Published in Proc Natl Acad Sci U S A on November 01, 1990
Human health risk assessment for aluminium, aluminium oxide, and aluminium hydroxide. J Toxicol Environ Health B Crit Rev (2007) 1.49
Interaction of aluminum with PHFtau in Alzheimer's disease neurofibrillary degeneration evidenced by desferrioxamine-assisted chelating autoclave method. Am J Pathol (1999) 1.10
Brain capillary endothelium and choroid plexus epithelium regulate transport of transferrin-bound and free iron into the rat brain. J Neurochem (2004) 1.08
A calorie-restricted diet decreases brain iron accumulation and preserves motor performance in old rhesus monkeys. J Neurosci (2010) 1.02
A novel model for brain iron uptake: introducing the concept of regulation. J Cereb Blood Flow Metab (2014) 0.91
The biological speciation and toxicokinetics of aluminum. Environ Health Perspect (1994) 0.86
Cognitive deterioration and associated pathology induced by chronic low-level aluminum ingestion in a translational rat model provides an explanation of Alzheimer's disease, tests for susceptibility and avenues for treatment. Int J Alzheimers Dis (2012) 0.81
Determination of metallic traces in kidneys, livers, lungs and spleens of rats with metallic implants after a long implantation time. J Mater Sci Mater Med (2007) 0.76
Aluminium in biological environments: a computational approach. Comput Struct Biotechnol J (2014) 0.76
X-ray small angle scattering of the human transferrin protein aggregates. A fractal study. Biophys J (1993) 0.76
X-ray absorption near-edge spectroscopy of transferrins: a theoretical and experimental probe of the metal site local structure. Eur Biophys J (2003) 0.76
Dialysis-associated encephalopathy: light and electron microscopic morphology and topography with evidence of aluminum by laser microprobe mass analysis. Acta Neuropathol (1993) 0.75
Receptor-mediated endocytosis of transferrin in developmentally totipotent mouse teratocarcinoma stem cells. J Biol Chem (1981) 4.86
Binding of apotransferrin to K562 cells: explanation of the transferrin cycle. Proc Natl Acad Sci U S A (1983) 4.68
Geographical relation between Alzheimer's disease and aluminum in drinking water. Lancet (1989) 4.57
Defective gallium-transferrin binding in Alzheimer disease and Down syndrome: possible mechanism for accumulation of aluminium in brain. Lancet (1990) 3.48
Transferrin receptor on endothelium of brain capillaries. Nature (1984) 3.37
The physiology of transferrin and transferrin receptors. Physiol Rev (1987) 2.60
Alzheimer's disease: X-ray spectrometric evidence of aluminum accumulation in neurofibrillary tangle-bearing neurons. Science (1980) 2.45
The regional distribution and cellular localization of iron in the rat brain. Neuroscience (1984) 1.62
Receptor-mediated transcytosis of transferrin across the blood-brain barrier. J Neurosci Res (1987) 1.51
Human blood-brain barrier transferrin receptor. Metabolism (1987) 1.50
Transferrin receptors in rat brain: neuropeptide-like pattern and relationship to iron distribution. Proc Natl Acad Sci U S A (1985) 1.35
Transferrin binding of Al3+ and Fe3+. Clin Chem (1987) 1.34
Aluminum, chemical physiology, and Alzheimer's disease. Lancet (1988) 1.20
Thermodynamic binding constants for gallium transferrin. Biochemistry (1983) 1.11
Transferrin receptors: structure and function. Curr Top Hematol (1985) 1.08
Transferrin receptors of human fibroblasts. Analysis of receptor properties and regulation. Biochem J (1982) 1.03
The distribution of transferrin immunoreactivity in the rat central nervous system. Brain Res (1986) 0.98
Plasma aluminum is bound to transferrin. Life Sci (1983) 0.96
Thermodynamic binding constants of the zinc-human serum transferrin complex. Biochemistry (1983) 0.95
The competitive equilibrium between aluminium and ferric ions for the binding sites of transferrin. FEBS Lett (1984) 0.92
Effect of iron and transferrin on pure oligodendrocytes in culture; characterization of a high-affinity transferrin receptor at different ages. Brain Res (1987) 0.89
Studies of the slow bidirectional transport of iron and transferrin across the blood-brain barrier. Brain Res Bull (1988) 0.88
Effects of transferrin-indium on cellular proliferation of a human leukemia cell line. Cancer Res (1989) 0.80
Bradykinin as a pain mediator: receptors are localized to sensory neurons, and antagonists have analgesic actions. Proc Natl Acad Sci U S A (1988) 2.57
Cathepsin K, but not cathepsins B, L, or S, is abundantly expressed in human osteoclasts. J Biol Chem (1996) 2.33
A CSF biomarker panel for identification of patients with amyotrophic lateral sclerosis. Neurology (2008) 2.21
Human osteoclasts, not osteoblasts, deposit osteopontin onto resorption surfaces: an in vitro and ex vivo study of remodeling bone. J Bone Miner Res (1995) 2.01
Rat model of perinatal hypoxic-ischemic brain damage. J Neurosci Res (1999) 1.86
Receptor for interleukin 13 is a marker and therapeutic target for human high-grade gliomas. Clin Cancer Res (1999) 1.84
Abnormalities in CSF concentrations of ferritin and transferrin in restless legs syndrome. Neurology (2000) 1.75
Transferrin and iron in normal, Alzheimer's disease, and Parkinson's disease brain regions. J Neurochem (1995) 1.65
Peptide aldehyde inhibitors of cathepsin K inhibit bone resorption both in vitro and in vivo. J Bone Miner Res (1997) 1.63
Iron in the brain. Nutr Rev (1993) 1.58
Effect of manipulation of iron storage, transport, or availability on myelin composition and brain iron content in three different animal models. J Neurosci Res (2004) 1.57
Receptor-mediated transcytosis of transferrin across the blood-brain barrier. J Neurosci Res (1987) 1.51
Characterization of a novel brain-derived microglial cell line isolated from neonatal rat brain. Glia (2001) 1.51
Regional brain iron, ferritin and transferrin concentrations during iron deficiency and iron repletion in developing rats. J Nutr (1997) 1.45
Reduced progression of experimental osteoarthritis in vivo by selective inhibition of inducible nitric oxide synthase. Arthritis Rheum (1998) 1.44
Distribution of divalent metal transporter 1 and metal transport protein 1 in the normal and Belgrade rat. J Neurosci Res (2001) 1.38
Interleukin 1 amplifies receptor-mediated activation of phospholipase A2 in 3T3 fibroblasts. Proc Natl Acad Sci U S A (1988) 1.29
Ferritin: a novel mechanism for delivery of iron to the brain and other organs. Am J Physiol Cell Physiol (2007) 1.29
Insight into the pathophysiology of restless legs syndrome. J Neurosci Res (2000) 1.26
Surgically induced osteoarthritis in the rat results in the development of both osteoarthritis-like joint pain and secondary hyperalgesia. Osteoarthritis Cartilage (2006) 1.26
Induction and expression of human cartilage glycoprotein 39 in rheumatoid inflammatory and peripheral blood monocyte-derived macrophages. Exp Cell Res (1997) 1.22
Selective inhibition of inducible nitric oxide synthase reduces progression of experimental osteoarthritis in vivo: possible link with the reduction in chondrocyte apoptosis and caspase 3 level. Arthritis Rheum (2000) 1.19
Selective inhibition of inducible nitric oxide synthase in experimental osteoarthritis is associated with reduction in tissue levels of catabolic factors. J Rheumatol (1999) 1.18
Viruses and the versatile macrophage. Br Med Bull (1985) 1.15
Identification and cloning of a connective tissue growth factor-like cDNA from human osteoblasts encoding a novel regulator of osteoblast functions. J Biol Chem (1999) 1.14
Mechanisms and regulation of transferrin and iron transport in a model blood-brain barrier system. Neuroscience (2003) 1.14
NPC 15669 inhibits the reversed passive Arthus reaction in rats by blocking neutrophil recruitment. J Pharmacol Exp Ther (1992) 1.12
Acute and chronic effects of developmental iron deficiency on mRNA expression patterns in the brain. J Neural Transm Suppl (2006) 1.12
Cellular distribution of ferritin subunits in postnatal rat brain. J Comp Neurol (1998) 1.11
Variations in dietary iron alter brain iron metabolism in developing rats. J Nutr (2000) 1.11
Do oligodendrocytes mediate iron regulation in the human brain? Ann Neurol (1989) 1.10
Cellular iron status influences the functional relationship between microglia and oligodendrocytes. Glia (2006) 1.09
N-(fluorenyl-9-methoxycarbonyl) amino acids, a class of antiinflammatory agents with a different mechanism of action. Proc Natl Acad Sci U S A (1991) 1.08
Existing and emerging mechanisms for transport of iron and manganese to the brain. J Neurosci Res (1999) 1.08
Iron and neurodegenerative disorders. Brain Res Bull (2001) 1.08
Abnormal localization of iron regulatory protein in Alzheimer's disease. Brain Res (1998) 1.08
Iron, transferrin, and ferritin in the rat brain during development and aging. J Neurochem (1994) 1.06
Cellular distribution of iron in the brain of the Belgrade rat. Neuroscience (1999) 1.03
Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries. Osteoarthritis Cartilage (2001) 1.02
Identification and localization of divalent metal transporter-1 (DMT-1) in term human placenta. Placenta (2000) 1.01
Ferritin, transferrin, and iron in selected regions of the adult and aged rat brain. J Comp Neurol (1993) 0.99
The distribution of transferrin immunoreactivity in the rat central nervous system. Brain Res (1986) 0.98
Distribution of divalent metal transporter-1 in the monkey basal ganglia. Neuroscience (2004) 0.97
Changes in iron histochemistry after hypoxic-ischemic brain injury in the neonatal rat. J Neurosci Res (1999) 0.97
Oligodendrocyte progenitor cells internalize ferritin via clathrin-dependent receptor mediated endocytosis. J Neurosci Res (2000) 0.95
CKbeta-8 [CCL23], a novel CC chemokine, is chemotactic for human osteoclast precursors and is expressed in bone tissues. J Cell Physiol (2000) 0.95
Human osteoclast cathepsin K is processed intracellularly prior to attachment and bone resorption. J Bone Miner Res (2001) 0.94
2,6-Diamino-N-([1-(1-oxotridecyl)-2-piperidinyl] methyl)hexanamide (NPC 15437): a novel inhibitor of protein kinase C interacting at the regulatory domain. Mol Pharmacol (1992) 0.94
Distribution of injected iron 59 and manganese 54 in hypotransferrinemic mice. J Lab Clin Med (1996) 0.93
Transferrin is required for normal distribution of 59Fe and 54Mn in mouse brain. J Neurol Sci (1999) 0.93
Expression of cathepsin K messenger RNA in giant cells and their precursors in human osteoarthritic synovial tissues. Arthritis Rheum (1999) 0.93
Hypoxia-inducible factor pathway activation in restless legs syndrome patients. Eur J Neurol (2011) 0.92
Interleukin-1beta increases binding of the iron regulatory protein and the synthesis of ferritin by increasing the labile iron pool. Biochim Biophys Acta (2000) 0.91
2-Iminopiperidine and other 2-iminoazaheterocycles as potent inhibitors of human nitric oxide synthase isoforms. J Med Chem (1996) 0.90
cDNA cloning by amplification of circularized first strand cDNAs reveals non-IRE-regulated iron-responsive mRNAs. Biochem Biophys Res Commun (2000) 0.89
The effect of inhibitors of inducible nitric oxide synthase on chronic colitis in the rhesus monkey. J Pharmacol Exp Ther (1997) 0.89
The soluble form of E-selectin is an asymmetric monomer. Expression, purification, and characterization of the recombinant protein. J Biol Chem (1994) 0.88
Inhibition of IFN-gamma-induced Ia antigen expression on synovial fibroblasts by IL-1. J Immunol (1989) 0.88
Distribution of transferrin and ferritin binding in normal and multiple sclerotic human brains. J Neurol Sci (1999) 0.88
Biochemical characteristics of dissociatively isolated aortic proteoglycans and their binding capacity to hyaluronic acid. J Biol Chem (1983) 0.88
Interleukin 1 stimulates prostaglandin synthesis and cyclic AMP accumulation in Swiss 3T3 fibroblasts: interactions between two second messenger systems. J Cell Physiol (1989) 0.88
Identification of iron responsive genes by screening cDNA libraries from suppression subtractive hybridization with antisense probes from three iron conditions. Nucleic Acids Res (2000) 0.88
Differential effects of SB 242235, a selective p38 mitogen-activated protein kinase inhibitor, on IL-1 treated bovine and human cartilage/chondrocyte cultures. Osteoarthritis Cartilage (2000) 0.87
Iron deficiency alters H- and L-ferritin expression in rat brain. Cell Mol Biol (Noisy-le-grand) (2000) 0.87
Reduction in the structural changes of experimental osteoarthritis by a nitric oxide inhibitor. Osteoarthritis Cartilage (1999) 0.87
Alterations in the interaction between iron regulatory proteins and their iron responsive element in normal and Alzheimer's diseased brains. Cell Mol Biol (Noisy-le-grand) (2000) 0.86
A comparison of dendritic spine number and type on pyramidal neurons of the visual cortex of old adult rats from social or isolated environments. J Comp Neurol (1982) 0.86
The kallikrein-kininogen-kinin system in chronic inflammation. Agents Actions (1989) 0.86
A demonstration of glial filament distribution in astrocytes isolated from rat cerebral cortex. Neuroscience (1985) 0.85
FrzB-2: a human secreted frizzled-related protein with a potential role in chondrocyte apoptosis. Osteoarthritis Cartilage (2000) 0.85
Demonstration and characterization of the iron regulatory protein in human brain. J Neurochem (1996) 0.85
Regional distribution of iron, transferrin, ferritin, and oxidatively-modified proteins in young and aged Fischer 344 rat brains. Neuroscience (1997) 0.85
Expression of transferrin mRNA in the CNS of normal and jimpy mice. J Neurochem (1991) 0.85
D-Phe7-substituted peptide bradykinin antagonists are not substrates for kininase II. Peptides (1989) 0.85
Brain iron, transferrin and ferritin concentrations are altered in developing iron-deficient rats. J Nutr (1995) 0.85
2-Iminohomopiperidinium salts as selective inhibitors of inducible nitric oxide synthase (iNOS). J Med Chem (1998) 0.85
2-Iminopyrrolidines as potent and selective inhibitors of human inducible nitric oxide synthase. J Med Chem (1998) 0.84
The development of the transferrin-transferrin receptor system in relation to astrocytes, MBP and galactocerebroside in normal and myelin-deficient rat optic nerves. Brain Res Dev Brain Res (1989) 0.84
Purification and characterization of fully functional human osteoclast precursors. J Bone Miner Res (1996) 0.84
Accumulation of iron by primary rat hepatocytes in long-term culture: changes in nuclear shape mediated by non-transferrin-bound forms of iron. Am J Pathol (1998) 0.84
Cathepsin K mRNA detection is restricted to osteoclasts during fetal mouse development. J Bone Miner Res (1998) 0.84
Vasoactive intestinal polypeptide-immunoreactive neurons in rat visual cortex. Neuroscience (1984) 0.84
Cloning and characterization of a novel integrin beta3 subunit. J Biol Chem (1997) 0.83
Characterization and distribution of ferritin binding sites in the adult mouse brain. J Neurochem (1999) 0.83
Increase in ferric and ferrous iron in the rat hippocampus with time after kainate-induced excitotoxic injury. Exp Brain Res (2002) 0.83
Immunohistochemical analysis of transferrin receptor: regional and cellular distribution in the hypotransferrinemic (hpx) mouse brain. Brain Res (1998) 0.83
NPC 15437 interacts with the C1 domain of protein kinase C. An analysis using mutant PKC constructs. FEBS Lett (1991) 0.81
Mutation of aspartate residues in the third extracellular loop of the rat B2 bradykinin receptor decreases affinity for bradykinin. Biochem Biophys Res Commun (1994) 0.81
Plasticity of the aging cerebral cortex. Exp Brain Res (1982) 0.81
Ferritin binding in the developing mouse brain follows a pattern similar to myelination and is unaffected by the jimpy mutation. Dev Neurosci (2002) 0.81
An in vitro model for analysis of oxidative death in primary mouse astrocytes. Brain Res (1998) 0.81
Evidence for non-transferrin-mediated uptake and release of iron and manganese in glial cell cultures from hypotransferrinemic mice. J Neurosci Res (1998) 0.81
Activation of the IL-1 gene in UV-irradiated mouse skin: association with inflammatory sequelae and pharmacologic intervention. J Invest Dermatol (1991) 0.81
Interleukin-1 induces interleukin-1 alpha and interleukin-1 beta gene expression in synovial fibroblasts and peripheral blood monocytes. Arthritis Rheum (1989) 0.81
Comparison of herpes simplex virus type 1 DNA replication and virus production in murine bone marrow-derived and resident peritoneal macrophages. J Gen Virol (1985) 0.81
A light and electron microscopic study of the iron transporter protein DMT-1 in the monkey cerebral neocortex and hippocampus. J Neurocytol (2001) 0.80
2,6-Diamino-N-([1-oxotridecyl)-2-piperidinyl]methyl)hexanamide (NPC 15437): a selective inhibitor of protein kinase C. Agents Actions (1991) 0.80
Regulation of arachidonic acid metabolism in resident and BCG-activated alveolar macrophages: role of lyso(bis)phosphatidic acid. J Immunol (1987) 0.80
Hypoxic/ischemic insult alters ferritin expression and myelination in neonatal rat brains. J Comp Neurol (2001) 0.80