Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling.

PubWeight™: 1.01‹?› | Rank: Top 15%

🔗 View Article (PMID 22561606)

Published in Nat Immunol on May 06, 2012

Authors

Di Wang1, Mingzhu Zheng, Lei Lei, Jian Ji, Yunliang Yao, Yuanjun Qiu, Lie Ma, Jun Lou, Chuan Ouyang, Xue Zhang, Yuewei He, Jun Chi, Lie Wang, Ying Kuang, Jianli Wang, Xuetao Cao, Linrong Lu

Author Affiliations

1: Institute of Immunology, Zhejiang University School of Medicine, Hangzhou, China.

Articles citing this

The self-obsession of T cells: how TCR signaling thresholds affect fate 'decisions' and effector function. Nat Immunol (2014) 1.30

Fine-tuning T cell receptor signaling to control T cell development. Trends Immunol (2014) 0.85

THEMIS is required for pathogenesis of cerebral malaria and protection against pulmonary tuberculosis. Infect Immun (2014) 0.83

Tespa1: another gatekeeper for positive selection. Nat Immunol (2012) 0.82

Suppression of Th17 cell differentiation by misshapen/NIK-related kinase MINK1. J Exp Med (2017) 0.81

Tespa1 negatively regulates FcεRI-mediated signaling and the mast cell-mediated allergic response. J Exp Med (2014) 0.79

Lack of association between TESPA1 gene polymorphisms (rs1801876, rs2171497, rs4758994, and rs997173) and ankylosing spondylitis in a Chinese population. Inflammation (2014) 0.77

Gene targeting RhoA reveals its essential role in coordinating mitochondrial function and thymocyte development. J Immunol (2014) 0.77

Tespa1 is a novel inositol 1,4,5-trisphosphate receptor binding protein in T and B lymphocytes. FEBS Open Bio (2012) 0.77

Indoctrinating T cells to attack pathogens through homeschooling. Trends Immunol (2015) 0.77

ShcA regulates late stages of T cell development and peripheral CD4+ T cell numbers. J Immunol (2015) 0.76

Selection signatures in Canchim beef cattle. J Anim Sci Biotechnol (2016) 0.75

CBAP promotes thymocyte negative selection by facilitating T-cell receptor proximal signaling. Cell Death Dis (2014) 0.75

Tespa1 is associated with susceptibility but not severity of rheumatoid arthritis in the Zhejiang Han population in China. Clin Rheumatol (2015) 0.75

Articles cited by this

Positive and negative selection of T cells. Annu Rev Immunol (2002) 8.32

BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes. Nature (2002) 5.98

Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling. Nature (2006) 5.05

A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol (2011) 4.84

Essential role of LAT in T cell development. Immunity (1999) 3.94

T-cell development and the CD4-CD8 lineage decision. Nat Rev Immunol (2002) 3.09

Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice. Nat Rev Immunol (2008) 2.98

The role of erk1 and erk2 in multiple stages of T cell development. Immunity (2005) 2.96

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal (2009) 2.92

Skint1, the prototype of a newly identified immunoglobulin superfamily gene cluster, positively selects epidermal gammadelta T cells. Nat Genet (2008) 2.31

A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection. Immunity (1995) 2.31

CCR7-dependent cortex-to-medulla migration of positively selected thymocytes is essential for establishing central tolerance. Immunity (2006) 2.12

Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling. Nat Immunol (2009) 2.12

Themis, a T cell-specific protein important for late thymocyte development. Nat Immunol (2009) 2.00

Nonstimulatory peptides contribute to antigen-induced CD8-T cell receptor interaction at the immunological synapse. Nat Immunol (2005) 1.85

Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection. Nat Immunol (2009) 1.84

Coreceptor reversal in the thymus: signaled CD4+8+ thymocytes initially terminate CD8 transcription even when differentiating into CD8+ T cells. Immunity (2000) 1.83

Unexpectedly complex regulation of CD4/CD8 coreceptor expression supports a revised model for CD4+CD8+ thymocyte differentiation. Immunity (1996) 1.83

CD4/CD8-lineage differentiation in the thymus: from nuclear effectors to membrane signals. Nat Rev Immunol (2004) 1.69

Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: a new perspective on thymic commitment and selection. Immunity (1995) 1.59

The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells. J Exp Med (1996) 1.56

The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate. Nature (2000) 1.49

T cell receptor (TCR)-induced tyrosine phosphorylation dynamics identifies THEMIS as a new TCR signalosome component. J Biol Chem (2010) 1.44

Duration of TCR signaling controls CD4-CD8 lineage differentiation in vivo. Nat Immunol (2004) 1.39

The T-cell receptor signalosome: a dynamic structure with expanding complexity. Curr Opin Immunol (2002) 1.22

Ras-related protein Rab10 facilitates TLR4 signaling by promoting replenishment of TLR4 onto the plasma membrane. Proc Natl Acad Sci U S A (2010) 1.22

Surface molecules that drive T cell development in vitro in the absence of thymic epithelium and in the absence of lineage-specific signals. Immunity (1997) 1.20

Receptor avidity and costimulation specify the intracellular Ca2+ signaling pattern in CD4(+)CD8(+) thymocytes. J Exp Med (1999) 1.10

A role for calcium influx in setting the threshold for CD4+CD8+ thymocyte negative selection. J Immunol (1996) 1.04

Contrasting effects of two tumour promoters, phorbol myristate acetate and okadaic acid, on T-cell responses and activation of p42 MAP-kinase/ERK-2. Immunology (1993) 0.99

Molecular and cellular mechanisms of T lymphocyte apoptosis. Adv Immunol (1998) 0.97

LKB1 regulates TCR-mediated PLCγ1 activation and thymocyte positive selection. EMBO J (2011) 0.94

Differential impact of the CD45 juxtamembrane wedge on central and peripheral T cell receptor responses. Proc Natl Acad Sci U S A (2009) 0.83

Investigating central tolerance with reaggregate thymus organ cultures. Methods Mol Biol (2007) 0.80

Articles by these authors

Essential role for nuclear PTEN in maintaining chromosomal integrity. Cell (2007) 6.52

Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990-2013: quantifying the epidemiological transition. Lancet (2015) 6.13

Identification of miRNomes in human liver and hepatocellular carcinoma reveals miR-199a/b-3p as therapeutic target for hepatocellular carcinoma. Cancer Cell (2011) 4.54

The microRNA miR-29 controls innate and adaptive immune responses to intracellular bacterial infection by targeting interferon-γ. Nat Immunol (2011) 3.77

MicroRNA-146a feedback inhibits RIG-I-dependent Type I IFN production in macrophages by targeting TRAF6, IRAK1, and IRAK2. J Immunol (2009) 3.72

Osteopontin expression is essential for interferon-alpha production by plasmacytoid dendritic cells. Nat Immunol (2006) 3.70

Inhibition of follicular T-helper cells by CD8(+) regulatory T cells is essential for self tolerance. Nature (2010) 3.68

Analysis of regulatory CD8 T cells in Qa-1-deficient mice. Nat Immunol (2004) 3.41

Mutations in SLC20A2 link familial idiopathic basal ganglia calcification with phosphate homeostasis. Nat Genet (2012) 3.34

Cancer-expanded myeloid-derived suppressor cells induce anergy of NK cells through membrane-bound TGF-beta 1. J Immunol (2009) 3.27

Splenic stroma drives mature dendritic cells to differentiate into regulatory dendritic cells. Nat Immunol (2004) 3.25

Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk. Nat Immunol (2011) 3.12

The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway. Nat Immunol (2010) 2.95

Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1. Nat Immunol (2008) 2.89

Large scale growth and characterization of atomic hexagonal boron nitride layers. Nano Lett (2010) 2.66

Large-area vapor-phase growth and characterization of MoS(2) atomic layers on a SiO(2) substrate. Small (2012) 2.66

The STAT3-binding long noncoding RNA lnc-DC controls human dendritic cell differentiation. Science (2014) 2.63

Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b. Nat Immunol (2010) 2.58

Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease. Proc Natl Acad Sci U S A (2004) 2.50

Defining the critical hurdles in cancer immunotherapy. J Transl Med (2011) 2.32

Efficacy, safety, and tolerability of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 as monotherapy in patients with hypercholesterolaemia (MENDEL): a randomised, double-blind, placebo-controlled, phase 2 study. Lancet (2012) 2.31

Gamma-secretase gene mutations in familial acne inversa. Science (2010) 2.30

Leptin exacerbates collagen-induced arthritis via enhancement of Th17 cell response. Arthritis Rheum (2012) 2.26

Inducible microRNA-155 feedback promotes type I IFN signaling in antiviral innate immunity by targeting suppressor of cytokine signaling 1. J Immunol (2010) 2.12

The E3 ubiquitin ligase Nrdp1 'preferentially' promotes TLR-mediated production of type I interferon. Nat Immunol (2009) 2.12

Recurrent subthreshold depression in type 2 diabetes: an important risk factor for poor health outcomes. Diabetes Care (2013) 2.08

Hepatic microenvironment programs hematopoietic progenitor differentiation into regulatory dendritic cells, maintaining liver tolerance. Blood (2008) 2.02

Themis, a T cell-specific protein important for late thymocyte development. Nat Immunol (2009) 2.00

Notch1 signaling inhibits growth of human hepatocellular carcinoma through induction of cell cycle arrest and apoptosis. Cancer Res (2003) 1.92

MicroRNA-148b is frequently down-regulated in gastric cancer and acts as a tumor suppressor by inhibiting cell proliferation. Mol Cancer (2011) 1.89

MicroRNA-99a inhibits hepatocellular carcinoma growth and correlates with prognosis of patients with hepatocellular carcinoma. J Biol Chem (2011) 1.88

Mutations in proteasome subunit β type 8 cause chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature with evidence of genetic and phenotypic heterogeneity. Arthritis Rheum (2012) 1.87

Fas signal promotes lung cancer growth by recruiting myeloid-derived suppressor cells via cancer cell-derived PGE2. J Immunol (2009) 1.85

Vapour phase growth and grain boundary structure of molybdenum disulphide atomic layers. Nat Mater (2013) 1.83

SHP-2 phosphatase negatively regulates the TRIF adaptor protein-dependent type I interferon and proinflammatory cytokine production. Immunity (2006) 1.79

MicroRNA-148/152 impair innate response and antigen presentation of TLR-triggered dendritic cells by targeting CaMKIIα. J Immunol (2010) 1.77

MicroRNA-466l upregulates IL-10 expression in TLR-triggered macrophages by antagonizing RNA-binding protein tristetraprolin-mediated IL-10 mRNA degradation. J Immunol (2010) 1.74

TLR4 signaling promotes immune escape of human lung cancer cells by inducing immunosuppressive cytokines and apoptosis resistance. Mol Immunol (2007) 1.72

CD69+ CD4+ CD25- T cells, a new subset of regulatory T cells, suppress T cell proliferation through membrane-bound TGF-beta 1. J Immunol (2009) 1.70

Variation in health services utilization among ethnic populations. CMAJ (2006) 1.64

Activation of MAPK kinase 9 induces ethylene and camalexin biosynthesis and enhances sensitivity to salt stress in Arabidopsis. J Biol Chem (2008) 1.64

MicroRNA-494 is required for the accumulation and functions of tumor-expanded myeloid-derived suppressor cells via targeting of PTEN. J Immunol (2012) 1.63

Mutations of the EPHA2 receptor tyrosine kinase gene cause autosomal dominant congenital cataract. Hum Mutat (2009) 1.60

Novel function of B cell-activating factor in the induction of IL-10-producing regulatory B cells. J Immunol (2010) 1.57

In-plane heterostructures of graphene and hexagonal boron nitride with controlled domain sizes. Nat Nanotechnol (2013) 1.57

Cellulose synthase interactive protein 1 (CSI1) links microtubules and cellulose synthase complexes. Proc Natl Acad Sci U S A (2011) 1.57

CCR4-NOT deadenylates mRNA associated with RNA-induced silencing complexes in human cells. Mol Cell Biol (2010) 1.55

A genome-wide profiling of the humoral immune response to Chlamydia trachomatis infection reveals vaccine candidate antigens expressed in humans. J Immunol (2010) 1.55

Interleukin-17 and its expanding biological functions. Cell Mol Immunol (2010) 1.55

Risk factors for aortic valve disease in bicuspid aortic valve: a family-based study. Am J Med Genet A (2011) 1.55

Possible genomic imprinting of three human obesity-related genetic loci. Am J Hum Genet (2005) 1.54

Deletion of Nf1 in neurons induces increased axon collateral branching after dorsal root injury. J Neurosci (2007) 1.54

Involvement of ERK, p38 and NF-kappaB signal transduction in regulation of TLR2, TLR4 and TLR9 gene expression induced by lipopolysaccharide in mouse dendritic cells. Immunology (2002) 1.53

Src homology 2 domain-containing inositol-5-phosphatase 1 (SHIP1) negatively regulates TLR4-mediated LPS response primarily through a phosphatase activity- and PI-3K-independent mechanism. Blood (2005) 1.53

Genetic variants in SCN5A promoter are associated with arrhythmia phenotype severity in patients with heterozygous loss-of-function mutation. Heart Rhythm (2012) 1.51

Mice deficient in MyD88 Develop a Th2-dominant response and severe pathology in the upper genital tract following Chlamydia muridarum infection. J Immunol (2010) 1.49

Tumor-educated CD11bhighIalow regulatory dendritic cells suppress T cell response through arginase I. J Immunol (2009) 1.49

CaMKII promotes TLR-triggered proinflammatory cytokine and type I interferon production by directly binding and activating TAK1 and IRF3 in macrophages. Blood (2008) 1.47

Ligand-dependent activation of Slo family channels is defined by interchangeable cytosolic domains. J Neurosci (2004) 1.46

Lysosome-associated small Rab GTPase Rab7b negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Blood (2007) 1.45

Heat shock protein 70, released from heat-stressed tumor cells, initiates antitumor immunity by inducing tumor cell chemokine production and activating dendritic cells via TLR4 pathway. J Immunol (2009) 1.44

Cold welding of ultrathin gold nanowires. Nat Nanotechnol (2010) 1.44

Direct growth of graphene/hexagonal boron nitride stacked layers. Nano Lett (2011) 1.43

Qa-1 restriction of CD8+ suppressor T cells. J Clin Invest (2004) 1.41

Identification of a novel mutation in solute carrier family 29, member 3 in a Chinese patient with H syndrome. Chin Med J (Engl) (2015) 1.39

Work-family conflict and burnout among Chinese doctors: the mediating role of psychological capital. J Occup Health (2012) 1.39

A MyD88-dependent early IL-17 production protects mice against airway infection with the obligate intracellular pathogen Chlamydia muridarum. J Immunol (2009) 1.39

Mutations in PRRT2 result in paroxysmal dyskinesias with marked variability in clinical expression. J Med Genet (2011) 1.38

Intrinsic structural defects in monolayer molybdenum disulfide. Nano Lett (2013) 1.38

Zinc finger protein ZBTB20 is a key repressor of alpha-fetoprotein gene transcription in liver. Proc Natl Acad Sci U S A (2008) 1.38

Inhibition of Kv2.1 voltage-dependent K+ channels in pancreatic beta-cells enhances glucose-dependent insulin secretion. J Biol Chem (2002) 1.37

Melittin, a major component of bee venom, sensitizes human hepatocellular carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by activating CaMKII-TAK1-JNK/p38 and inhibiting IkappaBalpha kinase-NFkappaB. J Biol Chem (2008) 1.34

Chlamydia vaccine candidates and tools for chlamydial antigen discovery. Expert Rev Vaccines (2009) 1.34

Adopting evidence-based practice in clinical decision making: nurses' perceptions, knowledge, and barriers. J Med Libr Assoc (2011) 1.33

Notch1 signaling sensitizes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human hepatocellular carcinoma cells by inhibiting Akt/Hdm2-mediated p53 degradation and up-regulating p53-dependent DR5 expression. J Biol Chem (2009) 1.33

Black phosphorus-monolayer MoS2 van der Waals heterojunction p-n diode. ACS Nano (2014) 1.32

Characterization of Chlamydia trachomatis plasmid-encoded open reading frames. J Bacteriol (2013) 1.31

Loss-of-function mutations of an inhibitory upstream ORF in the human hairless transcript cause Marie Unna hereditary hypotrichosis. Nat Genet (2009) 1.31

Transcription factor KLF7 is important for neuronal morphogenesis in selected regions of the nervous system. Mol Cell Biol (2005) 1.31

Induction of Siglec-G by RNA viruses inhibits the innate immune response by promoting RIG-I degradation. Cell (2013) 1.30

MicroRNA-98 negatively regulates IL-10 production and endotoxin tolerance in macrophages after LPS stimulation. FEBS Lett (2011) 1.29

More efficient induction of HLA-A*0201-restricted and carcinoembryonic antigen (CEA)-specific CTL response by immunization with exosomes prepared from heat-stressed CEA-positive tumor cells. Clin Cancer Res (2005) 1.29

Imaging nigral pathology and clinical progression in Parkinson's disease. Mov Disord (2012) 1.27

Endothelial stroma programs hematopoietic stem cells to differentiate into regulatory dendritic cells through IL-10. Blood (2006) 1.27

CREB is a novel nuclear target of PTEN phosphatase. Cancer Res (2011) 1.27

NO signaling and S-nitrosylation regulate PTEN inhibition in neurodegeneration. Mol Neurodegener (2010) 1.23

Human CD14+ CTLA-4+ regulatory dendritic cells suppress T-cell response by cytotoxic T-lymphocyte antigen-4-dependent IL-10 and indoleamine-2,3-dioxygenase production in hepatocellular carcinoma. Hepatology (2013) 1.23

Ras-related protein Rab10 facilitates TLR4 signaling by promoting replenishment of TLR4 onto the plasma membrane. Proc Natl Acad Sci U S A (2010) 1.22

Notch signal suppresses Toll-like receptor-triggered inflammatory responses in macrophages by inhibiting extracellular signal-regulated kinase 1/2-mediated nuclear factor κB activation. J Biol Chem (2011) 1.21

Suppression of cyclin-dependent kinase 5 activation by amyloid precursor protein: a novel excitoprotective mechanism involving modulation of tau phosphorylation. J Neurosci (2005) 1.21

Inducible microRNA-223 down-regulation promotes TLR-triggered IL-6 and IL-1β production in macrophages by targeting STAT3. PLoS One (2012) 1.20