Facts and fiction: the impact of hypothermia on molecular mechanisms following major challenge.

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Published in Mediators Inflamm on March 13, 2012

Authors

Michael Frink1, Sascha Flohé, Martijn van Griensven, Philipp Mommsen, Frank Hildebrand

Author Affiliations

1: Trauma Department, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany. Michaelfrink@web.de

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Leukocyte-endothelial adhesion molecules. Blood (1994) 8.62

BCL-2 family: regulators of cell death. Annu Rev Immunol (1998) 6.41

Apoptosis in the nervous system. Nature (2000) 5.82

PI3K/Akt signalling pathway and cancer. Cancer Treat Rev (2004) 5.46

Reactive oxygen species and the central nervous system. J Neurochem (1992) 4.27

European Resuscitation Council guidelines for resuscitation 2005. Section 4. Adult advanced life support. Resuscitation (2005) 3.99

Mechanisms of action, physiological effects, and complications of hypothermia. Crit Care Med (2009) 3.59

The Fas signaling pathway: more than a paradigm. Science (2002) 3.45

Small differences in intraischemic brain temperature critically determine the extent of ischemic neuronal injury. J Cereb Blood Flow Metab (1987) 3.04

Prolonged therapeutic hypothermia after traumatic brain injury in adults: a systematic review. JAMA (2003) 2.73

Inflammatory response in acute traumatic brain injury: a double-edged sword. Curr Opin Crit Care (2002) 2.48

Cytokines in inflammatory brain lesions: helpful and harmful. Trends Neurosci (1996) 2.20

Hypothermia in the management of traumatic brain injury. A systematic review and meta-analysis. Intensive Care Med (2003) 2.18

Closed head injury--an inflammatory disease? Brain Res Brain Res Rev (2005) 1.91

Hypothermia in trauma victims: an ominous predictor of survival. J Trauma (1987) 1.89

Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat. Brain Res Bull (1992) 1.80

Therapeutic hypothermia for head injury. Cochrane Database Syst Rev (2004) 1.76

Moderate hypothermia delays proinflammatory cytokine production of human peripheral blood mononuclear cells. Crit Care Med (2002) 1.73

Chemokines in the CNS: plurifunctional mediators in diverse states. Trends Neurosci (1999) 1.73

Neuroprotective effects of human recombinant interleukin-1 receptor antagonist in focal cerebral ischaemia in the rat. J Cereb Blood Flow Metab (1996) 1.72

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L-selectin function is required for beta 2-integrin-mediated neutrophil adhesion at physiological shear rates in vivo. Am J Physiol (1992) 1.64

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Intrahepatic synthesis of tumor necrosis factor-alpha related to cardiac surgery is inhibited by interleukin-10 via the Janus kinase (Jak)/signal transducers and activator of transcription (STAT) pathway. Crit Care Med (2003) 1.56

Incidence and effect of hypothermia in seriously injured patients. J Trauma (1987) 1.52

Apoptosis after traumatic brain injury. J Neurotrauma (2000) 1.45

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New horizons in management of hypothermia and frostbite injury. Surg Clin North Am (1991) 1.44

A multicenter prospective randomized controlled trial of the efficacy of mild hypothermia for severely head injured patients with low intracranial pressure. Mild Hypothermia Study Group in Japan. J Neurosurg (2001) 1.39

Injury-associated hypothermia: an analysis of the 2004 National Trauma Data Bank. Shock (2005) 1.38

Is hypothermia in the victim of major trauma protective or harmful? A randomized, prospective study. Ann Surg (1997) 1.34

Therapeutic hypothermia: neuroprotective mechanisms. Front Biosci (2007) 1.31

Effect of moderate hypothermia on systemic and internal jugular plasma IL-6 levels after traumatic brain injury in humans. J Neurotrauma (1999) 1.30

Incidence and timing of hypothermia in trauma patients undergoing operations. J Trauma (1991) 1.28

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IL-6 predicts organ dysfunction and mortality in patients with multiple injuries. Scand J Trauma Resusc Emerg Med (2009) 1.25

Tumor necrosis factor alpha expression and protein levels after fluid percussion injury in rats: the effect of injury severity and brain temperature. Neurosurgery (2004) 1.23

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Mild hypothermia reduces ICAM-1 expression, neutrophil infiltration and microglia/monocyte accumulation following experimental stroke. Neuroscience (2002) 1.20

The progression and topographic distribution of interleukin-1beta expression after permanent middle cerebral artery occlusion in the rat. J Cereb Blood Flow Metab (1999) 1.20

Hypothermia in the trauma patient. Injury (2004) 1.18

Interleukin-1beta and the interleukin-1 receptor antagonist act in the striatum to modify excitotoxic brain damage in the rat. Eur J Neurosci (1998) 1.17

Hypothermia after cardiac arrest. Prog Cardiovasc Dis (2009) 1.17

Mitochondrial activation of apoptosis. Cell (2004) 1.17

An ICE inhibitor, z-VAD-DCB attenuates ischaemic brain damage in the rat. Neuroreport (1996) 1.15

Effects of hypothermia and hyperthermia on cytokine production by cultured human mononuclear phagocytes from adults and newborns. J Interferon Cytokine Res (2000) 1.13

Increased matrix metalloproteinase-9 in blood in association with activation of interleukin-6 after traumatic brain injury: influence of hypothermic therapy. J Neurotrauma (2004) 1.13

Mitochondrial uncoupling as a therapeutic target following neuronal injury. J Bioenerg Biomembr (2004) 1.11

Excitotoxic brain damage in the rat induces interleukin-1beta protein in microglia and astrocytes: correlation with the progression of cell death. Glia (1999) 1.11

Detection of free radical activity during transient global ischemia and recirculation: effects of intraischemic brain temperature modulation. J Neurochem (1995) 1.11

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Induction of interleukin-1 beta mRNA after focal cerebral ischaemia in the rat. Brain Res Mol Brain Res (1994) 1.08

The role of hypothermia in the management of severe brain injury: a meta-analysis. Arch Neurol (2002) 1.05

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Therapeutic hypothermia for head injury. Cochrane Database Syst Rev (2002) 1.04

Early polymorphonuclear leukocyte accumulation correlates with the development of posttraumatic cerebral edema in rats. J Neurotrauma (1990) 1.04

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Hypothermic protection of the ischemic heart via alterations in apoptotic pathways as assessed by gene array analysis. J Appl Physiol (1985) (2002) 1.03

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Changes in interleukin-10 mRNA expression are predictive for 9-day survival of pigs in an emergency preservation and resuscitation model. Resuscitation (2010) 0.90

Brain damage and temperature: cellular and molecular mechanisms. Adv Neurol (1996) 0.90

Early induction of moderate hypothermia suppresses systemic inflammatory cytokines and intracellular adhesion molecule-1 in rats with caerulein-induced pancreatitis and endotoxemia. Pancreas (2008) 0.89

Cortical protection by localized striatal injection of IL-1ra following cerebral ischemia in the rat. J Cereb Blood Flow Metab (1997) 0.89

Cortical cell death induced by IL-1 is mediated via actions in the hypothalamus of the rat. Proc Natl Acad Sci U S A (2000) 0.88

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Abrogation of NF-κB signaling in human neutrophils induces neutrophil survival through sustained p38-MAPK activation. J Leukoc Biol (2010) 0.87

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