Published in J Immunol on May 01, 2007
Complement inhibition in cancer therapy. Semin Immunol (2013) 1.20
Mucosal adjuvant activity of flagellin in aged mice. Mech Ageing Dev (2008) 1.12
Leucocyte/endothelium interactions and microvessel permeability: coupled or uncoupled? Cardiovasc Res (2010) 1.08
p38MAPK, ERK and PI3K signaling pathways are involved in C5a-primed neutrophils for ANCA-mediated activation. PLoS One (2012) 1.01
C5a mediates peripheral blood neutrophil dysfunction in critically ill patients. Am J Respir Crit Care Med (2009) 1.01
New developments in C5a receptor signaling. Cell Health Cytoskelet (2012) 0.97
Downstream signals for MyD88-mediated phagocytosis of Borrelia burgdorferi can be initiated by TRIF and are dependent on PI3K. J Immunol (2009) 0.94
Effect of leptin on polymorphonuclear leucocyte functions in healthy subjects and haemodialysis patients. Nephrol Dial Transplant (2011) 0.84
Distinct different contributions of the alternative and classical complement activation pathway for the innate host response during sepsis. J Immunol (2011) 0.84
Role of complement in multiorgan failure. Clin Dev Immunol (2012) 0.83
Complement mediates a primed inflammatory response after traumatic lung injury. J Trauma Acute Care Surg (2014) 0.82
Endothelial p110γPI3K Mediates Endothelial Regeneration and Vascular Repair After Inflammatory Vascular Injury. Circulation (2016) 0.82
Inhibition of serum- and glucocorticoid-inducible kinase 1 enhances TLR-mediated inflammation and promotes endotoxin-driven organ failure. FASEB J (2015) 0.82
Phosphoinositide 3-kinase gamma required for lipopolysaccharide-induced transepithelial neutrophil trafficking in the lung. Eur Respir J (2009) 0.80
New insights for C5a and C5a receptors in sepsis. Front Immunol (2012) 0.79
Adiponectin inhibits neutrophil phagocytosis of Escherichia coli by inhibition of PKB and ERK 1/2 MAPK signalling and Mac-1 activation. PLoS One (2013) 0.77
Ventilator-induced lung injury and mechanotransduction: why should we care? Crit Care (2007) 0.76
Complement-induced activation of MAPKs and Akt during sepsis: role in cardiac dysfunction. FASEB J (2017) 0.75
Immunodesign of experimental sepsis by cecal ligation and puncture. Nat Protoc (2009) 6.71
Harmful molecular mechanisms in sepsis. Nat Rev Immunol (2008) 6.03
Perioperative fluid therapy with tetrastarch and gelatin in cardiac surgery--a prospective sequential analysis*. Crit Care Med (2013) 5.88
Generation of C5a in the absence of C3: a new complement activation pathway. Nat Med (2006) 5.26
Novel strategies for the treatment of sepsis. Nat Med (2003) 5.14
The NLR gene family: a standard nomenclature. Immunity (2008) 4.77
Role of C5a in inflammatory responses. Annu Rev Immunol (2005) 4.38
The enigma of sepsis. J Clin Invest (2003) 4.32
Functional roles for C5a receptors in sepsis. Nat Med (2008) 3.33
The disconnect between animal models of sepsis and human sepsis. J Leukoc Biol (2006) 3.11
Adverse functions of IL-17A in experimental sepsis. FASEB J (2008) 2.60
Phagocyte-derived catecholamines enhance acute inflammatory injury. Nature (2007) 2.56
Renal effects of synthetic colloids and crystalloids in patients with severe sepsis: a prospective sequential comparison. Crit Care Med (2011) 2.30
Molecular intercommunication between the complement and coagulation systems. J Immunol (2010) 2.12
New approaches to sepsis: molecular diagnostics and biomarkers. Clin Microbiol Rev (2012) 2.01
Protective effects of IL-6 blockade in sepsis are linked to reduced C5a receptor expression. J Immunol (2003) 2.00
Changes in the management of femoral shaft fractures in polytrauma patients: from early total care to damage control orthopedic surgery. J Trauma (2002) 1.89
Chlamydia inhibit host cell apoptosis by degradation of proapoptotic BH3-only proteins. J Exp Med (2004) 1.89
Selective blockade of interleukin-6 trans-signaling improves survival in a murine polymicrobial sepsis model. Crit Care Med (2011) 1.87
Impact of the method of initial stabilization for femoral shaft fractures in patients with multiple injuries at risk for complications (borderline patients). Ann Surg (2007) 1.87
The complement system. Cell Tissue Res (2010) 1.86
Increased C5a receptor expression in sepsis. J Clin Invest (2002) 1.79
The late phase of sepsis is characterized by an increased microbiological burden and death rate. Crit Care (2011) 1.77
Five freely circulating miRNAs and bone tissue miRNAs are associated with osteoporotic fractures. J Bone Miner Res (2014) 1.76
Generation of C5a by phagocytic cells. Am J Pathol (2002) 1.72
Role of oxidants in lung injury during sepsis. Antioxid Redox Signal (2007) 1.71
Functional outcome following scapulothoracic dissociation. J Bone Joint Surg Am (2004) 1.71
Interaction between the coagulation and complement system. Adv Exp Med Biol (2008) 1.65
Dose-dependent immunomodulatory effect of human stem cells from amniotic membrane: a comparison with human mesenchymal stem cells from adipose tissue. Tissue Eng (2007) 1.59
Comparison of different thoracic trauma scoring systems in regards to prediction of post-traumatic complications and outcome in blunt chest trauma. J Surg Res (2011) 1.58
C5a initiates the inflammatory cascade in immune complex peritonitis. J Immunol (2004) 1.57
Changes and regulation of the C5a receptor on neutrophils during septic shock in humans. J Immunol (2013) 1.57
Influence of sex and age on mods and cytokines after multiple injuries. Shock (2007) 1.56
Regulation by C5a of neutrophil activation during sepsis. Immunity (2003) 1.54
Evidence for a functional role of the second C5a receptor C5L2. FASEB J (2005) 1.53
Expression and function of C5a receptor in mouse microvascular endothelial cells. J Immunol (2002) 1.53
Role of nitric oxide in acute lung inflammation: lessons learned from the inducible nitric oxide synthase knockout mouse. Crit Care Med (2002) 1.51
Navigated femoral nailing using noninvasive registration of the contralateral intact femur to restore anteversion. Technique and clinical use. J Orthop Trauma (2007) 1.47
Evaluation of endotoxin models for the study of sepsis. Shock (2005) 1.47
The effect of anti-L-selectin (aselizumab) in multiple traumatized patients--results of a phase II clinical trial. Crit Care Med (2004) 1.47
Impact of intramedullary instrumentation versus damage control for femoral fractures on immunoinflammatory parameters: prospective randomized analysis by the EPOFF Study Group. J Trauma (2003) 1.46
Interactions between coagulation and complement--their role in inflammation. Semin Immunopathol (2011) 1.46
Navigated femoral anteversion measurements: a new intraoperative technique. Injury (2008) 1.45
The human complement fragment receptor, C5L2, is a recycling decoy receptor. Mol Immunol (2008) 1.45
Complement-induced impairment of innate immunity during sepsis. J Immunol (2002) 1.44
Total hip arthroplasty in young patients using the thrust plate prosthesis: clinical and radiological results. Arch Orthop Trauma Surg (2004) 1.44
Protection of innate immunity by C5aR antagonist in septic mice. FASEB J (2002) 1.44
The challenge of establishing preclinical models for segmental bone defect research. Biomaterials (2009) 1.43
Novel chemokine responsiveness and mobilization of neutrophils during sepsis. Am J Pathol (2004) 1.42
Regulatory role of C5a in LPS-induced IL-6 production by neutrophils during sepsis. FASEB J (2003) 1.42
Regulatory effects of iNOS on acute lung inflammatory responses in mice. Am J Pathol (2003) 1.42
Harmful and protective roles of neutrophils in sepsis. Shock (2005) 1.41
Targeting of microRNA-142-3p in dendritic cells regulates endotoxin-induced mortality. Blood (2011) 1.39
30 years of polytrauma care: An analysis of the change in strategies and results of 4849 cases treated at a single institution. Injury (2008) 1.38
C5 deficiency and C5a or C5aR blockade protects against cerebral malaria. J Exp Med (2008) 1.38
Humanizing the mouse: in defense of murine models of critical illness. Am J Respir Crit Care Med (2013) 1.36
New indications for computer-assisted surgery: tumor resection in the pelvis. Clin Orthop Relat Res (2004) 1.35
Mediators and regulation of neutrophil accumulation in inflammatory responses in lung: insights from the IgG immune complex model. Free Radic Biol Med (2002) 1.35
The inflammatory response in sepsis. Trends Immunol (2012) 1.34
C5a-induced gene expression in human umbilical vein endothelial cells. Am J Pathol (2004) 1.34
Role of C3, C5 and anaphylatoxin receptors in acute lung injury and in sepsis. Adv Exp Med Biol (2012) 1.34
The timing of fracture treatment in polytrauma patients: relevance of damage control orthopedic surgery. Am J Surg (2002) 1.33
Anti-c5a ameliorates coagulation/fibrinolytic protein changes in a rat model of sepsis. Am J Pathol (2002) 1.33
Relationship of acute lung inflammatory injury to Fas/FasL system. Am J Pathol (2005) 1.33
Regulatory effects of estrogen on acute lung inflammation in mice. Am J Physiol Cell Physiol (2005) 1.32
Leg lengthening using intramedullay skeletal kinetic distractor: results of 57 consecutive applications. Injury (2011) 1.31
Modulation of proliferation and differentiation of human bone marrow stromal cells by fibroblast growth factor 2: potential implications for tissue engineering of tendons and ligaments. Tissue Eng (2005) 1.31
C5a receptor and thymocyte apoptosis in sepsis. FASEB J (2002) 1.31
Anti-inflammatory effects of β2 adrenergic receptor agonists in experimental acute lung injury. FASEB J (2012) 1.31
Functions of the complement components C3 and C5 during sepsis. FASEB J (2008) 1.30
An essential role for complement C5a in the pathogenesis of septic cardiac dysfunction. J Exp Med (2005) 1.29
Liver dysfunction and phosphatidylinositol-3-kinase signalling in early sepsis: experimental studies in rodent models of peritonitis. PLoS Med (2012) 1.27
Extracellular histones are essential effectors of C5aR- and C5L2-mediated tissue damage and inflammation in acute lung injury. FASEB J (2013) 1.26
Comparison of surgical repair or reconstruction of the cruciate ligaments versus nonsurgical treatment in patients with traumatic knee dislocations. Am J Sports Med (2002) 1.25
Survival benefit of helicopter emergency medical services compared to ground emergency medical services in traumatized patients. Crit Care (2013) 1.25
IL-6 predicts organ dysfunction and mortality in patients with multiple injuries. Scand J Trauma Resusc Emerg Med (2009) 1.25
Inhibition of the alternative complement activation pathway in traumatic brain injury by a monoclonal anti-factor B antibody: a randomized placebo-controlled study in mice. J Neuroinflammation (2007) 1.24
Circulating NT-proCNP predicts sepsis in multiple-traumatized patients without traumatic brain injury. Crit Care Med (2010) 1.23
C5a mutants are potent antagonists of the C5a receptor (CD88) and of C5L2: position 69 is the locus that determines agonism or antagonism. J Biol Chem (2003) 1.22
Immunosuppression in sepsis. JAMA (2011) 1.22
Acute lung injury induced by lipopolysaccharide is independent of complement activation. J Immunol (2008) 1.22
Regulation of lung inflammation in the model of IgG immune-complex injury. Annu Rev Pathol (2006) 1.20
Inhibition of complement C5a prevents breakdown of the blood-brain barrier and pituitary dysfunction in experimental sepsis. Crit Care (2009) 1.20
Catecholamines-crafty weapons in the inflammatory arsenal of immune/inflammatory cells or opening pandora's box? Mol Med (2008) 1.20
Cross-talk between TLR4 and FcgammaReceptorIII (CD16) pathways. PLoS Pathog (2009) 1.20
Whole-body CT in haemodynamically unstable severely injured patients--a retrospective, multicentre study. PLoS One (2013) 1.19
Changes in the novel orphan, C5a receptor (C5L2), during experimental sepsis and sepsis in humans. J Immunol (2005) 1.19
Evidence for anti-inflammatory effects of C5a on the innate IL-17A/IL-23 axis. FASEB J (2011) 1.19
Molecular events in the cardiomyopathy of sepsis. Mol Med (2008) 1.18
Stat3 activation in acute lung injury. J Immunol (2004) 1.18