Published in EMBO Rep on April 10, 2012
Gene regulation by the act of long non-coding RNA transcription. BMC Biol (2013) 1.97
Genetic and molecular control of osterix in skeletal formation. J Cell Biochem (2013) 1.19
Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells. Cell (2016) 1.10
Characterization of the p53 cistrome--DNA binding cooperativity dissects p53's tumor suppressor functions. PLoS Genet (2013) 1.08
The role of chromatin insulators in nuclear architecture and genome function. Curr Opin Genet Dev (2013) 1.04
Identification of biologically relevant enhancers in human erythroid cells. J Biol Chem (2013) 1.03
Distant activation of transcription: mechanisms of enhancer action. Mol Cell Biol (2012) 1.03
Hierarchy within the mammary STAT5-driven Wap super-enhancer. Nat Genet (2016) 0.97
TNF-α blockade induces IL-10 expression in human CD4+ T cells. Nat Commun (2014) 0.96
Global transcriptome analysis and enhancer landscape of human primary T follicular helper and T effector lymphocytes. Blood (2014) 0.95
Developmental enhancers revealed by extensive DNA methylome maps of zebrafish early embryos. Nat Commun (2015) 0.95
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Epigenetic control of cytokine gene expression: regulation of the TNF/LT locus and T helper cell differentiation. Adv Immunol (2013) 0.94
TP53 engagement with the genome occurs in distinct local chromatin environments via pioneer factor activity. Genome Res (2014) 0.93
Multilocus loss of DNA methylation in individuals with mutations in the histone H3 lysine 4 demethylase KDM5C. BMC Med Genomics (2013) 0.92
RNA transcribed from a distal enhancer is required for activating the chromatin at the promoter of the gonadotropin α-subunit gene. Proc Natl Acad Sci U S A (2015) 0.91
Chromatin remodeling mediated by the FOXA1/A2 transcription factors activates CFTR expression in intestinal epithelial cells. Epigenetics (2014) 0.91
Diverse patterns of genomic targeting by transcriptional regulators in Drosophila melanogaster. Genome Res (2014) 0.90
Myogenic enhancers regulate expression of the facioscapulohumeral muscular dystrophy-associated DUX4 gene. Mol Cell Biol (2014) 0.87
Divergent transcriptional regulatory logic at the intersection of tissue growth and developmental patterning. PLoS Genet (2013) 0.83
How has the study of the human placenta aided our understanding of partially methylated genes? Epigenomics (2013) 0.83
Regulation of gene expression in the genomic context. Comput Struct Biotechnol J (2014) 0.83
The interplay of DNA methylation over time with Th2 pathway genetic variants on asthma risk and temporal asthma transition. Clin Epigenetics (2014) 0.83
Impact of tissue-specific stem cells on lineage-specific differentiation: a focus on the musculoskeletal system. Stem Cell Rev (2015) 0.83
The emerging roles of eRNAs in transcriptional regulatory networks. RNA Biol (2014) 0.83
Comparative epigenomics in distantly related teleost species identifies conserved cis-regulatory nodes active during the vertebrate phylotypic period. Genome Res (2014) 0.82
Identifying transcriptional cis-regulatory modules in animal genomes. Wiley Interdiscip Rev Dev Biol (2014) 0.82
Genetic and molecular alterations across medulloblastoma subgroups. J Mol Med (Berl) (2015) 0.81
BET-ting on chromatin-based therapeutics for heart failure. J Mol Cell Cardiol (2014) 0.80
Human genetic variation within neural crest enhancers: molecular and phenotypic implications. Philos Trans R Soc Lond B Biol Sci (2013) 0.79
Distinct Enhancer Activity of Oct4 in Naive and Primed Mouse Pluripotency. Stem Cell Reports (2016) 0.79
A distal intergenic region controls pancreatic endocrine differentiation by acting as a transcriptional enhancer and as a polycomb response element. PLoS One (2017) 0.77
Transcriptional Enhancers in the Regulation of T Cell Differentiation. Front Immunol (2015) 0.77
Spatiotemporal control of estrogen-responsive transcription in ERα-positive breast cancer cells. Oncogene (2015) 0.77
Overlapping DNA methylation dynamics in mouse intestinal cell differentiation and early stages of malignant progression. PLoS One (2015) 0.77
Epigenetic mechanisms in heart failure pathogenesis. Circ Heart Fail (2014) 0.76
Developmental control of transcriptional and proliferative potency during the evolutionary emergence of animals. Dev Dyn (2015) 0.76
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Cell-type specific cis-regulatory networks: insights from Hox transcription factors. Fly (Austin) (2012) 0.75
FOXD3 controls pluripotency through modulating enhancer activity. Stem Cell Investig (2016) 0.75
Global reorganisation of cis-regulatory units upon lineage commitment of human embryonic stem cells. Elife (2017) 0.75
Increased expression of prion protein gene is accompanied by demethylation of CpG sites in a mouse embryonal carcinoma cell line, P19C6. J Vet Med Sci (2017) 0.75
Super-Enhancer-Driven Transcriptional Dependencies in Cancer. Trends Cancer (2017) 0.75
Human Long Noncoding RNA Regulation of Stem Cell Potency and Differentiation. Stem Cells Int (2017) 0.75
High-resolution profiling of histone methylations in the human genome. Cell (2007) 85.74
Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome. Nat Genet (2007) 32.41
Histone modifications at human enhancers reflect global cell-type-specific gene expression. Nature (2009) 24.41
Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol Cell (2010) 23.97
Expression of a beta-globin gene is enhanced by remote SV40 DNA sequences. Cell (1981) 20.72
ChIP-seq accurately predicts tissue-specific activity of enhancers. Nature (2009) 18.38
Combinatorial patterns of histone acetylations and methylations in the human genome. Nat Genet (2008) 18.28
Widespread transcription at neuronal activity-regulated enhancers. Nature (2010) 16.52
Histone H3K27ac separates active from poised enhancers and predicts developmental state. Proc Natl Acad Sci U S A (2010) 15.13
CTCF: master weaver of the genome. Cell (2009) 15.09
Genome-scale identification of nucleosome positions in S. cerevisiae. Science (2005) 15.04
Chromosomal subunits in active genes have an altered conformation. Science (1976) 14.63
Mediator and cohesin connect gene expression and chromatin architecture. Nature (2010) 14.34
FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription. Cell (2008) 14.18
A unique chromatin signature uncovers early developmental enhancers in humans. Nature (2010) 14.02
Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells. Nature (2011) 13.94
Long noncoding RNAs with enhancer-like function in human cells. Cell (2010) 13.00
A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression. Nature (2011) 11.59
Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nat Biotechnol (2008) 10.97
ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex. Science (2003) 10.04
The biology of chromatin remodeling complexes. Annu Rev Biochem (2009) 10.02
Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark. Mol Cell (2007) 9.73
Distinct factors control histone variant H3.3 localization at specific genomic regions. Cell (2010) 8.79
Distinct epigenomic landscapes of pluripotent and lineage-committed human cells. Cell Stem Cell (2010) 8.74
Chromatin signatures in multipotent human hematopoietic stem cells indicate the fate of bivalent genes during differentiation. Cell Stem Cell (2009) 8.62
Opening of compacted chromatin by early developmental transcription factors HNF3 (FoxA) and GATA-4. Mol Cell (2002) 8.59
Genome-scale mapping of DNase I sensitivity in vivo using tiling DNA microarrays. Nat Methods (2006) 8.52
Transcriptional regulatory elements in the human genome. Annu Rev Genomics Hum Genet (2006) 7.18
Chromatin accessibility pre-determines glucocorticoid receptor binding patterns. Nat Genet (2011) 6.98
Geminin, an inhibitor of DNA replication, is degraded during mitosis. Cell (1998) 6.69
CTCF-mediated functional chromatin interactome in pluripotent cells. Nat Genet (2011) 6.55
Preferential associations between co-regulated genes reveal a transcriptional interactome in erythroid cells. Nat Genet (2009) 6.39
Distinctive chromatin in human sperm packages genes for embryo development. Nature (2009) 6.18
Cohesins form chromosomal cis-interactions at the developmentally regulated IFNG locus. Nature (2009) 5.96
Nucleosome dynamics define transcriptional enhancers. Nat Genet (2010) 5.94
H3.3/H2A.Z double variant-containing nucleosomes mark 'nucleosome-free regions' of active promoters and other regulatory regions. Nat Genet (2009) 5.82
Enhancer function: new insights into the regulation of tissue-specific gene expression. Nat Rev Genet (2011) 5.27
Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. Cell (2011) 5.27
Relationship between nucleosome positioning and DNA methylation. Nature (2010) 5.27
FOXA1 is a key determinant of estrogen receptor function and endocrine response. Nat Genet (2010) 5.22
CpG islands influence chromatin structure via the CpG-binding protein Cfp1. Nature (2010) 4.86
Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells. Nat Cell Biol (2011) 4.77
The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation. Nat Rev Genet (2010) 4.46
ChIP-Seq identification of weakly conserved heart enhancers. Nat Genet (2010) 4.32
Nucleosome stability mediated by histone variants H3.3 and H2A.Z. Genes Dev (2007) 4.19
Histone replacement marks the boundaries of cis-regulatory domains. Science (2007) 4.06
Genome-wide profiling of salt fractions maps physical properties of chromatin. Genome Res (2008) 4.03
Master transcription factors determine cell-type-specific responses to TGF-β signaling. Cell (2011) 3.94
Enhancer decommissioning by LSD1 during embryonic stem cell differentiation. Nature (2012) 3.67
Epigenetic signatures distinguish multiple classes of enhancers with distinct cellular functions. Genome Res (2011) 3.57
Pluripotency factors in embryonic stem cells regulate differentiation into germ layers. Cell (2011) 3.53
Histone crosstalk between H3S10ph and H4K16ac generates a histone code that mediates transcription elongation. Cell (2009) 3.45
Cofactor binding evokes latent differences in DNA binding specificity between Hox proteins. Cell (2011) 3.40
Repressive and active histone methylation mark distinct promoters in human and mouse spermatozoa. Nat Struct Mol Biol (2010) 3.07
Transcription factor AP1 potentiates chromatin accessibility and glucocorticoid receptor binding. Mol Cell (2011) 2.97
Tissue-specific analysis of chromatin state identifies temporal signatures of enhancer activity during embryonic development. Nat Genet (2012) 2.94
CHD7 cooperates with PBAF to control multipotent neural crest formation. Nature (2010) 2.88
Lineage-specific DNA methylation in T cells correlates with histone methylation and enhancer activity. Genome Res (2009) 2.87
Transcription initiation platforms and GTF recruitment at tissue-specific enhancers and promoters. Nat Struct Mol Biol (2011) 2.79
Transcriptional competence and the active marking of tissue-specific enhancers by defined transcription factors in embryonic and induced pluripotent stem cells. Genes Dev (2009) 2.70
Chromatin signature of embryonic pluripotency is established during genome activation. Nature (2010) 2.64
Methods for making induced pluripotent stem cells: reprogramming à la carte. Nat Rev Genet (2011) 2.60
Architectural roles of multiple chromatin insulators at the human apolipoprotein gene cluster. EMBO J (2009) 2.56
The transcriptional and signalling networks of pluripotency. Nat Cell Biol (2011) 2.54
Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration. Cell (2011) 2.53
Transcriptional enhancers in animal development and evolution. Curr Biol (2010) 2.41
Polycomb-repressed genes have permissive enhancers that initiate reprogramming. Cell (2011) 2.14
Prepatterning of developmental gene expression by modified histones before zygotic genome activation. Dev Cell (2011) 2.05
DNA methylation status predicts cell type-specific enhancer activity. EMBO J (2011) 1.98
Sequentially acting Sox transcription factors in neural lineage development. Genes Dev (2011) 1.97
Genes for embryo development are packaged in blocks of multivalent chromatin in zebrafish sperm. Genome Res (2011) 1.94
Epigenetic switch involved in activation of pioneer factor FOXA1-dependent enhancers. Genome Res (2011) 1.92
Differential H3K4 methylation identifies developmentally poised hematopoietic genes. Dev Cell (2008) 1.89
Characterization of the stability and folding of H2A.Z chromatin particles: implications for transcriptional activation. J Biol Chem (2001) 1.77
Turning straw into gold: directing cell fate for regenerative medicine. Nat Rev Genet (2011) 1.73
Geminin, a neuralizing molecule that demarcates the future neural plate at the onset of gastrulation. Development (1998) 1.72
Regulation of mammalian DNA methyltransferases: a route to new mechanisms. EMBO Rep (2011) 1.71
Chromatin "prepattern" and histone modifiers in a fate choice for liver and pancreas. Science (2011) 1.70
SAGA and ATAC histone acetyl transferase complexes regulate distinct sets of genes and ATAC defines a class of p300-independent enhancers. Mol Cell (2011) 1.68
Multilineage priming of enhancer repertoires precedes commitment to the B and myeloid cell lineages in hematopoietic progenitors. Immunity (2011) 1.66
Epigenetic priming of a pre-B cell-specific enhancer through binding of Sox2 and Foxd3 at the ESC stage. Cell Stem Cell (2010) 1.32
Recognition of enhancer element-specific histone methylation by TIP60 in transcriptional activation. Nat Struct Mol Biol (2011) 1.29
Geminin promotes neural fate acquisition of embryonic stem cells by maintaining chromatin in an accessible and hyperacetylated state. Proc Natl Acad Sci U S A (2011) 1.10
Geminin cooperates with Polycomb to restrain multi-lineage commitment in the early embryo. Development (2010) 1.08
CTCF: master weaver of the genome. Cell (2009) 15.09
Architectural protein subclasses shape 3D organization of genomes during lineage commitment. Cell (2013) 6.37
Enhancer function: new insights into the regulation of tissue-specific gene expression. Nat Rev Genet (2011) 5.27
Phosphorylation of histone H3: a balancing act between chromosome condensation and transcriptional activation. Trends Genet (2004) 3.69
Gene density, transcription, and insulators contribute to the partition of the Drosophila genome into physical domains. Mol Cell (2012) 3.08
Three subclasses of a Drosophila insulator show distinct and cell type-specific genomic distributions. Genes Dev (2009) 2.58
The centrosomal protein CP190 is a component of the gypsy chromatin insulator. Mol Cell (2004) 2.49
Boundary elements and nuclear organization. Biol Cell (2004) 2.48
Chromatin insulators: regulatory mechanisms and epigenetic inheritance. Mol Cell (2008) 2.31
Setting the boundaries of chromatin domains and nuclear organization. Cell (2002) 2.27
RNA interference machinery influences the nuclear organization of a chromatin insulator. Nat Genet (2006) 2.22
Coordinated control of dCTCF and gypsy chromatin insulators in Drosophila. Mol Cell (2007) 2.14
The role of histone H2Av variant replacement and histone H4 acetylation in the establishment of Drosophila heterochromatin. Genes Dev (2005) 2.09
Visualization of chromatin domains created by the gypsy insulator of Drosophila. J Cell Biol (2003) 1.93
Phosphorylation of histone H3 at Ser10 facilitates RNA polymerase II release from promoter-proximal pausing in Drosophila. Genes Dev (2007) 1.79
Regulation of chromatin organization and inducible gene expression by a Drosophila insulator. Mol Cell (2011) 1.75
Poly(ADP-ribosyl)ation regulates insulator function and intrachromosomal interactions in Drosophila. Cell (2013) 1.70
Insulator function and topological domain border strength scale with architectural protein occupancy. Genome Biol (2014) 1.70
The ubiquitin ligase dTopors directs the nuclear organization of a chromatin insulator. Mol Cell (2005) 1.68
Drosophila CTCF tandemly aligns with other insulator proteins at the borders of H3K27me3 domains. Genome Res (2012) 1.52
Chromatin insulators: linking genome organization to cellular function. Mol Cell (2013) 1.51
Competencies: a cure for pre-med curriculum. Science (2011) 1.47
Genomic organization of gypsy chromatin insulators in Drosophila melanogaster. Genetics (2006) 1.28
Phosphorylation of histone H3 during transcriptional activation depends on promoter structure. Genes Dev (2003) 1.25
Insulators, long-range interactions, and genome function. Curr Opin Genet Dev (2012) 1.24
Trans-splicing as a novel mechanism to explain interallelic complementation in Drosophila. Genetics (2002) 1.23
SUMO conjugation attenuates the activity of the gypsy chromatin insulator. EMBO J (2006) 1.22
Nuclear organization and genome function. Annu Rev Cell Dev Biol (2012) 1.21
Protein phosphatase 2A activity affects histone H3 phosphorylation and transcription in Drosophila melanogaster. Mol Cell Biol (2003) 1.21
Chromatin insulators: lessons from the fly. Brief Funct Genomic Proteomic (2009) 1.17
The role of insulator elements in large-scale chromatin structure in interphase. Semin Cell Dev Biol (2007) 1.11
14-3-3 mediates histone cross-talk during transcription elongation in Drosophila. PLoS Genet (2010) 1.10
The role of chromatin insulators in nuclear architecture and genome function. Curr Opin Genet Dev (2013) 1.04
Genome-wide phosphoacetylation of histone H3 at Drosophila enhancers and promoters. Genome Res (2012) 1.03
Chromatin insulators: a role in nuclear organization and gene expression. Adv Cancer Res (2011) 1.01
A subset of Drosophila Myc sites remain associated with mitotic chromosomes colocalized with insulator proteins. Nat Commun (2013) 0.97
The BEAF-32 insulator coordinates genome organization and function during the evolution of Drosophila species. Genome Res (2012) 0.95
tDNA insulators and the emerging role of TFIIIC in genome organization. Transcription (2012) 0.95
Dynamic changes in the genomic localization of DNA replication-related element binding factor during the cell cycle. Cell Cycle (2013) 0.94
Extensive exon reshuffling over evolutionary time coupled to trans-splicing in Drosophila. Genome Res (2003) 0.94
Insulators as mediators of intra- and inter-chromosomal interactions: a common evolutionary theme. J Biol (2009) 0.93
DNA topoisomerase II modulates insulator function in Drosophila. PLoS One (2011) 0.89
Distinct isoforms of the Drosophila Brd4 homologue are present at enhancers, promoters and insulator sites. Nucleic Acids Res (2013) 0.88
Nups take leave of the nuclear envelope to regulate transcription. Cell (2010) 0.88
Throwing transcription for a loop: expression of the genome in the 3D nucleus. Chromosoma (2011) 0.86
A long-distance relationship between RNAi and Polycomb. Cell (2006) 0.83
Opening pathways for underrepresented high school students to biomedical research careers: the Emory University RISE program. Genetics (2011) 0.83
Insulator and Ovo proteins determine the frequency and specificity of insertion of the gypsy retrotransposon in Drosophila melanogaster. Genetics (2008) 0.82
CTCF-dependent co-localization of canonical Smad signaling factors at architectural protein binding sites in D. melanogaster. Cell Cycle (2015) 0.81
The Drosophila transcription factor Adf-1 (nalyot) regulates dendrite growth by controlling FasII and Staufen expression downstream of CaMKII and neural activity. J Neurosci (2013) 0.80
The nuclear pore complex and chromatin boundaries. Trends Cell Biol (2002) 0.80
Spinning the web of cell fate. Cell (2013) 0.80
The BEAF insulator regulates genes involved in cell polarity and neoplastic growth. Dev Biol (2012) 0.78
Wt1 flip-flops chromatin in a CTCF domain. Dev Cell (2011) 0.78
The Lawc protein is required for proper transcription by RNA polymerase II in Drosophila. Mol Genet Genomics (2008) 0.77
Modulation of CTCF insulator function by transcription of a noncoding RNA. Dev Cell (2008) 0.75
Identification and characterization of proteins involved in nuclear organization using Drosophila GFP protein trap lines. PLoS One (2013) 0.75
Insulators and imprinting from flies to mammals. BMC Biol (2010) 0.75