Published in J Am Chem Soc on May 25, 2012
Navigating the fungal polyketide chemical space: from genes to molecules. J Org Chem (2012) 1.36
Strategies for mining fungal natural products. J Ind Microbiol Biotechnol (2013) 1.21
Bioinformatics tools for genome mining of polyketide and non-ribosomal peptides. J Ind Microbiol Biotechnol (2013) 0.96
Discovery of cryptic polyketide metabolites from dermatophytes using heterologous expression in Aspergillus nidulans. ACS Synth Biol (2013) 0.96
A cytochrome P450 serves as an unexpected terpene cyclase during fungal meroterpenoid biosynthesis. J Am Chem Soc (2013) 0.90
Genome mining of a prenylated and immunosuppressive polyketide from pathogenic fungi. Org Lett (2013) 0.90
Total synthesis and structural revision of viridicatumtoxin B. Angew Chem Int Ed Engl (2013) 0.84
Next-generation sequencing approach for connecting secondary metabolites to biosynthetic gene clusters in fungi. Front Microbiol (2015) 0.82
A genome-wide survey of the secondary metabolite biosynthesis genes in the wheat pathogen Parastagonospora nodorum. Mycology (2014) 0.81
Oxidative Cyclization in Natural Product Biosynthesis. Chem Rev (2016) 0.81
Evolution of Chemical Diversity in a Group of Non-Reduced Polyketide Gene Clusters: Using Phylogenetics to Inform the Search for Novel Fungal Natural Products. Toxins (Basel) (2015) 0.79
Tandem prenyltransferases catalyze isoprenoid elongation and complexity generation in biosynthesis of quinolone alkaloids. J Am Chem Soc (2015) 0.77
Total synthesis of viridicatumtoxin B and analogues thereof: strategy evolution, structural revision, and biological evaluation. J Am Chem Soc (2014) 0.75
MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Mol Biol Evol (2011) 220.97
Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus. Nature (2005) 8.55
Engineering a mevalonate pathway in Escherichia coli for production of terpenoids. Nat Biotechnol (2003) 6.74
Crystal structure of pentalenene synthase: mechanistic insights on terpenoid cyclization reactions in biology. Science (1997) 4.63
Crystal structures of complexes of the small ribosomal subunit with tetracycline, edeine and IF3. EMBO J (2001) 3.68
Structure and mechanism of inosine monophosphate dehydrogenase in complex with the immunosuppressant mycophenolic acid. Cell (1996) 2.31
Identification and characterization of the asperthecin gene cluster of Aspergillus nidulans. Appl Environ Microbiol (2008) 1.71
Segregation of random amplified DNA markers in F1 progeny of conifers. Theor Appl Genet (1991) 1.63
Tryprostatin A, a specific and novel inhibitor of microtubule assembly. Biochem J (1998) 1.63
Prenyl transfer to aromatic substrates: genetics and enzymology. Curr Opin Chem Biol (2009) 1.62
Identification of the viridicatumtoxin and griseofulvin gene clusters from Penicillium aethiopicum. Chem Biol (2010) 1.51
The ABBA family of aromatic prenyltransferases: broadening natural product diversity. Cell Mol Life Sci (2008) 1.50
The structure of dimethylallyl tryptophan synthase reveals a common architecture of aromatic prenyltransferases in fungi and bacteria. Proc Natl Acad Sci U S A (2009) 1.48
Fungal indole alkaloid biosynthesis: genetic and biochemical investigation of the tryptoquialanine pathway in Penicillium aethiopicum. J Am Chem Soc (2011) 1.41
Metabolomics of Aspergillus fumigatus. Med Mycol (2008) 1.36
Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi. Genome Biol (2011) 1.34
Genome-based deletion analysis reveals the prenyl xanthone biosynthesis pathway in Aspergillus nidulans. J Am Chem Soc (2011) 1.32
Reconstitution of a fungal meroterpenoid biosynthesis reveals the involvement of a novel family of terpene cyclases. Nat Chem (2010) 1.31
Indole prenyltransferases from fungi: a new enzyme group with high potential for the production of prenylated indole derivatives. Curr Med Chem (2009) 1.24
Comparative characterization of fungal anthracenone and naphthacenedione biosynthetic pathways reveals an α-hydroxylation-dependent Claisen-like cyclization catalyzed by a dimanganese thioesterase. J Am Chem Soc (2011) 1.22
Molecular cloning and genetic analysis of an indole-diterpene gene cluster from Penicillium paxilli. Mol Microbiol (2001) 1.21
Molecular basis for mycophenolic acid biosynthesis in Penicillium brevicompactum. Appl Environ Microbiol (2011) 1.17
Evolutionary relationships of microbial aromatic prenyltransferases. PLoS One (2011) 1.09
Viridicatumtoxin, a new mycotoxin from Penicillium viridicatum Westling. Toxicol Appl Pharmacol (1973) 1.08
Novel prenyltransferase enzymes as a tool for flavonoid prenylation. Trends Pharmacol Sci (2005) 1.08
Reversal of breast cancer resistance protein-mediated drug resistance by tryprostatin A. Int J Cancer (2003) 1.07
Structure-function analysis of an enzymatic prenyl transfer reaction identifies a reaction chamber with modifiable specificity. J Am Chem Soc (2010) 1.05
Prenylation enhances cytotoxicity of apigenin and liquiritigenin in rat H4IIE hepatoma and C6 glioma cells. Food Chem Toxicol (2006) 1.00
A tyrosine O-prenyltransferase catalyses the first pathway-specific step in the biosynthesis of sirodesmin PL. Microbiology (2009) 0.99
Viridicatumtoxin B, a new anti-MRSA agent from Penicillium sp. FR11. J Antibiot (Tokyo) (2008) 0.99
Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575. J Am Chem Soc (2009) 0.98
Inhibition of DNA gyrase and DNA topoisomerase IV of Staphylococcus aureus and Escherichia coli by aminocoumarin antibiotics. J Antimicrob Chemother (2011) 0.96
Identifying the minimal enzymes required for anhydrotetracycline biosynthesis. J Am Chem Soc (2008) 0.95
Cloning and sequence characterization of a non-reducing polyketide synthase gene from the lichen Xanthoparmelia semiviridis. Mycol Res (2007) 0.90
A new group of aromatic prenyltransferases in fungi, catalyzing a 2,7-dihydroxynaphthalene 3-dimethylallyl-transferase reaction. J Biol Chem (2010) 0.86
Anthrotainin, an inhibitor of substance P binding produced by Gliocladium catenulatum. J Antibiot (Tokyo) (1993) 0.83
Prenylation of flavonoids by biotransformation of yeast expressing plant membrane-bound prenyltransferase SfN8DT-1. Biosci Biotechnol Biochem (2009) 0.82
Chemistry. A new route to designer antibiotics. Science (2005) 0.81
Inhibition of NF-kappa B activation by panepoxydone. Biochem Biophys Res Commun (1996) 0.81
Synthesis and structure-activity relationship studies on tryprostatin A, an inhibitor of breast cancer resistance protein. Bioorg Med Chem (2008) 0.79
Evolutionary and biomedical insights from the rhesus macaque genome. Science (2007) 16.21
Open-source genomic analysis of Shiga-toxin-producing E. coli O104:H4. N Engl J Med (2011) 7.11
The Drosophila RNA methyltransferase, DmHen1, modifies germline piRNAs and single-stranded siRNAs in RISC. Curr Biol (2007) 5.35
Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell (2002) 5.11
Negative regulation of the deacetylase SIRT1 by DBC1. Nature (2008) 4.29
Rates of adult schizophrenia following prenatal exposure to the Chinese famine of 1959-1961. JAMA (2005) 3.83
MicroRNA-146a feedback inhibits RIG-I-dependent Type I IFN production in macrophages by targeting TRAF6, IRAK1, and IRAK2. J Immunol (2009) 3.72
Improved graft mesenchymal stem cell survival in ischemic heart with a hypoxia-regulated heme oxygenase-1 vector. J Am Coll Cardiol (2005) 3.40
Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease. Nat Neurosci (2009) 3.24
Lysine propionylation and butyrylation are novel post-translational modifications in histones. Mol Cell Proteomics (2007) 3.09
Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo. Proc Natl Acad Sci U S A (2004) 3.06
Complete reconstitution of a highly reducing iterative polyketide synthase. Science (2009) 2.68
Image-based genome-wide siRNA screen identifies selective autophagy factors. Nature (2011) 2.58
Near-infrared fluorescent nanoparticles as combined MR/optical imaging probes. Bioconjug Chem (2002) 2.45
GLK transcription factors coordinate expression of the photosynthetic apparatus in Arabidopsis. Plant Cell (2009) 2.35
Tembusu virus in ducks, china. Emerg Infect Dis (2011) 2.30
Immune epitope database analysis resource (IEDB-AR). Nucleic Acids Res (2008) 2.14
Transcriptional reprogramming of mature CD4⁺ helper T cells generates distinct MHC class II-restricted cytotoxic T lymphocytes. Nat Immunol (2013) 2.11
Immune epitope database analysis resource. Nucleic Acids Res (2012) 2.09
Engineered lentivector targeting of dendritic cells for in vivo immunization. Nat Biotechnol (2008) 2.05
PUMA Dissociates Bax and Bcl-X(L) to induce apoptosis in colon cancer cells. J Biol Chem (2006) 2.02
The anti-inflammatory TIPE2 is an inhibitor of the oncogenic Ras. Mol Cell (2012) 2.01
Following cytochrome c release, autophagy is inhibited during chemotherapy-induced apoptosis by caspase 8-mediated cleavage of Beclin 1. Cancer Res (2011) 1.99
A novel intracellular protein delivery platform based on single-protein nanocapsules. Nat Nanotechnol (2009) 1.94
HMGB1 contributes to kidney ischemia reperfusion injury. J Am Soc Nephrol (2010) 1.89
Common variants on 8p12 and 1q24.2 confer risk of schizophrenia. Nat Genet (2011) 1.88
MicroRNA-99a inhibits hepatocellular carcinoma growth and correlates with prognosis of patients with hepatocellular carcinoma. J Biol Chem (2011) 1.88
Phosphorylation of Tip60 by GSK-3 determines the induction of PUMA and apoptosis by p53. Mol Cell (2011) 1.87
A comprehensive analysis of the dual roles of BMPs in regulating adipogenic and osteogenic differentiation of mesenchymal progenitor cells. Stem Cells Dev (2009) 1.87
Dynamic O-GlcNAc cycling at promoters of Caenorhabditis elegans genes regulating longevity, stress, and immunity. Proc Natl Acad Sci U S A (2010) 1.86
A major QTL, Ghd8, plays pleiotropic roles in regulating grain productivity, plant height, and heading date in rice. Mol Plant (2010) 1.80
An organic D-π-A dye for record efficiency solid-state sensitized heterojunction solar cells. Nano Lett (2011) 1.74
MicroRNA-466l upregulates IL-10 expression in TLR-triggered macrophages by antagonizing RNA-binding protein tristetraprolin-mediated IL-10 mRNA degradation. J Immunol (2010) 1.74
K-ras(G12V) transformation leads to mitochondrial dysfunction and a metabolic switch from oxidative phosphorylation to glycolysis. Cell Res (2011) 1.72
Targeting lentiviral vectors to specific cell types in vivo. Proc Natl Acad Sci U S A (2006) 1.71
Tgf-Beta signaling in development. Sci STKE (2007) 1.70
Regulation of Cdx2 expression by promoter methylation, and effects of Cdx2 transfection on morphology and gene expression of human esophageal epithelial cells. Carcinogenesis (2006) 1.68
Enhance the optical absorptivity of nanocrystalline TiO2 film with high molar extinction coefficient ruthenium sensitizers for high performance dye-sensitized solar cells. J Am Chem Soc (2008) 1.68
Fabrication of porous ultra-short single-walled carbon nanotube nanocomposite scaffolds for bone tissue engineering. Biomaterials (2007) 1.67
Free-standing graphene at atomic resolution. Nat Nanotechnol (2008) 1.63
High-resolution detection of Au catalyst atoms in Si nanowires. Nat Nanotechnol (2008) 1.61
Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis. World J Gastroenterol (2004) 1.58
p53 independent induction of PUMA mediates intestinal apoptosis in response to ischaemia-reperfusion. Gut (2006) 1.56
Enzymatic synthesis of aromatic polyketides using PKS4 from Gibberella fujikuroi. J Am Chem Soc (2007) 1.55
Functional CT for quantifying tumor perfusion in antiangiogenic therapy in a rat model. Radiology (2005) 1.55
Assembly of bacterial inner membrane proteins. Annu Rev Biochem (2011) 1.54
A polyketide macrolactone synthase from the filamentous fungus Gibberella zeae. Proc Natl Acad Sci U S A (2008) 1.54
Listeriosis at a tertiary care hospital in beijing, china: high prevalence of nonclustered healthcare-associated cases among adult patients. Clin Infect Dis (2012) 1.52
Identification of the viridicatumtoxin and griseofulvin gene clusters from Penicillium aethiopicum. Chem Biol (2010) 1.51
Protection from ischemic heart injury by a vigilant heme oxygenase-1 plasmid system. Hypertension (2004) 1.50
Cutting edge: murine cytomegalovirus induces a polyfunctional CD4 T cell response. J Immunol (2008) 1.50
Glioma therapy and real-time imaging of neural precursor cell migration and tumor regression. Ann Neurol (2005) 1.48
Genomewide clonal analysis of lethal mutations in the Drosophila melanogaster eye: comparison of the X chromosome and autosomes. Genetics (2007) 1.44
Tailoring nanocarriers for intracellular protein delivery. Chem Soc Rev (2011) 1.42
Matrix metalloproteinases in human sclerotic dentine of attrited molars. Arch Oral Biol (2012) 1.42
Enzymatic synthesis of resorcylic acid lactones by cooperation of fungal iterative polyketide synthases involved in hypothemycin biosynthesis. J Am Chem Soc (2010) 1.41
Fungal indole alkaloid biosynthesis: genetic and biochemical investigation of the tryptoquialanine pathway in Penicillium aethiopicum. J Am Chem Soc (2011) 1.41
Extracellular matrix metalloproteinase inducer (CD147) confers resistance of breast cancer cells to Anoikis through inhibition of Bim. J Biol Chem (2006) 1.41
A tumor suppressor function of Smurf2 associated with controlling chromatin landscape and genome stability through RNF20. Nat Med (2012) 1.40
Magnetic sensors for protease assays. Angew Chem Int Ed Engl (2003) 1.39
Post-anthesis development of inferior and superior spikelets in rice in relation to abscisic acid and ethylene. J Exp Bot (2005) 1.38
Effects of low concentrations of benzene exposure on levels of platelet-associated antibodies and platelet parameters. J Occup Environ Med (2014) 1.38
Navigating the fungal polyketide chemical space: from genes to molecules. J Org Chem (2012) 1.36
The role of TGF-beta and Wnt signaling in gastrointestinal stem cells and cancer. Oncogene (2005) 1.35
Crystal structure and functional analysis of tetracenomycin ARO/CYC: implications for cyclization specificity of aromatic polyketides. Proc Natl Acad Sci U S A (2008) 1.34
Molecular characterization of propionyllysines in non-histone proteins. Mol Cell Proteomics (2008) 1.33
Redirecting the cyclization steps of fungal polyketide synthase. J Am Chem Soc (2007) 1.32
Cyclophosphamide increases transgene expression mediated by an oncolytic adenovirus in glioma-bearing mice monitored by bioluminescence imaging. Mol Ther (2006) 1.32
Classification, prediction, and verification of the regioselectivity of fungal polyketide synthase product template domains. J Biol Chem (2010) 1.28
Role of Nedd4 and ubiquitination of Rous sarcoma virus Gag in budding of virus-like particles from cells. J Virol (2004) 1.27
Ablation of Smurf2 reveals an inhibition in TGF-β signalling through multiple mono-ubiquitination of Smad3. EMBO J (2011) 1.27
A pilot study of morphometric analysis of choroidal vasculature in vivo, using en face optical coherence tomography. PLoS One (2012) 1.27
Degradation of regulator of calcineurin 1 (RCAN1) is mediated by both chaperone-mediated autophagy and ubiquitin proteasome pathways. FASEB J (2009) 1.25
Quantification of nanoscale nuclear refractive index changes during the cell cycle. J Biomed Opt (2011) 1.25
TLR-induced NF-κB activation regulates NLRP3 expression in murine macrophages. FEBS Lett (2012) 1.24
9-Ethyl-3,6-bis-(1H-imidazol-1-yl)-9H-carbazole. Acta Crystallogr Sect E Struct Rep Online (2008) 1.24
Overexpression of 5-lipoxygenase and cyclooxygenase 2 in hamster and human oral cancer and chemopreventive effects of zileuton and celecoxib. Clin Cancer Res (2005) 1.23
A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-kappaB signaling. J Biol Chem (2010) 1.23
microRNA-210 negatively regulates LPS-induced production of proinflammatory cytokines by targeting NF-κB1 in murine macrophages. FEBS Lett (2012) 1.23
Plasmonic gold nanocrystals coupled with photonic crystal seamlessly on TiO2 nanotube photoelectrodes for efficient visible light photoelectrochemical water splitting. Nano Lett (2012) 1.22
Comparative characterization of fungal anthracenone and naphthacenedione biosynthetic pathways reveals an α-hydroxylation-dependent Claisen-like cyclization catalyzed by a dimanganese thioesterase. J Am Chem Soc (2011) 1.22
A designed phenylalanyl-tRNA synthetase variant allows efficient in vivo incorporation of aryl ketone functionality into proteins. J Am Chem Soc (2002) 1.22
Metabolic engineering for the production of natural products. Annu Rev Chem Biomol Eng (2011) 1.22
A dishevelled-1/Smad1 interaction couples WNT and bone morphogenetic protein signaling pathways in uncommitted bone marrow stromal cells. J Biol Chem (2006) 1.22
Interferon gamma induces neurite outgrowth by up-regulation of p35 neuron-specific cyclin-dependent kinase 5 activator via activation of ERK1/2 pathway. J Biol Chem (2005) 1.22
Expression of miR-21, miR-31, miR-96 and miR-135b is correlated with the clinical parameters of colorectal cancer. Oncol Lett (2012) 1.21
High-performance dye-sensitized solar cells based on solvent-free electrolytes produced from eutectic melts. Nat Mater (2008) 1.21
In vitro evaluation of cytotoxicity of engineered metal oxide nanoparticles. Sci Total Environ (2009) 1.20
Geographical, seasonal and gender differences in folate status among Chinese adults. J Nutr (2003) 1.19
Regeneration of the cavernous nerve by Sonic hedgehog using aligned peptide amphiphile nanofibers. Biomaterials (2010) 1.18
Immunization delivered by lentiviral vectors for cancer and infectious diseases. Immunol Rev (2011) 1.18
Quantitative evaluation of protein-DNA interactions using an optimized knowledge-based potential. Nucleic Acids Res (2005) 1.18
Acyltransferase mediated polyketide release from a fungal megasynthase. J Am Chem Soc (2009) 1.18
Shewanella psychrophila sp. nov. and Shewanella piezotolerans sp. nov., isolated from west Pacific deep-sea sediment. Int J Syst Evol Microbiol (2007) 1.18
Insights into radicicol biosynthesis via heterologous synthesis of intermediates and analogs. J Biol Chem (2010) 1.17
A fungal ketoreductase domain that displays substrate-dependent stereospecificity. Nat Chem Biol (2012) 1.17
Cortical microhemorrhages cause local inflammation but do not trigger widespread dendrite degeneration. PLoS One (2011) 1.17
Real-time imaging of TRAIL-induced apoptosis of glioma tumors in vivo. Oncogene (2003) 1.17