Published in Nature on June 14, 2009
Missing heritability and strategies for finding the underlying causes of complex disease. Nat Rev Genet (2010) 14.81
Most "dark matter" transcripts are associated with known genes. PLoS Biol (2010) 6.60
Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals. Cell (2010) 5.22
Epigenetic reprogramming in plant and animal development. Science (2010) 5.18
Molecular signals of epigenetic states. Science (2010) 4.81
Histone variants--ancient wrap artists of the epigenome. Nat Rev Mol Cell Biol (2010) 4.45
Targets and dynamics of promoter DNA methylation during early mouse development. Nat Genet (2010) 4.27
Epigenetics and the environment: emerging patterns and implications. Nat Rev Genet (2012) 4.04
Epigenomic analysis of multilineage differentiation of human embryonic stem cells. Cell (2013) 3.81
Sperm methylation profiles reveal features of epigenetic inheritance and evolution in primates. Cell (2011) 3.39
Non-invasive imaging of human embryos before embryonic genome activation predicts development to the blastocyst stage. Nat Biotechnol (2010) 3.22
Repressive and active histone methylation mark distinct promoters in human and mouse spermatozoa. Nat Struct Mol Biol (2010) 3.07
Epigenetic modifications in pluripotent and differentiated cells. Nat Biotechnol (2010) 3.02
Understanding transgenerational epigenetic inheritance via the gametes in mammals. Nat Rev Genet (2012) 2.93
Transgenerational epigenetic inheritance: myths and mechanisms. Cell (2014) 2.88
Epigenetic transgenerational actions of environmental factors in disease etiology. Trends Endocrinol Metab (2010) 2.86
Chromatin signature of embryonic pluripotency is established during genome activation. Nature (2010) 2.64
beta-Catenin primes organizer gene expression by recruiting a histone H3 arginine 8 methyltransferase, Prmt2. Dev Cell (2010) 2.44
PGC7 binds histone H3K9me2 to protect against conversion of 5mC to 5hmC in early embryos. Nature (2012) 2.38
Human RNA polymerase III transcriptomes and relationships to Pol II promoter chromatin and enhancer-binding factors. Nat Struct Mol Biol (2010) 2.30
Multigenerational epigenetic adaptation of the hepatic wound-healing response. Nat Med (2012) 2.28
Maternal control of early mouse development. Development (2010) 2.13
Transgenerational genetic effects on phenotypic variation and disease risk. Hum Mol Genet (2009) 2.01
Reprogramming the maternal zebrafish genome after fertilization to match the paternal methylation pattern. Cell (2013) 1.95
Genes for embryo development are packaged in blocks of multivalent chromatin in zebrafish sperm. Genome Res (2011) 1.94
A set of genes critical to development is epigenetically poised in mouse germ cells from fetal stages through completion of meiosis. Proc Natl Acad Sci U S A (2013) 1.75
Transgenerational epigenetic inheritance: more questions than answers. Genome Res (2010) 1.67
Epigenetic disruption of the PIWI pathway in human spermatogenic disorders. PLoS One (2012) 1.64
Genome-wide parent-of-origin DNA methylation analysis reveals the intricacies of human imprinting and suggests a germline methylation-independent mechanism of establishment. Genome Res (2014) 1.64
Epigenetic conservation at gene regulatory elements revealed by non-methylated DNA profiling in seven vertebrates. Elife (2013) 1.63
A survey of small RNAs in human sperm. Hum Reprod (2011) 1.62
Every amino acid matters: essential contributions of histone variants to mammalian development and disease. Nat Rev Genet (2014) 1.62
Gene repression. H3K27me and PRC2 transmit a memory of repression across generations and during development. Science (2014) 1.61
Transgenerational epigenetic inheritance in plants. Biochim Biophys Acta (2011) 1.58
Molecular determinants of nucleosome retention at CpG-rich sequences in mouse spermatozoa. Nat Struct Mol Biol (2013) 1.54
Genome wide identification of promoter binding sites for H4K12ac in human sperm and its relevance for early embryonic development. Epigenetics (2012) 1.53
New insights into establishment and maintenance of DNA methylation imprints in mammals. Philos Trans R Soc Lond B Biol Sci (2013) 1.49
Daddy issues: paternal effects on phenotype. Cell (2012) 1.49
Coordinated histone modifications are associated with gene expression variation within and between species. Genome Res (2011) 1.49
Bivalent histone modifications in early embryogenesis. Curr Opin Cell Biol (2012) 1.48
Two-step imprinted X inactivation: repeat versus genic silencing in the mouse. Mol Cell Biol (2010) 1.46
Epigenetic mechanisms of depression and antidepressant action. Annu Rev Pharmacol Toxicol (2012) 1.45
Stable and dynamic nucleosome states during a meiotic developmental process. Genome Res (2011) 1.44
Function of sperm chromatin structural elements in fertilization and development. Mol Hum Reprod (2009) 1.44
High-resolution mapping of chromatin packaging in mouse embryonic stem cells and sperm. Dev Cell (2014) 1.44
Histone variants in metazoan development. Dev Cell (2010) 1.42
Acetylation-mediated proteasomal degradation of core histones during DNA repair and spermatogenesis. Cell (2013) 1.35
Paternally induced transgenerational inheritance of susceptibility to diabetes in mammals. Proc Natl Acad Sci U S A (2014) 1.34
Human transgenerational responses to early-life experience: potential impact on development, health and biomedical research. J Med Genet (2014) 1.34
The RNA Pol II elongation factor Ell3 marks enhancers in ES cells and primes future gene activation. Cell (2012) 1.33
Histone regulation in the CNS: basic principles of epigenetic plasticity. Neuropsychopharmacology (2012) 1.33
A paternal environmental legacy: evidence for epigenetic inheritance through the male germ line. Bioessays (2014) 1.33
Structural basis of instability of the nucleosome containing a testis-specific histone variant, human H3T. Proc Natl Acad Sci U S A (2010) 1.32
Transgenerational genetic effects of the paternal Y chromosome on daughters' phenotypes. Epigenomics (2010) 1.31
Zygotic genome activation during the maternal-to-zygotic transition. Annu Rev Cell Dev Biol (2014) 1.30
Chromatin organization in sperm may be the major functional consequence of base composition variation in the human genome. PLoS Genet (2011) 1.27
Chromatin mechanisms in genomic imprinting. Mamm Genome (2009) 1.26
Enhancers: emerging roles in cell fate specification. EMBO Rep (2012) 1.23
A role for Set1/MLL-related components in epigenetic regulation of the Caenorhabditis elegans germ line. PLoS Genet (2011) 1.22
Stability, delivery and functions of human sperm RNAs at fertilization. Nucleic Acids Res (2013) 1.20
The sperm nucleus: chromatin, RNA, and the nuclear matrix. Reproduction (2010) 1.18
Genome-wide analysis identifies changes in histone retention and epigenetic modifications at developmental and imprinted gene loci in the sperm of infertile men. Hum Reprod (2011) 1.18
Low paternal dietary folate alters the mouse sperm epigenome and is associated with negative pregnancy outcomes. Nat Commun (2013) 1.18
Bivalent chromatin marks developmental regulatory genes in the mouse embryonic germline in vivo. Cell Rep (2013) 1.18
Systematic screen reveals new functional dynamics of histones H3 and H4 during gametogenesis. Genes Dev (2010) 1.17
Bridging the transgenerational gap with epigenetic memory. Trends Genet (2013) 1.17
Novel insights into DNA methylation features in spermatozoa: stability and peculiarities. PLoS One (2012) 1.16
X-inactivation and X-reactivation: epigenetic hallmarks of mammalian reproduction and pluripotent stem cells. Hum Genet (2011) 1.14
RNF8 regulates active epigenetic modifications and escape gene activation from inactive sex chromosomes in post-meiotic spermatids. Genes Dev (2012) 1.13
Nuclear transfer to eggs and oocytes. Cold Spring Harb Perspect Biol (2011) 1.13
Age-associated sperm DNA methylation alterations: possible implications in offspring disease susceptibility. PLoS Genet (2014) 1.11
A global change in RNA polymerase II pausing during the Drosophila midblastula transition. Elife (2013) 1.11
The presence, role and clinical use of spermatozoal RNAs. Hum Reprod Update (2013) 1.11
Assisted reproduction treatment and epigenetic inheritance. Hum Reprod Update (2012) 1.11
What obesity research tells us about epigenetic mechanisms. Philos Trans R Soc Lond B Biol Sci (2013) 1.11
Polycomb function during oogenesis is required for mouse embryonic development. Genes Dev (2012) 1.09
Ancestral paternal genotype controls body weight and food intake for multiple generations. Hum Mol Genet (2010) 1.08
Human-specific histone methylation signatures at transcription start sites in prefrontal neurons. PLoS Biol (2012) 1.08
Epigenetic inheritance of disease and disease risk. Neuropsychopharmacology (2012) 1.07
Epigenetic inheritance: histone bookmarks across generations. Trends Cell Biol (2014) 1.05
Heterochromatin, small RNA and post-fertilization dysgenesis in allopolyploid and interploid hybrids of Arabidopsis. New Phytol (2010) 1.02
Chd5 orchestrates chromatin remodelling during sperm development. Nat Commun (2014) 1.01
H2A.Bbd: an X-chromosome-encoded histone involved in mammalian spermiogenesis. Nucleic Acids Res (2009) 1.01
Mouse zygotes respond to severe sperm DNA damage by delaying paternal DNA replication and embryonic development. PLoS One (2013) 1.01
Conservation of miR-15a/16-1 and miR-15b/16-2 clusters. Mamm Genome (2009) 1.01
Stage-specific histone modification profiles reveal global transitions in the Xenopus embryonic epigenome. PLoS One (2011) 1.01
Intergenerational programming of metabolic disease: evidence from human populations and experimental animal models. Cell Mol Life Sci (2013) 1.00
Haspin: a newly discovered regulator of mitotic chromosome behavior. Chromosoma (2009) 1.00
Epigenetic patterns maintained in early Caenorhabditis elegans embryos can be established by gene activity in the parental germ cells. PLoS Genet (2011) 1.00
The human imprintome: regulatory mechanisms, methods of ascertainment, and roles in disease susceptibility. ILAR J (2012) 0.99
Environmental signals and transgenerational epigenetics. Epigenomics (2009) 0.98
Nucleosome distribution and linker DNA: connecting nuclear function to dynamic chromatin structure. Biochem Cell Biol (2011) 0.97
Analysing the sperm epigenome: roles in early embryogenesis and assisted reproduction. Nat Rev Urol (2012) 0.97
Male Reproductive Disorders and Fertility Trends: Influences of Environment and Genetic Susceptibility. Physiol Rev (2016) 0.96
Proteomics and the genetics of sperm chromatin condensation. Asian J Androl (2010) 0.96
Epigenetic inheritance and the missing heritability. Hum Genomics (2015) 0.95
Novel insights into the genetic and epigenetic paternal contribution to the human embryo. Clinics (Sao Paulo) (2013) 0.95
Specific changes in the expression of imprinted genes in prostate cancer--implications for cancer progression and epigenetic regulation. Asian J Androl (2012) 0.95
Multivalent di-nucleosome recognition enables the Rpd3S histone deacetylase complex to tolerate decreased H3K36 methylation levels. EMBO J (2012) 0.95
KDM6 demethylase independent loss of histone H3 lysine 27 trimethylation during early embryonic development. PLoS Genet (2014) 0.95
Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell (2007) 101.42
A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell (2006) 48.80
Core transcriptional regulatory circuitry in human embryonic stem cells. Cell (2005) 34.93
A mammalian microRNA expression atlas based on small RNA library sequencing. Cell (2007) 34.03
In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature (2007) 28.24
Control of developmental regulators by Polycomb in human embryonic stem cells. Cell (2006) 28.21
Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science (2002) 24.31
A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis. Nat Biotechnol (2008) 21.72
Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome. Nat Genet (2007) 20.22
The Polycomb group protein EZH2 directly controls DNA methylation. Nature (2005) 13.67
DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA. Nature (2007) 11.14
Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer. Nat Genet (2006) 10.47
A novel CpG island set identifies tissue-specific methylation at developmental gene loci. PLoS Biol (2008) 7.95
Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors. Mol Cell (2008) 7.68
Methylation of histone H3 Lys 4 in coding regions of active genes. Proc Natl Acad Sci U S A (2002) 7.67
Genome-wide analysis of Polycomb targets in Drosophila melanogaster. Nat Genet (2006) 6.48
Dynamic reprogramming of DNA methylation in the early mouse embryo. Dev Biol (2002) 5.86
Promoter CpG methylation contributes to ES cell gene regulation in parallel with Oct4/Nanog, PcG complex, and histone H3 K4/K27 trimethylation. Cell Stem Cell (2008) 5.40
Empirical methods for controlling false positives and estimating confidence in ChIP-Seq peaks. BMC Bioinformatics (2008) 4.41
Global mapping of DNA methylation in mouse promoters reveals epigenetic reprogramming of pluripotency genes. PLoS Genet (2008) 3.89
Small increases in the level of Sox2 trigger the differentiation of mouse embryonic stem cells. Stem Cells (2008) 2.93
Genomic imprinting at the mammalian Dlk1-Dio3 domain. Trends Genet (2008) 2.92
Polycomb response elements and targeting of Polycomb group proteins in Drosophila. Curr Opin Genet Dev (2006) 2.76
Chromatin remodelling and epigenetic features of germ cells. Nature (2005) 2.49
Hyperconserved CpG domains underlie Polycomb-binding sites. Proc Natl Acad Sci U S A (2007) 2.41
Pericentric heterochromatin becomes enriched with H2A.Z during early mammalian development. EMBO J (2003) 2.23
Delta-like and gtl2 are reciprocally expressed, differentially methylated linked imprinted genes on mouse chromosome 12. Curr Biol (2000) 2.19
DNA packaging and organization in mammalian spermatozoa: comparison with somatic cells. Biol Reprod (1991) 1.99
The structural organization of sperm chromatin. J Biol Chem (2003) 1.86
Origin, evolution, and biological role of miRNA cluster in DLK-DIO3 genomic region in placental mammals. Mol Biol Evol (2008) 1.77
Mammalian epigenomics: reprogramming the genome for development and therapy. Theriogenology (2003) 1.45
Isolation of four core histones from human sperm chromatin representing a minor subset of somatic histones. J Biol Chem (1990) 1.32
Chromatin structure of telomere domain in human sperm. Biochem Biophys Res Commun (2000) 1.23
Genome-wide dynamics of SAPHIRE, an essential complex for gene activation and chromatin boundaries. Mol Cell Biol (2007) 1.18
DNA condensation by protamine and arginine-rich peptides: analysis of toroid stability using single DNA molecules. Mol Reprod Dev (2000) 1.17
Analysis of gene expression in single human oocytes and preimplantation embryos. Biochem Biophys Res Commun (2005) 1.02
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09
RNA maps reveal new RNA classes and a possible function for pervasive transcription. Science (2007) 18.59
The biology of chromatin remodeling complexes. Annu Rev Biochem (2009) 10.02
ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. Nature (2006) 9.30
DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and gadd45. Cell (2008) 8.62
Genome-wide analysis of Polycomb targets in Drosophila melanogaster. Nat Genet (2006) 6.48
Genome-wide dynamics of Htz1, a histone H2A variant that poises repressed/basal promoters for activation through histone loss. Cell (2005) 5.36
Tumour-initiating cells: challenges and opportunities for anticancer drug discovery. Nat Rev Drug Discov (2009) 4.12
Systematic evaluation of variability in ChIP-chip experiments using predefined DNA targets. Genome Res (2008) 4.08
Dynamic transcriptome of Schizosaccharomyces pombe shown by RNA-DNA hybrid mapping. Nat Genet (2008) 4.03
Large-scale turnover of functional transcription factor binding sites in Drosophila. PLoS Comput Biol (2006) 4.01
Chromatin remodelling: the industrial revolution of DNA around histones. Nat Rev Mol Cell Biol (2006) 3.79
Genome-wide RNA-seq analysis of human and mouse platelet transcriptomes. Blood (2011) 3.37
Chromatin remodeling by RSC involves ATP-dependent DNA translocation. Genes Dev (2002) 2.97
Chromatin remodeling through directional DNA translocation from an internal nucleosomal site. Nat Struct Mol Biol (2005) 2.81
The RNA polymerase III transcriptome revealed by genome-wide localization and activity-occupancy relationships. Proc Natl Acad Sci U S A (2003) 2.61
Distinct roles for the RSC and Swi/Snf ATP-dependent chromatin remodelers in DNA double-strand break repair. Genes Dev (2005) 2.47
Tandem bromodomains in the chromatin remodeler RSC recognize acetylated histone H3 Lys14. EMBO J (2004) 2.46
Apixaban metabolism and pharmacokinetics after oral administration to humans. Drug Metab Dispos (2008) 2.45
Paternal aging and associated intraindividual alterations of global sperm 5-methylcytosine and 5-hydroxymethylcytosine levels. Fertil Steril (2013) 2.33
The draft genome of watermelon (Citrullus lanatus) and resequencing of 20 diverse accessions. Nat Genet (2012) 2.33
Human RNA polymerase III transcriptomes and relationships to Pol II promoter chromatin and enhancer-binding factors. Nat Struct Mol Biol (2010) 2.30
The HSA domain binds nuclear actin-related proteins to regulate chromatin-remodeling ATPases. Nat Struct Mol Biol (2008) 2.26
DNA translocation and loop formation mechanism of chromatin remodeling by SWI/SNF and RSC. Mol Cell (2006) 2.25
Elevated maternal interleukin-8 levels and risk of schizophrenia in adult offspring. Am J Psychiatry (2004) 2.23
Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents. J Biol Chem (2003) 2.18
The genome-wide localization of Rsc9, a component of the RSC chromatin-remodeling complex, changes in response to stress. Mol Cell (2002) 2.10
Reprogramming the maternal zebrafish genome after fertilization to match the paternal methylation pattern. Cell (2013) 1.95
Genes for embryo development are packaged in blocks of multivalent chromatin in zebrafish sperm. Genome Res (2011) 1.94
RSC regulates nucleosome positioning at Pol II genes and density at Pol III genes. EMBO J (2007) 1.93
Transcriptional inhibition of genes with severe histone h3 hypoacetylation in the coding region. Mol Cell (2002) 1.91
Human Chk1 expression is dispensable for somatic cell death and critical for sustaining G2 DNA damage checkpoint. Mol Cancer Ther (2003) 1.90
DNA demethylase activity maintains intestinal cells in an undifferentiated state following loss of APC. Cell (2010) 1.89
Autoregulation of the rsc4 tandem bromodomain by gcn5 acetylation. Mol Cell (2007) 1.85
Male obesity and alteration in sperm parameters. Fertil Steril (2008) 1.84
The GNUMAP algorithm: unbiased probabilistic mapping of oligonucleotides from next-generation sequencing. Bioinformatics (2009) 1.83
Identification and evaluation of a novel sperm protamine abnormality in a population of infertile males. Hum Reprod (2005) 1.80
The Yaf9 component of the SWR1 and NuA4 complexes is required for proper gene expression, histone H4 acetylation, and Htz1 replacement near telomeres. Mol Cell Biol (2004) 1.80
Dephosphorylation and genome-wide association of Maf1 with Pol III-transcribed genes during repression. Mol Cell (2006) 1.74
Comparison of chromatin assays for DNA fragmentation evaluation in human sperm. J Androl (2006) 1.74
Zebra fish Dnmt1 and Suv39h1 regulate organ-specific terminal differentiation during development. Mol Cell Biol (2006) 1.71
Dnmt2 functions in the cytoplasm to promote liver, brain, and retina development in zebrafish. Genes Dev (2007) 1.69
Comprehensive identification of Drosophila dorsal-ventral patterning genes using a whole-genome tiling array. Proc Natl Acad Sci U S A (2006) 1.66
Rsc4 connects the chromatin remodeler RSC to RNA polymerases. Mol Cell Biol (2006) 1.63
Impact of male obesity on infertility: a critical review of the current literature. Fertil Steril (2008) 1.56
Histone trimethylation by Set1 is coordinated by the RRM, autoinhibitory, and catalytic domains. EMBO J (2005) 1.55
Selective Chk1 inhibitors differentially sensitize p53-deficient cancer cells to cancer therapeutics. Int J Cancer (2006) 1.53
Screening the SPO11 and EIF5A2 genes in a population of infertile men. Fertil Steril (2005) 1.51
Targeted disruption of the murine zyxin gene. Mol Cell Biol (2003) 1.51
Conformational flexibility in the chromatin remodeler RSC observed by electron microscopy and the orthogonal tilt reconstruction method. Proc Natl Acad Sci U S A (2007) 1.49
Testosterone is associated with erectile dysfunction: a cross-sectional study in Chinese men. PLoS One (2012) 1.46
Identification of direct targets and modified bases of RNA cytosine methyltransferases. Nat Biotechnol (2013) 1.44
The nuclear actin-related proteins Arp7 and Arp9: a dimeric module that cooperates with architectural proteins for chromatin remodeling. EMBO J (2003) 1.44
Structure and function of the SWIRM domain, a conserved protein module found in chromatin regulatory complexes. Proc Natl Acad Sci U S A (2006) 1.44
An aromatase polymorphism modulates the relationship between weight and estradiol levels in obese men. Fertil Steril (2009) 1.43
Dnmt3 and G9a cooperate for tissue-specific development in zebrafish. J Biol Chem (2009) 1.42
Induction of interleukin 2 expression in the liver for the treatment of H22 hepatoma in mice. Dig Liver Dis (2012) 1.41
Regulation of ISWI involves inhibitory modules antagonized by nucleosomal epitopes. Nature (2012) 1.40
Sperm DNA: organization, protection and vulnerability: from basic science to clinical applications--a position report. Hum Reprod (2010) 1.37
Low serum osteocalcin level is a potential marker for metabolic syndrome: results from a Chinese male population survey. Metabolism (2011) 1.34
A consensus linkage map for molecular markers and quantitative trait loci associated with economically important traits in melon (Cucumis melo L.). BMC Plant Biol (2011) 1.33
A novel mechanism of checkpoint abrogation conferred by Chk1 downregulation. Oncogene (2005) 1.32
Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. Hum Reprod (2010) 1.32
A high resolution genetic map anchoring scaffolds of the sequenced watermelon genome. PLoS One (2012) 1.32
Differential roles of checkpoint kinase 1, checkpoint kinase 2, and mitogen-activated protein kinase-activated protein kinase 2 in mediating DNA damage-induced cell cycle arrest: implications for cancer therapy. Mol Cancer Ther (2006) 1.30
Characterization of transcriptome dynamics during watermelon fruit development: sequencing, assembly, annotation and gene expression profiles. BMC Genomics (2011) 1.28
Dicer's helicase domain is required for accumulation of some, but not all, C. elegans endogenous siRNAs. RNA (2010) 1.26
The RSC chromatin remodeling complex bears an essential fungal-specific protein module with broad functional roles. Genetics (2005) 1.25
Obesity and male reproductive potential. J Androl (2006) 1.24
The RSC chromatin remodelling ATPase translocates DNA with high force and small step size. EMBO J (2011) 1.24
Distribution and clinical correlates of viral and host genotypes in Chinese patients with chronic hepatitis C virus infection. J Gastroenterol Hepatol (2014) 1.23
Alterations in sperm DNA methylation patterns at imprinted loci in two classes of infertility. Fertil Steril (2009) 1.20
Meaningful peer review is integral to quality science and should provide benefits to the authors and reviewers alike. Andrology (2013) 1.18
Genome-wide analysis identifies changes in histone retention and epigenetic modifications at developmental and imprinted gene loci in the sperm of infertile men. Hum Reprod (2011) 1.18
Genome-wide dynamics of SAPHIRE, an essential complex for gene activation and chromatin boundaries. Mol Cell Biol (2007) 1.18
Detection and characterization of metabolites in biological matrices using mass defect filtering of liquid chromatography/high resolution mass spectrometry data. Drug Metab Dispos (2006) 1.15
Normalization strategies for metabonomic analysis of urine samples. J Chromatogr B Analyt Technol Biomed Life Sci (2009) 1.14
Spreading of Sir3 protein in cells with severe histone H3 hypoacetylation. Proc Natl Acad Sci U S A (2003) 1.13
Factors that predict prematurity and preeclampsia in pregnancies that are complicated by systemic lupus erythematosus. Am J Obstet Gynecol (2005) 1.13
Genome-wide study of single-nucleotide polymorphisms associated with azoospermia and severe oligozoospermia. J Androl (2009) 1.12
Identification of human sperm transcripts as candidate markers of male fertility. J Mol Med (Berl) (2009) 1.12
Drug metabolite profiling and identification by high-resolution mass spectrometry. J Biol Chem (2011) 1.11
Subcutaneous methylnaltrexone for treatment of opioid-induced constipation in patients with chronic, nonmalignant pain: a randomized controlled study. J Pain (2011) 1.11
The sperm epigenome and potential implications for the developing embryo. Reproduction (2012) 1.09
Uterine artery myosin phosphatase isoform switching and increased sensitivity to SNP in a rat L-NAME model of hypertension of pregnancy. Am J Physiol Cell Physiol (2007) 1.08
Human spermatogenic failure purges deleterious mutation load from the autosomes and both sex chromosomes, including the gene DMRT1. PLoS Genet (2013) 1.08
Epigenetic regulation of colon cancer and intestinal stem cells. Curr Opin Cell Biol (2013) 1.07
A genome-wide association and gene-environment interaction study for serum triglycerides levels in a healthy Chinese male population. Hum Mol Genet (2011) 1.06
Kinetic model for the ATP-dependent translocation of Saccharomyces cerevisiae RSC along double-stranded DNA. Biochemistry (2007) 1.04
Antitumor activity of orally bioavailable farnesyltransferase inhibitor, ABT-100, is mediated by antiproliferative, proapoptotic, and antiangiogenic effects in xenograft models. Clin Cancer Res (2005) 1.03
Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men. Hum Mol Genet (2012) 1.02