Ginsenoside-Rp1 inhibits platelet activation and thrombus formation via impaired glycoprotein VI signalling pathway, tyrosine phosphorylation and MAPK activation.

PubWeight™: 1.01‹?› | Rank: Top 15%

🔗 View Article (PMC 3448917)

Published in Br J Pharmacol on September 01, 2012

Authors

M Endale1, W M Lee, S M Kamruzzaman, S D Kim, J Y Park, M H Park, T Y Park, H J Park, J Y Cho, M H Rhee

Author Affiliations

1: Laboratory of Physiology & Cell Signaling, College of Veterinary Medicine, Kyungpook National University, Daegu, Korea.

Articles citing this

Commonly Used Dietary Supplements on Coagulation Function during Surgery. Medicines (Basel) (2015) 0.97

Ginsenoside-Rp1-induced apolipoprotein A-1 expression in the LoVo human colon cancer cell line. J Ginseng Res (2014) 0.95

Dual Roles of Quercetin in Platelets: Phosphoinositide-3-Kinase and MAP Kinases Inhibition, and cAMP-Dependent Vasodilator-Stimulated Phosphoprotein Stimulation. Evid Based Complement Alternat Med (2012) 0.88

Platelet P2Y₁₂ receptors are involved in the haemostatic effect of notoginsenoside Ft1, a saponin isolated from Panax notoginseng. Br J Pharmacol (2014) 0.79

Antiatherosclerotic effect of korean red ginseng extract involves regulator of g-protein signaling 5. Evid Based Complement Alternat Med (2014) 0.79

Inhibitory effects of total saponin from Korean Red Ginseng on [Ca(2+)]i mobilization through phosphorylation of cyclic adenosine monophosphate-dependent protein kinase catalytic subunit and inositol 1,4,5-trisphosphate receptor type I in human platelets. J Ginseng Res (2015) 0.77

Anti-platelet activity of panaxatriol saponins is mediated by suppression of intracellular calcium mobilization and ERK2/p38 activation. BMC Complement Altern Med (2016) 0.76

Total saponin from Korean Red Ginseng inhibits binding of adhesive proteins to glycoprotein IIb/IIIa via phosphorylation of VASP (Ser(157)) and dephosphorylation of PI3K and Akt. J Ginseng Res (2015) 0.75

The inhibitory activity of ginsenoside Rp4 in adenosine diphosphate-induced platelet aggregation. J Ginseng Res (2016) 0.75

Antiplatelet and antithrombotic effects of cordycepin-enriched WIB-801CE from Cordyceps militaris ex vivo, in vivo, and in vitro. BMC Complement Altern Med (2016) 0.75

Schisandra chinensis and Morus alba Synergistically Inhibit In Vivo Thrombus Formation and Platelet Aggregation by Impairing the Glycoprotein VI Pathway. Evid Based Complement Alternat Med (2017) 0.75

Inhibitory effects of yuzu and its components on human platelet aggregation. Biomol Ther (Seoul) (2015) 0.75

Potassium 2-(1-hydroxypentyl)-benzoate inhibits ADP-induced rat platelet aggregation through P2Y1-PLC signaling pathways. Naunyn Schmiedebergs Arch Pharmacol (2015) 0.75

Ginsenoside Rg3-enriched red ginseng extract inhibits platelet activation and in vivo thrombus formation. J Ginseng Res (2017) 0.75

Articles cited by this

Guidelines for reporting experiments involving animals: the ARRIVE guidelines. Br J Pharmacol (2010) 13.76

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP. Nature (1998) 9.30

Ginseng pharmacology: multiple constituents and multiple actions. Biochem Pharmacol (1999) 6.30

Platelet activation and atherothrombosis. N Engl J Med (2007) 6.18

Platelets in atherothrombosis. Nat Med (2002) 5.81

Mechanisms of thrombus formation. N Engl J Med (2008) 4.67

Platelets amplify inflammation in arthritis via collagen-dependent microparticle production. Science (2010) 4.22

Platelets in inflammation and atherogenesis. J Clin Invest (2005) 4.10

Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E. Nat Med (2002) 4.02

PI 3-kinase p110beta: a new target for antithrombotic therapy. Nat Med (2005) 3.96

Platelet-collagen interaction: is GPVI the central receptor? Blood (2003) 3.81

Triggers, targets and treatments for thrombosis. Nature (2008) 3.51

Adhesion mechanisms in platelet function. Circ Res (2007) 3.34

Integrin activation. J Cell Sci (2004) 3.02

Platelet-derived growth factor expression and function in idiopathic pulmonary arterial hypertension. Am J Respir Crit Care Med (2008) 2.48

Ginseng compounds: an update on their molecular mechanisms and medical applications. Curr Vasc Pharmacol (2009) 2.44

The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen. EMBO J (1997) 2.34

Activation of platelet function through G protein-coupled receptors. Circ Res (2006) 2.13

Platelet-neutrophil-interactions: linking hemostasis and inflammation. Blood Rev (2006) 2.08

Signaling events underlying thrombus formation. J Thromb Haemost (2003) 2.07

Cell adhesion mechanisms in platelets. Arterioscler Thromb Vasc Biol (2008) 1.98

The vasodilator-stimulated phosphoprotein (VASP) is involved in cGMP- and cAMP-mediated inhibition of agonist-induced platelet aggregation, but is dispensable for smooth muscle function. EMBO J (1999) 1.95

Pharmacology of ginsenosides: a literature review. Chin Med (2010) 1.94

Platelet physiology and thrombosis. Thromb Res (2004) 1.90

Degradation of ginsenosides in humans after oral administration. Drug Metab Dispos (2003) 1.90

Genetic evidence for a predominant role of PI3Kbeta catalytic activity in ITAM- and integrin-mediated signaling in platelets. Blood (2009) 1.90

Fyn and Lyn phosphorylate the Fc receptor gamma chain downstream of glycoprotein VI in murine platelets, and Lyn regulates a novel feedback pathway. Blood (2000) 1.75

Tyrosine phosphorylation of the Fc receptor gamma-chain in collagen-stimulated platelets. J Biol Chem (1996) 1.71

Antiplatelet and anticoagulant effects of Panax notoginseng: comparison of raw and steamed Panax notoginseng with Panax ginseng and Panax quinquefolium. J Ethnopharmacol (2009) 1.68

Current evaluation of the millennium phytomedicine- ginseng (II): Collected chemical entities, modern pharmacology, and clinical applications emanated from traditional Chinese medicine. Curr Med Chem (2009) 1.67

Antiplatelet therapies for the treatment of cardiovascular disease. Nat Rev Drug Discov (2010) 1.66

Platelet adhesion signalling and the regulation of thrombus formation. J Cell Sci (2004) 1.65

Collagen receptor signalling in platelets: extending the role of the ITAM. Immunol Today (1998) 1.59

A predominant role for cAMP-dependent protein kinase in the cGMP-induced phosphorylation of vasodilator-stimulated phosphoprotein and platelet inhibition in humans. Blood (2003) 1.55

In vivo thrombus formation in murine models. Circ Res (2007) 1.54

Phosphorylation of focal adhesion vasodilator-stimulated phosphoprotein at Ser157 in intact human platelets correlates with fibrinogen receptor inhibition. Eur J Biochem (1994) 1.48

Thrombin and collagen induce a feedback inhibitory signaling pathway in platelets involving dissociation of the catalytic subunit of protein kinase A from an NFkappaB-IkappaB complex. J Biol Chem (2010) 1.47

Use of ginseng in medicine with emphasis on neurodegenerative disorders. J Pharmacol Sci (2006) 1.40

Trends in ginseng research in 2010. J Ginseng Res (2011) 1.39

LAT is required for tyrosine phosphorylation of phospholipase cgamma2 and platelet activation by the collagen receptor GPVI. Mol Cell Biol (1999) 1.38

Collagen stimulates tyrosine phosphorylation of phospholipase C-gamma 2 but not phospholipase C-gamma 1 in human platelets. FEBS Lett (1994) 1.31

ZSTK474 is an ATP-competitive inhibitor of class I phosphatidylinositol 3 kinase isoforms. Cancer Sci (2007) 1.30

The p85 subunit of phosphatidylinositol 3-kinase associates with the Fc receptor gamma-chain and linker for activitor of T cells (LAT) in platelets stimulated by collagen and convulxin. J Biol Chem (1998) 1.25

Platelet JNK1 is involved in secretion and thrombus formation. Blood (2010) 1.20

Mitogen-activated protein kinases in hemostasis and thrombosis. J Thromb Haemost (2008) 1.16

Phosphoinositide 3-kinases and the regulation of platelet function. Biochem Soc Trans (2004) 1.15

Role of cyclic nucleotide-dependent protein kinases and their common substrate VASP in the regulation of human platelets. Adv Exp Med Biol (1993) 1.14

Future innovations in anti-platelet therapies. Br J Pharmacol (2008) 1.13

PKCdelta regulates collagen-induced platelet aggregation through inhibition of VASP-mediated filopodia formation. Blood (2006) 1.12

Deletion of the p110beta isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo. Blood (2010) 1.12

Role of phosphoinositide 3-kinase beta in glycoprotein VI-mediated Akt activation in platelets. J Biol Chem (2009) 1.11

Antithrombotic and antiplatelet activities of Korean red ginseng extract. Basic Clin Pharmacol Toxicol (2007) 1.09

A dual role for integrin-linked kinase in platelets: regulating integrin function and alpha-granule secretion. Blood (2008) 1.09

A collagen-related peptide regulates phospholipase Cgamma2 via phosphatidylinositol 3-kinase in human platelets. Biochem J (1999) 1.05

Effect of selective inhibition of the p38 MAP kinase pathway on platelet aggregation. Thromb Haemost (2004) 1.05

Effect of 1-methyl-2-mercapto-5-(3-pyridyl)-imidazole (KC-6141), an anti-aggregating compound, on experimental thrombosis in rats. Thromb Haemost (1978) 1.04

Quercetin inhibits collagen-stimulated platelet activation through inhibition of multiple components of the glycoprotein VI signaling pathway. J Thromb Haemost (2003) 1.04

The role of the platelet in the pathogenesis of atherothrombosis. Am J Cardiovasc Drugs (2005) 1.04

Inhibitory mechanisms of dihydroginsenoside Rg3 in platelet aggregation: critical roles of ERK2 and cAMP. J Pharm Pharmacol (2008) 1.03

Vasodilator-stimulated phosphoprotein (VASP) is phosphorylated on Ser157 by protein kinase C-dependent and -independent mechanisms in thrombin-stimulated human platelets. Biochem J (2006) 1.03

Platelet free calcium concentrations measured with fura-2 are influenced by the transmembrane sodium gradient. Cell Calcium (1989) 1.02

Non-genomic effects of PPARgamma ligands: inhibition of GPVI-stimulated platelet activation. J Thromb Haemost (2009) 0.96

Effects of dietary supplementation of lipophilic fraction from Panax ginseng on cGMP and cAMP in rat platelets and on blood coagulation. Biol Pharm Bull (1996) 0.95

Anti-metastatic potential of ginsenoside Rp1, a novel ginsenoside derivative. Biol Pharm Bull (2008) 0.95

Differential Involvement of ERK2 and p38 in platelet adhesion to collagen. J Biol Chem (2005) 0.95

Korean red ginseng attenuates hypercholesterolemia-enhanced platelet aggregation through suppression of diacylglycerol liberation in high-cholesterol-diet-fed rabbits. Phytother Res (2008) 0.95

A noble function of BAY 11-7082: Inhibition of platelet aggregation mediated by an elevated cAMP-induced VASP, and decreased ERK2/JNK1 phosphorylations. Eur J Pharmacol (2009) 0.94

Platelet activating factor antagonist activity of ginsenosides. Biol Pharm Bull (1998) 0.94

Ginsenoside Rp1, a ginsenoside derivative, blocks lipopolysaccharide-induced interleukin-1beta production via suppression of the NF-kappaB pathway. Planta Med (2009) 0.93

Phosphoinositide 3-kinase p110 beta regulates integrin alpha IIb beta 3 avidity and the cellular transmission of contractile forces. J Biol Chem (2009) 0.92

P2X1-mediated ERK2 activation amplifies the collagen-induced platelet secretion by enhancing myosin light chain kinase activation. J Biol Chem (2003) 0.92

Non-redundant roles of phosphoinositide 3-kinase isoforms alpha and beta in glycoprotein VI-induced platelet signaling and thrombus formation. J Biol Chem (2009) 0.92

Role of phosphoinositide 3-kinase beta in platelet aggregation and thromboxane A2 generation mediated by Gi signalling pathways. Biochem J (2010) 0.89

Effects of various ginseng saponins on 5-hydroxytryptamine release and aggregation in human platelets. J Pharm Pharmacol (1988) 0.89

Phosphorylation of the vasodilator-stimulated phosphoprotein (VASP) by the anti-platelet drug, cilostazol, in platelets. Platelets (2003) 0.89

Costimulation of the Gi-coupled ADP receptor and the Gq-coupled TXA2 receptor is required for ERK2 activation in collagen-induced platelet aggregation. FEBS Lett (2004) 0.89

DX-9065a, a new synthetic, potent anticoagulant and selective inhibitor for factor Xa. Thromb Haemost (1994) 0.88

Role of the ERK pathway in the activation of store-mediated calcium entry in human platelets. J Biol Chem (2001) 0.87

Inhibitory effects of Bulnesia sarmienti aqueous extract on agonist-induced platelet activation and thrombus formation involves mitogen-activated protein kinases. J Ethnopharmacol (2010) 0.85

Role of the p110delta PI 3-kinase in integrin and ITAM receptor signalling in platelets. Platelets (2005) 0.85

Molecular mechanisms of ginsenoside Rp1-mediated growth arrest and apoptosis. Int J Mol Med (2009) 0.85

Evaluation of chemopreventive action of Ginsenoside Rp1. Biofactors (2006) 0.85

Cyclic nucleotides inhibit MAP kinase activity in low-dose collagen-stimulated platelets. Thromb Res (2010) 0.82

Regulatory role of ginsenoside Rp1, a novel ginsenoside derivative, on CD29-mediated cell adhesion. Planta Med (2009) 0.81

Mouse antithrombotic assay. Inhibition of platelet thromboembolism by disintegrins. Thromb Res (1993) 0.80

cAMP is an important messenger for ADP-induced platelet aggregation. Platelets (1999) 0.80

Antithrombotic drugs in coronary artery disease: risk benefit ratio and bleeding. J Thromb Haemost (2010) 0.78

Articles by these authors

(truncated to the top 100)

Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C. Hepatitis Interventional Therapy Group. N Engl J Med (1998) 14.40

Phylogenetic affiliation of the pseudomonads based on 16S rRNA sequence. Int J Syst Evol Microbiol (2000) 4.31

Acetaminophen toxicity in an urban county hospital. N Engl J Med (1997) 4.26

Identification of the human c-myc protein nuclear translocation signal. Mol Cell Biol (1988) 3.30

Nuclear and nucleolar targeting sequences of c-erb-A, c-myb, N-myc, p53, HSP70, and HIV tat proteins. J Biol Chem (1989) 2.89

Max: functional domains and interaction with c-Myc. Genes Dev (1992) 2.88

The prevalence of premature ejaculation and its clinical characteristics in Korean men according to different definitions. Int J Impot Res (2012) 2.88

Search for a resonance decaying into WZ boson pairs in pp collisions. Phys Rev Lett (2010) 2.83

Etiology and outcome for 295 patients with acute liver failure in the United States. Liver Transpl Surg (1999) 2.79

Involvement of the 'leucine zipper' region in the oligomerization and transforming activity of human c-myc protein. Nature (1989) 2.70

c-myc gene expression is stimulated by agents that activate protein kinase C and does not account for the mitogenic effect of PDGF. Cell (1985) 2.69

Species identification of mycobacteria by PCR-restriction fragment length polymorphism of the rpoB gene. J Clin Microbiol (2000) 2.62

Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery. Gene Ther (2004) 2.55

Fungal infections in patients with acute leukemia. Am J Med (1982) 2.43

Thermal response of rat fibroblasts stably transfected with the human 70-kDa heat shock protein-encoding gene. Proc Natl Acad Sci U S A (1991) 2.26

Colonic necrosis with Kayexalate-sorbitol enemas after renal transplantation. Ann Intern Med (1989) 2.24

Microvascular and macrovascular reactivity is reduced in subjects at risk for type 2 diabetes. Diabetes (1999) 2.21

Polyamines as physiological substrates for transglutaminases. J Biol Chem (1980) 2.15

Factors affecting insertion time and patient discomfort during colonoscopy. Gastrointest Endosc (2000) 2.13

Mucin-hypersecreting bile duct tumor characterized by a striking homology with an intraductal papillary mucinous tumor (IPMT) of the pancreas. Endoscopy (2000) 2.13

Preparation and characterization of chitosan microparticles intended for controlled drug delivery. Int J Pharm (2002) 2.10

Mutants in three genes affecting transport of magnesium in Escherichia coli: genetics and physiology. J Bacteriol (1976) 2.09

An internalization signal in the simian immunodeficiency virus transmembrane protein cytoplasmic domain modulates expression of envelope glycoproteins on the cell surface. J Cell Biol (1996) 2.06

Retracted New findings of the correlation between acupoints and corresponding brain cortices using functional MRI. Proc Natl Acad Sci U S A (1998) 2.05

Cardiac myocyte hypertrophy is associated with c-myc protooncogene expression. Proc Natl Acad Sci U S A (1986) 2.00

Identification of hypusine, an unusual amino acid, in a protein from human lymphocytes and of spermidine as its biosynthetic precursor. Proc Natl Acad Sci U S A (1981) 1.95

Interleukin-12 and interleukin-18 synergistically induce murine tumor regression which involves inhibition of angiogenesis. J Clin Invest (1998) 1.93

Induction of reversible complexes between eukaryotic DNA topoisomerase I and DNA-containing oxidative base damages. 7, 8-dihydro-8-oxoguanine and 5-hydroxycytosine. J Biol Chem (1999) 1.91

Structure of human rhinovirus complexed with Fab fragments from a neutralizing antibody. J Virol (1993) 1.90

A precision measurement of the mass of the top quark. Nature (2004) 1.87

Hepatitis B and C virus, Clonorchis sinensis for the risk of liver cancer: a case-control study in Pusan, Korea. Int J Epidemiol (1996) 1.86

Augmented expression of normal c-myc is sufficient for cotransformation of rat embryo cells with a mutant ras gene. Mol Cell Biol (1985) 1.84

An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity. Eur J Pharmacol (1998) 1.83

The structure of human rhinovirus 16. Structure (1993) 1.83

Mitochondrial decay in hepatocytes from old rats: membrane potential declines, heterogeneity and oxidants increase. Proc Natl Acad Sci U S A (1997) 1.83

Relationship between sonographic and pathologic findings in epidermal inclusion cysts. J Clin Ultrasound (2001) 1.77

Identification of the hypusine-containing protein hy+ as translation initiation factor eIF-4D. Proc Natl Acad Sci U S A (1983) 1.76

Efficacy of ramosetron in the treatment of male patients with irritable bowel syndrome with diarrhea: a multicenter, randomized clinical trial, compared with mebeverine. Neurogastroenterol Motil (2011) 1.75

Features of the spermidine-binding site of deoxyhypusine synthase as derived from inhibition studies. Effective inhibition by bis- and mono-guanylated diamines and polyamines. J Biol Chem (1993) 1.74

In vitro anti-inflammatory effects of cynaropicrin, a sesquiterpene lactone, from Saussurea lappa. Eur J Pharmacol (2000) 1.70

A new strategy to predict the neoplastic polyps of the gallbladder based on a scoring system using EUS. Gastrointest Endosc (2000) 1.69

Exposure and immunity to hepatitis-B virus in a liver unit. Lancet (1974) 1.68

Association between hepatitis B virus infection and HLA-DR type in Korea. Hepatology (2000) 1.65

Regulation of acetyl-CoA carboxylase. Biochem Soc Trans (2006) 1.64

Inhibition of the G1-S transition of the cell cycle by inhibitors of deoxyhypusine hydroxylation. Biochim Biophys Acta (1994) 1.62

Neonatal tolerance induced by antibody against antigen-specific receptor. Science (1974) 1.61

Radiological response predicts survival following transarterial chemoembolisation in patients with unresectable hepatocellular carcinoma. Aliment Pharmacol Ther (2012) 1.60

The oxidative burst protects plants against pathogen attack: mechanism and role as an emergency signal for plant bio-defence--a review. Gene (1996) 1.59

Racial differences in responses to therapy with interferon in chronic hepatitis C. Consensus Interferon Study Group. Hepatology (1999) 1.59

Posttranslational synthesis of hypusine: evolutionary progression and specificity of the hypusine modification. Amino Acids (2007) 1.57

Implications of increased tumor blood flow and oxygenation caused by mild temperature hyperthermia in tumor treatment. Int J Hyperthermia (2005) 1.56

Where has the tumor gone? The characteristics of cases of negative pathologic diagnosis after endoscopic mucosal resection. Endoscopy (2009) 1.55

Heat shock protein hsp70 protects cells from thermal stress even after deletion of its ATP-binding domain. Proc Natl Acad Sci U S A (1992) 1.54

Gastro-oesophageal reflux disease in Asia. J Gastroenterol Hepatol (2000) 1.53

Enterococcus avium bacteremia: a 12-year clinical experience with 53 patients. Eur J Clin Microbiol Infect Dis (2011) 1.53

Measurement of the forward-backward charge asymmetry in top-quark pair production. Phys Rev Lett (2008) 1.53

Preparation of alginate beads for floating drug delivery system: effects of CO(2) gas-forming agents. Int J Pharm (2002) 1.52

A novel influenza a (H1N1) virus as a possible cause of pityriasis rosea? J Eur Acad Dermatol Venereol (2011) 1.49

Efficacy and safety of pegylated (40-kd) interferon alpha-2a compared with interferon alpha-2a in noncirrhotic patients with chronic hepatitis C. Hepatology (2001) 1.49

Tumor cell responses to IFNgamma affect tumorigenicity and response to IL-12 therapy and antiangiogenesis. Immunity (1998) 1.49

Cellular and humoral immunity to hepatitis-B surface antigen in active chronic hepatitis. Br Med J (1975) 1.47

Frequent somatic mutations of the beta-catenin gene in intestinal-type gastric cancer. Cancer Res (1999) 1.47

Measurement of the W boson mass with the D0 detector. Phys Rev Lett (2012) 1.46

Transforming growth factor-beta3 perturbs the inter-Sertoli tight junction permeability barrier in vitro possibly mediated via its effects on occludin, zonula occludens-1, and claudin-11. Endocrinology (2001) 1.45

Preparation and characterization of drug-loaded polymethacrylate microspheres by an emulsion solvent evaporation method. J Microencapsul (2003) 1.44

Combination of propofol and remifentanil target-controlled infusion for laryngeal mask airway insertion in children. Minerva Anestesiol (2011) 1.44

[Increased expression of hypoxia-inducible factor-1α and connective tissue growth factor accompanied by fibrosis in the rat testis of varicocele]. Actas Urol Esp (2012) 1.44

Deoxyhypusine hydroxylase from rat testis. Partial purification and characterization. J Biol Chem (1986) 1.44

Chronic hepatitis B virus infection: treatment strategies for the next millennium. Ann Intern Med (2000) 1.43

Heterogeneity of human papillomavirus DNA in a patient with Bowenoid papulosis that progressed to squamous cell carcinoma. Br J Dermatol (1998) 1.42

Combination therapy of testosterone enanthate and tadalafil on PDE5 inhibitor non-reponders with severe and intermediate testosterone deficiency. Int J Impot Res (2012) 1.42

Sensory and motor dysfunction assessed by anorectal manometry in uterine cervical carcinoma patients with radiation-induced late rectal complication. Int J Radiat Oncol Biol Phys (1998) 1.42

Targeted expression of the ret/PTC1 oncogene induces papillary thyroid carcinomas. Endocrinology (1996) 1.42

Risk factors for recurrence of primary bile duct stones after endoscopic biliary sphincterotomy. Gastrointest Endosc (2001) 1.42

Multiple functional interactions between components of the Lsm2-Lsm8 complex, U6 snRNA, and the yeast La protein. Genetics (2001) 1.42

Neuropathic pruritus following Wallenberg syndrome. Neurology (2009) 1.40

Cloning and expression of human deoxyhypusine synthase cDNA. Structure-function studies with the recombinant enzyme and mutant proteins. J Biol Chem (1995) 1.39

The biosynthesis of protein-bound hypusine (N epsilon -(4-amino-2-hydroxybutyl)lysine). Lysine as the amino acid precursor and the intermediate role of deoxyhypusine (N epsilon -(4-aminobutyl)lysine). J Biol Chem (1982) 1.39

Endoscopic band ligation of active cardiac variceal bleeding. Endoscopy (2006) 1.38

Migration of three endoclips following laparoscopic cholecystectomy. J R Coll Surg Edinb (1999) 1.38

Domains of human c-myc protein required for autosuppression and cooperation with ras oncogenes are overlapping. Mol Cell Biol (1990) 1.38

Specificity of DNA binding activity of the Bacillus subtilis catabolite control protein CcpA. J Bacteriol (1995) 1.37

Rhinovirus enters but does not replicate inside monocytes and airway macrophages. J Immunol (1996) 1.37

Half-dose gadolinium-enhanced MR imaging with magnetization transfer technique in brain tumors: comparison with conventional contrast-enhanced MR imaging. AJR Am J Roentgenol (1998) 1.37

Idiopathic thrombocytopenic purpura during interferon-alpha 2B treatment for chronic hepatitis. Am J Gastroenterol (1994) 1.37

Protein oxidation associated with aging is reduced by dietary restriction of protein or calories. Proc Natl Acad Sci U S A (1992) 1.36

Induction of plant gp91 phox homolog by fungal cell wall, arachidonic acid, and salicylic acid in potato. Mol Plant Microbe Interact (2001) 1.35

High incidence of resistance to multiple antimicrobials in clinical isolates of Streptococcus pneumoniae from a university hospital in Korea. Clin Infect Dis (1995) 1.34

An immunohistochemical study of Na+/I- symporter in human thyroid tissues and salivary gland tissues. Endocrinology (1998) 1.34

The plasma alpha-synuclein levels in patients with Parkinson's disease and multiple system atrophy. J Neural Transm (Vienna) (2006) 1.33

Posttranslational formation of hypusine in a single major protein occurs generally in growing cells and is associated with activation of lymphocyte growth. Cell (1982) 1.33

Acute hepatic failure: a Western perspective. J Gastroenterol Hepatol (2000) 1.32

A 22-amino acid synthetic peptide corresponding to the second extracellular loop of rat occludin perturbs the blood-testis barrier and disrupts spermatogenesis reversibly in vivo. Biol Reprod (2001) 1.31

Mutations of tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1) and receptor 2 (TRAIL-R2) genes in metastatic breast cancers. Cancer Res (2001) 1.31

Amber suppression in mammalian cells dependent upon expression of an Escherichia coli aminoacyl-tRNA synthetase gene. Mol Cell Biol (1996) 1.29

Angiopoietin-1 and -2 coiled coil domains mediate distinct homo-oligomerization patterns, but fibrinogen-like domains mediate ligand activity. J Biol Chem (1999) 1.29

Enhanced HBsAb production in pathogenesis of fulminant viral hepatitis type B. Br Med J (1976) 1.28

Fecal carriage of serotype K1 Klebsiella pneumoniae ST23 strains closely related to liver abscess isolates in Koreans living in Korea. Eur J Clin Microbiol Infect Dis (2011) 1.28

Expression of Fas and Fas-related molecules in human hepatocellular carcinoma. Hum Pathol (2001) 1.27

Hybrid natural orifice transluminal endoscopic surgery: endoscopic full-thickness resection of early gastric cancer and laparoscopic regional lymph node dissection--14 human cases. Endoscopy (2010) 1.27