Published in Bioorg Med Chem on April 28, 2012
First-in-man clinical trial of the oral pan-AKT inhibitor MK-2206 in patients with advanced solid tumors. J Clin Oncol (2011) 4.53
IMA: an R package for high-throughput analysis of Illumina's 450K Infinium methylation data. Bioinformatics (2012) 2.97
Synthesis and antimicrobial activities of Schiff bases derived from 5-chloro-salicylaldehyde. Eur J Med Chem (2006) 2.78
Enamines as novel antibacterials and their structure-activity relationships. Eur J Med Chem (2007) 2.65
Extracellular matrix metalloproteinase inducer stimulates tumor angiogenesis by elevating vascular endothelial cell growth factor and matrix metalloproteinases. Cancer Res (2005) 2.42
Targeting CCL2 with systemic delivery of neutralizing antibodies induces prostate cancer tumor regression in vivo. Cancer Res (2007) 2.31
Synthesis, structure, and structure-activity relationship analysis of enamines as potential antibacterials. Bioorg Med Chem (2007) 2.29
Synthesis, molecular modeling, and biological evaluation of cinnamic acid metronidazole ester derivatives as novel anticancer agents. Bioorg Med Chem (2010) 2.25
The matrix metalloproteinase-9/neutrophil gelatinase-associated lipocalin complex plays a role in breast tumor growth and is present in the urine of breast cancer patients. Clin Cancer Res (2005) 2.14
Polyphenols based on isoflavones as inhibitors of Helicobacter pylori urease. Bioorg Med Chem (2007) 2.13
eEF-2 kinase dictates cross-talk between autophagy and apoptosis induced by Akt Inhibition, thereby modulating cytotoxicity of novel Akt inhibitor MK-2206. Cancer Res (2011) 2.10
CCL2 as an important mediator of prostate cancer growth in vivo through the regulation of macrophage infiltration. Neoplasia (2007) 1.91
TNF-alpha drives remodeling of blood vessels and lymphatics in sustained airway inflammation in mice. J Clin Invest (2009) 1.76
Tumor-stroma interaction: positive feedback regulation of extracellular matrix metalloproteinase inducer (EMMPRIN) expression and matrix metalloproteinase-dependent generation of soluble EMMPRIN. Mol Cancer Res (2004) 1.73
Synthesis and cytotoxic evaluation of a series of resveratrol derivatives modified in C2 position. Eur J Med Chem (2006) 1.65
Synthesis, antiproliferative activity, and structure-activity relationships of 3-aryl-1H-quinolin-4-ones. ChemMedChem (2008) 1.64
Metronidazole-flavonoid derivatives as anti-Helicobacter pylori agents with potent inhibitory activity against HPE-induced interleukin-8 production by AGS cells. ChemMedChem (2007) 1.62
Synthesis, molecular docking and biological evaluation of Schiff base transition metal complexes as potential urease inhibitors. Eur J Med Chem (2010) 1.61
Synthesis, crystal structure and antimicrobial activity of deoxybenzoin derivatives from genistein. Eur J Med Chem (2007) 1.57
Effect of a novel inhibitory mAb against beta-subunit of F1F0 ATPase on HCC. Cancer Biol Ther (2008) 1.54
Passive smoke exposure and risk of diabetes: a meta-analysis of prospective studies. Endocrine (2014) 1.52
Selective fluorescent probes for live-cell monitoring of sulphide. Nat Commun (2011) 1.51
Synthesis, antiproliferative evaluation, and structure-activity relationships of 3-arylquinolines. ChemMedChem (2008) 1.50
Regulation of vascular endothelial growth factor expression by EMMPRIN via the PI3K-Akt signaling pathway. Mol Cancer Res (2006) 1.45
Synthesis, structure, molecular docking, and structure-activity relationship analysis of enamines: 3-aryl-4-alkylaminofuran-2(5H)-ones as potential antibacterials. Bioorg Med Chem (2011) 1.44
Extracellular matrix metalloproteinase inducer (CD147) confers resistance of breast cancer cells to Anoikis through inhibition of Bim. J Biol Chem (2006) 1.41
Synthesis, molecular docking and kinetic properties of β-hydroxy-β-phenylpropionyl-hydroxamic acids as Helicobacter pylori urease inhibitors. Eur J Med Chem (2013) 1.40
Up-regulation of tumor suppressor genes might promote the malignant phenotype of cancer cells. Med Hypotheses (2007) 1.39
Schiff base transition metal complexes as novel inhibitors of xanthine oxidase. Eur J Med Chem (2007) 1.36
MK-2206, a novel allosteric inhibitor of Akt, synergizes with gefitinib against malignant glioma via modulating both autophagy and apoptosis. Mol Cancer Ther (2011) 1.33
Synthesis of some N-alkyl substituted urea derivatives as antibacterial and antifungal agents. Eur J Med Chem (2010) 1.33
Soft-templated mesoporous carbon-carbon nanotube composites for high performance lithium-ion batteries. Adv Mater (2011) 1.32
Distribution of enteroviruses in hospitalized children with hand, foot and mouth disease and relationship between pathogens and nervous system complications. Virol J (2012) 1.30
Expression profile of cancer-testis genes in 121 human colorectal cancer tissue and adjacent normal tissue. Clin Cancer Res (2005) 1.24
Differential expression of extracellular matrix metalloproteinase inducer (CD147) in normal and ulcerated corneas: role in epithelio-stromal interactions and matrix metalloproteinase induction. Am J Pathol (2005) 1.24
Synthesis and antiproliferative activity of indolizine derivatives incorporating a cyclopropylcarbonyl group against Hep-G2 cancer cell line. Eur J Med Chem (2010) 1.23
Synthesis, structure and antibacterial activity of new 2-(1-(2-(substituted-phenyl)-5-methyloxazol-4-yl)-3-(2-substitued-phenyl)-4,5-dihydro-1H-pyrazol-5-yl)-7-substitued-1,2,3,4-tetrahydroisoquinoline derivatives. Bioorg Med Chem (2008) 1.20
Phase 1 trial of the oral AKT inhibitor MK-2206 plus carboplatin/paclitaxel, docetaxel, or erlotinib in patients with advanced solid tumors. J Hematol Oncol (2014) 1.20
The synthesis, structure and activity evaluation of pyrogallol and catechol derivatives as Helicobacter pylori urease inhibitors. Eur J Med Chem (2010) 1.20
Generation, characterization and biological activity of CCL2 (MCP-1/JE) and CCL12 (MCP-5) specific antibodies. Hum Antibodies (2007) 1.19
HIV incidence among men who have sex with men in Beijing: a prospective cohort study. BMJ Open (2012) 1.19
Synthesis, molecular modeling and biological evaluation of chalcone thiosemicarbazide derivatives as novel anticancer agents. Eur J Med Chem (2011) 1.18
A novel hepatitis B virus genotyping system by using restriction fragment length polymorphism patterns of S gene amplicons. World J Gastroenterol (2004) 1.17
Synthesis, structure and structure-activity relationship analysis of 3-tert-butoxycarbonyl-2-arylthiazolidine-4-carboxylic acid derivatives as potential antibacterial agents. Eur J Med Chem (2009) 1.17
Evaluation of the 4q32-34 locus in European familial pancreatic cancer. Cancer Epidemiol Biomarkers Prev (2006) 1.16
Anti-EMMPRIN monoclonal antibody as a novel agent for therapy of head and neck cancer. Clin Cancer Res (2009) 1.16
Targeting the PI3K-AKT-mTOR signaling network in cancer. Chin J Cancer (2013) 1.15
Cohort profile: risk evaluation of cancers in Chinese diabetic individuals: a longitudinal (REACTION) study. J Diabetes (2014) 1.15
Synthesis, molecular docking and evaluation of thiazolyl-pyrazoline derivatives as EGFR TK inhibitors and potential anticancer agents. Bioorg Med Chem Lett (2011) 1.14
Synthesis, molecular docking and biological evaluation of metronidazole derivatives as potent Helicobacter pylori urease inhibitors. Bioorg Med Chem (2009) 1.14
A method for systematic mapping of protein lysine methylation identifies functions for HP1β in DNA damage response. Mol Cell (2013) 1.14
Synthesis and cytotoxic evaluation of a series of genistein derivatives. Chem Biodivers (2006) 1.14
Willingness to accept HIV pre-exposure prophylaxis among Chinese men who have sex with men. PLoS One (2012) 1.14
Physiologically based synthetic models of hepatic disposition. J Pharmacokinet Pharmacodyn (2006) 1.13
Synthesis of resveratrol analogues, and evaluation of their cytotoxic and xanthine oxidase inhibitory activities. Chem Biodivers (2008) 1.13
Tyrosyl-tRNA synthetase inhibitors as antibacterial agents: synthesis, molecular docking and structure-activity relationship analysis of 3-aryl-4-arylaminofuran-2(5H)-ones. Eur J Med Chem (2011) 1.12
Prenatal immune challenge is an environmental risk factor for brain and behavior change relevant to schizophrenia: evidence from MRI in a mouse model. PLoS One (2009) 1.10
Peer influences and access to cigarettes as correlates of adolescent smoking: a cross-cultural comparison of Wuhan, China, and California. Prev Med (2002) 1.10
Synthesis and antimicrobial activities of 7-O-modified genistein derivatives. Eur J Med Chem (2007) 1.10
Later onset phenotypes of Krabbe disease: results of the world-wide registry. Pediatr Neurol (2012) 1.09
Disruption of the AKT pathway inhibits metastasis in an orthotopic model of head and neck squamous cell carcinoma. Laryngoscope (2011) 1.09
Curcumin and its formulations: potential anti-cancer agents. Anticancer Agents Med Chem (2012) 1.08
Synthesis and biological evaluation of pyrazole derivatives containing thiourea skeleton as anticancer agents. Bioorg Med Chem (2010) 1.07
The expression of hypoxia-inducible factor-1alpha in hepatitis B virus-related hepatocellular carcinoma: correlation with patients' prognosis and hepatitis B virus X protein. Dig Dis Sci (2008) 1.07
4-alkoxy-3-arylfuran-2(5H)-ones as inhibitors of tyrosyl-tRNA synthetase: synthesis, molecular docking and antibacterial evaluation. Bioorg Med Chem (2011) 1.07
Effect of inhaled magnesium sulfate on bronchial hyperresponsiveness. Indian J Pediatr (2014) 1.06
Synthesis, antibacterial activities and molecular docking studies of Schiff bases derived from N-(2/4-benzaldehyde-amino) phenyl-N'-phenyl-thiourea. Bioorg Med Chem (2011) 1.06
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New irrigation methods sustain malaria control in Sichuan Province, China. Acta Trop (2004) 1.05
Cancer stem cell marker CD133+ tumour cells and clinical outcome in rectal cancer. Histopathology (2009) 1.04
Design and synthesis of potent inhibitors of beta-ketoacyl-acyl carrier protein synthase III (FabH) as potential antibacterial agents. Eur J Med Chem (2010) 1.04
Involvement of RAGE, MAPK and NF-κB pathways in AGEs-induced MMP-9 activation in HaCaT keratinocytes. Exp Dermatol (2012) 1.04
Toxic effect of gestational exposure to nonylphenol on F1 male rats. Birth Defects Res B Dev Reprod Toxicol (2010) 1.03
A serum proteomic pattern for the detection of colorectal adenocarcinoma using surface enhanced laser desorption and ionization mass spectrometry. Cancer Invest (2006) 1.03
MicroRNA-181a promotes tumor growth and liver metastasis in colorectal cancer by targeting the tumor suppressor WIF-1. Mol Cancer (2014) 1.03
A phase 1 study evaluating the combination of an allosteric AKT inhibitor (MK-2206) and trastuzumab in patients with HER2-positive solid tumors. Breast Cancer Res (2013) 1.03
Screening and prevalence of peripheral neuropathy in type 2 diabetic outpatients: a randomized multicentre survey in 12 city hospitals of China. Diabetes Metab Res Rev (2010) 1.02
The expression of monocyte chemotactic protein-1 in papillary thyroid carcinoma is correlated with lymph node metastasis and tumor recurrence. Thyroid (2009) 1.02
Mesenchymal stem cells alleviate TNBS-induced colitis by modulating inflammatory and autoimmune responses. World J Gastroenterol (2013) 1.02
Epithelial morphogenesis in hydra requires de novo expression of extracellular matrix components and matrix metalloproteinases. Development (2002) 1.01
Family characteristics and smoking among urban and rural adolescents living in China. Prev Med (2005) 1.01
Synthesis, structure and antibacterial activity of novel 1-(5-substituted-3-substituted-4,5-dihydropyrazol-1-yl)ethanone oxime ester derivatives. Bioorg Med Chem (2008) 1.01
Sodium tanshinone IIA sulfonate depresses angiotensin II-induced cardiomyocyte hypertrophy through MEK/ERK pathway. Exp Mol Med (2007) 1.00
Mesoporous TiO2-B microspheres with superior rate performance for lithium ion batteries. Adv Mater (2011) 1.00
Monoclonal antibodies as therapeutics in oncology. Curr Opin Biotechnol (2002) 1.00
Dynamic methylation of Numb by Set8 regulates its binding to p53 and apoptosis. Mol Cell (2013) 1.00
1,3,4-oxadiazole derivatives as potential biological agents. Mini Rev Med Chem (2013) 1.00
The role of G protein-coupled receptor 40 in lipoapoptosis in mouse beta-cell line NIT-1. J Mol Endocrinol (2007) 1.00
Neuronal activation of Ras regulates synaptic connectivity. Eur J Neurosci (2004) 0.99
Synthesis and cytotoxic evaluation of a series of resveratrol derivatives. Chem Biodivers (2006) 0.99
The function of the SNP in the MMP1 and MMP3 promoter in susceptibility to endometriosis in China. Mol Hum Reprod (2005) 0.98
Design, synthesis and biological evaluation of thiazolidinone derivatives as potential EGFR and HER-2 kinase inhibitors. Bioorg Med Chem (2009) 0.97
Use of eye care services among diabetic patients in urban and rural China. Ophthalmology (2010) 0.96
Dynamic changes in matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 levels during wound healing in diabetic rats. J Am Podiatr Med Assoc (2009) 0.96
ER+ /PR+ /TFF3+ /IMP3- immunoprofile distinguishes endometrioid from serous and clear cell carcinomas of the endometrium: a study of 401 cases. Histopathology (2013) 0.95
Urea derivatives as anticancer agents. Anticancer Agents Med Chem (2009) 0.95
Biphasic insulin aspart 30 three times daily is more effective than a twice-daily regimen, without increasing hypoglycemia, in Chinese subjects with type 2 diabetes inadequately controlled on oral antidiabetes drugs. Diabetes Care (2008) 0.95