Published in J Infect Dis on July 21, 2005
A pneumococcal pilus influences virulence and host inflammatory responses. Proc Natl Acad Sci U S A (2006) 4.40
Influenza enhances susceptibility to natural acquisition of and disease due to Streptococcus pneumoniae in ferrets. J Infect Dis (2010) 2.77
Identification of a Candidate Streptococcus pneumoniae core genome and regions of diversity correlated with invasive pneumococcal disease. Infect Immun (2006) 2.33
RrgA is a pilus-associated adhesin in Streptococcus pneumoniae. Mol Microbiol (2007) 2.01
Emergence of hypervirulent mutants resistant to early clearance during systemic serotype 1 pneumococcal infection in mice and humans. J Infect Dis (2014) 1.62
Streptococcus pneumoniae resistance to complement-mediated immunity is dependent on the capsular serotype. Infect Immun (2009) 1.35
Genomic diversity between strains of the same serotype and multilocus sequence type among pneumococcal clinical isolates. Infect Immun (2006) 1.27
The pneumococcus: epidemiology, microbiology, and pathogenesis. Cold Spring Harb Perspect Med (2013) 1.21
Regions of Diversity 8, 9 and 13 contribute to Streptococcus pneumoniae virulence. BMC Microbiol (2007) 1.11
A variable region within the genome of Streptococcus pneumoniae contributes to strain-strain variation in virulence. PLoS One (2011) 1.08
Animal models of Streptococcus pneumoniae disease. Clin Microbiol Rev (2008) 1.07
Streptococcus pneumoniae in saliva of Dutch primary school children. PLoS One (2014) 1.05
Increased susceptibility for superinfection with Streptococcus pneumoniae during influenza virus infection is not caused by TLR7-mediated lymphopenia. PLoS One (2009) 1.02
Two DHH subfamily 1 proteins contribute to pneumococcal virulence and confer protection against pneumococcal disease. Infect Immun (2011) 1.02
Temporal analysis of invasive pneumococcal clones from Scotland illustrates fluctuations in diversity of serotype and genotype in the absence of pneumococcal conjugate vaccine. J Clin Microbiol (2009) 0.96
Discovery of novel inhibitors of Streptococcus pneumoniae based on the virtual screening with the homology-modeled structure of histidine kinase (VicK). BMC Microbiol (2009) 0.93
Pilus adhesin RrgA interacts with complement receptor 3, thereby affecting macrophage function and systemic pneumococcal disease. MBio (2012) 0.88
Death or survival from invasive pneumococcal disease in Scotland: associations with serogroups and multilocus sequence types. J Med Microbiol (2011) 0.87
Genome analysis of a highly virulent serotype 1 strain of Streptococcus pneumoniae from West Africa. PLoS One (2012) 0.87
The influence of in vitro fitness defects on pneumococcal ability to colonize and to cause invasive disease. BMC Microbiol (2008) 0.86
Serotype-specific effect of influenza on adult invasive pneumococcal pneumonia. J Infect Dis (2013) 0.86
Contribution of different pneumococcal virulence factors to experimental meningitis in mice. BMC Infect Dis (2013) 0.82
Site of isolation determines biofilm formation and virulence phenotypes of Streptococcus pneumoniae serotype 3 clinical isolates. Infect Immun (2012) 0.82
Neisseria meningitidis sequence type and risk for death, Iceland. Emerg Infect Dis (2006) 0.80
A strain-independent method to induce progressive and lethal pneumococcal pneumonia in neutropenic mice. J Biomed Sci (2015) 0.76
Influenza A Virus Infection Predisposes Hosts to Secondary Infection with Different Streptococcus pneumoniae Serotypes with Similar Outcome but Serotype-Specific Manifestation. Infect Immun (2016) 0.76
Lung epithelium and myeloid cells cooperate to clear acute pneumococcal infection. Mucosal Immunol (2015) 0.75
A Perfect Storm: Increased Colonization and Failure of Vaccination Leads to Severe Secondary Bacterial Infection in Influenza Virus-Infected Obese Mice. MBio (2017) 0.75
Role of Escherichia coli curli operons in directing amyloid fiber formation. Science (2002) 5.58
Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci (2010) 5.54
An endonuclease allows Streptococcus pneumoniae to escape from neutrophil extracellular traps. Curr Biol (2006) 3.69
Functional adaptation of BabA, the H. pylori ABO blood group antigen binding adhesin. Science (2004) 3.06
Clinical and microbiological characteristics of severe Streptococcus pyogenes disease in Europe. J Clin Microbiol (2009) 2.80
Evolutionary pathway to increased virulence and epidemic group A Streptococcus disease derived from 3,615 genome sequences. Proc Natl Acad Sci U S A (2014) 2.63
Toll-like receptor 4 resides in the Golgi apparatus and colocalizes with internalized lipopolysaccharide in intestinal epithelial cells. J Exp Med (2002) 2.53
Bacterial adhesins in host-microbe interactions. Cell Host Microbe (2009) 2.43
Identification of a Candidate Streptococcus pneumoniae core genome and regions of diversity correlated with invasive pneumococcal disease. Infect Immun (2006) 2.33
Bacterial strategies for overcoming host innate and adaptive immune responses. Nat Immunol (2002) 2.33
The Salmonella enterica subspecies I specific centisome 7 genomic island encodes novel protein families present in bacteria living in close contact with eukaryotic cells. Res Microbiol (2002) 2.18
Discovery of a novel class of highly conserved vaccine antigens using genomic scale antigenic fingerprinting of pneumococcus with human antibodies. J Exp Med (2007) 2.11
Intracellular recognition of lipopolysaccharide by toll-like receptor 4 in intestinal epithelial cells. J Exp Med (2003) 2.05
A small-molecule inhibitor of type III secretion inhibits different stages of the infectious cycle of Chlamydia trachomatis. Proc Natl Acad Sci U S A (2006) 2.01
Induction of pro- and anti-inflammatory molecules in a mouse model of pneumococcal pneumonia after influenza. Comp Med (2007) 1.99
Capsule and D-alanylated lipoteichoic acids protect Streptococcus pneumoniae against neutrophil extracellular traps. Cell Microbiol (2007) 1.99
Clinical utility of PCR for common viruses in acute respiratory illness. Pediatrics (2014) 1.86
CD46 in meningococcal disease. Science (2003) 1.84
Intraclonal variations among Streptococcus pneumoniae isolates influence the likelihood of invasive disease in children. J Infect Dis (2013) 1.84
Polynucleotide phosphorylase is a global regulator of virulence and persistency in Salmonella enterica. Proc Natl Acad Sci U S A (2002) 1.83
Epidemiology of severe Streptococcus pyogenes disease in Europe. J Clin Microbiol (2008) 1.81
Neutrophil extracellular traps: casting the NET over pathogenesis. Curr Opin Microbiol (2007) 1.80
Intravenous zanamivir for oseltamivir-resistant 2009 H1N1 influenza. N Engl J Med (2009) 1.79
Defective development and function of Bcl10-deficient follicular, marginal zone and B1 B cells. Nat Immunol (2003) 1.70
Antibodies against PsrP, a novel Streptococcus pneumoniae adhesin, block adhesion and protect mice against pneumococcal challenge. J Infect Dis (2008) 1.67
Toll-like receptor 9 acts at an early stage in host defence against pneumococcal infection. Cell Microbiol (2006) 1.62
The Streptococcus pneumoniae adhesin PsrP binds to Keratin 10 on lung cells. Mol Microbiol (2009) 1.62
Emergence of hypervirulent mutants resistant to early clearance during systemic serotype 1 pneumococcal infection in mice and humans. J Infect Dis (2014) 1.62
beta-Arrestin 1 participates in platelet-activating factor receptor-mediated endocytosis of Streptococcus pneumoniae. Infect Immun (2005) 1.60
Myeloid differentiation factor 88-dependent signalling controls bacterial growth during colonization and systemic pneumococcal disease in mice. Cell Microbiol (2005) 1.59
The pneumococcal serine-rich repeat protein is an intra-species bacterial adhesin that promotes bacterial aggregation in vivo and in biofilms. PLoS Pathog (2010) 1.57
Dissemination of Toxoplasma gondii to immunoprivileged organs and role of Toll/interleukin-1 receptor signalling for host resistance assessed by in vivo bioluminescence imaging. Cell Microbiol (2005) 1.53
Small molecule inhibitors of type III secretion in Yersinia block the Chlamydia pneumoniae infection cycle. FEBS Lett (2007) 1.50
Streptococcus pneumoniae contains 3 rlrA pilus variants that are clonally related. J Infect Dis (2008) 1.49
Age-associated inflammation and toll-like receptor dysfunction prime the lungs for pneumococcal pneumonia. J Infect Dis (2009) 1.49
Solution structure of choline binding protein A, the major adhesin of Streptococcus pneumoniae. EMBO J (2004) 1.47
Organ-specific models of Streptococcus pneumoniae disease. Scand J Infect Dis (2003) 1.47
Statins protect against fulminant pneumococcal infection and cytolysin toxicity in a mouse model of sickle cell disease. J Clin Invest (2010) 1.44
The Escherichia coli BarA-UvrY two-component system is needed for efficient switching between glycolytic and gluconeogenic carbon sources. J Bacteriol (2003) 1.44
ETosis: a novel cell death pathway. Sci Signal (2008) 1.41
Gastric mucosal recognition of Helicobacter pylori is independent of Toll-like receptor 4. J Infect Dis (2003) 1.39
Platelet-activating factor receptor and innate immunity: uptake of gram-positive bacterial cell wall into host cells and cell-specific pathophysiology. J Immunol (2006) 1.37
Influence of neutropenia on the course of serotype 8 pneumococcal pneumonia in mice. Infect Immun (2007) 1.36
Roles of curli, cellulose and BapA in Salmonella biofilm morphology studied by atomic force microscopy. BMC Microbiol (2007) 1.33
The rise and fall of bacterial clones: Streptococcus pneumoniae. Nat Rev Microbiol (2008) 1.32
Correlation between cag pathogenicity island composition and Helicobacter pylori-associated gastroduodenal disease. Infect Immun (2003) 1.32
Structural requirements for TLR4-mediated LPS signalling: a biological role for LPS modifications. Microbes Infect (2003) 1.30
High abundance of virulence gene homologues in marine bacteria. Environ Microbiol (2009) 1.27
Lysogenic transfer of group A Streptococcus superantigen gene among Streptococci. J Infect Dis (2008) 1.24
LytA, major autolysin of Streptococcus pneumoniae, requires access to nascent peptidoglycan. J Biol Chem (2012) 1.23
Mechanism for sortase localization and the role of sortase localization in efficient pilus assembly in Enterococcus faecalis. J Bacteriol (2009) 1.23
The TLR2-MyD88-NOD2-RIPK2 signalling axis regulates a balanced pro-inflammatory and IL-10-mediated anti-inflammatory cytokine response to Gram-positive cell walls. Cell Microbiol (2008) 1.23
Sortase-mediated assembly and surface topology of adhesive pneumococcal pili. Mol Microbiol (2008) 1.22
Convergence of regulatory networks on the pilus locus of Streptococcus pneumoniae. Infect Immun (2008) 1.20
Determination of accessory gene patterns predicts the same relatedness among strains of Streptococcus pneumoniae as sequencing of housekeeping genes does and represents a novel approach in molecular epidemiology. J Clin Microbiol (2007) 1.20
Streptococcus pneumoniae evades human dendritic cell surveillance by pneumolysin expression. EMBO Mol Med (2009) 1.19
Capsular expression in Streptococcus pneumoniae negatively affects spontaneous and antibiotic-induced lysis and contributes to antibiotic tolerance. J Infect Dis (2003) 1.18
Clinical isolates of Streptococcus pneumoniae bind the complement inhibitor C4b-binding protein in a PspC allele-dependent fashion. J Immunol (2009) 1.18
Dominant role of nucleotide substitution in the diversification of serotype 3 pneumococci over decades and during a single infection. PLoS Genet (2013) 1.17
Streptococcus pneumoniae in biofilms are unable to cause invasive disease due to altered virulence determinant production. PLoS One (2011) 1.16
Molecular characterization of the acid-inducible asr gene of Escherichia coli and its role in acid stress response. J Bacteriol (2003) 1.16
Noninvasive monitoring of pneumococcal meningitis and evaluation of treatment efficacy in an experimental mouse model. Mol Imaging (2005) 1.13
Early biofilm formation on microtiter plates is not correlated with the invasive disease potential of Streptococcus pneumoniae. Microb Pathog (2010) 1.11
Developmental switch of intestinal antimicrobial peptide expression. J Exp Med (2008) 1.11
Regions of Diversity 8, 9 and 13 contribute to Streptococcus pneumoniae virulence. BMC Microbiol (2007) 1.11
Incidence of cardiovascular events after hospital admission for pneumonia. Am J Med (2011) 1.10
Disulfide bond formation and cysteine exclusion in gram-positive bacteria. J Biol Chem (2009) 1.09
An enzymatic ruler modulates Lewis antigen glycosylation of Helicobacter pylori LPS during persistent infection. Proc Natl Acad Sci U S A (2006) 1.09
Cellular senescence increases expression of bacterial ligands in the lungs and is positively correlated with increased susceptibility to pneumococcal pneumonia. Aging Cell (2011) 1.08
Age-related defects in TLR2 signaling diminish the cytokine response by alveolar macrophages during murine pneumococcal pneumonia. Exp Gerontol (2012) 1.07
Enteric-delivered rapamycin enhances resistance of aged mice to pneumococcal pneumonia through reduced cellular senescence. Exp Gerontol (2012) 1.07
Two crystal structures of pneumococcal pilus sortase C provide novel insights into catalysis and substrate specificity. J Mol Biol (2009) 1.05
C-terminal peptides of tissue factor pathway inhibitor are novel host defense molecules. J Biol Chem (2010) 1.02
Increased susceptibility for superinfection with Streptococcus pneumoniae during influenza virus infection is not caused by TLR7-mediated lymphopenia. PLoS One (2009) 1.02
Lipopolysaccharide diversity evolving in Helicobacter pylori communities through genetic modifications in fucosyltransferases. PLoS One (2008) 1.02