Published in Infect Genet Evol on July 27, 2007
Multilocus sequence typing: a portable approach to the identification of clones within populations of pathogenic microorganisms. Proc Natl Acad Sci U S A (1998) 39.20
Numerical index of the discriminatory ability of typing systems: an application of Simpson's index of diversity. J Clin Microbiol (1988) 28.11
Complete genome sequence of a virulent isolate of Streptococcus pneumoniae. Science (2001) 21.99
A multilocus sequence typing scheme for Streptococcus pneumoniae: identification of clones associated with serious invasive disease. Microbiology (1998) 17.05
A study of the genetic material determining an enzyme in Pneumococcus. Biochim Biophys Acta (1960) 16.02
Genome of the bacterium Streptococcus pneumoniae strain R6. J Bacteriol (2001) 7.97
Which pneumococcal serogroups cause the most invasive disease: implications for conjugate vaccine formulation and use, part I. Clin Infect Dis (2000) 5.52
Horizontal transfer of multiple penicillin-binding protein genes, and capsular biosynthetic genes, in natural populations of Streptococcus pneumoniae. Mol Microbiol (1991) 5.45
Infections caused by Streptococcus pneumoniae: clinical spectrum, pathogenesis, immunity, and treatment. Clin Infect Dis (1992) 5.17
Estimating recombinational parameters in Streptococcus pneumoniae from multilocus sequence typing data. Genetics (2000) 4.61
How to select and interpret molecular strain typing methods for epidemiological studies of bacterial infections: a review for healthcare epidemiologists. Molecular Typing Working Group of the Society for Healthcare Epidemiology of America. Infect Control Hosp Epidemiol (1997) 4.28
Effect of conjugate pneumococcal vaccine followed by polysaccharide pneumococcal vaccine on recurrent acute otitis media: a randomised study. Lancet (2003) 3.67
Analysis of multiply antimicrobial-resistant isolates of Streptococcus pneumoniae from the United States. Antimicrob Agents Chemother (1992) 3.39
Effect of clonal and serotype-specific properties on the invasive capacity of Streptococcus pneumoniae. J Infect Dis (2004) 3.14
Reduction of nasopharyngeal carriage of Streptococcus pneumoniae after administration of a 9-valent pneumococcal conjugate vaccine to toddlers attending day care centers. J Infect Dis (2002) 2.95
Spread of drug-resistant Streptococcus pneumoniae in Asian countries: Asian Network for Surveillance of Resistant Pathogens (ANSORP) Study. Clin Infect Dis (1999) 2.74
Clonal distribution of invasive pneumococcal isolates from children and selected adults in the United States prior to 7-valent conjugate vaccine introduction. J Clin Microbiol (2003) 2.59
Comparative study of five different DNA fingerprint techniques for molecular typing of Streptococcus pneumoniae strains. J Clin Microbiol (1995) 2.55
Identification of a Candidate Streptococcus pneumoniae core genome and regions of diversity correlated with invasive pneumococcal disease. Infect Immun (2006) 2.33
The molecular epidemiology of Streptococcus pneumoniae with quinolone resistance mutations. Clin Infect Dis (2004) 2.08
A molecular phylogeny of enteric bacteria and implications for a bacterial species concept. J Evol Biol (2003) 1.89
Identification of the major Spanish clones of penicillin-resistant pneumococci via the Internet using multilocus sequence typing. J Clin Microbiol (2000) 1.88
Multi-virulence-locus sequence typing of Listeria monocytogenes. Appl Environ Microbiol (2004) 1.85
Annotated draft genomic sequence from a Streptococcus pneumoniae type 19F clinical isolate. Microb Drug Resist (2001) 1.82
Multilocus sequence typing--what is resolved? Trends Microbiol (2004) 1.74
Population biology of Streptococcus pneumoniae isolated from oropharyngeal carriage and invasive disease. Microbiology (1999) 1.72
Major related sets of antibiotic-resistant Pneumococci in the United States as determined by pulsed-field gel electrophoresis and pbp1a-pbp2b-pbp2x-dhf restriction profiles. J Infect Dis (2000) 1.69
Levofloxacin-resistant invasive Streptococcus pneumoniae in the United States: evidence for clonal spread and the impact of conjugate pneumococcal vaccine. Antimicrob Agents Chemother (2004) 1.53
Molecular epidemiology of penicillin-resistant Streptococcus pneumoniae isolates recovered in Italy from 1993 to 1996. J Clin Microbiol (1998) 1.38
Characterization of the genetic lineages responsible for pneumococcal invasive disease in Portugal. J Clin Microbiol (2005) 1.37
Streptococcus pneumoniae carriage in children attending 59 Canadian child care centers. Toronto Child Care Centre Study Group. Arch Pediatr Adolesc Med (1999) 1.30
Comparison of E test with standard broth microdilution for determining antibiotic susceptibilities of penicillin-resistant strains of Streptococcus pneumoniae. J Clin Microbiol (1994) 1.29
Genomic diversity between strains of the same serotype and multilocus sequence type among pneumococcal clinical isolates. Infect Immun (2006) 1.27
The use of Streptococcus pneumoniae nasopharyngeal isolates from healthy children to predict features of invasive disease. Pediatr Infect Dis J (1998) 1.26
Molecular epidemiology: focus on infection. Am J Epidemiol (2001) 1.23
Clones of Streptococcus pneumoniae isolated from nasopharyngeal carriage and invasive disease in young children in central Tennessee. J Infect Dis (2001) 1.18
Molecular characterization of multidrug-resistant Streptococcus pneumoniae isolates in Korea. The Asian Network for Surveillance of Resistant Pathogens (ANSORP) Study Group. J Clin Microbiol (2000) 1.10
Microbiology of otitis media in Costa Rican children, 1999 through 2001. Pediatr Infect Dis J (2003) 1.08
Marked differences in pneumococcal carriage and resistance patterns between day care centers located within a small area. Clin Infect Dis (1999) 0.98
Novel antibiotic-resistant pneumococcal strains recovered from the upper respiratory tracts of HIV-infected adults and their children in Kisumu, Kenya. Microb Drug Resist (2005) 0.97
Genetic relatedness between pneumococcal populations originating from the nasopharynx, adenoid, and tympanic cavity of children with otitis media. J Clin Microbiol (2005) 0.94
Clonally related penicillin-nonsusceptible Streptococcus pneumoniae serotype 14 from cases of meningitis in Salvador, Brazil. Clin Infect Dis (2000) 0.93
Epidemiological study of Streptococcus pneumoniae carriers in healthy primary-school children. Eur J Clin Microbiol Infect Dis (1999) 0.90
Nasopharyngeal colonization with pathogens causing otitis media: how does this information help us? Pediatr Infect Dis J (1999) 0.88
Molecular epidemiology of multiple drug resistant type 6B Streptococcus pneumoniae in the Northern Territory and Queensland, Australia. Epidemiol Infect (2001) 0.85
Erythromycin resistance in invasive serotype 14 pneumococci is highly related to clonal type. J Med Microbiol (2004) 0.85
Comparison of genomic methods for differentiating strains of Enterococcus faecium: assessment using clinical epidemiologic data. J Clin Microbiol (1998) 0.84
DNA polymorphisms and variant penicillin-binding proteins as evidence that relatively penicillin-resistant pneumococci in western Canada are clonally related. J Infect Dis (1996) 0.84
Genetic analysis of serotype 23F Streptococcus pneumoniae isolates from several countries by penicillin-binding protein gene fingerprinting and pulsed-field gel electrophoresis. Chemotherapy (1999) 0.84
Dissemination of Streptococcus pneumoniae clone Colombia(5)-19 in Latin America. J Clin Microbiol (2002) 0.84
Genetic relatedness, antibiotic susceptibility, and serotype distribution of Streptococcus pneumoniae responsible for meningitis in Poland, 1997-2001. Microb Drug Resist (2003) 0.82
Clonal origin of the type 37 Streptococcus pneumoniae. Microb Drug Resist (2000) 0.79
Truncated xpt gene present in invasive Streptococcus pneumoniae may have implications for MLST schemes. J Med Microbiol (2005) 0.79
Cephalosporin-resistant pneumococci and sickle cell disease. Emerg Infect Dis (2005) 0.78
Molecular epidemiological characteristics of pneumococcal meningitis in children. Eur J Clin Microbiol Infect Dis (1996) 0.77
Genetic relatedness of antibiotic-resistant pneumococci isolated during case clusters. J Med Microbiol (2004) 0.76
Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci (2010) 5.54
Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens. Nat Immunol (2008) 4.31
Tissue-specific contributions of pneumococcal virulence factors to pathogenesis. J Infect Dis (2004) 3.43
Laminin receptor initiates bacterial contact with the blood brain barrier in experimental meningitis models. J Clin Invest (2009) 2.51
Pneumococcal pneumolysin and H(2)O(2) mediate brain cell apoptosis during meningitis. J Clin Invest (2002) 2.50
Microarray analysis of pneumococcal gene expression during invasive disease. Infect Immun (2004) 2.38
Identification of a Candidate Streptococcus pneumoniae core genome and regions of diversity correlated with invasive pneumococcal disease. Infect Immun (2006) 2.33
Role of the manganese efflux system mntE for signalling and pathogenesis in Streptococcus pneumoniae. Mol Microbiol (2009) 2.03
Induction of pro- and anti-inflammatory molecules in a mouse model of pneumococcal pneumonia after influenza. Comp Med (2007) 1.99
Serum immunoglobulin G response to candidate vaccine antigens during experimental human pneumococcal colonization. Infect Immun (2003) 1.83
Recognition of pneumococcal peptidoglycan: an expanded, pivotal role for LPS binding protein. Immunity (2003) 1.81
Preinfection systemic inflammatory markers and risk of hospitalization due to pneumonia. Am J Respir Crit Care Med (2005) 1.69
Antibodies against PsrP, a novel Streptococcus pneumoniae adhesin, block adhesion and protect mice against pneumococcal challenge. J Infect Dis (2008) 1.67
The Streptococcus pneumoniae adhesin PsrP binds to Keratin 10 on lung cells. Mol Microbiol (2009) 1.62
beta-Arrestin 1 participates in platelet-activating factor receptor-mediated endocytosis of Streptococcus pneumoniae. Infect Immun (2005) 1.60
The pneumococcal serine-rich repeat protein is an intra-species bacterial adhesin that promotes bacterial aggregation in vivo and in biofilms. PLoS Pathog (2010) 1.57
Hydroxyurea therapy of a murine model of sickle cell anemia inhibits the progression of pneumococcal disease by down-modulating E-selectin. Blood (2011) 1.54
Virulence in mice of pneumococcal clonal types with known invasive disease potential in humans. J Infect Dis (2005) 1.51
Age-associated inflammation and toll-like receptor dysfunction prime the lungs for pneumococcal pneumonia. J Infect Dis (2009) 1.49
Organ-specific models of Streptococcus pneumoniae disease. Scand J Infect Dis (2003) 1.47
Control of virulence by small RNAs in Streptococcus pneumoniae. PLoS Pathog (2012) 1.46
Statins protect against fulminant pneumococcal infection and cytolysin toxicity in a mouse model of sickle cell disease. J Clin Invest (2010) 1.44
Platelet-activating factor receptor and innate immunity: uptake of gram-positive bacterial cell wall into host cells and cell-specific pathophysiology. J Immunol (2006) 1.37
Calcium efflux is essential for bacterial survival in the eukaryotic host. Mol Microbiol (2008) 1.33
The pneumococcus: epidemiology, microbiology, and pathogenesis. Cold Spring Harb Perspect Med (2013) 1.21
Convergence of regulatory networks on the pilus locus of Streptococcus pneumoniae. Infect Immun (2008) 1.20
Pax3-FKHR knock-in mice show developmental aberrations but do not develop tumors. Mol Cell Biol (2002) 1.20
Capsular expression in Streptococcus pneumoniae negatively affects spontaneous and antibiotic-induced lysis and contributes to antibiotic tolerance. J Infect Dis (2003) 1.18
Streptococcus pneumoniae in biofilms are unable to cause invasive disease due to altered virulence determinant production. PLoS One (2011) 1.16
Innate sensors for Gram-positive bacteria. Curr Opin Immunol (2003) 1.15
Cell wall-mediated neuronal damage in early sepsis. Infect Immun (2006) 1.14
Early biofilm formation on microtiter plates is not correlated with the invasive disease potential of Streptococcus pneumoniae. Microb Pathog (2010) 1.11
Regions of Diversity 8, 9 and 13 contribute to Streptococcus pneumoniae virulence. BMC Microbiol (2007) 1.11
Dual phases of apoptosis in pneumococcal meningitis. J Infect Dis (2004) 1.11
Incidence of cardiovascular events after hospital admission for pneumonia. Am J Med (2011) 1.10
Cellular damage in bacterial meningitis: an interplay of bacterial and host driven toxicity. J Neuroimmunol (2007) 1.09
Cellular senescence increases expression of bacterial ligands in the lungs and is positively correlated with increased susceptibility to pneumococcal pneumonia. Aging Cell (2011) 1.08
Age-related defects in TLR2 signaling diminish the cytokine response by alveolar macrophages during murine pneumococcal pneumonia. Exp Gerontol (2012) 1.07
Enteric-delivered rapamycin enhances resistance of aged mice to pneumococcal pneumonia through reduced cellular senescence. Exp Gerontol (2012) 1.07
Vancomycin stress response in a sensitive and a tolerant strain of Streptococcus pneumoniae. J Bacteriol (2005) 1.04
Interplay of pneumococcal hydrogen peroxide and host-derived nitric oxide. Infect Immun (2006) 1.00
Toll-like receptor 2 mediates fatal immunopathology in mice during treatment of secondary pneumococcal pneumonia following influenza. J Infect Dis (2011) 0.99
Revising the role of the pneumococcal vex-vncRS locus in vancomycin tolerance. J Bacteriol (2004) 0.99
Changes in capsular serotype alter the surface exposure of pneumococcal adhesins and impact virulence. PLoS One (2011) 0.97
Hypersusceptibility to invasive pneumococcal infection in experimental sickle cell disease involves platelet-activating factor receptor. J Infect Dis (2007) 0.97
Pneumococci: immunology of the innate host response. Respirology (2010) 0.95
Immunohistochemical stains for p63 and alpha-methylacyl-CoA racemase, versus a cocktail comprising both, in the diagnosis of prostatic carcinoma: a comparison of the immunohistochemical staining of 430 foci in radical prostatectomy and needle biopsy tissues. Am J Surg Pathol (2005) 0.94
Broadly protective protein-based pneumococcal vaccine composed of pneumolysin toxoid-CbpA peptide recombinant fusion protein. J Infect Dis (2013) 0.94
Dysregulated inflammation as a risk factor for pneumonia in the elderly. Aging Dis (2011) 0.93
Prevalence and clonal distribution of pcpA, psrP and Pilus-1 among pediatric isolates of Streptococcus pneumoniae. PLoS One (2012) 0.93
Pneumococcal gene complex involved in resistance to extracellular oxidative stress. Infect Immun (2012) 0.92
Bacterial inhibition of phosphatidylcholine synthesis triggers apoptosis in the brain. J Exp Med (2004) 0.92
Tolerance to vancomycin in pneumococci: detection with a molecular marker and assessment of clinical impact. J Infect Dis (2004) 0.91
Impact of oral simvastatin therapy on acute lung injury in mice during pneumococcal pneumonia. BMC Microbiol (2012) 0.90
Pneumococcal microbial surface components recognizing adhesive matrix molecules targeting of the extracellular matrix. Mol Microbiol (2010) 0.90
Biofilm and planktonic pneumococci demonstrate disparate immunoreactivity to human convalescent sera. BMC Microbiol (2011) 0.88
Interactions between blood-borne Streptococcus pneumoniae and the blood-brain barrier preceding meningitis. PLoS One (2013) 0.88
The p53-target gene puma drives neutrophil-mediated protection against lethal bacterial sepsis. PLoS Pathog (2010) 0.87
Cardiotoxicity during invasive pneumococcal disease. Am J Respir Crit Care Med (2015) 0.86
PsrP, a protective pneumococcal antigen, is highly prevalent in children with pneumonia and is strongly associated with clonal type. Clin Vaccine Immunol (2010) 0.86
A live-attenuated pneumococcal vaccine elicits CD4+ T-cell dependent class switching and provides serotype independent protection against acute otitis media. EMBO Mol Med (2014) 0.86
Pneumococcal pathogenesis: "innate invasion" yet organ-specific damage. J Mol Med (Berl) (2010) 0.86
Future perspective on host-pathogen interactions during bacterial biofilm formation within the nasopharynx. Future Microbiol (2012) 0.85
Role played by psrP-secY2A2 (accessory region 34) in the invasive disease potential of Streptococcus pneumoniae. J Infect Dis (2009) 0.84
Bacterial Peptidoglycan Traverses the Placenta to Induce Fetal Neuroproliferation and Aberrant Postnatal Behavior. Cell Host Microbe (2016) 0.84
Planning and implementation of an infection control training program for healthcare providers in Latin America. Infect Control Hosp Epidemiol (2007) 0.82
Anatomical site-specific contributions of pneumococcal virulence determinants. Pneumonia (Nathan) (2016) 0.79
Simultaneous gene editing by injection of mRNAs encoding transcription activator-like effector nucleases into mouse zygotes. Mol Cell Biol (2014) 0.78
Cephalosporin-resistant pneumococci and sickle cell disease. Emerg Infect Dis (2005) 0.78
A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation. Am J Physiol Heart Circ Physiol (2008) 0.78
Chromogranin A levels and mortality in patients with severe sepsis. Biomarkers (2015) 0.77
Quinupristin-dalfopristin nonsusceptibility in pneumococci from sickle cell disease patients. Antimicrob Agents Chemother (2006) 0.75
Molecular analysis of antibiotic tolerance in pneumococci. Int J Med Microbiol (2002) 0.75