Published in Am J Physiol Regul Integr Comp Physiol on August 26, 2004
Choline and betaine in health and disease. J Inherit Metab Dis (2010) 1.61
Impaired de novo choline synthesis explains why phosphatidylethanolamine N-methyltransferase-deficient mice are protected from diet-induced obesity. J Biol Chem (2010) 1.44
Connexin30 deficiency causes instrastrial fluid-blood barrier disruption within the cochlear stria vascularis. Proc Natl Acad Sci U S A (2007) 1.41
S-alkylated homocysteine derivatives: new inhibitors of human betaine-homocysteine S-methyltransferase. J Med Chem (2006) 0.84
Variability of plasma and urine betaine in diabetes mellitus and its relationship to methionine load test responses: an observational study. Cardiovasc Diabetol (2012) 0.84
Metabolomics reveals the metabolic shifts following an intervention with rye bread in postmenopausal women--a randomized control trial. Nutr J (2012) 0.83
Molecular characterization and analysis of the porcine betaine homocysteine methyltransferase and betaine homocysteine methyltransferase-2 genes. Gene (2010) 0.78
Splicing variants of the porcine betaine-homocysteine S-methyltransferase gene: implications for mammalian metabolism. Gene (2013) 0.76
Evolutionary Analyses and Natural Selection of Betaine-Homocysteine S-Methyltransferase (BHMT) and BHMT2 Genes. PLoS One (2015) 0.75
Rat liver betaine-homocysteine S-methyltransferase equilibrium unfolding: insights into intermediate structure through tryptophan substitutions. Biochem J (2005) 0.75
Deletion of betaine-homocysteine S-methyltransferase in mice perturbs choline and 1-carbon metabolism, resulting in fatty liver and hepatocellular carcinomas. J Biol Chem (2011) 1.40
Folate deficiency disturbs hepatic methionine metabolism and promotes liver injury in the ethanol-fed micropig. Proc Natl Acad Sci U S A (2002) 1.28
Betaine-homocysteine methyltransferase: zinc in a distorted barrel. Structure (2002) 1.26
Investigations of a common genetic variant in betaine-homocysteine methyltransferase (BHMT) in coronary artery disease. Atherosclerosis (2003) 1.17
Inhibition of betaine-homocysteine S-methyltransferase causes hyperhomocysteinemia in mice. J Nutr (2006) 1.07
Common variant in betaine-homocysteine methyltransferase (BHMT) and risk for spina bifida. Am J Med Genet A (2003) 1.06
Betaine-homocysteine S-methyltransferase-2 is an S-methylmethionine-homocysteine methyltransferase. J Biol Chem (2008) 1.02
Effects of diabetes and insulin on betaine-homocysteine S-methyltransferase expression in rat liver. Am J Physiol Endocrinol Metab (2005) 1.01
Dissecting the catalytic mechanism of betaine-homocysteine S-methyltransferase by use of intrinsic tryptophan fluorescence and site-directed mutagenesis. Biochemistry (2004) 1.00
Type I diabetes leads to tissue-specific DNA hypomethylation in male rats. J Nutr (2008) 0.99
Dietary intake of S-(alpha-carboxybutyl)-DL-homocysteine induces hyperhomocysteinemia in rats. Nutr Res (2010) 0.95
Oligomerization is required for betaine-homocysteine S-methyltransferase function. Arch Biochem Biophys (2004) 0.94
Modulation of methyl group metabolism by streptozotocin-induced diabetes and all-trans-retinoic acid. J Biol Chem (2004) 0.90
Betaine can partially spare choline in chicks but only when added to diets containing a minimal level of choline. J Nutr (2007) 0.86
Folate status modulates the induction of hepatic glycine N-methyltransferase and homocysteine metabolism in diabetic rats. Am J Physiol Endocrinol Metab (2006) 0.85
Combining combinatorial chemistry and affinity chromatography: highly selective inhibitors of human betaine: homocysteine S-methyltransferase. Chem Biol (2003) 0.85
Liver betaine-homocysteine S-methyltransferase activity undergoes a redox switch at the active site zinc. Arch Biochem Biophys (2008) 0.85
Osmotic regulation of betaine homocysteine-S-methyltransferase expression in H4IIE rat hepatoma cells. Am J Physiol Gastrointest Liver Physiol (2007) 0.85
S-alkylated homocysteine derivatives: new inhibitors of human betaine-homocysteine S-methyltransferase. J Med Chem (2006) 0.84
Liver choline dehydrogenase and kidney betaine-homocysteine methyltransferase expression are not affected by methionine or choline intake in growing rats. J Nutr (2006) 0.83
Effects of betaine in a murine model of mild cystathionine-beta-synthase deficiency. Metabolism (2004) 0.83
Dietary S-methylmethionine, a component of foods, has choline-sparing activity in chickens. J Nutr (2005) 0.82
Conformation-dependent inactivation of human betaine-homocysteine S-methyltransferase by hydrogen peroxide in vitro. Biochem J (2005) 0.81
Random mutagenesis of the zinc-binding motif of betaine-homocysteine methyltransferase reveals that Gly 214 is essential. Arch Biochem Biophys (2002) 0.81
Determination of dissociation constant of phosphinate group in phosphinic pseudopeptides by capillary zone electrophoresis. J Chromatogr B Analyt Technol Biomed Life Sci (2002) 0.78
Analysis and characterization of phosphinic pseudopeptides by capillary zone electrophoresis. Electrophoresis (2002) 0.78
Betaine homocysteine methyltransferase is active in the mouse blastocyst and promotes inner cell mass development. J Biol Chem (2012) 0.78
Molecular characterization and analysis of the porcine betaine homocysteine methyltransferase and betaine homocysteine methyltransferase-2 genes. Gene (2010) 0.78
Inhibition of betaine-homocysteine S-methyltransferase in rats causes hyperhomocysteinemia and reduces liver cystathionine β-synthase activity and methylation capacity. Nutr Res (2011) 0.77
The development of a new class of inhibitors for betaine-homocysteine S-methyltransferase. Eur J Med Chem (2013) 0.77
Structure-activity study of new inhibitors of human betaine-homocysteine S-methyltransferase. J Med Chem (2009) 0.77
Double-headed sulfur-linked amino acids as first inhibitors for betaine-homocysteine S-methyltransferase 2. J Med Chem (2012) 0.75
Specific potassium ion interactions facilitate homocysteine binding to betaine-homocysteine S-methyltransferase. Proteins (2014) 0.75