sci (2006) 2.25
Phenolic anti-inflammatory antioxidant reversal of Abeta-induced cognitive deficits and neuropathology. Neurobiol Aging (2001) 2.20
Design of aging intervention studies: the NIA interventions testing program. Age (Dordr) (2008) 2.14
Polyphenolic flavanols as scavengers of aqueous phase radicals and as chain-breaking antioxidants. Arch Biochem Biophys (1995) 2.12
Life extension. N Engl J Med (1985) 1.83
Effects of beta-hydroxybutyrate on cognition in memory-impaired adults. Neurobiol Aging (2004) 1.81
Curcumin and turmeric delay streptozotocin-induced diabetic cataract in rats. Invest Ophthalmol Vis Sci (2005) 1.58
L-deprenyl treatment in aged mice slightly increases life spans, and greatly reduces fecundity by aged males. J Gerontol A Biol Sci Med Sci (1996) 1.48
Effect of oral curcumin administration on serum peroxides and cholesterol levels in human volunteers. Indian J Physiol Pharmacol (1992) 1.44
Natural health products that inhibit angiogenesis: a potential source for investigational new agents to treat cancer-Part 1. Curr Oncol (2006) 1.34
Medium-chain triglycerides increase energy expenditure and decrease adiposity in overweight men. Obes Res (2003) 1.19
Levodopa, fertility, and longevity. Science (1977) 1.19
Enhancement of antioxidant and phase II enzymes by oral feeding of green tea polyphenols in drinking water to SKH-1 hairless mice: possible role in cancer chemoprevention. Cancer Res (1992) 1.09
Modulation of alpha-crystallin chaperone activity in diabetic rat lens by curcumin. Mol Vis (2005) 1.05
Oxaloacetate supplementation increases lifespan in Caenorhabditis elegans through an AMPK/FOXO-dependent pathway. Aging Cell (2009) 1.04
NTP Toxicology and Carcinogenesis Studies of Turmeric Oleoresin (CAS No. 8024-37-1) (Major Component 79%-85% Curcumin, CAS No. 458-37-7) in F344/N Rats and B6C3F1 Mice (Feed Studies). Natl Toxicol Program Tech Rep Ser (1993) 1.01
Inhibition of lipid peroxidation and cholesterol levels in mice by curcumin. Indian J Physiol Pharmacol (1992) 1.00
The effects of tetrahydrocurcumin and green tea polyphenol on the survival of male C57BL/6 mice. Biogerontology (2007) 0.99
The relation between single/double or repeated tea catechin ingestions and plasma antioxidant activity in humans. Eur J Clin Nutr (2002) 0.95
Medium-chain oil reduces fat mass and down-regulates expression of adipogenic genes in rats. Obes Res (2003) 0.92
No prevention of liver and kidney tumors in Long-Evans Cinnamon rats by dietary curcumin, but inhibition at other sites and of metastases. Mutat Res (2003) 0.92
Protective effects of medium-chain triglycerides on the liver and gut in rats administered endotoxin. Ann Surg (2003) 0.91
Interventions in aging and age-associated pathologies by means of nutritional approaches. Ann N Y Acad Sci (2004) 0.91
Effects of green tea catechin on phospholipase A2 activity and antithrombus in streptozotocin diabetic rats. J Nutr Sci Vitaminol (Tokyo) (1999) 0.85
Metabolic effects induced by long-term feeding of medium-chain triglycerides in the rat. Metabolism (1987) 0.85
Green tea protection against age-dependent ethanol-induced oxidative stress. J Toxicol Environ Health A (2004) 0.85
Commentary: prescient visions of public health from Cornaro to Breslow. Int J Epidemiol (2005) 0.77
Resveratrol improves health and survival of mice on a high-calorie diet. Nature (2006) 20.91
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature (2009) 19.56
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature (2003) 17.52
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science (2004) 17.38
Randomized assessment of rapid endovascular treatment of ischemic stroke. N Engl J Med (2015) 12.70
Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov (2006) 11.77
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science (2004) 11.39
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature (2007) 10.21
Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis. Lancet (2009) 9.90
Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol (2010) 8.55
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature (2011) 8.45
The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Natl Acad Sci U S A (2010) 8.05
Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. Science (2012) 6.69
Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. Cell (2007) 6.47
Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae. Nature (2003) 6.25
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab (2008) 6.22
Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1. J Biol Chem (2002) 6.15
Cross-national prevalence and risk factors for suicidal ideation, plans and attempts. Br J Psychiatry (2008) 5.90
SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell (2008) 5.76
Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci (2010) 5.54
Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study. Nature (2012) 5.00
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. EMBO J (2007) 4.66
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. PLoS One (2008) 4.32
HST2 mediates SIR2-independent life-span extension by calorie restriction. Science (2005) 4.12
Specifying race-ethnic differences in risk for psychiatric disorder in a USA national sample. Psychol Med (2005) 4.05
Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. Sci Transl Med (2011) 3.84
Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening. Aging Cell (2009) 3.78
Rapamycin slows aging in mice. Aging Cell (2012) 3.76
Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis. Mol Cell (2004) 3.73
SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metab (2012) 3.69
Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat. Proc Natl Acad Sci U S A (2010) 3.54
Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science (2012) 3.52
Cellular senescence and the senescent secretory phenotype: therapeutic opportunities. J Clin Invest (2013) 3.47
Evidence for a common mechanism of SIRT1 regulation by allosteric activators. Science (2013) 3.40
Event-related beta desynchronization in human subthalamic nucleus correlates with motor performance. Brain (2004) 3.36
Fat tissue, aging, and cellular senescence. Aging Cell (2010) 3.34
Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model. Neuron (2004) 3.21
MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae. PLoS Biol (2007) 3.19
Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels. Aging Cell (2009) 3.16
Identification of depot-specific human fat cell progenitors through distinct expression profiles and developmental gene patterns. Am J Physiol Endocrinol Metab (2006) 3.03
Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels. J Biol Chem (2002) 2.91
Cross-national associations between gender and mental disorders in the World Health Organization World Mental Health Surveys. Arch Gen Psychiatry (2009) 2.85
Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake. Proc Natl Acad Sci U S A (2003) 2.82
Survival and neurologic outcomes in a randomized trial of motexafin gadolinium and whole-brain radiation therapy in brain metastases. J Clin Oncol (2003) 2.69
Metformin improves healthspan and lifespan in mice. Nat Commun (2013) 2.68
Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice. Aging Cell (2008) 2.65
Resveratrol induces mitochondrial biogenesis in endothelial cells. Am J Physiol Heart Circ Physiol (2009) 2.65
Scara5 is a ferritin receptor mediating non-transferrin iron delivery. Dev Cell (2009) 2.60
Fibroblast cell lines from young adult mice of long-lived mutant strains are resistant to multiple forms of stress. Am J Physiol Endocrinol Metab (2005) 2.59
Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy. Sci Transl Med (2012) 2.58
Neurocognitive function and progression in patients with brain metastases treated with whole-brain radiation and motexafin gadolinium: results of a randomized phase III trial. J Clin Oncol (2004) 2.55
Dietary deprivation extends lifespan in Caenorhabditis elegans. Aging Cell (2006) 2.54
An Aging Interventions Testing Program: study design and interim report. Aging Cell (2007) 2.54
Basal ganglia local field potential activity: character and functional significance in the human. Clin Neurophysiol (2005) 2.42
Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework. Toxicol Appl Pharmacol (2007) 2.37
A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model. J Neurosci (2005) 2.36
Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction. Aging Cell (2014) 2.35
Shoulder MR arthrography: which patient group benefits most? AJR Am J Roentgenol (2004) 2.31
Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy. Aging (Albany NY) (2010) 2.27
Interdisciplinary inpatient care for elderly people with hip fracture: a randomized controlled trial. CMAJ (2002) 2.25
Mechanisms of vascular aging: new perspectives. J Gerontol A Biol Sci Med Sci (2010) 2.24
Fat depot origin affects adipogenesis in primary cultured and cloned human preadipocytes. Am J Physiol Regul Integr Comp Physiol (2002) 2.23
Are sirtuins viable targets for improving healthspan and lifespan? Nat Rev Drug Discov (2012) 2.22
Comparison of high-field-strength versus low-field-strength MRI of the shoulder. AJR Am J Roentgenol (2003) 2.21
The role of nuclear architecture in genomic instability and ageing. Nat Rev Mol Cell Biol (2007) 2.17
Regional differences in cellular mechanisms of adipose tissue gain with overfeeding. Proc Natl Acad Sci U S A (2010) 2.17