Published in J Clin Microbiol on October 21, 2009
Observational Study of Sepsis and Pneumonia to Develop Diagnostic Tests | NCT00258869
Better tests, better care: improved diagnostics for infectious diseases. Clin Infect Dis (2013) 4.27
An integrated clinico-metabolomic model improves prediction of death in sepsis. Sci Transl Med (2013) 2.23
New approaches to sepsis: molecular diagnostics and biomarkers. Clin Microbiol Rev (2012) 2.01
Improved diagnosis of periprosthetic joint infection by multiplex PCR of sonication fluid from removed implants. J Clin Microbiol (2010) 1.94
Multiplex PCR system for rapid detection of pathogens in patients with presumed sepsis - a systemic review and meta-analysis. PLoS One (2013) 1.94
Personalized medicine: new genomics, old lessons. Hum Genet (2011) 1.85
Multiplex PCR allows rapid and accurate diagnosis of bloodstream infections in newborns and children with suspected sepsis. J Clin Microbiol (2011) 1.62
A host-based RT-PCR gene expression signature to identify acute respiratory viral infection. Sci Transl Med (2013) 1.46
Multiplex blood PCR in combination with blood cultures for improvement of microbiological documentation of infection in febrile neutropenia. J Clin Microbiol (2010) 1.38
Molecular diagnosis of sepsis: New aspects and recent developments. Eur J Microbiol Immunol (Bp) (2014) 1.30
Metabolomic derangements are associated with mortality in critically ill adult patients. PLoS One (2014) 1.08
Evaluation of a commercial multiplex PCR test (SeptiFast) in the etiological diagnosis of community-onset bloodstream infections. Eur J Clin Microbiol Infect Dis (2011) 1.08
Bench-to-bedside review: Rapid molecular diagnostics for bloodstream infection--a new frontier? Crit Care (2012) 1.08
Host gene expression classifiers diagnose acute respiratory illness etiology. Sci Transl Med (2016) 1.04
Comparison of pathogen DNA isolation methods from large volumes of whole blood to improve molecular diagnosis of bloodstream infections. PLoS One (2013) 1.04
Gene expression-based classifiers identify Staphylococcus aureus infection in mice and humans. PLoS One (2013) 0.99
Highly sensitive detection of Staphylococcus aureus directly from patient blood. PLoS One (2012) 0.98
Variation-tolerant capture and multiplex detection of nucleic acids: application to detection of microbes. J Clin Microbiol (2012) 0.98
Integrative "omic" analysis of experimental bacteremia identifies a metabolic signature that distinguishes human sepsis from systemic inflammatory response syndromes. Am J Respir Crit Care Med (2014) 0.94
Rapid diagnosis of bloodstream infections with PCR followed by mass spectrometry. PLoS One (2013) 0.94
An efficient strategy for broad-range detection of low abundance bacteria without DNA decontamination of PCR reagents. PLoS One (2011) 0.91
Combination of fluorescence color and melting temperature as a two-dimensional label for homogeneous multiplex PCR detection. Nucleic Acids Res (2013) 0.84
A Broad-Spectrum Infection Diagnostic that Detects Pathogen-Associated Molecular Patterns (PAMPs) in Whole Blood. EBioMedicine (2016) 0.84
An integrated transcriptome and expressed variant analysis of sepsis survival and death. Genome Med (2014) 0.84
Performance of the LightCycler SeptiFast test Mgrade in detecting microbial pathogens in purulent fluids. J Clin Microbiol (2011) 0.83
The development and application of a molecular community profiling strategy to identify polymicrobial bacterial DNA in the whole blood of septic patients. BMC Microbiol (2015) 0.80
Diagnosis by real-time polymerase chain reaction of pathogens and antimicrobial resistance genes in bone marrow transplant patients with bloodstream infections. BMC Infect Dis (2013) 0.80
Species-driven interpretation guidelines in case of a single-sampling strategy for blood culture. Eur J Clin Microbiol Infect Dis (2011) 0.80
Diagnostic performance and therapeutic impact of LightCycler SeptiFast assay in patients with suspected sepsis. Eur J Microbiol Immunol (Bp) (2013) 0.79
Renal systems biology of patients with systemic inflammatory response syndrome. Kidney Int (2015) 0.78
Clinical Relevance of Pathogens Detected by Multiplex PCR in Blood of Very-Low-Birth Weight Infants with Suspected Sepsis - Multicentre Study of the German Neonatal Network. PLoS One (2016) 0.76
Prospective comparison of a PCR assay and a microbiological culture technique for identification of pathogens from blood and non-blood samples in septic patients. J Intensive Care (2015) 0.75
The Role of 16S rRNA Gene Sequencing in Confirmation of Suspected Neonatal Sepsis. J Trop Pediatr (2015) 0.75
Beyond Blood Culture and Gram Stain Analysis: A Review of Molecular Techniques for the Early Detection of Bacteremia in Surgical Patients. Surg Infect (Larchmt) (2016) 0.75
Human genetic and metabolite variation reveals that methylthioadenosine is a prognostic biomarker and an inflammatory regulator in sepsis. Sci Adv (2017) 0.75
Salvage microbiology: opportunities and challenges in the detection of bacterial pathogens following initiation of antimicrobial treatment. Expert Rev Mol Diagn (2014) 0.75
Early aetiological agent identification of osteomyelitis with the Light Cycler SeptiFast test from peripheral blood. BMJ Case Rep (2013) 0.75
Prospective evaluation of SeptiFast Multiplex PCR in children with systemic inflammatory response syndrome under antibiotic treatment. BMC Infect Dis (2016) 0.75
Early Diagnosis of Sepsis: Is an Integrated Omics Approach the Way Forward? Mol Diagn Ther (2017) 0.75
Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med (2001) 51.99
Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med (2001) 46.58
The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med (2003) 32.30
Microbial ecology and evolution: a ribosomal RNA approach. Annu Rev Microbiol (1986) 22.39
The clinical significance of positive blood cultures in the 1990s: a prospective comprehensive evaluation of the microbiology, epidemiology, and outcome of bacteremia and fungemia in adults. Clin Infect Dis (1997) 9.39
Inadequate antimicrobial treatment of infections: a risk factor for hospital mortality among critically ill patients. Chest (1999) 7.40
PCR primers and probes for the 16S rRNA gene of most species of pathogenic bacteria, including bacteria found in cerebrospinal fluid. J Clin Microbiol (1994) 6.33
Real-time PCR in clinical microbiology: applications for routine laboratory testing. Clin Microbiol Rev (2006) 6.03
National Hospital Ambulatory Medical Care Survey: 2006 emergency department summary. Natl Health Stat Report (2008) 5.94
New approaches to typing and identification of bacteria using the 16S-23S rDNA spacer region. Microbiology (1996) 5.90
The effect of a quantitative resuscitation strategy on mortality in patients with sepsis: a meta-analysis. Crit Care Med (2008) 3.73
Gram-negative bacteremia. IV. Re-evaluation of clinical features and treatment in 612 patients. Am J Med (1980) 3.03
Panfungal PCR assay for detection of fungal infection in human blood specimens. J Clin Microbiol (1998) 2.92
The importance of underlying disease in patients with gram-negative bacteremia. Arch Intern Med (1968) 2.90
A multiplex real-time PCR assay for rapid detection and differentiation of 25 bacterial and fungal pathogens from whole blood samples. Med Microbiol Immunol (2007) 2.64
Determining the area under the ROC curve for a binary diagnostic test. Med Decis Making (2001) 2.54
Factors affecting mortality of gram-negative rod bacteremia. Arch Intern Med (1971) 2.51
Multiplex polymerase chain reaction detection enhancement of bacteremia and fungemia. Crit Care Med (2008) 2.39
Practice parameters for hemodynamic support of sepsis in adult patients: 2004 update. Crit Care Med (2004) 2.33
Multiplex real-time PCR and blood culture for identification of bloodstream pathogens in patients with suspected sepsis. Clin Microbiol Infect (2009) 2.28
Diagnosis of bacteremia in whole-blood samples by use of a commercial universal 16S rRNA gene-based PCR and sequence analysis. J Clin Microbiol (2009) 2.19
Rapid detection and identification of clinically important bacteria by high-resolution melting analysis after broad-range ribosomal RNA real-time PCR. Clin Chem (2006) 2.17
Molecular diagnosis of sepsis in neutropenic patients with haematological malignancies. J Med Microbiol (2008) 2.02
Gram-negative rod bacteremia: microbiologic, immunologic, and therapeutic considerations. Ann Intern Med (1977) 1.90
Clinical impact of a commercially available multiplex PCR system for rapid detection of pathogens in patients with presumed sepsis. BMC Infect Dis (2009) 1.83
Severe sepsis and septic shock: review of the literature and emergency department management guidelines. Ann Emerg Med (2006) 1.82
Utility of a commercially available multiplex real-time PCR assay to detect bacterial and fungal pathogens in febrile neutropenia. J Clin Microbiol (2009) 1.59
Disease progression in hemodynamically stable patients presenting to the emergency department with sepsis. Acad Emerg Med (2010) 1.54
Earlier positivity of central-venous- versus peripheral-blood cultures is highly predictive of catheter-related sepsis. J Clin Microbiol (1998) 1.42
Quality control in nucleic acid testing--where do we stand? J Clin Virol (2002) 1.27
Time to positivity in Staphylococcus aureus bacteremia: possible correlation with the source and outcome of infection. Clin Infect Dis (2005) 1.23
Contamination of catheter-drawn blood cultures. J Clin Microbiol (2001) 1.12
Lack of increase in time to blood culture positivity in a patient with persistent methicillin-resistant Staphylococcus aureus bacteremia predicts failure of antimicrobial therapy. J Microbiol Immunol Infect (2008) 0.82
Alternative isoform regulation in human tissue transcriptomes. Nature (2008) 52.76
Comprehensive human genome amplification using multiple displacement amplification. Proc Natl Acad Sci U S A (2002) 13.58
Ethical and scientific implications of the globalization of clinical research. N Engl J Med (2009) 11.42
Carrier testing for severe childhood recessive diseases by next-generation sequencing. Sci Transl Med (2011) 8.20
Clinical presentation, etiology, and outcome of infective endocarditis in the 21st century: the International Collaboration on Endocarditis-Prospective Cohort Study. Arch Intern Med (2009) 7.82
A highly annotated whole-genome sequence of a Korean individual. Nature (2009) 6.91
Unbiased whole-genome amplification directly from clinical samples. Genome Res (2003) 6.29
Early lactate clearance is associated with improved outcome in severe sepsis and septic shock. Crit Care Med (2004) 5.64
Transcriptome sequencing of malignant pleural mesothelioma tumors. Proc Natl Acad Sci U S A (2008) 4.75
Gene expression signatures diagnose influenza and other symptomatic respiratory viral infections in humans. Cell Host Microbe (2009) 4.55
Adverse clinical and economic outcomes attributable to methicillin resistance among patients with Staphylococcus aureus surgical site infection. Clin Infect Dis (2003) 4.06
Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis. Nature (2010) 3.90
In-hospital and 1-year mortality in patients undergoing early surgery for prosthetic valve endocarditis. JAMA Intern Med (2013) 3.72
Use of vancomycin or first-generation cephalosporins for the treatment of hemodialysis-dependent patients with methicillin-susceptible Staphylococcus aureus bacteremia. Clin Infect Dis (2006) 3.70
Clinical identifiers of complicated Staphylococcus aureus bacteremia. Arch Intern Med (2003) 3.31
Gram-negative bacteria aggravate murine small intestinal Th1-type immunopathology following oral infection with Toxoplasma gondii. J Immunol (2006) 3.24
Telavancin versus vancomycin for hospital-acquired pneumonia due to gram-positive pathogens. Clin Infect Dis (2011) 3.20
The diagnostic accuracy of plasma neutrophil gelatinase-associated lipocalin in the prediction of acute kidney injury in emergency department patients with suspected sepsis. Ann Emerg Med (2010) 3.13
Contemporary clinical profile and outcome of prosthetic valve endocarditis. JAMA (2007) 3.03
Clinical characteristics and outcome of infective endocarditis involving implantable cardiac devices. JAMA (2012) 3.01
Evaluation of four commercially available rapid serologic tests for diagnosis of leptospirosis. J Clin Microbiol (2003) 3.01
The patient experience and health outcomes. N Engl J Med (2012) 2.92
Multiplexed protein profiling on microarrays by rolling-circle amplification. Nat Biotechnol (2002) 2.86
Aorto-cavitary fistulous tract formation in infective endocarditis: clinical and echocardiographic features of 76 cases and risk factors for mortality. Eur Heart J (2004) 2.85
Infective Endocarditis in Adults: Diagnosis, Antimicrobial Therapy, and Management of Complications: A Scientific Statement for Healthcare Professionals From the American Heart Association. Circulation (2015) 2.84
Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1). Nat Genet (2003) 2.78
The etiology of febrile illness in adults presenting to Patan hospital in Kathmandu, Nepal. Am J Trop Med Hyg (2004) 2.77
Telavancin versus vancomycin for the treatment of complicated skin and skin-structure infections caused by gram-positive organisms. Clin Infect Dis (2008) 2.73
Early goal-directed therapy in severe sepsis and septic shock revisited: concepts, controversies, and contemporary findings. Chest (2006) 2.69
Changing patient characteristics and the effect on mortality in endocarditis. Arch Intern Med (2002) 2.68
Critical care medicine training and certification for emergency physicians. Ann Emerg Med (2005) 2.67
Use of a simple criteria set for guiding echocardiography in nosocomial Staphylococcus aureus bacteremia. Clin Infect Dis (2011) 2.62
Selective mass treatment with ivermectin to control intestinal helminthiases and parasitic skin diseases in a severely affected population. Bull World Health Organ (2004) 2.57
Is it time to replace vancomycin in the treatment of methicillin-resistant Staphylococcus aureus infections? Clin Infect Dis (2013) 2.44
Central venous-arterial carbon dioxide difference as an indicator of cardiac index. Intensive Care Med (2005) 2.43
An integrated transcriptome atlas of the crop model Glycine max, and its use in comparative analyses in plants. Plant J (2010) 2.41
ACCM/PALS haemodynamic support guidelines for paediatric septic shock: an outcomes comparison with and without monitoring central venous oxygen saturation. Intensive Care Med (2008) 2.40
Staphylococcus aureus native valve infective endocarditis: report of 566 episodes from the International Collaboration on Endocarditis Merged Database. Clin Infect Dis (2005) 2.36
Reduced susceptibility of Staphylococcus aureus to vancomycin and platelet microbicidal protein correlates with defective autolysis and loss of accessory gene regulator (agr) function. Antimicrob Agents Chemother (2005) 2.34
Impact of strain type on detection of toxigenic Clostridium difficile: comparison of molecular diagnostic and enzyme immunoassay approaches. J Clin Microbiol (2010) 2.32
Interleukin (IL)-23 mediates Toxoplasma gondii-induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17. J Exp Med (2009) 2.28
Relationship between patient satisfaction with inpatient care and hospital readmission within 30 days. Am J Manag Care (2011) 2.27
Early predictors of in-hospital death in infective endocarditis. Circulation (2004) 2.26
An integrated clinico-metabolomic model improves prediction of death in sepsis. Sci Transl Med (2013) 2.23
Genomic convergence analysis of schizophrenia: mRNA sequencing reveals altered synaptic vesicular transport in post-mortem cerebellum. PLoS One (2008) 2.22
Critical care medicine training and certification for emergency physicians. Crit Care Med (2005) 2.12
Temporal dynamics of host molecular responses differentiate symptomatic and asymptomatic influenza a infection. PLoS Genet (2011) 2.10
Shift towards pro-inflammatory intestinal bacteria aggravates acute murine colitis via Toll-like receptors 2 and 4. PLoS One (2007) 2.05
Multisociety Task Force for Critical Care Research: key issues and recommendations. Crit Care Med (2012) 2.05
The GENESIS project (GENeralized Early Sepsis Intervention Strategies): a multicenter quality improvement collaborative. J Intensive Care Med (2012) 2.05
Assessment of temporal trends in mortality with implementation of a statewide ST-segment elevation myocardial infarction (STEMI) regionalization program. Ann Emerg Med (2011) 2.03
Outbreak of leptospirosis among triathlon participants and community residents in Springfield, Illinois, 1998. Clin Infect Dis (2002) 2.02
H3N2 influenza infection elicits more cross-reactive and less clonally expanded anti-hemagglutinin antibodies than influenza vaccination. PLoS One (2011) 2.02
Analysis of the impact of early surgery on in-hospital mortality of native valve endocarditis: use of propensity score and instrumental variable methods to adjust for treatment-selection bias. Circulation (2010) 2.01
Complete transcriptome of the soybean root hair cell, a single-cell model, and its alteration in response to Bradyrhizobium japonicum infection. Plant Physiol (2009) 2.00
Neonatal meningitis: what is the correlation among cerebrospinal fluid cultures, blood cultures, and cerebrospinal fluid parameters? Pediatrics (2006) 1.98
Telavancin versus standard therapy for treatment of complicated skin and soft-tissue infections due to gram-positive bacteria. Clin Infect Dis (2005) 1.95
Risk factors for hematogenous complications of intravascular catheter-associated Staphylococcus aureus bacteremia. Clin Infect Dis (2005) 1.92
Genotypic characteristics of Staphylococcus aureus isolates from a multinational trial of complicated skin and skin structure infections. J Clin Microbiol (2007) 1.91
Increasing rates of cardiac device infections among Medicare beneficiaries: 1990-1999. Am Heart J (2004) 1.90
Surveillance for unexplained deaths and critical illnesses due to possibly infectious causes, United States, 1995-1998. Emerg Infect Dis (2002) 1.89
Aetiology of community-acquired, acute gastroenteritis in hospitalised adults: a prospective cohort study. BMC Infect Dis (2008) 1.85
Management of High-Throughput DNA Sequencing Projects: Alpheus. J Comput Sci Syst Biol (2008) 1.85
Telavancin versus standard therapy for treatment of complicated skin and skin structure infections caused by gram-positive bacteria: FAST 2 study. Antimicrob Agents Chemother (2006) 1.84
Severe sepsis and septic shock: review of the literature and emergency department management guidelines. Ann Emerg Med (2006) 1.82
Initial low-dose gentamicin for Staphylococcus aureus bacteremia and endocarditis is nephrotoxic. Clin Infect Dis (2009) 1.80
Native valve endocarditis due to coagulase-negative staphylococci: report of 99 episodes from the International Collaboration on Endocarditis Merged Database. Clin Infect Dis (2004) 1.80
Early surgery in patients with infective endocarditis: a propensity score analysis. Clin Infect Dis (2007) 1.78
Health care-associated native valve endocarditis: importance of non-nosocomial acquisition. Ann Intern Med (2009) 1.76
Endocarditis caused by Staphylococcus aureus with reduced susceptibility to vancomycin. Clin Infect Dis (2004) 1.73
Bartonella species in blood of immunocompetent persons with animal and arthropod contact. Emerg Infect Dis (2007) 1.73
Cerebral palsy is characterized by protein mediators in cord serum. Ann Neurol (2004) 1.73
Prevalence of infective endocarditis in patients with Staphylococcus aureus bacteraemia: the value of screening with echocardiography. Eur J Echocardiogr (2011) 1.72
Venous thrombosis in patients with short- and long-term central venous catheter-associated Staphylococcus aureus bacteremia. Crit Care Med (2008) 1.69
Costs and outcomes among hemodialysis-dependent patients with methicillin-resistant or methicillin-susceptible Staphylococcus aureus bacteremia. Infect Control Hosp Epidemiol (2005) 1.69
A prospective, multicenter derivation of a biomarker panel to assess risk of organ dysfunction, shock, and death in emergency department patients with suspected sepsis. Crit Care Med (2009) 1.68
Rising rates of carbapenem-resistant enterobacteriaceae in community hospitals: a mixed-methods review of epidemiology and microbiology practices in a network of community hospitals in the southeastern United States. Infect Control Hosp Epidemiol (2014) 1.67
Immunology of Toxoplasma gondii. Immunol Rev (2011) 1.66
Presence of genes encoding the panton-valentine leukocidin exotoxin is not the primary determinant of outcome in patients with complicated skin and skin structure infections due to methicillin-resistant Staphylococcus aureus: results of a multinational trial. J Clin Microbiol (2009) 1.64
Multiplex PCR allows rapid and accurate diagnosis of bloodstream infections in newborns and children with suspected sepsis. J Clin Microbiol (2011) 1.62