Autophagy in alcohol-induced liver diseases.

Gut-liver axis in alcoholic liver disease. Gastroenterology (2014) 1.42

Critical role of FoxO3a in alcohol-induced autophagy and hepatotoxicity. Am J Pathol (2013) 1.13

Pathogenesis of alcoholic liver disease: role of oxidative metabolism. World J Gastroenterol (2014) 1.06

Elevated autophagic sequestration of mitochondria and lipid droplets in steatotic hepatocytes of chronic ethanol-treated rats: an immunohistochemical and electron microscopic study. J Mol Histol (2013) 1.01

New advances in molecular mechanisms and emerging therapeutic targets in alcoholic liver diseases. World J Gastroenterol (2014) 0.96

Role of hypoxia inducing factor-1β in alcohol-induced autophagy, steatosis and liver injury in mice. PLoS One (2014) 0.86

Autophagy and ethanol neurotoxicity. Autophagy (2014) 0.85

Autophagy: A novel therapeutic target for hepatocarcinoma (Review). Oncol Lett (2014) 0.84

A Mechanistic Review of Mitophagy and Its Role in Protection against Alcoholic Liver Disease. Biomolecules (2015) 0.83

Ethanol-induced oxidant stress modulates hepatic autophagy and proteasome activity. Redox Biol (2014) 0.82

Regulation and Functions of Autophagic Lipolysis. Trends Endocrinol Metab (2016) 0.81

Autophagy Protects against CYP2E1/Chronic Ethanol-Induced Hepatotoxicity. Biomolecules (2015) 0.81

Autophagy in alcohol-induced multiorgan injury: mechanisms and potential therapeutic targets. Biomed Res Int (2014) 0.81

Chronic binge alcohol consumption alters myogenic gene expression and reduces in vitro myogenic differentiation potential of myoblasts from rhesus macaques. Am J Physiol Regul Integr Comp Physiol (2014) 0.80

Farnesoid X receptor regulates forkhead Box O3a activation in ethanol-induced autophagy and hepatotoxicity. Redox Biol (2014) 0.80

Involvement of sphingolipids in ethanol neurotoxicity in the developing brain. Brain Sci (2013) 0.78

Regulation of the effects of CYP2E1-induced oxidative stress by JNK signaling. Redox Biol (2014) 0.78

ALDH2 modulates autophagy flux to regulate acetaldehyde-mediated toxicity thresholds. Am J Cancer Res (2016) 0.78

Reply to: "The autophagic response to alcohol toxicity: the missing layer". J Hepatol (2013) 0.75

Oxidative Stress in the Healthy and Wounded Hepatocyte: A Cellular Organelles Perspective. Oxid Med Cell Longev (2015) 0.75

Store-Operated Ca(2+) Entry Controls Induction of Lipolysis and the Transcriptional Reprogramming to Lipid Metabolism. Cell Metab (2017) 0.75

1,4-Butanediol diglycidyl ether-cross-linked hyaluronan inhibits fibrosis in rat primary tenocytes by down-regulating autophagy modulation. J Mater Sci Mater Med (2016) 0.75

The Activation and Function of Autophagy in Alcoholic Liver Disease. Curr Mol Pharmacol (2017) 0.75

Autophagy fights disease through cellular self-digestion. Nature (2008) 33.83

Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol (2005) 18.60

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol (2008) 17.81

Autophagy in health and disease: a double-edged sword. Science (2004) 13.69

Selective degradation of mitochondria by mitophagy. Arch Biochem Biophys (2007) 8.24

The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis. Nat Cell Biol (2007) 6.22

Immune control of tuberculosis by IFN-gamma-inducible LRG-47. Science (2003) 5.50

The mitochondrial permeability transition initiates autophagy in rat hepatocytes. FASEB J (2001) 4.99

Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission. J Biol Chem (2009) 4.90

Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability. Am J Pathol (2007) 4.45

Cellular autophagy: surrender, avoidance and subversion by microorganisms. Nat Rev Microbiol (2004) 4.31

Novel sensing mechanisms and targets for the cAMP-protein kinase A pathway in the yeast Saccharomyces cerevisiae. Mol Microbiol (1999) 3.98

Differential effects of endoplasmic reticulum stress-induced autophagy on cell survival. J Biol Chem (2006) 3.74

Autophagy reduces acute ethanol-induced hepatotoxicity and steatosis in mice. Gastroenterology (2010) 3.57

Studies on cellular autophagocytosis. The formation of autophagic vacuoles in the liver after glucagon administration. Am J Pathol (1968) 3.13

The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88. Hepatology (2008) 2.99

Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL. Cell Death Differ (2009) 2.85

The Ras/cAMP-dependent protein kinase signaling pathway regulates an early step of the autophagy process in Saccharomyces cerevisiae. J Biol Chem (2004) 2.40

Activation of the RAS/cyclic AMP pathway suppresses a TOR deficiency in yeast. Mol Cell Biol (2004) 2.26

Leaky gut in alcoholic cirrhosis: a possible mechanism for alcohol-induced liver damage. Am J Gastroenterol (1999) 2.22

The turnover of mitochondria in a variety of tissues of young adult and aged rats. J Biol Chem (1971) 2.16

Defective autophagy leads to cancer. Cancer Cell (2003) 2.08

Following cytochrome c release, autophagy is inhibited during chemotherapy-induced apoptosis by caspase 8-mediated cleavage of Beclin 1. Cancer Res (2011) 1.99

Hepatic autophagy is suppressed in the presence of insulin resistance and hyperinsulinemia: inhibition of FoxO1-dependent expression of key autophagy genes by insulin. J Biol Chem (2009) 1.93

Mitophagy selectively degrades individual damaged mitochondria after photoirradiation. Antioxid Redox Signal (2011) 1.79

AMP-activated protein kinase: a universal regulator of autophagy? Autophagy (2007) 1.75

Impaired autolysosome formation correlates with Lamp-2 depletion: role of apoptosis, autophagy, and necrosis in pancreatitis. Gastroenterology (2009) 1.72

Cyclophilin D is required for mitochondrial removal by autophagy in cardiac cells. Autophagy (2010) 1.58

Inhibition of hepatocytic autophagy by adenosine, aminoimidazole-4-carboxamide riboside, and N6-mercaptopurine riboside. Evidence for involvement of amp-activated protein kinase. J Biol Chem (1998) 1.42

Recombinant Hep G2 cells that express alcohol dehydrogenase and cytochrome P450 2E1 as a model of ethanol-elicited cytotoxicity. Int J Biochem Cell Biol (2005) 1.34

Mitochondrial degradation by autophagy (mitophagy) in GFP-LC3 transgenic hepatocytes during nutrient deprivation. Am J Physiol Cell Physiol (2010) 1.32

Autophagy and ethanol-induced liver injury. World J Gastroenterol (2009) 1.26

Compound C induces protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway. Autophagy (2011) 1.22

Cellular signaling mechanisms in alcohol-induced liver damage. Semin Liver Dis (2004) 1.21

The effects of chronic ethanol consumption on hepatic mitochondrial energy metabolism. Alcohol Alcohol (1990) 1.19

The anti-ageing effects of caloric restriction may involve stimulation of macroautophagy and lysosomal degradation, and can be intensified pharmacologically. Biomed Pharmacother (2003) 1.14

The emerging role of autophagy in alcoholic liver disease. Exp Biol Med (Maywood) (2011) 1.13

Alcoholic hepatomegaly: accumulation of protein in the liver. Science (1975) 1.10

The effect of ethanol-induced CYP2E1 on proteasome activity: the role of 4-hydroxynonenal. Exp Mol Pathol (2004) 1.09

Selective taste of ethanol-induced autophagy for mitochondria and lipid droplets. Autophagy (2011) 1.04

Ethanol administration alters the proteolytic activity of hepatic lysosomes. Alcohol Clin Exp Res (1994) 1.01

Signaling pathway of autophagy associated with innate immunity. Autophagy (2007) 0.99

Imiquimod simultaneously induces autophagy and apoptosis in human basal cell carcinoma cells. Br J Dermatol (2010) 0.96

Phosphoinositide 3-kinase regulates maturation of lysosomes in rat hepatocytes. Biochem J (2003) 0.93

Effect of chronic ethanol administration on protein catabolism in rat liver. Alcohol Clin Exp Res (1989) 0.89

Proteasome activity and autophagosome content in liver are reciprocally regulated by ethanol treatment. Biochem Biophys Res Commun (2011) 0.89

Ethanol consumption decreases the synthesis of the mannose 6-phosphate/insulin-like growth factor II receptor but does not decrease its messenger RNA. Biochem Pharmacol (2003) 0.83

Flow cytometric analysis of vesicular pH in rat hepatocytes after ethanol administration. Hepatology (1997) 0.83

Ethanol consumption alters trafficking of lysosomal enzymes and affects the processing of procathepsin L in rat liver. Biochim Biophys Acta (1996) 0.83

Chronic ethanol administration decreases the ligand binding properties and the cellular content of the mannose 6-phosphate/insulin-like growth factor II receptor in rat hepatocytes. Biochem Pharmacol (2002) 0.81

The significance of lysosomes in pathology and medicine. Proc Inst Med Chic (1966) 0.81

Hepatic protein synthetic activity in vivo after ethanol administration. Alcohol Clin Exp Res (1987) 0.79

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08

Selective degradation of mitochondria by mitophagy. Arch Biochem Biophys (2007) 8.24

Mechanisms of hepatotoxicity. Toxicol Sci (2002) 4.13

NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis. J Clin Invest (2003) 3.69

Apoptosis and necrosis in the liver: a tale of two deaths? Hepatology (2006) 3.52

Apoptosis versus oncotic necrosis in hepatic ischemia/reperfusion injury. Gastroenterology (2003) 3.21

Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytes. Hepatology (2004) 2.92

Mitochondrial permeability transition: a common pathway to necrosis and apoptosis. Biochem Biophys Res Commun (2003) 2.58

Peroxynitrite-induced mitochondrial and endonuclease-mediated nuclear DNA damage in acetaminophen hepatotoxicity. J Pharmacol Exp Ther (2005) 2.41

Tracker dyes to probe mitochondrial autophagy (mitophagy) in rat hepatocytes. Autophagy (2006) 2.37

Minocycline and N-methyl-4-isoleucine cyclosporin (NIM811) mitigate storage/reperfusion injury after rat liver transplantation through suppression of the mitochondrial permeability transition. Hepatology (2008) 2.22

Activation of autophagy protects against acetaminophen-induced hepatotoxicity. Hepatology (2011) 2.15

Dissecting the dynamic turnover of GFP-LC3 in the autolysosome. Autophagy (2011) 2.11

Regulated and unregulated mitochondrial permeability transition pores: a new paradigm of pore structure and function? FEBS Lett (2002) 2.08

Reactive oxygen species, but not Ca2+ overloading, trigger pH- and mitochondrial permeability transition-dependent death of adult rat myocytes after ischemia-reperfusion. Am J Physiol Heart Circ Physiol (2006) 2.08

Acetaminophen-induced oxidant stress and cell injury in cultured mouse hepatocytes: protection by N-acetyl cysteine. Toxicol Sci (2004) 2.07

Role of mitochondrial permeability transition pores in mitochondrial autophagy. Int J Biochem Cell Biol (2004) 2.01

Following cytochrome c release, autophagy is inhibited during chemotherapy-induced apoptosis by caspase 8-mediated cleavage of Beclin 1. Cancer Res (2011) 1.99

Inhibition of the mitochondrial permeability transition by the nonimmunosuppressive cyclosporin derivative NIM811. Mol Pharmacol (2002) 1.95

Nuclear translocation of endonuclease G and apoptosis-inducing factor during acetaminophen-induced liver cell injury. Toxicol Sci (2006) 1.94

Cyclophilin D as a drug target. Curr Med Chem (2003) 1.87

Autophagy in the liver. Hepatology (2008) 1.84

c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity. Toxicol Appl Pharmacol (2010) 1.84

Functions of autophagy in normal and diseased liver. Autophagy (2013) 1.81

Mitophagy selectively degrades individual damaged mitochondria after photoirradiation. Antioxid Redox Signal (2011) 1.79

Differential requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis in hepatocytes. FASEB J (2004) 1.76

Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells. Gastroenterology (2004) 1.73

Mitochondrial bax translocation accelerates DNA fragmentation and cell necrosis in a murine model of acetaminophen hepatotoxicity. J Pharmacol Exp Ther (2007) 1.70

Mitochondrial permeability transition in the switch from necrotic to apoptotic cell death in ischemic rat hepatocytes. Gastroenterology (2003) 1.63

Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy. Nat Chem Biol (2012) 1.55

Differential roles of unsaturated and saturated fatty acids on autophagy and apoptosis in hepatocytes. J Pharmacol Exp Ther (2011) 1.49

Roles of mitophagy and the mitochondrial permeability transition in remodeling of cultured rat hepatocytes. Autophagy (2009) 1.49

Induction of macroautophagy by exogenously introduced calcium. Autophagy (2008) 1.48

Cyclophilin D deficiency protects against acetaminophen-induced oxidant stress and liver injury. Free Radic Res (2010) 1.45

Biochemical isolation and characterization of the tubulovesicular LC3-positive autophagosomal compartment. J Biol Chem (2009) 1.41

Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen-induced hepatocyte necrosis in mice. Hepatology (2013) 1.41

Discrimination of depolarized from polarized mitochondria by confocal fluorescence resonance energy transfer. Arch Biochem Biophys (2004) 1.40

Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injury. Toxicol Sci (2012) 1.38

Bid-cardiolipin interaction at mitochondrial contact site contributes to mitochondrial cristae reorganization and cytochrome C release. Mol Biol Cell (2004) 1.38

Mitochondrial degradation by autophagy (mitophagy) in GFP-LC3 transgenic hepatocytes during nutrient deprivation. Am J Physiol Cell Physiol (2010) 1.32

Translocation of iron from lysosomes into mitochondria is a key event during oxidative stress-induced hepatocellular injury. Hepatology (2008) 1.31

Death receptor activation-induced hepatocyte apoptosis and liver injury. Curr Mol Med (2003) 1.30

Free tubulin modulates mitochondrial membrane potential in cancer cells. Cancer Res (2010) 1.23

Reduced-size liver transplantation in the mouse. Transplantation (2003) 1.19

Heat shock suppresses the permeability transition in rat liver mitochondria. J Biol Chem (2003) 1.18

Nitric oxide protects rat hepatocytes against reperfusion injury mediated by the mitochondrial permeability transition. Hepatology (2004) 1.18

UCPs--unlikely calcium porters. Nat Cell Biol (2008) 1.17

L-Glycine: a novel antiinflammatory, immunomodulatory, and cytoprotective agent. Curr Opin Clin Nutr Metab Care (2003) 1.16

Apoptosis-inducing factor modulates mitochondrial oxidant stress in acetaminophen hepatotoxicity. Toxicol Sci (2011) 1.16

Bid activates multiple mitochondrial apoptotic mechanisms in primary hepatocytes after death receptor engagement. Gastroenterology (2003) 1.15

Expression of X-linked inhibitor-of-apoptosis protein in hepatocellular carcinoma promotes metastasis and tumor recurrence. Hepatology (2008) 1.15

Lysosomal iron mobilization and induction of the mitochondrial permeability transition in acetaminophen-induced toxicity to mouse hepatocytes. Toxicol Sci (2010) 1.15

TRAIL-mediated apoptosis requires NF-kappaB inhibition and the mitochondrial permeability transition in human hepatoma cells. Hepatology (2002) 1.14

Critical role of FoxO3a in alcohol-induced autophagy and hepatotoxicity. Am J Pathol (2013) 1.13

Mitochondrial permeability transition in liver ischemia and reperfusion: role of c-Jun N-terminal kinase 2. Transplantation (2008) 1.13

Gliotoxin-mediated apoptosis of activated human hepatic stellate cells. J Hepatol (2003) 1.13

Liver regeneration is suppressed in small-for-size liver grafts after transplantation: involvement of c-Jun N-terminal kinase, cyclin D1, and defective energy supply. Transplantation (2006) 1.11

Bid-independent mitochondrial activation in tumor necrosis factor alpha-induced apoptosis and liver injury. Mol Cell Biol (2006) 1.11

A voluntary oral ethanol-feeding rat model associated with necroinflammatory liver injury. Alcohol Clin Exp Res (2008) 1.10

Voltage-dependent anion channels modulate mitochondrial metabolism in cancer cells: regulation by free tubulin and erastin. J Biol Chem (2013) 1.09

Isolated mitochondria infusion mitigates ischemia-reperfusion injury of the liver in rats: mitotracker probes and mitochondrial membrane potential. Shock (2013) 1.09

Green tea polyphenols stimulate mitochondrial biogenesis and improve renal function after chronic cyclosporin a treatment in rats. PLoS One (2013) 1.07

Phosphorylation of voltage-dependent anion channel by serine/threonine kinases governs its interaction with tubulin. PLoS One (2011) 1.07

Polyphenols from Camellia sinenesis attenuate experimental cholestasis-induced liver fibrosis in rats. Am J Physiol Gastrointest Liver Physiol (2003) 1.07

Peroxynitrite alters the catalytic activity of rodent liver proteasome in vitro and in vivo. Hepatology (2004) 1.07

Involvement of autophagy in alcoholic liver injury and hepatitis C pathogenesis. World J Gastroenterol (2011) 1.06

Activation of the oxygen-sensing signal cascade prevents mitochondrial injury after mouse liver ischemia-reperfusion. Am J Physiol Gastrointest Liver Physiol (2008) 1.05

Effects of three superoxide dismutase genes delivered with an adenovirus on graft function after transplantation of fatty livers in the rat. Transplantation (2003) 1.05

The oxygen tension modulates acetaminophen-induced mitochondrial oxidant stress and cell injury in cultured hepatocytes. Toxicol Sci (2010) 1.05

Ethanol-induced oxidative stress suppresses generation of peptides for antigen presentation by hepatoma cells. Hepatology (2007) 1.04

Differential roles of JNK in ConA/GalN and ConA-induced liver injury in mice. Am J Pathol (2008) 1.03

Mitochondrial permeability transition in rat hepatocytes after anoxia/reoxygenation: role of Ca2+-dependent mitochondrial formation of reactive oxygen species. Am J Physiol Gastrointest Liver Physiol (2012) 1.02

Acetyl-L-carnitine protects neuronal function from alcohol-induced oxidative damage in the brain. Free Radic Biol Med (2010) 1.02

Proteasome activation by hepatitis C core protein is reversed by ethanol-induced oxidative stress. Gastroenterology (2008) 1.02

Alcohol and HIV decrease proteasome and immunoproteasome function in macrophages: implications for impaired immune function during disease. Cell Immunol (2004) 1.02

Saturated fatty acids activate ERK signaling to downregulate hepatic sortilin 1 in obese and diabetic mice. J Lipid Res (2013) 1.01

Targeting autophagy for the treatment of liver diseases. Pharmacol Res (2012) 1.01

Ethanol metabolism alters interferon gamma signaling in recombinant HepG2 cells. Hepatology (2005) 1.01

Mechanisms of pathogenesis in drug hepatotoxicity putting the stress on mitochondria. Mol Interv (2010) 1.00

Prevention of hepatic ischemia-reperfusion injury by green tea extract. Am J Physiol Gastrointest Liver Physiol (2002) 0.99

Transforming growth factor beta mediates hepatocyte apoptosis through Smad3 generation of reactive oxygen species. Biochimie (2007) 0.99

Dephosphorylation of the Rieske iron-sulfur protein after induction of the mitochondrial permeability transition. Biochem Biophys Res Commun (2005) 0.99

Dependence of liver injury after hemorrhage/resuscitation in mice on NADPH oxidase-derived superoxide. Shock (2003) 0.98

Interferon gamma enhances proteasome activity in recombinant Hep G2 cells that express cytochrome P4502E1: modulation by ethanol. Biochem Pharmacol (2003) 0.98

Zonated induction of autophagy and mitochondrial spheroids limits acetaminophen-induced necrosis in the liver. Redox Biol (2013) 0.97

Impact factors--a good thing? Gastroenterology (2003) 0.97

Free radical-dependent dysfunction of small-for-size rat liver grafts: prevention by plant polyphenols. Gastroenterology (2005) 0.97

Translocation of iron from lysosomes to mitochondria during ischemia predisposes to injury after reperfusion in rat hepatocytes. Free Radic Biol Med (2013) 0.97

Role of p62/SQSTM1 in liver physiology and pathogenesis. Exp Biol Med (Maywood) (2013) 0.96

Increased oxidative stress is associated with balanced increases in hepatocyte apoptosis and proliferation in glycerol-3-phosphate acyltransferase-1 deficient mice. Exp Mol Pathol (2006) 0.96

Differential effects of rapamycin on rods and cones during light-induced stress in albino mice. Invest Ophthalmol Vis Sci (2011) 0.96

Ethanol exposure decreases mitochondrial outer membrane permeability in cultured rat hepatocytes. Arch Biochem Biophys (2008) 0.96

Ischemic preconditioning prevents free radical production and mitochondrial depolarization in small-for-size rat liver grafts. Transplantation (2008) 0.95

Warburg revisited: regulation of mitochondrial metabolism by voltage-dependent anion channels in cancer cells. J Pharmacol Exp Ther (2012) 0.94

Multilevel regulation of autophagosome content by ethanol oxidation in HepG2 cells. Autophagy (2012) 0.94

Inhibition of mitochondrial respiration as a source of adaphostin-induced reactive oxygen species and cytotoxicity. J Biol Chem (2007) 0.94