Tissue-specific analysis of chromatin state identifies temporal signatures of enhancer activity during embryonic development.

PubWeight™: 2.94‹?› | Rank: Top 1%

🔗 View Article (PMID 22231485)

Published in Nat Genet on January 08, 2012

Authors

Stefan Bonn1, Robert P Zinzen, Charles Girardot, E Hilary Gustafson, Alexis Perez-Gonzalez, Nicolas Delhomme, Yad Ghavi-Helm, Bartek Wilczyński, Andrew Riddell, Eileen E M Furlong

Author Affiliations

1: Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.

Articles citing this

(truncated to the top 100)

Transcription factors: from enhancer binding to developmental control. Nat Rev Genet (2012) 5.00

Modification of enhancer chromatin: what, how, and why? Mol Cell (2013) 3.62

Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription. Mol Cell (2013) 2.55

Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants. Nat Genet (2014) 2.38

Enhancer loops appear stable during development and are associated with paused polymerase. Nature (2014) 2.36

Enhancer-associated H3K4 monomethylation by Trithorax-related, the Drosophila homolog of mammalian Mll3/Mll4. Genes Dev (2012) 2.04

The selection and function of cell type-specific enhancers. Nat Rev Mol Cell Biol (2015) 1.93

Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells. Science (2015) 1.91

Genome-scale functional characterization of Drosophila developmental enhancers in vivo. Nature (2014) 1.82

Reorganization of enhancer patterns in transition from naive to primed pluripotency. Cell Stem Cell (2014) 1.81

Epigenomic annotation of enhancers predicts transcriptional regulators of human neural crest. Cell Stem Cell (2012) 1.80

Rapid and pervasive changes in genome-wide enhancer usage during mammalian development. Cell (2013) 1.79

A LncRNA-MAF:MAFB transcription factor network regulates epidermal differentiation. Dev Cell (2015) 1.76

Disentangling the many layers of eukaryotic transcriptional regulation. Annu Rev Genet (2012) 1.68

RFECS: a random-forest based algorithm for enhancer identification from chromatin state. PLoS Comput Biol (2013) 1.66

Chromatin state signatures associated with tissue-specific gene expression and enhancer activity in the embryonic limb. Genome Res (2012) 1.57

Cfp1 integrates both CpG content and gene activity for accurate H3K4me3 deposition in embryonic stem cells. Genes Dev (2012) 1.55

HOT regions function as patterned developmental enhancers and have a distinct cis-regulatory signature. Genes Dev (2012) 1.53

Enhancers as information integration hubs in development: lessons from genomics. Trends Genet (2012) 1.52

AF9 YEATS domain links histone acetylation to DOT1L-mediated H3K79 methylation. Cell (2014) 1.43

Mechanisms of transcriptional precision in animal development. Trends Genet (2012) 1.38

The MLL3/MLL4 branches of the COMPASS family function as major histone H3K4 monomethylases at enhancers. Mol Cell Biol (2013) 1.35

Dynamics of enhancer chromatin signatures mark the transition from pluripotency to cell specification during embryogenesis. Genome Res (2012) 1.34

Human promoters are intrinsically directional. Mol Cell (2015) 1.31

Poised RNA polymerase II changes over developmental time and prepares genes for future expression. Cell Rep (2012) 1.25

i-cisTarget: an integrative genomics method for the prediction of regulatory features and cis-regulatory modules. Nucleic Acids Res (2012) 1.24

Epigenomic enhancer annotation reveals a key role for NFIX in neural stem cell quiescence. Genes Dev (2013) 1.23

Enhancers: emerging roles in cell fate specification. EMBO Rep (2012) 1.23

Functional annotation of colon cancer risk SNPs. Nat Commun (2014) 1.19

Integrating diverse datasets improves developmental enhancer prediction. PLoS Comput Biol (2014) 1.16

Enhancers as non-coding RNA transcription units: recent insights and future perspectives. Nat Rev Genet (2016) 1.15

Cell type-specific genomics of Drosophila neurons. Nucleic Acids Res (2012) 1.15

Architectural and Functional Commonalities between Enhancers and Promoters. Cell (2015) 1.14

Cell type-specific chromatin immunoprecipitation from multicellular complex samples using BiTS-ChIP. Nat Protoc (2012) 1.09

Predicting enhancer transcription and activity from chromatin modifications. Nucleic Acids Res (2013) 1.08

Enhancer activation requires trans-recruitment of a mega transcription factor complex. Cell (2014) 1.06

Argonaute-1 binds transcriptional enhancers and controls constitutive and alternative splicing in human cells. Proc Natl Acad Sci U S A (2014) 1.05

A dynamic H3K27ac signature identifies VEGFA-stimulated endothelial enhancers and requires EP300 activity. Genome Res (2013) 1.05

Genome-wide screens for in vivo Tinman binding sites identify cardiac enhancers with diverse functional architectures. PLoS Genet (2013) 1.05

Cell-type-specific profiling of gene expression and chromatin binding without cell isolation: assaying RNA Pol II occupancy in neural stem cells. Dev Cell (2013) 1.04

Highly parallel assays of tissue-specific enhancers in whole Drosophila embryos. Nat Methods (2013) 1.00

The active enhancer network operated by liganded RXR supports angiogenic activity in macrophages. Genes Dev (2014) 1.00

Epigenetic memory: the Lamarckian brain. EMBO J (2014) 0.99

BNFinder2: Faster Bayesian network learning and Bayesian classification. Bioinformatics (2013) 0.98

FlyBase at 25: looking to the future. Nucleic Acids Res (2016) 0.97

Trithorax monomethylates histone H3K4 and interacts directly with CBP to promote H3K27 acetylation and antagonize Polycomb silencing. Development (2014) 0.97

Identification and analysis of murine pancreatic islet enhancers. Diabetologia (2012) 0.96

DNA methylation changes in plasticity genes accompany the formation and maintenance of memory. Nat Neurosci (2015) 0.96

The genetic analysis of functional connectomics in Drosophila. Adv Genet (2012) 0.95

Transcription factor binding at enhancers: shaping a genomic regulatory landscape in flux. Front Genet (2012) 0.95

The relationship between long-range chromatin occupancy and polymerization of the Drosophila ETS family transcriptional repressor Yan. Genetics (2012) 0.94

Transcription-factor occupancy at HOT regions quantitatively predicts RNA polymerase recruitment in five human cell lines. BMC Genomics (2013) 0.93

Subtle changes in motif positioning cause tissue-specific effects on robustness of an enhancer's activity. PLoS Genet (2014) 0.92

Integrative analysis of the zinc finger transcription factor Lame duck in the Drosophila myogenic gene regulatory network. Proc Natl Acad Sci U S A (2012) 0.92

Proteomic profiling of cardiac tissue by isolation of nuclei tagged in specific cell types (INTACT). Development (2014) 0.92

Computational identification of active enhancers in model organisms. Genomics Proteomics Bioinformatics (2013) 0.92

Long ncRNA expression associates with tissue-specific enhancers. Cell Cycle (2015) 0.92

RNA transcribed from a distal enhancer is required for activating the chromatin at the promoter of the gonadotropin α-subunit gene. Proc Natl Acad Sci U S A (2015) 0.91

Characterization of the neural stem cell gene regulatory network identifies OLIG2 as a multifunctional regulator of self-renewal. Genome Res (2014) 0.91

Enhancer interaction networks as a means for singular olfactory receptor expression. Cell (2014) 0.91

Impacts of the ubiquitous factor Zelda on Bicoid-dependent DNA binding and transcription in Drosophila. Genes Dev (2014) 0.91

Zelda overcomes the high intrinsic nucleosome barrier at enhancers during Drosophila zygotic genome activation. Genome Res (2015) 0.91

Epigenomics of cancer - emerging new concepts. Biochimie (2012) 0.90

Identification of transcription factor binding sites from ChIP-seq data at high resolution. Bioinformatics (2013) 0.89

Epigenetic regulation in neural crest development. Dev Biol (2014) 0.89

Advanced Applications of RNA Sequencing and Challenges. Bioinform Biol Insights (2015) 0.88

Evolutionary conservation of the eumetazoan gene regulatory landscape. Genome Res (2014) 0.88

NeuroD1 reprograms chromatin and transcription factor landscapes to induce the neuronal program. EMBO J (2015) 0.86

Estrogen represses gene expression through reconfiguring chromatin structures. Nucleic Acids Res (2013) 0.85

Computational schemes for the prediction and annotation of enhancers from epigenomic assays. Methods (2014) 0.85

Integrating motif, DNA accessibility and gene expression data to build regulatory maps in an organism. Nucleic Acids Res (2015) 0.84

Foxd3 Promotes Exit from Naive Pluripotency through Enhancer Decommissioning and Inhibits Germline Specification. Cell Stem Cell (2016) 0.84

Regulation of gene expression in the genomic context. Comput Struct Biotechnol J (2014) 0.83

Timing of transcriptional quiescence during gametogenesis is controlled by global histone H3K4 demethylation. Dev Cell (2012) 0.83

Dynamics and function of distal regulatory elements during neurogenesis and neuroplasticity. Genome Res (2015) 0.83

Genetic networks governing heart development. Cold Spring Harb Perspect Med (2014) 0.83

Epigenomic annotation of gene regulatory alterations during evolution of the primate brain. Nat Neurosci (2016) 0.82

Deep conservation of cis-regulatory elements in metazoans. Philos Trans R Soc Lond B Biol Sci (2013) 0.82

Identifying transcriptional cis-regulatory modules in animal genomes. Wiley Interdiscip Rev Dev Biol (2014) 0.82

Inducible DamID systems for genomic mapping of chromatin proteins in Drosophila. Nucleic Acids Res (2016) 0.81

Phenotypic Plasticity through Transcriptional Regulation of the Evolutionary Hotspot Gene tan in Drosophila melanogaster. PLoS Genet (2016) 0.81

Histone H3 lysine 4 methylation revisited. Transcription (2012) 0.81

Developmental enhancers are marked independently of zygotic Nodal signals in Xenopus. Dev Biol (2014) 0.81

Coordinated repression and activation of two transcriptional programs stabilizes cell fate during myogenesis. Development (2014) 0.80

Akirin: a context-dependent link between transcription and chromatin remodeling. Bioarchitecture (2012) 0.80

Reprogramming of the human intestinal epigenome by surgical tissue transposition. Genome Res (2014) 0.80

Chromatin looping as a target for altering erythroid gene expression. Ann N Y Acad Sci (2016) 0.79

Cell-Type Specific Determinants of NRAMP1 Expression in Professional Phagocytes. Biology (Basel) (2013) 0.79

Dual functionality of cis-regulatory elements as developmental enhancers and Polycomb response elements. Genes Dev (2017) 0.79

Exploiting genomics and natural genetic variation to decode macrophage enhancers. Trends Immunol (2015) 0.79

Biased, non-equivalent gene-proximal and -distal binding motifs of orphan nuclear receptor TR4 in primary human erythroid cells. PLoS Genet (2014) 0.79

Acute TNF-induced repression of cell identity genes is mediated by NFκB-directed redistribution of cofactors from super-enhancers. Genome Res (2015) 0.79

Distinct Enhancer Activity of Oct4 in Naive and Primed Mouse Pluripotency. Stem Cell Reports (2016) 0.79

Interrogation of allelic chromatin states in human cells by high-density ChIP-genotyping. Epigenetics (2014) 0.79

Enhancers reside in a unique epigenetic environment during early zebrafish development. Genome Biol (2016) 0.79

Active enhancer positions can be accurately predicted from chromatin marks and collective sequence motif data. BMC Syst Biol (2013) 0.78

Identification of a Potential Regulatory Variant for Colorectal Cancer Risk Mapping to Chromosome 5q31.1: A Post-GWAS Study. PLoS One (2015) 0.78

A cohesin-OCT4 complex mediates Sox enhancers to prime an early embryonic lineage. Nat Commun (2015) 0.78

Combinatorial epigenetic patterns as quantitative predictors of chromatin biology. BMC Genomics (2014) 0.78

The FaceBase Consortium: a comprehensive resource for craniofacial researchers. Development (2016) 0.78

Articles cited by this

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Genome Biol (2009) 235.12

Bioconductor: open software development for computational biology and bioinformatics. Genome Biol (2004) 143.19

High-resolution profiling of histone methylations in the human genome. Cell (2007) 85.74

Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature (2007) 65.18

Model-based analysis of ChIP-Seq (MACS). Genome Biol (2008) 51.63

Causal protein-signaling networks derived from multiparameter single-cell data. Science (2005) 34.28

Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome. Nat Genet (2007) 32.41

Histone modifications at human enhancers reflect global cell-type-specific gene expression. Nature (2009) 24.41

Mapping and analysis of chromatin state dynamics in nine human cell types. Nature (2011) 24.37

Combinatorial patterns of histone acetylations and methylations in the human genome. Nat Genet (2008) 18.28

Widespread transcription at neuronal activity-regulated enhancers. Nature (2010) 16.52

Histone H3K27ac separates active from poised enhancers and predicts developmental state. Proc Natl Acad Sci U S A (2010) 15.13

Module networks: identifying regulatory modules and their condition-specific regulators from gene expression data. Nat Genet (2003) 14.56

A unique chromatin signature uncovers early developmental enhancers in humans. Nature (2010) 14.02

TM4 microarray software suite. Methods Enzymol (2006) 13.78

The UCSC genome browser database: update 2007. Nucleic Acids Res (2006) 13.04

Identification of functional elements and regulatory circuits by Drosophila modENCODE. Science (2010) 12.39

FlyBase: enhancing Drosophila Gene Ontology annotations. Nucleic Acids Res (2008) 12.15

A Bayesian networks approach for predicting protein-protein interactions from genomic data. Science (2003) 12.07

Inferring cellular networks using probabilistic graphical models. Science (2004) 9.91

RNA polymerase stalling at developmental control genes in the Drosophila melanogaster embryo. Nat Genet (2007) 9.56

Systematic protein location mapping reveals five principal chromatin types in Drosophila cells. Cell (2010) 9.50

Systematic determination of patterns of gene expression during Drosophila embryogenesis. Genome Biol (2002) 8.89

ShortRead: a bioconductor package for input, quality assessment and exploration of high-throughput sequence data. Bioinformatics (2009) 8.69

Chromatin signatures in multipotent human hematopoietic stem cells indicate the fate of bivalent genes during differentiation. Cell Stem Cell (2009) 8.62

Predicting gene expression from sequence. Cell (2004) 8.12

Differential chromatin marking of introns and expressed exons by H3K36me3. Nat Genet (2009) 8.11

Charting histone modifications and the functional organization of mammalian genomes. Nat Rev Genet (2010) 7.39

Transcriptional control of muscle development by myocyte enhancer factor-2 (MEF2) proteins. Annu Rev Cell Dev Biol (1998) 7.31

P[acman]: a BAC transgenic platform for targeted insertion of large DNA fragments in D. melanogaster. Science (2006) 7.03

Global analysis of patterns of gene expression during Drosophila embryogenesis. Genome Biol (2007) 6.27

A large fraction of extragenic RNA pol II transcription sites overlap enhancers. PLoS Biol (2010) 6.01

Nucleosome dynamics define transcriptional enhancers. Nat Genet (2010) 5.94

Multiplex detection of RNA expression in Drosophila embryos. Science (2004) 5.27

Functional and mechanistic diversity of distal transcription enhancers. Cell (2011) 5.22

A cis-regulatory map of the Drosophila genome. Nature (2011) 4.80

Empirical methods for controlling false positives and estimating confidence in ChIP-Seq peaks. BMC Bioinformatics (2008) 4.41

Regulation of organogenesis by the Caenorhabditis elegans FoxA protein PHA-4. Science (2002) 4.33

Histone modification levels are predictive for gene expression. Proc Natl Acad Sci U S A (2010) 4.00

Combinatorial binding predicts spatio-temporal cis-regulatory activity. Nature (2009) 3.85

Transcriptional control in the segmentation gene network of Drosophila. PLoS Biol (2004) 3.47

The dorsal morphogen gradient regulates the mesoderm determinant twist in early Drosophila embryos. Genes Dev (1991) 3.45

A temporal map of transcription factor activity: mef2 directly regulates target genes at all stages of muscle development. Dev Cell (2006) 3.29

A core transcriptional network for early mesoderm development in Drosophila melanogaster. Genes Dev (2007) 3.01

A hierarchy of H3K4me3 and H3K27me3 acquisition in spatial gene regulation in Xenopus embryos. Dev Cell (2009) 2.84

REDfly v3.0: toward a comprehensive database of transcriptional regulatory elements in Drosophila. Nucleic Acids Res (2010) 2.84

Transcription initiation platforms and GTF recruitment at tissue-specific enhancers and promoters. Nat Struct Mol Biol (2011) 2.79

Genome-wide chromatin maps derived from limited numbers of hematopoietic progenitors. Nat Methods (2010) 2.71

Efficient release from promoter-proximal stall sites requires transcript cleavage factor TFIIS. Mol Cell (2005) 2.68

Global and gene-specific analyses show distinct roles for Myod and Myog at a common set of promoters. EMBO J (2006) 2.38

Broad chromosomal domains of histone modification patterns in C. elegans. Genome Res (2010) 2.36

A simple method for gene expression and chromatin profiling of individual cell types within a tissue. Dev Cell (2010) 2.24

Epigenetic temporal control of mouse Hox genes in vivo. Science (2009) 2.17

Permutation P-values should never be zero: calculating exact P-values when permutations are randomly drawn. Stat Appl Genet Mol Biol (2010) 2.13

Developmental regulation and individual differences of neuronal H3K4me3 epigenomes in the prefrontal cortex. Proc Natl Acad Sci U S A (2010) 2.06

One-step purification of recombinant proteins using a nanomolar-affinity streptavidin-binding peptide, the SBP-Tag. Protein Expr Purif (2001) 1.95

Locus co-occupancy, nucleosome positioning, and H3K4me1 regulate the functionality of FOXA2-, HNF4A-, and PDX1-bound loci in islets and liver. Genome Res (2010) 1.90

Plasticity in patterns of histone modifications and chromosomal proteins in Drosophila heterochromatin. Genome Res (2010) 1.87

Single-tube linear DNA amplification (LinDA) for robust ChIP-seq. Nat Methods (2011) 1.60

Genetic programs activated by proneural proteins in the developing Drosophila PNS. Dev Cell (2005) 1.54

Disperse versus compact elements for the regulation of runt stripes in Drosophila. Dev Biol (1996) 1.48

Temporal ChIP-on-chip reveals Biniou as a universal regulator of the visceral muscle transcriptional network. Genes Dev (2007) 1.43

Zebrafish promoter microarrays identify actively transcribed embryonic genes. Genome Biol (2006) 1.42

A systematic analysis of Tinman function reveals Eya and JAK-STAT signaling as essential regulators of muscle development. Dev Cell (2009) 1.36

BNFinder: exact and efficient method for learning Bayesian networks. Bioinformatics (2008) 1.36

ChIP-on-chip protocol for genome-wide analysis of transcription factor binding in Drosophila melanogaster embryos. Nat Protoc (2006) 1.35

Identification of regulatory regions driving the expression of the Drosophila spalt complex at different developmental stages. Dev Biol (1999) 1.35

Dynamic CRM occupancy reflects a temporal map of developmental progression. Mol Syst Biol (2010) 1.13

Combinatorial binding leads to diverse regulatory responses: Lmd is a tissue-specific modulator of Mef2 activity. PLoS Genet (2010) 0.98

Identifying functional cis-acting regulatory modules of the yan gene in Drosophila melanogaster. Dev Genes Evol (2003) 0.79

Articles by these authors

Gene expression during the life cycle of Drosophila melanogaster. Science (2002) 11.36

Transcription factors: from enhancer binding to developmental control. Nat Rev Genet (2012) 5.00

The Norway spruce genome sequence and conifer genome evolution. Nature (2013) 4.74

Whole-genome ChIP-chip analysis of Dorsal, Twist, and Snail suggests integration of diverse patterning processes in the Drosophila embryo. Genes Dev (2007) 4.59

Combinatorial binding predicts spatio-temporal cis-regulatory activity. Nature (2009) 3.85

The genomic and transcriptomic landscape of a HeLa cell line. G3 (Bethesda) (2013) 3.82

A temporal map of transcription factor activity: mef2 directly regulates target genes at all stages of muscle development. Dev Cell (2006) 3.29

A core transcriptional network for early mesoderm development in Drosophila melanogaster. Genes Dev (2007) 3.01

Dynamic regulation by polycomb group protein complexes controls pattern formation and the cell cycle in Drosophila. Dev Cell (2008) 2.41

4DXpress: a database for cross-species expression pattern comparisons. Nucleic Acids Res (2007) 2.38

A transcription factor collective defines cardiac cell fate and reflects lineage history. Cell (2012) 2.02

Analysis of variation at transcription factor binding sites in Drosophila and humans. Genome Biol (2012) 1.97

Mediator-dependent recruitment of TFIIH modules in preinitiation complex. Mol Cell (2008) 1.88

Multigenome analysis identifies a worldwide distributed epidemic Legionella pneumophila clone that emerged within a highly diverse species. Genome Res (2008) 1.84

Applying dynamic Bayesian networks to perturbed gene expression data. BMC Bioinformatics (2006) 1.77

Predicting spatial and temporal gene expression using an integrative model of transcription factor occupancy and chromatin state. PLoS Comput Biol (2012) 1.71

Identification of tightly regulated groups of genes during Drosophila melanogaster embryogenesis. Mol Syst Biol (2007) 1.53

Temporal ChIP-on-chip reveals Biniou as a universal regulator of the visceral muscle transcriptional network. Genes Dev (2007) 1.43

Model-based method for transcription factor target identification with limited data. Proc Natl Acad Sci U S A (2010) 1.38

A systematic analysis of Tinman function reveals Eya and JAK-STAT signaling as essential regulators of muscle development. Dev Cell (2009) 1.36

ChIP-on-chip protocol for genome-wide analysis of transcription factor binding in Drosophila melanogaster embryos. Nat Protoc (2006) 1.35

Evolution of the dorsal-ventral patterning network in the mosquito, Anopheles gambiae. Development (2007) 1.34

FACT--a framework for the functional interpretation of high-throughput experiments. BMC Bioinformatics (2005) 1.29

Genomic binding of Pol III transcription machinery and relationship with TFIIS transcription factor distribution in mouse embryonic stem cells. Nucleic Acids Res (2011) 1.23

The baker's yeast diploid genome is remarkably stable in vegetative growth and meiosis. PLoS Genet (2010) 1.20

Challenges for modeling global gene regulatory networks during development: insights from Drosophila. Dev Biol (2009) 1.14

Dynamic CRM occupancy reflects a temporal map of developmental progression. Mol Syst Biol (2010) 1.13

Cell type-specific chromatin immunoprecipitation from multicellular complex samples using BiTS-ChIP. Nat Protoc (2012) 1.09

Elucidation of an archaeal replication protein network to generate enhanced PCR enzymes. J Biol Chem (2002) 1.08

Impact of genomic structural variation in Drosophila melanogaster based on population-scale sequencing. Genome Res (2012) 1.07

Mutations of RNA polymerase II activate key genes of the nucleoside triphosphate biosynthetic pathways. EMBO J (2008) 1.04

cis-Regulatory networks during development: a view of Drosophila. Curr Opin Genet Dev (2008) 1.04

Seamless gene tagging by endonuclease-driven homologous recombination. PLoS One (2011) 0.98

Combinatorial binding leads to diverse regulatory responses: Lmd is a tissue-specific modulator of Mef2 activity. PLoS Genet (2010) 0.98

The cell cycle dependent mislocalisation of emerin may contribute to the Emery-Dreifuss muscular dystrophy phenotype. J Cell Sci (2002) 0.98

A conserved role for Snail as a potentiator of active transcription. Genes Dev (2014) 0.97

Differential retinoic acid signaling in tumors of long- and short-term glioblastoma survivors. J Natl Cancer Inst (2011) 0.94

Myofilin, a protein in the thick filaments of insect muscle. J Cell Sci (2005) 0.90

Conservation and divergence in developmental networks: a view from Drosophila myogenesis. Curr Opin Cell Biol (2009) 0.90

Nos2 inactivation promotes the development of medulloblastoma in Ptch1(+/-) mice by deregulation of Gap43-dependent granule cell precursor migration. PLoS Genet (2012) 0.89

Molecular biology: A fly in the face of genomics. Nature (2011) 0.86

Logical modelling of Drosophila signalling pathways. Mol Biosyst (2013) 0.85

Template requirements for telomerase translocation in Kluyveromyces lactis. Mol Cell Biol (2004) 0.84

Divergence in cis-regulatory networks: taking the 'species' out of cross-species analysis. Genome Biol (2008) 0.82

Analyzing transcription factor occupancy during embryo development using ChIP-seq. Methods Mol Biol (2012) 0.80

Fragmentation of DNA in a sub-microliter microfluidic sonication device. Lab Chip (2012) 0.79

Active enhancer positions can be accurately predicted from chromatin marks and collective sequence motif data. BMC Syst Biol (2013) 0.78

Cellular uptake of PNA--terpyridine conjugates and its enhancement by Zn2+ ions. J Am Chem Soc (2006) 0.77

Thanatop: a novel 5-nitrofuran that is a highly active, cell-permeable inhibitor of topoisomerase II. Cancer Res (2007) 0.76

Populus tremula (European aspen) shows no evidence of sexual dimorphism. BMC Plant Biol (2014) 0.76

Corrigendum: Enhancer loops appear stable during development and are associated with paused polymerase. Nature (2016) 0.75

Supervised learning method for predicting chromatin boundary associated insulator elements. J Bioinform Comput Biol (2014) 0.75

Genomics and development: Taking developmental biology to new heights. Dev Cell (2006) 0.75

CoCo: a web application to display, store and curate ChIP-on-chip data integrated with diverse types of gene expression data. Bioinformatics (2007) 0.75