p63 regulates glutaminase 2 expression.

Serine and glycine metabolism in cancer. Trends Biochem Sci (2014) 1.70

Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis. J Clin Invest (2015) 1.67

p53 Family and Cellular Stress Responses in Cancer. Front Oncol (2014) 1.33

GLS2 is transcriptionally regulated by p73 and contributes to neuronal differentiation. Cell Cycle (2013) 1.32

Bioinformatics analysis of the serine and glycine pathway in cancer cells. Oncotarget (2014) 1.02

Metabolic effect of TAp63α: enhanced glycolysis and pentose phosphate pathway, resulting in increased antioxidant defense. Oncotarget (2014) 0.97

Redox control of glutamine utilization in cancer. Cell Death Dis (2014) 0.93

p63 controls cell migration and invasion by transcriptional regulation of MTSS1. Oncogene (2015) 0.91

Discovery of selective inhibitors of Glutaminase-2, which inhibit mTORC1, activate autophagy and inhibit proliferation in cancer cells. Oncotarget (2014) 0.88

DNA repair and aging: the impact of the p53 family. Aging (Albany NY) (2015) 0.87

Screening for E3-ubiquitin ligase inhibitors: challenges and opportunities. Oncotarget (2014) 0.86

The microRNA feedback regulation of p63 in cancer progression. Oncotarget (2015) 0.86

p63 threonine phosphorylation signals the interaction with the WW domain of the E3 ligase Itch. Cell Cycle (2014) 0.84

Novel therapeutic targets of tumor metabolism. Cancer J (2015) 0.82

p63 transcriptionally regulates the expression of matrix metallopeptidase 13. Oncotarget (2014) 0.82

Stress eating and tuning out: cancer cells re-wire metabolism to counter stress. Crit Rev Biochem Mol Biol (2013) 0.82

Glutaminolysis as a target for cancer therapy. Oncogene (2015) 0.78

p63α protein upregulates heat shock protein 70 expression via E2F1 transcription factor 1, promoting Wasf3/Wave3/MMP9 signaling and bladder cancer invasion. J Biol Chem (2017) 0.78

TAp73 transcriptionally represses BNIP3 expression. Cell Cycle (2015) 0.77

p73 keeps metabolic control in balance. Cell Cycle (2013) 0.77

Two-way communication between the metabolic and cell cycle machineries: the molecular basis. Cell Cycle (2015) 0.77

NF-Y activates genes of metabolic pathways altered in cancer cells. Oncotarget (2016) 0.76

Myc promotes glutaminolysis in human neuroblastoma through direct activation of glutaminase 2. Oncotarget (2015) 0.76

Metabolic pathways regulated by TAp73 in response to oxidative stress. Oncotarget (2016) 0.76

FOXM1 regulates proliferation, senescence and oxidative stress in keratinocytes and cancer cells. Aging (Albany NY) (2016) 0.75

Gata6 promotes hair follicle progenitor cell renewal by genome maintenance during proliferation. EMBO J (2016) 0.75

Glutamine Metabolism in Cancer: Understanding the Heterogeneity. Trends Cancer (2017) 0.75

On the origin of cancer cells. Science (1956) 49.55

p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature (1999) 14.38

TIGAR, a p53-inducible regulator of glycolysis and apoptosis. Cell (2006) 11.85

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction. Proc Natl Acad Sci U S A (2008) 11.71

p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol Cell (1998) 11.54

Brick by brick: metabolism and tumor cell growth. Curr Opin Genet Dev (2008) 7.87

The antioxidant function of the p53 tumor suppressor. Nat Med (2005) 7.57

p63 Is essential for the proliferative potential of stem cells in stratified epithelia. Cell (2007) 6.50

A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis. Cell (2009) 6.03

Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD. Science (2004) 5.88

Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer. Oncogene (2009) 5.81

Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo. Mol Cell (2002) 5.41

p53 and metabolism. Nat Rev Cancer (2009) 5.05

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function. Proc Natl Acad Sci U S A (2010) 4.99

Mutant p53 drives invasion by promoting integrin recycling. Cell (2009) 4.75

Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species. Proc Natl Acad Sci U S A (2010) 4.18

Gene expression-based classification of non-small cell lung carcinomas and survival prediction. PLoS One (2010) 3.96

Glycolytic enzymes can modulate cellular life span. Cancer Res (2005) 3.78

TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs. Nature (2010) 3.37

p63 regulates an adhesion programme and cell survival in epithelial cells. Nat Cell Biol (2006) 3.37

REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species. Mol Cell (2002) 3.29

The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression. Cancer Res (2004) 2.56

Expression profile-defined classification of lung adenocarcinoma shows close relationship with underlying major genetic changes and clinicopathologic behaviors. J Clin Oncol (2006) 2.37

Differential roles of p63 isoforms in epidermal development: selective genetic complementation in p63 null mice. Cell Death Differ (2006) 2.25

Identification of ALDH4 as a p53-inducible gene and its protective role in cellular stresses. J Hum Genet (2004) 2.20

Redox-dependent signal transduction. FEBS Lett (2000) 2.14

Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer. Proc Natl Acad Sci U S A (2012) 1.97

p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53. Cell Death Differ (2011) 1.94

TAp63alpha induces apoptosis by activating signaling via death receptors and mitochondria. EMBO J (2005) 1.90

Complex transcriptional effects of p63 isoforms: identification of novel activation and repression domains. Mol Cell Biol (2002) 1.89

Glucose catabolism in cancer cells. The type II hexokinase promoter contains functionally active response elements for the tumor suppressor p53. J Biol Chem (1997) 1.83

Frequent alteration of p63 expression in human primary bladder carcinomas. Cancer Res (2000) 1.80

TAp63 is a master transcriptional regulator of lipid and glucose metabolism. Cell Metab (2012) 1.77

Co-expression of glutaminase K and L isoenzymes in human tumour cells. Biochem J (2005) 1.76

Biological functions of p53 isoforms through evolution: lessons from animal and cellular models. Cell Death Differ (2011) 1.74

DeltaNp63 regulates thymic development through enhanced expression of FgfR2 and Jag2. Proc Natl Acad Sci U S A (2007) 1.70

Genome-wide expression profiling reveals EBV-associated inhibition of MHC class I expression in nasopharyngeal carcinoma. Cancer Res (2006) 1.62

Identification of two human glutaminase loci and tissue-specific expression of the two related genes. Mamm Genome (2000) 1.57

The unique NH2-terminally deleted (DeltaN) residues, the PXXP motif, and the PPXY motif are required for the transcriptional activity of the DeltaN variant of p63. J Biol Chem (2005) 1.49

Glutaminase isoform expression in cell lines derived from human colorectal adenomas and carcinomas. Biochem J (2003) 1.47

TAp73 depletion accelerates aging through metabolic dysregulation. Genes Dev (2012) 1.45

GPX2, a direct target of p63, inhibits oxidative stress-induced apoptosis in a p53-dependent manner. J Biol Chem (2006) 1.44

p63-microRNA feedback in keratinocyte senescence. Proc Natl Acad Sci U S A (2012) 1.41

ΔNp63 is an ectodermal gatekeeper of epidermal morphogenesis. Cell Death Differ (2010) 1.39

ER stress response: getting the UPR hand on misfolded proteins. Curr Biol (2000) 1.38

Glutaminase isoenzymes as key regulators in metabolic and oxidative stress against cancer. Curr Mol Med (2013) 1.36

p63 is upstream of IKK alpha in epidermal development. J Cell Sci (2006) 1.35

Properties of the six isoforms of p63: p53-like regulation in response to genotoxic stress and cross talk with DeltaNp73. Carcinogenesis (2007) 1.34

Gain-of-function mutation in ADULT syndrome reveals the presence of a second transactivation domain in p63. Hum Mol Genet (2002) 1.29

Sestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced death. Cell Death Differ (2012) 1.27

Transfection with liver-type glutaminase cDNA alters gene expression and reduces survival, migration and proliferation of T98G glioma cells. Glia (2009) 1.19

miR-143 regulates hexokinase 2 expression in cancer cells. Oncogene (2012) 1.19

Structure, function and regulation of p63 and p73. Cell Death Differ (1999) 1.12

Differential altered stability and transcriptional activity of ΔNp63 mutants in distinct ectodermal dysplasias. J Cell Sci (2011) 1.11

Expression of functional human glutaminase in baculovirus system: affinity purification, kinetic and molecular characterization. Int J Biochem Cell Biol (2006) 1.08

Chemotherapy-induced apoptosis in hepatocellular carcinoma involves the p53 family and is mediated via the extrinsic and the intrinsic pathway. Int J Cancer (2010) 1.05

Proliferation and tissue remodeling in cancer: the hallmarks revisited. Cell Death Dis (2012) 1.03

ΔNp63α regulates keratinocyte proliferation by controlling PTEN expression and localization. Cell Death Differ (2011) 1.02

Mammalian glutaminase Gls2 gene encodes two functional alternative transcripts by a surrogate promoter usage mechanism. PLoS One (2012) 1.01

MyoD induces apoptosis in the absence of RB function through a p21(WAF1)-dependent re-localization of cyclin/cdk complexes to the nucleus. Oncogene (2002) 0.99

p63 the guardian of human reproduction. Cell Cycle (2012) 0.98

The ubiquitin-specific protease USP47 is a novel beta-TRCP interactor regulating cell survival. Oncogene (2009) 0.97

Caloric restriction: is mammalian life extension linked to p53? Aging (Albany NY) (2012) 0.94

The E3 ubiquitin ligase WWP1 regulates ΔNp63-dependent transcription through Lys63 linkages. Biochem Biophys Res Commun (2010) 0.92

Functional interplay between p63 and p53 controls RUNX1 function in the transition from proliferation to differentiation in human keratinocytes. Cell Death Dis (2012) 0.92

The flick of a switch: which death program to choose? Cell Death Differ (2012) 0.90

Fetal hemoglobin induction by histone deacetylase inhibitors involves generation of reactive oxygen species. Exp Hematol (2006) 0.90

p53 is a major component of the transcriptional and apoptotic program regulated by PI 3-kinase/Akt/GSK3 signaling. Cell Death Dis (2012) 0.87

Emerging concepts: linking hypoxic signaling and cancer metabolism. Cell Death Dis (2012) 0.85

Recognition mechanism of p63 by the E3 ligase Itch: novel strategy in the study and inhibition of this interaction. Cell Cycle (2012) 0.84

Induction of TAp63 by histone deacetylase inhibitors. Biochem Biophys Res Commun (2009) 0.84

Essential amino acids and glutamine regulate induction of mitochondrial elongation during autophagy. Cell Cycle (2011) 0.84

Glutamine depletion and glucose depletion trigger growth inhibition via distinctive gene expression reprogramming. Cell Cycle (2012) 0.83

Induction of autophagy does not alter the anti-tumor effects of HDAC inhibitors. Cell Death Dis (2012) 0.79

p73 and p63: Estranged relatives? Cell Cycle (2011) 0.77

Stochastic gene expression in a single cell. Science (2002) 34.54

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci U S A (2003) 15.59

Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9. Nature (2006) 11.90

The p53 pathway: positive and negative feedback loops. Oncogene (2005) 9.75

Dynamics of the p53-Mdm2 feedback loop in individual cells. Nat Genet (2004) 8.30

A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans. Cell (2004) 8.18

Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nat Rev Cancer (2006) 7.53

The coordinate regulation of the p53 and mTOR pathways in cells. Proc Natl Acad Sci U S A (2005) 7.38

The cornified envelope: a model of cell death in the skin. Nat Rev Mol Cell Biol (2005) 6.27

S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth. Science (2006) 5.94

H3K79 methylation profiles define murine and human MLL-AF4 leukemias. Cancer Cell (2008) 5.23

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function. Proc Natl Acad Sci U S A (2010) 4.99

TAp73 knockout shows genomic instability with infertility and tumor suppressor functions. Genes Dev (2008) 4.85

MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L. Cancer Cell (2011) 4.56

The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML. Science (2010) 4.37

p53 regulates maternal reproduction through LIF. Nature (2007) 4.12

Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway. Cell (2012) 4.09

The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint. Cell (2008) 4.04

The genetics of the p53 pathway, apoptosis and cancer therapy. Nat Rev Drug Discov (2008) 4.03

Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats. Nat Neurosci (2002) 3.64

The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways. Cancer Res (2007) 3.55

The HECT family of E3 ubiquitin ligases: multiple players in cancer development. Cancer Cell (2008) 3.35

Relationship of gene expression and chromosomal abnormalities in colorectal cancer. Cancer Res (2006) 3.32

MDM2 SNP309 accelerates tumor formation in a gender-specific and hormone-dependent manner. Cancer Res (2006) 3.26

The regulation of exosome secretion: a novel function of the p53 protein. Cancer Res (2006) 3.22

Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production. Nat Med (2003) 3.21

MDM2 is a central node in the p53 pathway: 12 years and counting. Curr Cancer Drug Targets (2005) 3.04

Central administration of oleic acid inhibits glucose production and food intake. Diabetes (2002) 2.91

Suppression of immediate-early viral gene expression by herpesvirus-coded microRNAs: implications for latency. Proc Natl Acad Sci U S A (2008) 2.90

Genetic and pharmacologic inhibition of β-catenin targets imatinib-resistant leukemia stem cells in CML. Cell Stem Cell (2012) 2.89

p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation. J Biol Chem (2003) 2.69

Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways. Genes Dev (2006) 2.66

CpG island methylator phenotype associates with low-degree chromosomal abnormalities in colorectal cancer. Clin Cancer Res (2008) 2.65

Allele-specific p53 mutant reactivation. Cancer Cell (2012) 2.51

Identifying mRNA targets of microRNA dysregulated in cancer: with application to clear cell Renal Cell Carcinoma. BMC Syst Biol (2010) 2.49

High expression of lymphocyte-associated genes in node-negative HER2+ breast cancers correlates with lower recurrence rates. Cancer Res (2007) 2.48

Control of chromosome stability by the beta-TrCP-REST-Mad2 axis. Nature (2008) 2.46

Molecular classification of prostate cancer using curated expression signatures. Proc Natl Acad Sci U S A (2011) 2.46

The ubiquitin-protein ligase Itch regulates p73 stability. EMBO J (2005) 2.38

Declining p53 function in the aging process: a possible mechanism for the increased tumor incidence in older populations. Proc Natl Acad Sci U S A (2007) 2.36

The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein. Trends Cell Biol (2010) 2.33

Unexpected inheritance: multiple integrations of ancient bornavirus and ebolavirus/marburgvirus sequences in vertebrate genomes. PLoS Pathog (2010) 2.32

A plausible model for the digital response of p53 to DNA damage. Proc Natl Acad Sci U S A (2005) 2.32

The p53 family: guardians of maternal reproduction. Nat Rev Mol Cell Biol (2011) 2.13

Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway. Genes Dev (2010) 2.06

Comparison of avian and human influenza A viruses reveals a mutational bias on the viral genomes. J Virol (2006) 2.06

Highly conserved regions of influenza a virus polymerase gene segments are critical for efficient viral RNA packaging. J Virol (2007) 2.05

MicroRNA 217 modulates endothelial cell senescence via silent information regulator 1. Circulation (2009) 2.05

Inhibition of the c-Abl-TAp63 pathway protects mouse oocytes from chemotherapy-induced death. Nat Med (2009) 2.03

The E3 ubiquitin ligase Itch controls the protein stability of p63. Proc Natl Acad Sci U S A (2006) 2.01

Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer. Proc Natl Acad Sci U S A (2012) 1.97

Patterns of evolution and host gene mimicry in influenza and other RNA viruses. PLoS Pathog (2008) 1.96

Negative regulation of tumor suppressor p53 by microRNA miR-504. Mol Cell (2010) 1.92

Tissue-specific codon usage and the expression of human genes. Proc Natl Acad Sci U S A (2004) 1.91

Functional association between Wwox tumor suppressor protein and p73, a p53 homolog. Proc Natl Acad Sci U S A (2004) 1.91

TAp63alpha induces apoptosis by activating signaling via death receptors and mitochondria. EMBO J (2005) 1.90

The origins and evolution of the p53 family of genes. Cold Spring Harb Perspect Biol (2009) 1.90

MiR-203 controls proliferation, migration and invasive potential of prostate cancer cell lines. Cell Cycle (2011) 1.89

Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect. Proc Natl Acad Sci U S A (2011) 1.87

Tissue transglutaminase does not affect fibrotic matrix stability or regression of liver fibrosis in mice. Gastroenterology (2011) 1.85

TAp63 and DeltaNp63 in cancer and epidermal development. Cell Cycle (2007) 1.84

WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. Genes Dev (2002) 1.80

Determination of dual effects of parathyroid hormone on skeletal gene expression in vivo by microarray and network analysis. J Biol Chem (2007) 1.79

Single-nucleotide polymorphisms in the p53 pathway regulate fertility in humans. Proc Natl Acad Sci U S A (2009) 1.79

Inactivation of p53 in breast cancers correlates with stem cell transcriptional signatures. Proc Natl Acad Sci U S A (2010) 1.78

p53 and NF-κB: different strategies for responding to stress lead to a functional antagonism. FASEB J (2010) 1.77

The impact of p53 and p73 on aneuploidy and cancer. Trends Cell Biol (2008) 1.76

Association of survival and disease progression with chromosomal instability: a genomic exploration of colorectal cancer. Proc Natl Acad Sci U S A (2009) 1.72

DeltaNp63 regulates thymic development through enhanced expression of FgfR2 and Jag2. Proc Natl Acad Sci U S A (2007) 1.70

The presence of p53 mutations in human osteosarcomas correlates with high levels of genomic instability. Proc Natl Acad Sci U S A (2003) 1.69

A single nucleotide polymorphism in the MDM2 gene disrupts the oscillation of p53 and MDM2 levels in cells. Cancer Res (2007) 1.67

The tumor suppressor p53: cancer and aging. Cell Cycle (2008) 1.66

Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis. Cancer Cell (2004) 1.65

Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response. Mol Cell Biol (2004) 1.63

Proteomics applied on plant abiotic stresses: role of heat shock proteins (HSP). J Proteomics (2008) 1.63

microRNA-34a regulates neurite outgrowth, spinal morphology, and function. Proc Natl Acad Sci U S A (2011) 1.60

Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets. Proc Natl Acad Sci U S A (2011) 1.58

p53 regulates cell survival by inhibiting PIK3CA in squamous cell carcinomas. Genes Dev (2002) 1.57

The red blood cell proteome and interactome: an update. J Proteome Res (2010) 1.56

Regulation of the apoptosis-necrosis switch. Oncogene (2004) 1.54

Altered tumor formation and evolutionary selection of genetic variants in the human MDM4 oncogene. Proc Natl Acad Sci U S A (2009) 1.54

FLASH and NPAT positive but not Coilin positive Cajal Bodies correlate with cell ploidy. Cell Cycle (2008) 1.52

An update on red blood cell storage lesions, as gleaned through biochemistry and omics technologies. Transfusion (2014) 1.51

p63, a story of mice and men. J Invest Dermatol (2011) 1.50

New p63 targets in keratinocytes identified by a genome-wide approach. EMBO J (2006) 1.50

A high-frequency regulatory polymorphism in the p53 pathway accelerates tumor development. Cancer Cell (2010) 1.49

Transglutaminase 2-/- mice reveal a phagocytosis-associated crosstalk between macrophages and apoptotic cells. Proc Natl Acad Sci U S A (2003) 1.48

A chromatin-associated and transcriptionally inactive p53-Mdm2 complex occurs in mdm2 SNP309 homozygous cells. J Biol Chem (2005) 1.47