Involvement of the 'leucine zipper' region in the oligomerization and transforming activity of human c-myc protein.

PubWeight™: 2.70‹?› | Rank: Top 1%

🔗 View Article (PMID 2645525)

Published in Nature on February 16, 1989

Authors

C V Dang1, M McGuire, M Buckmire, W M Lee

Author Affiliations

1: Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.

Articles citing this

The MYC protein activates transcription of the alpha-prothymosin gene. EMBO J (1991) 4.96

The ornithine decarboxylase gene is a transcriptional target of c-Myc. Proc Natl Acad Sci U S A (1993) 4.66

An amino-terminal c-myc domain required for neoplastic transformation activates transcription. Mol Cell Biol (1990) 4.24

Structure and function of the b/HLH/Z domain of USF. EMBO J (1994) 3.70

c-Myc represses transcription in vivo by a novel mechanism dependent on the initiator element and Myc box II. EMBO J (1994) 3.01

A helix-loop-helix protein related to the immunoglobulin E box-binding proteins. Mol Cell Biol (1990) 2.90

Blocking of tumor promoter-induced AP-1 activity inhibits induced transformation in JB6 mouse epidermal cells. Proc Natl Acad Sci U S A (1994) 2.43

Negative autoregulation of c-myc transcription. EMBO J (1990) 2.38

c-Myc promotes differentiation of human epidermal stem cells. Genes Dev (1997) 2.37

Determination of the c-MYC DNA-binding site. Proc Natl Acad Sci U S A (1991) 2.19

Characterization of hepatitis delta antigen: specific binding to hepatitis delta virus RNA. J Virol (1990) 2.17

Both the basic region and the 'leucine zipper' domain of the cyclic AMP response element binding (CREB) protein are essential for transcriptional activation. EMBO J (1990) 2.11

An E-box-mediated increase in cad transcription at the G1/S-phase boundary is suppressed by inhibitory c-Myc mutants. Mol Cell Biol (1995) 2.08

Fragments of ATM which have dominant-negative or complementing activity. Mol Cell Biol (1997) 1.99

An overview of the basic helix-loop-helix proteins. Genome Biol (2004) 1.85

Intracellular leucine zipper interactions suggest c-Myc hetero-oligomerization. Mol Cell Biol (1991) 1.84

Isolation of cDNAs for DNA-binding proteins which specifically bind to a tax-responsive enhancer element in the long terminal repeat of human T-cell leukemia virus type I. J Virol (1991) 1.80

myc boxes, which are conserved in myc family proteins, are signals for protein degradation via the proteasome. Mol Cell Biol (1998) 1.77

Chromatin structure modulation in Saccharomyces cerevisiae by centromere and promoter factor 1. Mol Cell Biol (1994) 1.74

DNA replication origin and transcriptional enhancer in c-myc gene share the c-myc protein binding sequences. EMBO J (1989) 1.60

A link between increased transforming activity of lymphoma-derived MYC mutant alleles, their defective regulation by p107, and altered phosphorylation of the c-Myc transactivation domain. Mol Cell Biol (1995) 1.59

The basic domain of myogenic basic helix-loop-helix (bHLH) proteins is the novel target for direct inhibition by another bHLH protein, Twist. Mol Cell Biol (1997) 1.56

Sequence-specific DNA binding by Myc proteins. Proc Natl Acad Sci U S A (1991) 1.55

mTFE3, an X-linked transcriptional activator containing basic helix-loop-helix and zipper domains, utilizes the zipper to stabilize both DNA binding and multimerization. Mol Cell Biol (1992) 1.49

Visualization of Myc/Max/Mad family dimers and the competition for dimerization in living cells. Mol Cell Biol (2004) 1.47

Activation domains of L-Myc and c-Myc determine their transforming potencies in rat embryo cells. Mol Cell Biol (1992) 1.39

An E-box element localized in the first intron mediates regulation of the prothymosin alpha gene by c-myc. Mol Cell Biol (1994) 1.38

Oligomerization of the hydrophobic heptad repeat of gp41. J Virol (1995) 1.38

Domains of human c-myc protein required for autosuppression and cooperation with ras oncogenes are overlapping. Mol Cell Biol (1990) 1.38

Myc oncogenes: the enigmatic family. Biochem J (1996) 1.32

A point mutation in the MyoD basic domain imparts c-Myc-like properties. Proc Natl Acad Sci U S A (1992) 1.32

Oligomerization of hepatitis delta antigen is required for both the trans-activating and trans-dominant inhibitory activities of the delta antigen. J Virol (1992) 1.32

The leucine zipper of c-Myc is required for full inhibition of erythroleukemia differentiation. Mol Cell Biol (1990) 1.23

c-Myc/Max heterodimers bind cooperatively to the E-box sequences located in the first intron of the rat ornithine decarboxylase (ODC) gene. Nucleic Acids Res (1997) 1.20

Stem cell-specific activation of an ancestral myc protooncogene with conserved basic functions in the early metazoan Hydra. Proc Natl Acad Sci U S A (2010) 1.19

The centromere and promoter factor 1 of yeast contains a dimerisation domain located carboxy-terminal to the bHLH domain. Nucleic Acids Res (1992) 1.18

Trans-dominant negative mutants of Fos and Jun. Proc Natl Acad Sci U S A (1990) 1.18

DNA-binding domain of human c-Myc produced in Escherichia coli. Mol Cell Biol (1989) 1.15

Transcriptional suppression of cellular gene expression by c-Myc. Mol Cell Biol (1991) 1.14

Myc represses transcription of the growth arrest gene gas1. Proc Natl Acad Sci U S A (1997) 1.13

The basic helix-loop-helix-zipper domain of TFE3 mediates enhancer-promoter interaction. Mol Cell Biol (1994) 1.12

Determination of the DNA sequence recognized by the bHLH-zip domain of the N-Myc protein. Nucleic Acids Res (1992) 1.11

Differential expression of two Xenopus c-myc proto-oncogenes during development. EMBO J (1989) 1.11

The action mechanism of the Myc inhibitor termed Omomyc may give clues on how to target Myc for cancer therapy. PLoS One (2011) 1.10

Domain swapping reveals the modular nature of Fos, Jun, and CREB proteins. Mol Cell Biol (1990) 1.09

Analyses of loss-of-function mutations of the MITF gene suggest that haploinsufficiency is a cause of Waardenburg syndrome type 2A. Am J Hum Genet (1996) 1.09

TFE3 contains two activation domains, one acidic and the other proline-rich, that synergistically activate transcription. Nucleic Acids Res (1995) 1.08

A link between c-Myc-mediated transcriptional repression and neoplastic transformation. J Clin Invest (1996) 1.06

B-myc inhibits neoplastic transformation and transcriptional activation by c-myc. Mol Cell Biol (1993) 1.01

The nerve growth factor-responsive PC12 cell line does not express the Myc dimerization partner Max. Mol Cell Biol (1995) 0.93

Coupled and uncoupled induction of fos and jun transcription by different second messengers in cells of hematopoietic origin. Nucleic Acids Res (1990) 0.92

Analysis of the DNA-binding and dimerization activities of Neurospora crassa transcription factor NUC-1. Mol Cell Biol (1994) 0.92

Evolution of the Max and Mlx networks in animals. Genome Biol Evol (2011) 0.88

Mxi1 inhibits the proliferation of U87 glioma cells through down-regulation of cyclin B1 gene expression. Br J Cancer (2002) 0.88

Differential patterns of DNA binding by myc and max proteins. Proc Natl Acad Sci U S A (1993) 0.88

Mutations within the 5' half of the avian retrovirus MC29 v-myc gene alter or abolish transformation of chicken embryo fibroblasts and macrophages. J Virol (1992) 0.87

A leucine zipper-like domain is essential for dimerization and encapsidation of bluetongue virus nucleocapsid protein VP4. J Virol (1998) 0.83

BzpF is a CREB-like transcription factor that regulates spore maturation and stability in Dictyostelium. Dev Biol (2011) 0.83

CRTC1/MAML2 gain-of-function interactions with MYC create a gene signature predictive of cancers with CREB-MYC involvement. Proc Natl Acad Sci U S A (2014) 0.81

Transcription and cancer. Br J Cancer (1991) 0.81

A nuclear protein associated with human cancer cells binds preferentially to a human repetitive DNA sequence. Proc Natl Acad Sci U S A (1989) 0.81

Max-E47, a designed minimalist protein that targets the E-box DNA site in vivo and in vitro. J Am Chem Soc (2009) 0.78

Apparent uncoupling of oncogenicity from fibroblast transformation and apoptosis in a mutant myc gene transduced by feline leukemia virus. J Virol (1996) 0.78

Articles by these authors

Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C. Hepatitis Interventional Therapy Group. N Engl J Med (1998) 14.40

Acetaminophen toxicity in an urban county hospital. N Engl J Med (1997) 4.26

The Roscommon Family Study. I. Methods, diagnosis of probands, and risk of schizophrenia in relatives. Arch Gen Psychiatry (1993) 3.61

Identification of the human c-myc protein nuclear translocation signal. Mol Cell Biol (1988) 3.30

Nuclear and nucleolar targeting sequences of c-erb-A, c-myb, N-myc, p53, HSP70, and HIV tat proteins. J Biol Chem (1989) 2.89

Max: functional domains and interaction with c-Myc. Genes Dev (1992) 2.88

Search for a resonance decaying into WZ boson pairs in pp collisions. Phys Rev Lett (2010) 2.83

Etiology and outcome for 295 patients with acute liver failure in the United States. Liver Transpl Surg (1999) 2.79

c-myc gene expression is stimulated by agents that activate protein kinase C and does not account for the mitogenic effect of PDGF. Cell (1985) 2.69

Fungal infections in patients with acute leukemia. Am J Med (1982) 2.43

Thermal response of rat fibroblasts stably transfected with the human 70-kDa heat shock protein-encoding gene. Proc Natl Acad Sci U S A (1991) 2.26

Colonic necrosis with Kayexalate-sorbitol enemas after renal transplantation. Ann Intern Med (1989) 2.24

An internalization signal in the simian immunodeficiency virus transmembrane protein cytoplasmic domain modulates expression of envelope glycoproteins on the cell surface. J Cell Biol (1996) 2.06

Cardiac myocyte hypertrophy is associated with c-myc protooncogene expression. Proc Natl Acad Sci U S A (1986) 2.00

Interleukin-12 and interleukin-18 synergistically induce murine tumor regression which involves inhibition of angiogenesis. J Clin Invest (1998) 1.93

Structure of human rhinovirus complexed with Fab fragments from a neutralizing antibody. J Virol (1993) 1.90

A precision measurement of the mass of the top quark. Nature (2004) 1.87

Augmented expression of normal c-myc is sufficient for cotransformation of rat embryo cells with a mutant ras gene. Mol Cell Biol (1985) 1.84

The structure of human rhinovirus 16. Structure (1993) 1.83

Relationship between sonographic and pathologic findings in epidermal inclusion cysts. J Clin Ultrasound (2001) 1.77

Exposure and immunity to hepatitis-B virus in a liver unit. Lancet (1974) 1.68

Regulation of acetyl-CoA carboxylase. Biochem Soc Trans (2006) 1.64

Neonatal tolerance induced by antibody against antigen-specific receptor. Science (1974) 1.61

Effectiveness of a nurse-based outreach program for identifying and treating psychiatric illness in the elderly. JAMA (2000) 1.59

Racial differences in responses to therapy with interferon in chronic hepatitis C. Consensus Interferon Study Group. Hepatology (1999) 1.59

The Roscommon Family Study. IV. Affective illness, anxiety disorders, and alcoholism in relatives. Arch Gen Psychiatry (1993) 1.58

Management of large scalp defects with local pedicle flaps. Plast Reconstr Surg (1993) 1.58

Heat shock protein hsp70 protects cells from thermal stress even after deletion of its ATP-binding domain. Proc Natl Acad Sci U S A (1992) 1.54

Measurement of the forward-backward charge asymmetry in top-quark pair production. Phys Rev Lett (2008) 1.53

The Roscommon Family Study. III. Schizophrenia-related personality disorders in relatives. Arch Gen Psychiatry (1993) 1.51

Efficacy and safety of pegylated (40-kd) interferon alpha-2a compared with interferon alpha-2a in noncirrhotic patients with chronic hepatitis C. Hepatology (2001) 1.49

Tumor cell responses to IFNgamma affect tumorigenicity and response to IL-12 therapy and antiangiogenesis. Immunity (1998) 1.49

Swiveling-domain mechanism for enzymatic phosphotransfer between remote reaction sites. Proc Natl Acad Sci U S A (1996) 1.48

Cellular and humoral immunity to hepatitis-B surface antigen in active chronic hepatitis. Br Med J (1975) 1.47

Schizotypal symptoms and signs in the Roscommon Family Study. Their factor structure and familial relationship with psychotic and affective disorders. Arch Gen Psychiatry (1995) 1.46

Measurement of the W boson mass with the D0 detector. Phys Rev Lett (2012) 1.46

Transforming growth factor-beta3 perturbs the inter-Sertoli tight junction permeability barrier in vitro possibly mediated via its effects on occludin, zonula occludens-1, and claudin-11. Endocrinology (2001) 1.45

Chronic hepatitis B virus infection: treatment strategies for the next millennium. Ann Intern Med (2000) 1.43

Metallic "ferroelectricity" in the pyrochlore Cd2Re2O7. Phys Rev Lett (2004) 1.42

Studies on human lymphocytes stimulated in vitro with anti-gamma and anti-mu antibodies. Experientia (1967) 1.40

Migration of three endoclips following laparoscopic cholecystectomy. J R Coll Surg Edinb (1999) 1.38

Domains of human c-myc protein required for autosuppression and cooperation with ras oncogenes are overlapping. Mol Cell Biol (1990) 1.38

Rhinovirus enters but does not replicate inside monocytes and airway macrophages. J Immunol (1996) 1.37

Idiopathic thrombocytopenic purpura during interferon-alpha 2B treatment for chronic hepatitis. Am J Gastroenterol (1994) 1.37

Acute hepatic failure: a Western perspective. J Gastroenterol Hepatol (2000) 1.32

A 22-amino acid synthetic peptide corresponding to the second extracellular loop of rat occludin perturbs the blood-testis barrier and disrupts spermatogenesis reversibly in vivo. Biol Reprod (2001) 1.31

Angiopoietin-1 and -2 coiled coil domains mediate distinct homo-oligomerization patterns, but fibrinogen-like domains mediate ligand activity. J Biol Chem (1999) 1.29

Enhanced HBsAb production in pathogenesis of fulminant viral hepatitis type B. Br Med J (1976) 1.28

Poor performance of hepatitis C antibody tests in hospital patients in Uganda. J Med Virol (2010) 1.25

Treatment of chronic hepatitis C with consensus interferon: a multicenter, randomized, controlled trial. Consensus Interferon Study Group. Hepatology (1997) 1.25

WIN 52035-dependent human rhinovirus 16: assembly deficiency caused by mutations near the canyon surface. J Virol (1998) 1.24

Antibody-mediated neutralization of human rhinovirus 14 explored by means of cryoelectron microscopy and X-ray crystallography of virus-Fab complexes. J Virol (1998) 1.23

The Roscommon Family Study. II. The risk of nonschizophrenic nonaffective psychoses in relatives. Arch Gen Psychiatry (1993) 1.23

Hepatitis B in a hospital for the mentally subnormal in southern England. Br Med J (1978) 1.20

Immune suppression by recombinant interleukin (rIL)-12 involves interferon gamma induction of nitric oxide synthase 2 (iNOS) activity: inhibitors of NO generation reveal the extent of rIL-12 vaccine adjuvant effect. J Exp Med (1998) 1.20

Anti-receptor antibody. II. Induction of long-term unresponsiveness in neonatal mice. J Immunol (1975) 1.19

Structure determination of an Fab fragment that neutralizes human rhinovirus 14 and analysis of the Fab-virus complex. J Mol Biol (1994) 1.19

Clinical outcome and virological characteristics of hepatitis B-related acute liver failure in the United States. J Viral Hepat (2005) 1.19

Identification of sequences in c-myc mRNA that regulate its steady-state levels. Mol Cell Biol (1996) 1.18

Spermatogonial stem cells alone are not sufficient to re-initiate spermatogenesis in the rat testis following adjudin-induced infertility. Int J Androl (2011) 1.18

Estrogen-induced post-transcriptional modulation of c-myc proto-oncogene expression in human breast cancer cells. J Biol Chem (1988) 1.15

DNA-binding domain of human c-Myc produced in Escherichia coli. Mol Cell Biol (1989) 1.15

Evaluation of a Hong Kong Chinese version of a self-administered questionnaire for assessing symptom severity and functional status of carpal tunnel syndrome: cross-cultural adaptation and reliability. Hong Kong Med J (2007) 1.14

Recognition and identification of facial stimuli by schizophrenics and patients with affective disorders. Br J Clin Psychol (1984) 1.14

Definition of the activities and properties of c-myc required to inhibit cell differentiation. Cell Growth Differ (1990) 1.14

Decreased plasma gelsolin concentrations in acute liver failure, myocardial infarction, septic shock, and myonecrosis. Crit Care Med (1997) 1.14

In-fiber common-path optical coherence tomography using a conical-tip fiber. Opt Express (2009) 1.12

Src kinase-targeted anti-inflammatory activity of davallialactone from Inonotus xeranticus in lipopolysaccharide-activated RAW264.7 cells. Br J Pharmacol (2008) 1.11

The prevalence of psychiatric disorders in elderly residents of public housing. J Gerontol A Biol Sci Med Sci (1996) 1.10

The empty sella syndrome. J Neurosurg (1968) 1.10

Alterations in population dynamics of arterial smooth muscle cells during atherogenesis. IV. Evidence for a polyclonal origin of hypercholesterolemic diet-induced atherosclerotic lesions in young swine. Exp Mol Pathol (1976) 1.10

Plasma tumor necrosis factor alpha predicts decreased long-term survival in severe alcoholic hepatitis. Alcohol Clin Exp Res (1990) 1.10

Measurement of the electron charge asymmetry in pp[over ]-->W+X-->enu+X events at sqrt[s]=1.96 TeV. Phys Rev Lett (2008) 1.09

Evidence for a particle produced in association with weak bosons and decaying to a bottom-antibottom quark pair in higgs boson searches at the tevatron. Phys Rev Lett (2012) 1.08

Immune responses to the hepatitis B surface antigen and liver-specific lipoprotein in acute type B hepatitis. Gut (1977) 1.08

Cell-mediated immunity to hepatitis B surface antigen in blood donors with persistent antigenaemia. Gut (1975) 1.08

Prevention of tumorigenesis of oncogene-transformed rat fibroblasts with DNA site inhibitors of poly(ADP ribose) polymerase. Proc Natl Acad Sci U S A (1987) 1.08

Adrenal gland sampling during transjugular liver biopsy leads to misdiagnosis of hepatocellular carcinoma. Am J Gastroenterol (1999) 1.07

Controlled duodenostomy for difficult duodenal stump. Aust N Z J Surg (1996) 1.06

Cutaneous vasculitis and rheumatoid factor positivity as presenting signs of hepatitis C virus-induced mixed cryoglobulinemia. Arch Dermatol (1995) 1.06

Determination of the width of the top quark. Phys Rev Lett (2011) 1.05

Mutagenesis of the peptidyltransferase center of 23S rRNA: the invariant U2449 is dispensable. Nucleic Acids Res (2001) 1.04

Coding elements in exons 2 and 3 target c-myc mRNA downregulation during myogenic differentiation. Mol Cell Biol (1997) 1.04

Doppler ultrasound imaging detects changes in tumor perfusion during antivascular therapy associated with vascular anatomic alterations. Cancer Res (2001) 1.04

General exercise training improves ventilatory and peripheral muscle strength and endurance in chronic airflow limitation. Am J Respir Crit Care Med (1998) 1.04

Search for large extra dimensions via single photon plus missing energy final states at sqrt s = 1.96 TeV. Phys Rev Lett (2008) 1.04

Eosinophils bind rhinovirus and activate virus-specific T cells. J Immunol (1998) 1.04

Need and unmet need for mental health care among elderly public housing residents. Gerontologist (1997) 1.03

Validity of the rapid strip assay test for detecting HBsAg in patients admitted to hospital in Uganda. J Med Virol (2010) 1.03

Quantitative T1rho magnetic resonance imaging of RIF-1 tumors in vivo: detection of early response to cyclophosphamide therapy. Cancer Res (2001) 1.03

Examining the validity of DSM-III-R schizoaffective disorder and its putative subtypes in the Roscommon Family Study. Am J Psychiatry (1995) 1.02

Search for doubly charged Higgs boson pair production in pp¯ collisions at √s=1.96 TeV. Phys Rev Lett (2012) 1.02

B7-1 and interleukin 12 synergistically induce effective antitumor immunity. Cancer Res (1995) 1.01

Ginsenoside-Rp1 inhibits platelet activation and thrombus formation via impaired glycoprotein VI signalling pathway, tyrosine phosphorylation and MAPK activation. Br J Pharmacol (2012) 1.01

Fibrinogen sialic acid residues are low affinity calcium-binding sites that influence fibrin assembly. J Biol Chem (1989) 1.00

Functional domains of c-Myc involved in the commitment and differentiation of murine erythroleukemia cells. Oncogene (1993) 0.99