Published in Free Radic Biol Med on December 01, 1998
Role of oxidative carbonylation in protein quality control and senescence. EMBO J (2005) 3.59
Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases. BMC Med Genomics (2009) 2.36
Transcriptional profiles associated with aging and middle age-onset caloric restriction in mouse hearts. Proc Natl Acad Sci U S A (2002) 1.97
Mechanisms underlying caloric restriction and lifespan regulation: implications for vascular aging. Circ Res (2008) 1.75
Stress resistance and aging: influence of genes and nutrition. Mech Ageing Dev (2006) 1.36
Mitochondrial energy metabolism and redox signaling in brain aging and neurodegeneration. Antioxid Redox Signal (2012) 1.32
Skeletal muscle mitochondria and aging: a review. J Aging Res (2012) 1.27
Selectivity of protein oxidative damage during aging in Drosophila melanogaster. Biochem J (2001) 1.24
Does calorie restriction induce mitochondrial biogenesis? A reevaluation. FASEB J (2010) 1.23
Caloric restriction shortens lifespan through an increase in lipid peroxidation, inflammation and apoptosis in the G93A mouse, an animal model of ALS. PLoS One (2010) 1.09
Comparison of metabolic rate and oxidative stress between two different strains of mice with varying response to caloric restriction. Exp Gerontol (2008) 1.08
Reactive oxygen species and redox-regulation of skeletal muscle adaptations to exercise. Philos Trans R Soc Lond B Biol Sci (2005) 1.06
Long-term supplementation with resveratrol alleviates oxidative stress but does not attenuate sarcopenia in aged mice. J Gerontol A Biol Sci Med Sci (2011) 1.06
Denervation induces cytosolic phospholipase A2-mediated fatty acid hydroperoxide generation by muscle mitochondria. J Biol Chem (2008) 1.04
Longevity in mice: is stress resistance a common factor? Age (Dordr) (2006) 1.03
The age-related failure of adaptive responses to contractile activity in skeletal muscle is mimicked in young mice by deletion of Cu,Zn superoxide dismutase. Aging Cell (2010) 1.03
Age-associated declines in mitochondrial biogenesis and protein quality control factors are minimized by exercise training. Am J Physiol Regul Integr Comp Physiol (2012) 1.02
Starvation, detoxification, and multidrug resistance in cancer therapy. Drug Resist Updat (2012) 1.01
Testing hypotheses of aging in long-lived mice of the genus Peromyscus: association between longevity and mitochondrial stress resistance, ROS detoxification pathways, and DNA repair efficiency. Age (Dordr) (2008) 1.01
The mitochondrial and kidney disease phenotypes of kd/kd mice under germfree conditions. J Autoimmun (2005) 1.01
Caloric restriction and the aging process: a critique. Free Radic Biol Med (2014) 0.97
Aging increases mitochondrial DNA damage and oxidative stress in liver of rhesus monkeys. Exp Gerontol (2011) 0.96
Aging and the intestine. World J Gastroenterol (2006) 0.95
Secrets of the lac operon. Glucose hysteresis as a mechanism in dietary restriction, aging and disease. Interdiscip Top Gerontol (2007) 0.93
Association between life-span extension by caloric restriction and thiol redox state in two different strains of mice. Free Radic Biol Med (2011) 0.88
Gender-specific prandial response to dietary restriction and oxidative stress in Drosophila melanogaster. Fly (Austin) (2011) 0.88
The influence of dietary lipid composition on skeletal muscle mitochondria from mice following 1 month of calorie restriction. J Gerontol A Biol Sci Med Sci (2012) 0.87
The effects of dietary restriction on oxidative stress in rodents. Free Radic Biol Med (2013) 0.85
One size may not fit all: anti-aging therapies and sarcopenia. Aging (Albany NY) (2011) 0.85
Mitochondria, oxidative DNA damage, and aging. J Am Aging Assoc (2000) 0.85
Superior proteome stability in the longest lived animal. Age (Dordr) (2013) 0.82
Mitophagy in maintaining skeletal muscle mitochondrial proteostasis and metabolic health with aging. J Physiol (2017) 0.81
Calorie restriction in mice overexpressing UCP3: evidence that prior mitochondrial uncoupling alters response. Exp Gerontol (2012) 0.81
Effects of age and caloric restriction on mitochondrial protein oxidative damage in mice. Mech Ageing Dev (2011) 0.81
Mouse liver plasma membrane redox system activity is altered by aging and modulated by calorie restriction. Age (Dordr) (2005) 0.80
Role of the mitochondrial DNA replication machinery in mitochondrial DNA mutagenesis, aging and age-related diseases. Ageing Res Rev (2016) 0.78
Asymmetric superoxide release inside and outside the mitochondria in skeletal muscle under conditions of aging and disuse. J Appl Physiol (1985) (2010) 0.78
Hyperglycemia and redox status regulate RUNX2 DNA-binding and an angiogenic phenotype in endothelial cells. Microvasc Res (2014) 0.78
Mitophagy plays a central role in mitochondrial ageing. Mamm Genome (2016) 0.77
The influence of dietary lipid composition on skeletal muscle mitochondria from mice following eight months of calorie restriction. Physiol Res (2013) 0.77
Senemorphism: a novel perspective on aging patterns and its implication for diet-related biology. Biogerontology (2012) 0.77
Thioredoxin, oxidative stress, cancer and aging. Longev Healthspan (2012) 0.76
Mitochondria and ageing: role in heart, skeletal muscle and adipose tissue. J Cachexia Sarcopenia Muscle (2017) 0.75
Ischaemia-reperfusion modulates inflammation and fibrosis of skeletal muscle after contusion injury. Int J Exp Pathol (2010) 0.75
Aging: a theory based on free radical and radiation chemistry. J Gerontol (1956) 20.39
Hydroperoxide metabolism in mammalian organs. Physiol Rev (1979) 14.13
Oxidative stress, caloric restriction, and aging. Science (1996) 11.07
Protein oxidation and aging. Science (1992) 7.69
Oxidative damage and mitochondrial decay in aging. Proc Natl Acad Sci U S A (1994) 6.84
Assessment of mitochondrial oxidative phosphorylation in patient muscle biopsies, lymphoblasts, and transmitochondrial cell lines. Methods Enzymol (1996) 5.40
An assay for superoxide dismutase activity in mammalian tissue homogenates. Anal Biochem (1989) 3.02
Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse. Mech Ageing Dev (1994) 2.96
Oxidative damage during aging targets mitochondrial aconitase. Proc Natl Acad Sci U S A (1997) 2.76
Biochemical, physiological and medical aspects of ubiquinone function. Biochim Biophys Acta (1995) 2.71
What is sarcopenia? J Gerontol A Biol Sci Med Sci (1995) 2.31
Relationship between mitochondrial superoxide and hydrogen peroxide production and longevity of mammalian species. Free Radic Biol Med (1993) 2.22
Effect of age and caloric restriction on DNA oxidative damage in different tissues of C57BL/6 mice. Mech Ageing Dev (1994) 2.16
Protein oxidative damage is associated with life expectancy of houseflies. Proc Natl Acad Sci U S A (1993) 2.13
Lipoperoxides in plasma as measured by liquid-chromatographic separation of malondialdehyde-thiobarbituric acid adduct. Clin Chem (1987) 1.75
Aging and oxidative stress: modulation by dietary restriction. Free Radic Biol Med (1996) 1.74
Effect of age and caloric intake on protein oxidation in different brain regions and on behavioral functions of the mouse. Arch Biochem Biophys (1996) 1.70
Longevity, body weight, and neoplasia in ad libitum-fed and diet-restricted C57BL6 mice fed NIH-31 open formula diet. Toxicol Pathol (1996) 1.69
Mitochondrial superoxide and hydrogen peroxide generation, protein oxidative damage, and longevity in different species of flies. Free Radic Biol Med (1995) 1.62
DNA oxidative damage and life expectancy in houseflies. Proc Natl Acad Sci U S A (1994) 1.62
Mitochondrial oxidative damage, hydrogen peroxide release, and aging. Free Radic Biol Med (1994) 1.61
Do mitochondria produce oxygen radicals in vivo? Eur J Biochem (1978) 1.51
Hydrogen peroxide release by mitochondria increases during aging. Mech Ageing Dev (1991) 1.50
Dietary restriction benefits learning and motor performance of aged mice. J Gerontol (1987) 1.48
Dietary restriction and aging. J Am Geriatr Soc (1993) 1.18
Interventions based on the possibility that oxidative stress contributes to sarcopenia. J Gerontol A Biol Sci Med Sci (1995) 1.11
Effect of age on the function of mitochondria isolated from brain and heart tissue. Exp Gerontol (1980) 0.93
Age-related changes in skeletal muscle function. Aging (Milano) (1990) 0.87
The physiology and biochemistry of skeletal muscle atrophy as a function of age. Proc Soc Exp Biol Med (1994) 0.87
Effect of aging on the oxidative phosphorylation pathway. Mech Ageing Dev (1990) 0.82
Changes in the expression of genes involved in protecting cells against stress and free radicals. Aging (Milano) (1991) 0.80
Oxidative stress, caloric restriction, and aging. Science (1996) 11.07
Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science (2005) 9.57
Gene expression profile of aging and its retardation by caloric restriction. Science (1999) 8.06
Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster. Science (1994) 5.86
Gene-expression profile of the ageing brain in mice. Nat Genet (2000) 5.46
The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake. J Nutr (1986) 4.81
Seminars in medicine of the Beth Israel Deaconess Medical Center. Caloric intake and aging. N Engl J Med (1997) 4.26
Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys. Proc Natl Acad Sci U S A (2001) 3.63
Dietary restriction in mice beginning at 1 year of age: effect on life-span and spontaneous cancer incidence. Science (1982) 3.59
Biomarkers of oxidative stress study II: are oxidation products of lipids, proteins, and DNA markers of CCl4 poisoning? Free Radic Biol Med (2005) 3.13
Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse. Mech Ageing Dev (1994) 2.96
Oxidative damage during aging targets mitochondrial aconitase. Proc Natl Acad Sci U S A (1997) 2.76
Food production and the energy crisis. Science (1973) 2.55
N.m.r. and molecular-modelling studies of the solution conformation of heparin. Biochem J (1993) 2.36
Calorie restriction lowers body temperature in rhesus monkeys, consistent with a postulated anti-aging mechanism in rodents. Proc Natl Acad Sci U S A (1996) 2.23
Relationship between mitochondrial superoxide and hydrogen peroxide production and longevity of mammalian species. Free Radic Biol Med (1993) 2.22
Dietary restriction of adult male rhesus monkeys: design, methodology, and preliminary findings from the first year of study. J Gerontol (1993) 2.17
Effect of age and caloric restriction on DNA oxidative damage in different tissues of C57BL/6 mice. Mech Ageing Dev (1994) 2.16
Mitochondrial adenine nucleotide translocase is modified oxidatively during aging. Proc Natl Acad Sci U S A (1998) 2.15
Dietary restriction increases insulin sensitivity and lowers blood glucose in rhesus monkeys. Am J Physiol (1994) 2.13
Dietary restriction and aging in rhesus monkeys: the University of Wisconsin study. Exp Gerontol (2000) 2.02
Age-related losses of cognitive function and motor skills in mice are associated with oxidative protein damage in the brain. Proc Natl Acad Sci U S A (1996) 1.97
Coxsackie B viral myocarditis and valvulitis identified in routine autopsy specimens by immunofluorescent techniques. Am Heart J (1967) 1.88
Conformation and dynamics of heparin and heparan sulfate. Glycobiology (2000) 1.88
Dietary restriction and aging: the initiation of a primate study. J Gerontol (1990) 1.84
Effect of age and caloric intake on protein oxidation in different brain regions and on behavioral functions of the mouse. Arch Biochem Biophys (1996) 1.70
Lifelong voluntary exercise in the mouse prevents age-related alterations in gene expression in the heart. Physiol Genomics (2003) 1.66
Age-related changes in activities of mitochondrial electron transport complexes in various tissues of the mouse. Arch Biochem Biophys (2000) 1.63
Caloric restriction of rhesus monkeys lowers oxidative damage in skeletal muscle. FASEB J (2000) 1.63
Mitochondrial superoxide and hydrogen peroxide generation, protein oxidative damage, and longevity in different species of flies. Free Radic Biol Med (1995) 1.62
DNA oxidative damage and life expectancy in houseflies. Proc Natl Acad Sci U S A (1994) 1.62
Controlling caloric consumption: protocols for rodents and rhesus monkeys. Neurobiol Aging (1999) 1.61
Restriction of energy intake, energy expenditure, and aging. Free Radic Biol Med (2000) 1.51
Hydrogen peroxide release by mitochondria increases during aging. Mech Ageing Dev (1991) 1.50
Interleukin-6 and aging: blood levels and mononuclear cell production increase with advancing age and in vitro production is modifiable by dietary restriction. Lymphokine Cytokine Res (1993) 1.49
Short-term consumption of a resveratrol-containing nutraceutical mixture mimics gene expression of long-term caloric restriction in mouse heart. Exp Gerontol (2008) 1.49
Dietary restriction benefits learning and motor performance of aged mice. J Gerontol (1987) 1.48
Ageing, oxidative stress, and mitochondrial uncoupling. Acta Physiol Scand (2004) 1.42
Caloric intake and aging: mechanisms in rodents and a study in nonhuman primates. Toxicol Sci (1999) 1.37
Dietary intervention at middle age: caloric restriction but not dehydroepiandrosterone sulfate increases lifespan and lifetime cancer incidence in mice. Cancer Res (1999) 1.36
Influences of dietary restriction and age on liver enzyme activities and lipid peroxidation in mice. J Nutr (1987) 1.32
Substrate and site specificity of hydrogen peroxide generation in mouse mitochondria. Arch Biochem Biophys (1998) 1.31
Comparison of mitochondrial pro-oxidant generation and anti-oxidant defenses between rat and pigeon: possible basis of variation in longevity and metabolic potential. Mech Ageing Dev (1993) 1.31
A novel hypothesis of lipofuscinogenesis and cellular aging based on interactions between oxidative stress and autophagocytosis. Mutat Res (1992) 1.31
High levels of mitochondrial DNA deletions in skeletal muscle of old rhesus monkeys. Mech Ageing Dev (1995) 1.29
The peroxiredoxin gene family in Drosophila melanogaster. Free Radic Biol Med (2001) 1.26
Selectivity of protein oxidative damage during aging in Drosophila melanogaster. Biochem J (2001) 1.24
Relationship between physical activity and life span in the adult housefly, Musca domestica. Exp Gerontol (1981) 1.24
Acromegaly. Clinical and biochemical features in 500 patients. Medicine (Baltimore) (1994) 1.24
Oxidative stress and aging reduce COX I RNA and cytochrome oxidase activity in Drosophila. Free Radic Biol Med (1998) 1.23
Effects of Cu-Zn superoxide dismutase overexpression of life span and resistance to oxidative stress in transgenic Drosophila melanogaster. Arch Biochem Biophys (1993) 1.23
Coxsackie virus B4 pancarditis in cynomolgus monkeys resembling rheumatic heart lesions. Br J Exp Pathol (1967) 1.23
Mitotic activity in mice is suppressed by energy restriction-induced torpor. J Nutr (1992) 1.21
Electron transport-linked ubiquinone-dependent recycling of alpha-tocopherol inhibits autooxidation of mitochondrial membranes. Arch Biochem Biophys (1998) 1.19
Caloric restriction reduces fiber loss and mitochondrial abnormalities in aged rat muscle. FASEB J (1997) 1.19
Biomarkers of oxidative stress study: are plasma antioxidants markers of CCl(4) poisoning? Free Radic Biol Med (2000) 1.19
Adult-onset energy restriction of rhesus monkeys attenuates oxidative stress-induced cytokine expression by peripheral blood mononuclear cells. J Nutr (1997) 1.19
Energy expenditure of adult male rhesus monkeys during the first 30 mo of dietary restriction. Am J Physiol (1997) 1.19
Aging and proteolysis of oxidized proteins. Arch Biochem Biophys (1994) 1.18
Association of age-related mitochondrial abnormalities with skeletal muscle fiber atrophy. Free Radic Biol Med (1998) 1.18
Effect of antioxidants on androgen-induced AP-1 and NF-kappaB DNA-binding activity in prostate carcinoma cells. J Natl Cancer Inst (1999) 1.14
Influences of age and dietary restriction on gastrocnemius electron transport system activities in mice. Arch Biochem Biophys (1996) 1.14
Effects of coenzyme Q10 and alpha-tocopherol administration on their tissue levels in the mouse: elevation of mitochondrial alpha-tocopherol by coenzyme Q10. Free Radic Biol Med (1999) 1.13
The effects of catalase gene overexpression on life span and resistance to oxidative stress in transgenic Drosophila melanogaster. Arch Biochem Biophys (1992) 1.13
Overexpression of glutathione reductase extends survival in transgenic Drosophila melanogaster under hyperoxia but not normoxia. FASEB J (1999) 1.13
Antioxidant status and stress resistance in long- and short-lived lines of Drosophila melanogaster. Exp Gerontol (2001) 1.12
Reversible effects of long-term caloric restriction on protein oxidative damage. J Gerontol A Biol Sci Med Sci (2000) 1.12
Relationship between life expectancy, endogenous antioxidants and products of oxygen free radical reactions in the housefly, Musca domestica. Mech Ageing Dev (1986) 1.10
Age-associated alterations of the mitochondrial genome. Free Radic Biol Med (1997) 1.10
Relationship between susceptibility to protein oxidation, aging, and maximum life span potential of different species. Exp Gerontol (1998) 1.09
Overexpression of Mn-containing superoxide dismutase in transgenic Drosophila melanogaster. Arch Biochem Biophys (1999) 1.08
Influences of dietary restriction on immunity to influenza in aged mice. J Gerontol (1991) 1.06
Dietary restriction and aging: historical phases, mechanisms and current directions. J Nutr (1987) 1.06
Immunofluorescent study of B4 Coxsackievirus valvulitis in mice. Proc Soc Exp Biol Med (1967) 1.06
Prevention of flight activity prolongs the life span of the housefly, Musca domestica, and attenuates the age-associated oxidative damamge to specific mitochondrial proteins. Free Radic Biol Med (2000) 1.06
Influence of dietary restriction and aging on natural killer cell activity in mice. J Immunol (1983) 1.05
Age-related changes in antioxidant enzymes and prooxidant generation in tissues of the rat with special reference to parameters in two insect species. Free Radic Biol Med (1990) 1.05
Multiple mitochondrial DNA deletions associated with age in skeletal muscle of rhesus monkeys. J Gerontol (1993) 1.04
Identification of oxidized proteins based on sodium dodecyl sulfate-polyacrylamide gel electrophoresis, immunochemical detection, isoelectric focusing, and microsequencing. Anal Biochem (1998) 1.03
Oxidative stress and aging in the Mongolian gerbil (Meriones unguiculatus). Mech Ageing Dev (1995) 1.03
Caloric restriction attenuates dityrosine cross-linking of cardiac and skeletal muscle proteins in aging mice. Arch Biochem Biophys (1997) 1.02
Caloric restriction and body weight independently affect longevity in Wistar rats. Int J Obes Relat Metab Disord (2004) 1.02
Cellular phenotypes of age-associated skeletal muscle mitochondrial abnormalities in rhesus monkeys. Mutat Res (2000) 1.02
Ultrastructural localization of Coxsackie B4 virus in mouse myocardium. Nature (1967) 1.01
Mating behavior, physical activity and aging in the housefly, Musca domestica. Exp Gerontol (1973) 1.01
Superoxide anion radical production in different animal species. Mech Ageing Dev (1989) 1.01
Modification of age-related immune decline in mice dietarily restricted from or after midadulthood. Proc Natl Acad Sci U S A (1982) 1.00
Interstitial and coxsackievirus B myocarditis in infants and children. A comparative histologic and immunofluorescent study of 50 autopsied hearts. JAMA (1968) 1.00
Changes in ultrastructure and respiratory control in mitochondria of rat heart hypertrophied by exercise. Exp Mol Pathol (1968) 1.00
Dopamine transporter binding without cocaine-like behavioral effects: synthesis and evaluation of benztropine analogs alone and in combination with cocaine in rodents. Psychopharmacology (Berl) (2001) 1.00
Multiple age-associated mitochondrial DNA deletions in skeletal muscle of mice. Aging (Milano) (1994) 1.00
Effect of age and caloric restriction on bleomycin-chelatable and nonheme iron in different tissues of C57BL/6 mice. Free Radic Biol Med (1999) 0.99
Relationship between antioxidant defenses and longevity in different mammalian species. Mech Ageing Dev (1990) 0.99
Relationship between catalase activity, life span and some parameters associated with antioxidant defenses in Drosophila melanogaster. Mech Ageing Dev (1992) 0.98
Relationship between metabolic rate, free radicals, differentiation and aging: a unified theory. Basic Life Sci (1985) 0.98