Mitochondrial degradation by autophagy (mitophagy) in GFP-LC3 transgenic hepatocytes during nutrient deprivation.

PubWeight™: 1.32‹?› | Rank: Top 10%

🔗 View Article (PMC 3043636)

Published in Am J Physiol Cell Physiol on November 24, 2010

Authors

Insil Kim1, John J Lemasters

Author Affiliations

1: Center for Cell Death, Injury & Regeneration, Medical University of South Carolina, QF308 Quadrangle Bldg., 280 Calhoun St., P. O Box 250140, Charleston, SC 29425, USA.

Articles citing this

Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling. Biochem J (2012) 3.37

Preconditioning involves selective mitophagy mediated by Parkin and p62/SQSTM1. PLoS One (2011) 2.21

Integration of cellular bioenergetics with mitochondrial quality control and autophagy. Biol Chem (2012) 2.08

Functions of autophagy in normal and diseased liver. Autophagy (2013) 1.81

Mitophagy selectively degrades individual damaged mitochondria after photoirradiation. Antioxid Redox Signal (2011) 1.79

Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy. Nat Chem Biol (2012) 1.55

mTOR inhibitors synergize on regression, reversal of gene expression, and autophagy in hepatocellular carcinoma. Sci Transl Med (2012) 1.21

Mitochondrial autophagy in cells with mtDNA mutations results from synergistic loss of transmembrane potential and mTORC1 inhibition. Hum Mol Genet (2011) 1.18

BNip3 regulates mitochondrial function and lipid metabolism in the liver. Mol Cell Biol (2012) 1.17

Autophagy is a cell death mechanism in Toxoplasma gondii. Cell Microbiol (2012) 1.16

High-mobility group box 1 is dispensable for autophagy, mitochondrial quality control, and organ function in vivo. Cell Metab (2014) 1.12

Mitochondrial dynamics and mitochondrial quality control. Redox Biol (2014) 1.09

Autophagy: a cyto-protective mechanism which prevents primary human hepatocyte apoptosis during oxidative stress. Autophagy (2012) 1.08

Muscle choline kinase beta defect causes mitochondrial dysfunction and increased mitophagy. Hum Mol Genet (2011) 1.06

Molecular mechanisms of mitochondrial autophagy/mitophagy in the heart. Circ Res (2015) 1.06

Variants of mitochondrial autophagy: Types 1 and 2 mitophagy and micromitophagy (Type 3). Redox Biol (2014) 1.03

Mitochondrial dynamics and autophagy aid in removal of persistent mitochondrial DNA damage in Caenorhabditis elegans. Nucleic Acids Res (2012) 1.02

ATG5 is essential for ATG8-dependent autophagy and mitochondrial homeostasis in Leishmania major. PLoS Pathog (2012) 1.01

Autophagy in alcohol-induced liver diseases. Alcohol Clin Exp Res (2012) 0.97

Mitochondrial morphology and dynamics in hepatocytes from normal and ethanol-fed rats. Pflugers Arch (2012) 0.91

Mitochondrial roles and cytoprotection in chronic liver injury. Biochem Res Int (2012) 0.90

Teaching the basics of autophagy and mitophagy to redox biologists--mechanisms and experimental approaches. Redox Biol (2015) 0.90

Cannabidiol protects liver from binge alcohol-induced steatosis by mechanisms including inhibition of oxidative stress and increase in autophagy. Free Radic Biol Med (2014) 0.88

UVC-induced mitochondrial degradation via autophagy correlates with mtDNA damage removal in primary human fibroblasts. J Biochem Mol Toxicol (2012) 0.87

Mitophagy mechanisms and role in human diseases. Int J Biochem Cell Biol (2014) 0.86

Murine Mesenchymal Stem Cell Commitment to Differentiation Is Regulated by Mitochondrial Dynamics. Stem Cells (2015) 0.86

Autophagy and ethanol neurotoxicity. Autophagy (2014) 0.85

Mitochondrial quality control: Easy come, easy go. Biochim Biophys Acta (2015) 0.85

Ceramide induced mitophagy and tumor suppression. Biochim Biophys Acta (2015) 0.84

A Mechanistic Review of Mitophagy and Its Role in Protection against Alcoholic Liver Disease. Biomolecules (2015) 0.83

Nucleoside reverse transcriptase inhibitors induce a mitophagy-associated endothelial cytotoxicity that is reversed by coenzyme Q10 cotreatment. Toxicol Sci (2013) 0.82

Glycosome turnover in Leishmania major is mediated by autophagy. Autophagy (2014) 0.79

Mitochondrial quality control and age-associated arterial stiffening. Exp Gerontol (2014) 0.77

Cross Talk of Proteostasis and Mitostasis in Cellular Homeodynamics, Ageing, and Disease. Oxid Med Cell Longev (2016) 0.77

ATM mediates spermidine-induced mitophagy via PINK1 and Parkin regulation in human fibroblasts. Sci Rep (2016) 0.77

Targeting Pink1-Parkin-mediated mitophagy for treating liver injury. Pharmacol Res (2015) 0.77

Branched Chain Amino Acids Cause Liver Injury in Obese/Diabetic Mice by Promoting Adipocyte Lipolysis and Inhibiting Hepatic Autophagy. EBioMedicine (2016) 0.76

Defective Autophagy, Mitochondrial Clearance and Lipophagy in Niemann-Pick Type B Lymphocytes. PLoS One (2016) 0.75

Protocols for assessing mitophagy in neuronal cell lines and primary neurons. Neuromethods (2017) 0.75

Articles cited by this

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J (2000) 41.48

Autophagy fights disease through cellular self-digestion. Nature (2008) 33.83

The role of autophagy during the early neonatal starvation period. Nature (2004) 22.40

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol (2008) 17.81

In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell (2003) 17.55

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J (2008) 12.89

Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature (2004) 11.59

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum. J Cell Biol (2008) 9.37

The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation. EMBO J (2001) 8.84

Mitochondria supply membranes for autophagosome biogenesis during starvation. Cell (2010) 8.29

Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress. Proc Natl Acad Sci U S A (1997) 5.95

Mitochondria-anchored receptor Atg32 mediates degradation of mitochondria via selective autophagy. Dev Cell (2009) 5.85

Studies on the mechanisms of autophagy: formation of the autophagic vacuole. J Cell Biol (1990) 5.79

Atg32 is a mitochondrial protein that confers selectivity during mitophagy. Dev Cell (2009) 5.77

Measurement of mitochondrial membrane potential using fluorescent rhodamine derivatives. Biophys J (1999) 5.05

The mitochondrial permeability transition initiates autophagy in rat hepatocytes. FASEB J (2001) 4.99

Autophagy and other vacuolar protein degradation mechanisms. Experientia (1992) 4.68

Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons. EMBO J (2006) 4.43

Convergence of multiple autophagy and cytoplasm to vacuole targeting components to a perivacuolar membrane compartment prior to de novo vesicle formation. J Biol Chem (2001) 3.90

Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging. Rejuvenation Res (2005) 3.54

Autophagy, cytoplasm-to-vacuole targeting pathway, and pexophagy in yeast and mammalian cells. Annu Rev Biochem (2000) 3.44

An overview of the molecular mechanism of autophagy. Curr Top Microbiol Immunol (2009) 3.29

Studies on cellular autophagocytosis. The formation of autophagic vacuoles in the liver after glucagon administration. Am J Pathol (1968) 3.13

BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagy. Mol Cell Biol (2007) 3.10

Uth1p is involved in the autophagic degradation of mitochondria. J Biol Chem (2004) 3.07

Role of BNIP3 and NIX in cell death, autophagy, and mitophagy. Cell Death Differ (2009) 2.93

Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytes. Hepatology (2004) 2.92

The organization and inheritance of the mitochondrial genome. Nat Rev Genet (2005) 2.57

Atg9 cycles between mitochondria and the pre-autophagosomal structure in yeasts. Autophagy (2005) 2.52

Tracker dyes to probe mitochondrial autophagy (mitophagy) in rat hepatocytes. Autophagy (2006) 2.37

Characterization of the isolation membranes and the limiting membranes of autophagosomes in rat hepatocytes by lectin cytochemistry. J Histochem Cytochem (1990) 2.32

Aup1p, a yeast mitochondrial protein phosphatase homolog, is required for efficient stationary phase mitophagy and cell survival. J Biol Chem (2006) 2.32

The turnover of mitochondria in a variety of tissues of young adult and aged rats. J Biol Chem (1971) 2.16

Ultrastructural and immunocytochemical characterization of autophagic vacuoles in isolated hepatocytes: effects of vinblastine and asparagine on vacuole distributions. Exp Cell Res (1995) 2.03

Autophagy in the liver. Hepatology (2008) 1.84

Detection of mitochondrial DNA depletion in living human cells using PicoGreen staining. Exp Cell Res (2004) 1.74

Current knowledge of the pre-autophagosomal structure (PAS). FEBS Lett (2010) 1.72

DNase II: genes, enzymes and function. Gene (2003) 1.72

Inhibition by insulin of the formation of autophagic vacuoles in rat liver. A morphometric approach to the kinetics of intracellular degradation by autophagy. J Cell Biol (1978) 1.65

Mitochondrial permeability transition in the switch from necrotic to apoptotic cell death in ischemic rat hepatocytes. Gastroenterology (2003) 1.63

Ordered organelle degradation during starvation-induced autophagy. Mol Cell Proteomics (2008) 1.61

Peroxisome biogenesis and selective degradation converge at Pex14p. J Biol Chem (2001) 1.52

Roles of mitophagy and the mitochondrial permeability transition in remodeling of cultured rat hepatocytes. Autophagy (2009) 1.49

Glycogen autophagy in glucose homeostasis. Pathol Res Pract (2006) 1.45

Non-selective autophagy. Semin Cell Biol (1990) 1.42

Immunocytochemical study of the surrounding envelope of autophagic vacuoles in cultured rat hepatocytes. Exp Cell Res (1990) 1.37

The mitochondrial permeability transition mediates both necrotic and apoptotic death of hepatocytes exposed to Br-A23187. Toxicol Appl Pharmacol (1999) 1.34

Mitochondrial and plasma membrane potential of cultured cerebellar neurons during glutamate-induced necrosis, apoptosis, and tolerance. J Neurosci (2007) 1.18

Response of autophagic protein degradation to physiologic and pathologic stimuli in rat hepatocyte monolayer cultures. Lab Invest (1988) 0.86

Role of leukocytes in reperfusion injury of skeletal muscle after partial ischemia. Am J Physiol (1989) 0.85

DNase II in bull and ram sperm tail and mitochondria. Arch Androl (1980) 0.77

Articles by these authors

(truncated to the top 100)

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08

Selective degradation of mitochondria by mitophagy. Arch Biochem Biophys (2007) 8.24

Mechanisms of hepatotoxicity. Toxicol Sci (2002) 4.13

NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis. J Clin Invest (2003) 3.69

Apoptosis and necrosis in the liver: a tale of two deaths? Hepatology (2006) 3.52

Apoptosis versus oncotic necrosis in hepatic ischemia/reperfusion injury. Gastroenterology (2003) 3.21

Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytes. Hepatology (2004) 2.92

Mitochondrial permeability transition: a common pathway to necrosis and apoptosis. Biochem Biophys Res Commun (2003) 2.58

Peroxynitrite-induced mitochondrial and endonuclease-mediated nuclear DNA damage in acetaminophen hepatotoxicity. J Pharmacol Exp Ther (2005) 2.41

Tracker dyes to probe mitochondrial autophagy (mitophagy) in rat hepatocytes. Autophagy (2006) 2.37

Minocycline and N-methyl-4-isoleucine cyclosporin (NIM811) mitigate storage/reperfusion injury after rat liver transplantation through suppression of the mitochondrial permeability transition. Hepatology (2008) 2.22

Regulated and unregulated mitochondrial permeability transition pores: a new paradigm of pore structure and function? FEBS Lett (2002) 2.08

Reactive oxygen species, but not Ca2+ overloading, trigger pH- and mitochondrial permeability transition-dependent death of adult rat myocytes after ischemia-reperfusion. Am J Physiol Heart Circ Physiol (2006) 2.08

Acetaminophen-induced oxidant stress and cell injury in cultured mouse hepatocytes: protection by N-acetyl cysteine. Toxicol Sci (2004) 2.07

Role of mitochondrial permeability transition pores in mitochondrial autophagy. Int J Biochem Cell Biol (2004) 2.01

Inhibition of the mitochondrial permeability transition by the nonimmunosuppressive cyclosporin derivative NIM811. Mol Pharmacol (2002) 1.95

Nuclear translocation of endonuclease G and apoptosis-inducing factor during acetaminophen-induced liver cell injury. Toxicol Sci (2006) 1.94

Cyclophilin D as a drug target. Curr Med Chem (2003) 1.87

c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity. Toxicol Appl Pharmacol (2010) 1.84

Functions of autophagy in normal and diseased liver. Autophagy (2013) 1.81

Mitophagy selectively degrades individual damaged mitochondria after photoirradiation. Antioxid Redox Signal (2011) 1.79

Differential requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis in hepatocytes. FASEB J (2004) 1.76

Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells. Gastroenterology (2004) 1.73

Mitochondrial bax translocation accelerates DNA fragmentation and cell necrosis in a murine model of acetaminophen hepatotoxicity. J Pharmacol Exp Ther (2007) 1.70

Mitochondrial permeability transition in the switch from necrotic to apoptotic cell death in ischemic rat hepatocytes. Gastroenterology (2003) 1.63

Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy. Nat Chem Biol (2012) 1.55

Roles of mitophagy and the mitochondrial permeability transition in remodeling of cultured rat hepatocytes. Autophagy (2009) 1.49

Cyclophilin D deficiency protects against acetaminophen-induced oxidant stress and liver injury. Free Radic Res (2010) 1.45

Discrimination of depolarized from polarized mitochondria by confocal fluorescence resonance energy transfer. Arch Biochem Biophys (2004) 1.40

Translocation of iron from lysosomes into mitochondria is a key event during oxidative stress-induced hepatocellular injury. Hepatology (2008) 1.31

Free tubulin modulates mitochondrial membrane potential in cancer cells. Cancer Res (2010) 1.23

Reduced-size liver transplantation in the mouse. Transplantation (2003) 1.19

Nitric oxide protects rat hepatocytes against reperfusion injury mediated by the mitochondrial permeability transition. Hepatology (2004) 1.18

Heat shock suppresses the permeability transition in rat liver mitochondria. J Biol Chem (2003) 1.18

UCPs--unlikely calcium porters. Nat Cell Biol (2008) 1.17

L-Glycine: a novel antiinflammatory, immunomodulatory, and cytoprotective agent. Curr Opin Clin Nutr Metab Care (2003) 1.16

Apoptosis-inducing factor modulates mitochondrial oxidant stress in acetaminophen hepatotoxicity. Toxicol Sci (2011) 1.16

Bid activates multiple mitochondrial apoptotic mechanisms in primary hepatocytes after death receptor engagement. Gastroenterology (2003) 1.15

Lysosomal iron mobilization and induction of the mitochondrial permeability transition in acetaminophen-induced toxicity to mouse hepatocytes. Toxicol Sci (2010) 1.15

TRAIL-mediated apoptosis requires NF-kappaB inhibition and the mitochondrial permeability transition in human hepatoma cells. Hepatology (2002) 1.14

Mitochondrial permeability transition in liver ischemia and reperfusion: role of c-Jun N-terminal kinase 2. Transplantation (2008) 1.13

Gliotoxin-mediated apoptosis of activated human hepatic stellate cells. J Hepatol (2003) 1.13

Liver regeneration is suppressed in small-for-size liver grafts after transplantation: involvement of c-Jun N-terminal kinase, cyclin D1, and defective energy supply. Transplantation (2006) 1.11

Voltage-dependent anion channels modulate mitochondrial metabolism in cancer cells: regulation by free tubulin and erastin. J Biol Chem (2013) 1.09

Isolated mitochondria infusion mitigates ischemia-reperfusion injury of the liver in rats: mitotracker probes and mitochondrial membrane potential. Shock (2013) 1.09

Green tea polyphenols stimulate mitochondrial biogenesis and improve renal function after chronic cyclosporin a treatment in rats. PLoS One (2013) 1.07

Phosphorylation of voltage-dependent anion channel by serine/threonine kinases governs its interaction with tubulin. PLoS One (2011) 1.07

Polyphenols from Camellia sinenesis attenuate experimental cholestasis-induced liver fibrosis in rats. Am J Physiol Gastrointest Liver Physiol (2003) 1.07

Effects of three superoxide dismutase genes delivered with an adenovirus on graft function after transplantation of fatty livers in the rat. Transplantation (2003) 1.05

Activation of the oxygen-sensing signal cascade prevents mitochondrial injury after mouse liver ischemia-reperfusion. Am J Physiol Gastrointest Liver Physiol (2008) 1.05

The oxygen tension modulates acetaminophen-induced mitochondrial oxidant stress and cell injury in cultured hepatocytes. Toxicol Sci (2010) 1.05

Mitochondrial permeability transition in rat hepatocytes after anoxia/reoxygenation: role of Ca2+-dependent mitochondrial formation of reactive oxygen species. Am J Physiol Gastrointest Liver Physiol (2012) 1.02

Mechanisms of pathogenesis in drug hepatotoxicity putting the stress on mitochondria. Mol Interv (2010) 1.00

Transforming growth factor beta mediates hepatocyte apoptosis through Smad3 generation of reactive oxygen species. Biochimie (2007) 0.99

Prevention of hepatic ischemia-reperfusion injury by green tea extract. Am J Physiol Gastrointest Liver Physiol (2002) 0.99

Dephosphorylation of the Rieske iron-sulfur protein after induction of the mitochondrial permeability transition. Biochem Biophys Res Commun (2005) 0.99

Dependence of liver injury after hemorrhage/resuscitation in mice on NADPH oxidase-derived superoxide. Shock (2003) 0.98

Impact factors--a good thing? Gastroenterology (2003) 0.97

Translocation of iron from lysosomes to mitochondria during ischemia predisposes to injury after reperfusion in rat hepatocytes. Free Radic Biol Med (2013) 0.97

Free radical-dependent dysfunction of small-for-size rat liver grafts: prevention by plant polyphenols. Gastroenterology (2005) 0.97

Autophagy in alcohol-induced liver diseases. Alcohol Clin Exp Res (2012) 0.97

Increased oxidative stress is associated with balanced increases in hepatocyte apoptosis and proliferation in glycerol-3-phosphate acyltransferase-1 deficient mice. Exp Mol Pathol (2006) 0.96

Differential effects of rapamycin on rods and cones during light-induced stress in albino mice. Invest Ophthalmol Vis Sci (2011) 0.96

Ethanol exposure decreases mitochondrial outer membrane permeability in cultured rat hepatocytes. Arch Biochem Biophys (2008) 0.96

Ischemic preconditioning prevents free radical production and mitochondrial depolarization in small-for-size rat liver grafts. Transplantation (2008) 0.95

Warburg revisited: regulation of mitochondrial metabolism by voltage-dependent anion channels in cancer cells. J Pharmacol Exp Ther (2012) 0.94

Inhibition of mitochondrial respiration as a source of adaphostin-induced reactive oxygen species and cytotoxicity. J Biol Chem (2007) 0.94

NIM811 prevents mitochondrial dysfunction, attenuates liver injury, and stimulates liver regeneration after massive hepatectomy. Transplantation (2011) 0.94

Closure of VDAC causes oxidative stress and accelerates the Ca(2+)-induced mitochondrial permeability transition in rat liver mitochondria. Arch Biochem Biophys (2010) 0.94

NIM811 (N-methyl-4-isoleucine cyclosporine), a mitochondrial permeability transition inhibitor, attenuates cholestatic liver injury but not fibrosis in mice. J Pharmacol Exp Ther (2008) 0.93

Polyphenols from Camellia sinenesis prevent primary graft failure after transplantation of ethanol-induced fatty livers from rats. Free Radic Biol Med (2004) 0.93

Role of apoptosis in acetaminophen hepatotoxicity. J Gastroenterol Hepatol (2007) 0.92

Inhibition of transforming growth factor-beta/Smad signaling improves regeneration of small-for-size rat liver grafts. Liver Transpl (2010) 0.91

Nitric oxide: a signaling molecule against mitochondrial permeability transition- and pH-dependent cell death after reperfusion. Free Radic Biol Med (2004) 0.91

Ethanol suppresses ureagenesis in rat hepatocytes: role of acetaldehyde. J Biol Chem (2012) 0.91

Sphingosine kinase-2 inhibition improves mitochondrial function and survival after hepatic ischemia-reperfusion. J Hepatol (2011) 0.91

Cyclosporin A in left ventricular remodeling after myocardial infarction. Am J Physiol Heart Circ Physiol (2013) 0.91

Lysosomal signaling enhances mitochondria-mediated photodynamic therapy in A431 cancer cells: role of iron. Photochem Photobiol (2012) 0.90

Basal reactive oxygen species determine the susceptibility to apoptosis in cirrhotic hepatocytes. Free Radic Biol Med (2006) 0.90

Mitoferrin-2-dependent mitochondrial iron uptake sensitizes human head and neck squamous carcinoma cells to photodynamic therapy. J Biol Chem (2012) 0.89

Lipopolysaccharide-binding protein modulates hepatic damage and the inflammatory response after hemorrhagic shock and resuscitation. Am J Physiol Gastrointest Liver Physiol (2006) 0.88

Inhibition of the mitochondrial permeability transition by protein kinase A in rat liver mitochondria and hepatocytes. Biochem J (2010) 0.88

Attenuation of acute rejection in a rat liver transplantation model by a liver-targeted dextran prodrug of methylprednisolone. Transplantation (2006) 0.88

Minocycline and doxycycline, but not other tetracycline-derived compounds, protect liver cells from chemical hypoxia and ischemia/reperfusion injury by inhibition of the mitochondrial calcium uniporter. Toxicol Appl Pharmacol (2013) 0.88

Salicylate enhances necrosis and apoptosis mediated by the mitochondrial permeability transition. Toxicol Sci (2003) 0.87

Inhibition of sphingosine kinase-2 suppresses inflammation and attenuates graft injury after liver transplantation in rats. PLoS One (2012) 0.87

Graft tumor necrosis factor receptor-1 protects after mouse liver transplantation whereas host tumor necrosis factor receptor-1 promotes injury. Transplantation (2006) 0.87

Extrahepatic cells contribute to the progenitor/stem cell response following reduced-size liver transplantation in mice. Exp Biol Med (Maywood) (2007) 0.86

Targeted gene delivery to sinusoidal endothelial cells: DNA nanoassociate bearing hyaluronan-glycocalyx. FASEB J (2004) 0.85

Isolated mouse liver mitochondria are devoid of glucokinase. Biochem Biophys Res Commun (2005) 0.84

Role of free radicals in failure of fatty liver grafts caused by ethanol. Alcohol (2004) 0.83

Signaling From Lysosomes Enhances Mitochondria-Mediated Photodynamic Therapy In Cancer Cells. Proc SPIE Int Soc Opt Eng (2009) 0.81

Pinhole shifting lifetime imaging microscopy. J Biomed Opt (2009) 0.81

Role of inducible nitric oxide synthase in mitochondrial depolarization and graft injury after transplantation of fatty livers. Free Radic Biol Med (2012) 0.81

Lysosomal instability and cathepsin B release during acetaminophen hepatotoxicity. Basic Clin Pharmacol Toxicol (2012) 0.81

Different patterns of renal cell killing after warm and cold ischemia. Ren Fail (2002) 0.80

Role of pH in protection by low sodium against hypoxic injury in isolated perfused rat livers. J Hepatol (2005) 0.80

Elevated levels of endothelin-1 in hepatic venous blood are associated with intrapulmonary vasodilatation in humans. Dig Dis Sci (2011) 0.80

Rusty notions of cell injury. J Hepatol (2004) 0.78

Minocycline and doxycycline, but not tetracycline, mitigate liver and kidney injury after hemorrhagic shock/resuscitation. Shock (2014) 0.78