Published in Chest on August 20, 2009
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The impact of early monitored management on survival in hospitalized adult Ugandan patients with severe sepsis: a prospective intervention study*. Crit Care Med (2012) 2.29
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Procalcitonin to guide initiation and duration of antibiotic treatment in acute respiratory infections: an individual patient data meta-analysis. Clin Infect Dis (2012) 1.67
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Invasive candidiasis as a cause of sepsis in the critically ill patient. Virulence (2013) 1.32
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Influence of multidrug resistance and appropriate empirical therapy on the 30-day mortality rate of Pseudomonas aeruginosa bacteremia. Antimicrob Agents Chemother (2012) 1.20
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An evaluation of three processing methods and the effect of reduced culture times for faster direct identification of pathogens from BacT/ALERT blood cultures by MALDI-TOF MS. Eur J Clin Microbiol Infect Dis (2011) 1.19
Procalcitonin decrease over 72 hours in US critical care units predicts fatal outcome in sepsis patients. Crit Care (2013) 1.19
Comparison of an in-house method and the commercial Sepsityper™ kit for bacterial identification directly from positive blood culture broths by matrix-assisted laser desorption-ionisation time-of-flight mass spectrometry. Eur J Clin Microbiol Infect Dis (2012) 1.16
Polymyxins: Antibacterial Activity, Susceptibility Testing, and Resistance Mechanisms Encoded by Plasmids or Chromosomes. Clin Microbiol Rev (2017) 1.15
Evaluation of matrix-assisted laser desorption ionization-time of flight mass spectrometry for rapid detection of β-lactam resistance in Enterobacteriaceae derived from blood cultures. J Clin Microbiol (2014) 1.14
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Direct identification of bacteria from charcoal-containing blood culture bottles using matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry. Eur J Clin Microbiol Infect Dis (2012) 1.06
Evaluation of the Broad-Range PCR/ESI-MS Technology in Blood Specimens for the Molecular Diagnosis of Bloodstream Infections. PLoS One (2015) 1.05
Timing of vasopressor initiation and mortality in septic shock: a cohort study. Crit Care (2014) 1.05
Early goal-directed therapy in severe sepsis and septic shock: insights and comparisons to ProCESS, ProMISe, and ARISE. Crit Care (2016) 1.04
Comparison of pathogen DNA isolation methods from large volumes of whole blood to improve molecular diagnosis of bloodstream infections. PLoS One (2013) 1.04
Evaluation of the FilmArray Blood Culture Identification Panel: Results of a Multicenter Controlled Trial. J Clin Microbiol (2016) 1.02
The role of potentially preventable hospital exposures in the development of acute respiratory distress syndrome: a population-based study. Crit Care Med (2014) 1.01
Impact of compliance with infection management guidelines on outcome in patients with severe sepsis: a prospective observational multi-center study. Crit Care (2014) 1.00
Antimicrobial treatment of "complicated" intra-abdominal infections and the new IDSA guidelines ? a commentary and an alternative European approach according to clinical definitions. Eur J Med Res (2011) 1.00
Gene expression-based classifiers identify Staphylococcus aureus infection in mice and humans. PLoS One (2013) 0.99
The Japanese guidelines for the management of sepsis. J Intensive Care (2014) 0.99
Ion mobility spectrometry for microbial volatile organic compounds: a new identification tool for human pathogenic bacteria. Appl Microbiol Biotechnol (2012) 0.98
Improving the diagnosis of bloodstream infections: PCR coupled with mass spectrometry. Biomed Res Int (2014) 0.98
The use of an early alert system to improve compliance with sepsis bundles and to assess impact on mortality. Crit Care Res Pract (2012) 0.98
Emerging technologies for rapid identification of bloodstream pathogens. Clin Infect Dis (2014) 0.98
Clinical review: flow cytometry perspectives in the ICU - from diagnosis of infection to monitoring of injury-induced immune dysfunctions. Crit Care (2011) 0.97
Novel approaches are needed to develop tomorrow's antibacterial therapies. Am J Respir Crit Care Med (2015) 0.95
Diagnostic and prognostic utilities of multimarkers approach using procalcitonin, B-type natriuretic peptide, and neutrophil gelatinase-associated lipocalin in critically ill patients with suspected sepsis. BMC Infect Dis (2014) 0.94
Rapid diagnosis of bloodstream infections with PCR followed by mass spectrometry. PLoS One (2013) 0.94
Colistin and Polymyxin B Dosage Regimens against Acinetobacter baumannii: Differences in Activity and the Emergence of Resistance. Antimicrob Agents Chemother (2016) 0.94
Nosocomial methicillin-resistant Staphylococcus aureus (MRSA) pneumonia: linezolid or vancomycin? - Comparison of pharmacology and clinical efficacy. Eur J Med Res (2010) 0.94
Quantitative matrix-assisted laser desorption ionization-time of flight mass spectrometry for rapid resistance detection. J Clin Microbiol (2014) 0.94
Impact of inappropriate empiric antimicrobial therapy on mortality of septic patients with bacteremia: a retrospective study. Interdiscip Perspect Infect Dis (2012) 0.93
Detection and validation of volatile metabolic patterns over different strains of two human pathogenic bacteria during their growth in a complex medium using multi-capillary column-ion mobility spectrometry (MCC-IMS). Appl Microbiol Biotechnol (2013) 0.92
Treatment of complicated intra-abdominal infections in the era of multi-drug resistant bacteria. Eur J Med Res (2010) 0.91
Aetiology, antimicrobial therapy and outcome of patients with community acquired severe sepsis: a prospective study in a Norwegian university hospital. BMC Infect Dis (2014) 0.91
Antimicrobial therapeutic determinants of outcomes from septic shock among patients with cirrhosis. Hepatology (2012) 0.91
Spontaneous neutrophil migration patterns during sepsis after major burns. PLoS One (2014) 0.90
Developments for improved diagnosis of bacterial bloodstream infections. Eur J Clin Microbiol Infect Dis (2014) 0.90
Impact of multiplex PCR on antimicrobial treatment in febrile neutropenia: a randomized controlled study. Med Microbiol Immunol (2015) 0.88
Using quality improvement principles to improve the care of patients with severe sepsis and septic shock. Ochsner J (2013) 0.87
Initial use of one or two antibiotics for critically ill patients with community-acquired pneumonia: impact on survival and bacterial resistance. Crit Care (2013) 0.86
Reductions in Sepsis Mortality and Costs After Design and Implementation of a Nurse-Based Early Recognition and Response Program. Jt Comm J Qual Patient Saf (2015) 0.86
An alternate pathophysiologic paradigm of sepsis and septic shock: implications for optimizing antimicrobial therapy. Virulence (2013) 0.86
Treatment of invasive candidiasis in the elderly: a review. Clin Interv Aging (2013) 0.86
Sepsis and septic shock. Nat Rev Dis Prim (2016) 0.85
Use of a pathway quality improvement care bundle to reduce mortality after emergency laparotomy. Br J Surg (2014) 0.84
Controversies in Antimicrobial Stewardship: Focus on New Rapid Diagnostic Technologies and Antimicrobials. Antibiotics (Basel) (2016) 0.84
Incidence and outcome of inappropriate in-hospital empiric antibiotics for severe infection: a systematic review and meta-analysis. Crit Care (2015) 0.83
Adequate antibiotic therapy prior to ICU admission in patients with severe sepsis and septic shock reduces hospital mortality. Crit Care (2015) 0.83
A differential centrifugation protocol and validation criterion for enhancing mass spectrometry (MALDI-TOF) results in microbial identification using blood culture growth bottles. Eur J Clin Microbiol Infect Dis (2012) 0.83
Rapid detection of ESBL-producing Enterobacteriaceae in blood cultures. Emerg Infect Dis (2015) 0.83
Acute kidney injury in septic patients admitted to emergency clinical room: risk factors and outcome. Clin Exp Nephrol (2014) 0.83
What's new in multidrug-resistant pathogens in the ICU? Ann Intensive Care (2016) 0.83
Early management of sepsis. Clin Exp Emerg Med (2014) 0.82
Risk factors for kidney injury during vancomycin and piperacillin/tazobactam administration, including increased odds of injury with combination therapy. BMC Res Notes (2015) 0.82
Volatile organic compound analysis by ion molecule reaction mass spectrometry for Gram-positive bacteria differentiation. Eur J Clin Microbiol Infect Dis (2012) 0.82
Examination with next-generation sequencing technology of the bacterial microbiota in bronchoalveolar lavage samples after traumatic injury. Surg Infect (Larchmt) (2013) 0.82
Treatment of bloodstream infections in ICUs. BMC Infect Dis (2014) 0.82
Acute respiratory distress syndrome: prevention and early recognition. Ann Intensive Care (2013) 0.81
Third-generation cephalosporin-resistant spontaneous bacterial peritonitis: a single-centre experience and summary of existing studies. Can J Gastroenterol Hepatol (2013) 0.81
Empiric antimicrobial therapy in severe sepsis and septic shock: optimizing pathogen clearance. Curr Infect Dis Rep (2015) 0.81
Diagnostic and prognostic value of soluble CD14 subtype (Presepsin) for sepsis and community-acquired pneumonia in ICU patients. Ann Intensive Care (2016) 0.80
Commercial multiplex technologies for the microbiological diagnosis of sepsis. Mol Diagn Ther (2013) 0.80
Effects of echinocandin preparations on adult rat ventricular cardiomyocytes. Preliminary results of an in vitro study. Anaesthesist (2014) 0.80
Development of a rapid and simplified protocol for direct bacterial identification from positive blood cultures by using matrix assisted laser desorption ionization time-of- flight mass spectrometry. BMC Microbiol (2015) 0.80
Prognostic impact of left ventricular diastolic function in patients with septic shock. Ann Intensive Care (2016) 0.80
The impact of inappropriate antibiotics on bacteremia patients in a community hospital in Taiwan: an emphasis on the impact of referral information for cases from a hospital affiliated nursing home. BMC Infect Dis (2013) 0.79
Impact of bacterial coinfection on clinical outcomes in pneumococcal pneumonia. Eur J Clin Microbiol Infect Dis (2015) 0.79
Advances in Rapid Identification and Susceptibility Testing of Bacteria in the Clinical Microbiology Laboratory: Implications for Patient Care and Antimicrobial Stewardship Programs. Infect Dis Rep (2017) 0.79
Development of quality indicators for antimicrobial treatment in adults with sepsis. BMC Infect Dis (2014) 0.79
Current concepts in combination antibiotic therapy for critically ill patients. Indian J Crit Care Med (2014) 0.79
Community-onset bacteraemia of unknown origin: clinical characteristics, epidemiology and outcome. Eur J Clin Microbiol Infect Dis (2014) 0.79
Fatal Septicaemia Following Suprapubic Cystostomy in a Paraplegic Patient: Never Do a Cystostomy without Prior Urine Culture and Appropriate Antibiogram! Case Rep Med (2010) 0.79
Bloodstream infections in neutropenic cancer patients: A practical update. Virulence (2016) 0.79
Management bundles for candidaemia: the impact of compliance on clinical outcomes. J Antimicrob Chemother (2014) 0.79
Compliance with guidelines-recommended processes in pneumonia: impact of health status and initial signs. PLoS One (2012) 0.79
Differential outcome of an antimicrobial stewardship audit and feedback program in two intensive care units: a controlled interrupted time series study. BMC Infect Dis (2015) 0.79
Application of a methicillin-resistant Staphylococcus aureus risk score for community-onset pneumonia patients and outcomes with initial treatment. BMC Infect Dis (2015) 0.78
Intensive versus conventional glucose control in critically ill patients. N Engl J Med (2009) 26.30
Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med (2006) 23.62
Critically ill patients with 2009 influenza A(H1N1) infection in Canada. JAMA (2009) 13.00
Definition of clinically distinct molecular subtypes in estrogen receptor-positive breast carcinomas through genomic grade. J Clin Oncol (2007) 8.65
Strong time dependence of the 76-gene prognostic signature for node-negative breast cancer patients in the TRANSBIG multicenter independent validation series. Clin Cancer Res (2007) 8.41
Validation and clinical utility of a 70-gene prognostic signature for women with node-negative breast cancer. J Natl Cancer Inst (2006) 8.38
Withdrawal of mechanical ventilation in anticipation of death in the intensive care unit. N Engl J Med (2003) 7.32
Noninvasive positive-pressure ventilation for respiratory failure after extubation. N Engl J Med (2004) 7.03
Daily sedation interruption in mechanically ventilated critically ill patients cared for with a sedation protocol: a randomized controlled trial. JAMA (2012) 6.69
Outcomes of kidney transplantation in HIV-infected recipients. N Engl J Med (2010) 6.26
Hypoglycemia and risk of death in critically ill patients. N Engl J Med (2012) 6.17
Canadian clinical practice guidelines for nutrition support in mechanically ventilated, critically ill adult patients. JPEN J Parenter Enteral Nutr (2003) 5.90
What matters most in end-of-life care: perceptions of seriously ill patients and their family members. CMAJ (2006) 5.70
Translating research to clinical practice: a 1-year experience with implementing early goal-directed therapy for septic shock in the emergency department. Chest (2006) 5.31
Vital signs after cardiac arrest following withdrawal of life-sustaining therapy: a multicenter prospective observational study. Crit Care Med (2014) 5.07
Outcomes of liver transplant recipients with hepatitis C and human immunodeficiency virus coinfection. Liver Transpl (2012) 4.65
Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: a randomized controlled trial. JAMA (2003) 4.54
A survival benefit of combination antibiotic therapy for serious infections associated with sepsis and septic shock is contingent only on the risk of death: a meta-analytic/meta-regression study. Crit Care Med (2010) 4.45
Early combination antibiotic therapy yields improved survival compared with monotherapy in septic shock: a propensity-matched analysis. Crit Care Med (2010) 4.39
Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortality. JAMA (2010) 4.37
Chlorhexidine-impregnated dressing for prevention of catheter-related bloodstream infection: a meta-analysis*. Crit Care Med (2014) 3.79
Failure to engage hospitalized elderly patients and their families in advance care planning. JAMA Intern Med (2013) 3.77
Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer. Genome Res (2007) 3.45
Evolution of mechanical ventilation in response to clinical research. Am J Respir Crit Care Med (2007) 3.45
Early microcirculatory perfusion derangements in patients with severe sepsis and septic shock: relationship to hemodynamics, oxygen transport, and survival. Ann Emerg Med (2006) 3.36
Predicting prognosis using molecular profiling in estrogen receptor-positive breast cancer treated with tamoxifen. BMC Genomics (2008) 3.24
Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsis. Intensive Care Med (2008) 3.14
Evolution of mortality over time in patients receiving mechanical ventilation. Am J Respir Crit Care Med (2013) 2.95
Impact of an intensivist-led multidisciplinary extended rapid response team on hospital-wide cardiopulmonary arrests and mortality. Crit Care Med (2013) 2.85
PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor-positive breast cancer. Proc Natl Acad Sci U S A (2010) 2.79
New paradigm for macromolecular crystallography experiments at SSRL: automated crystal screening and remote data collection. Acta Crystallogr D Biol Crystallogr (2008) 2.79
The Very Elderly Admitted to ICU: A Quality Finish? Crit Care Med (2015) 2.77
Facilitating clinician adherence to guidelines in the intensive care unit: A multicenter, qualitative study. Crit Care Med (2007) 2.72
A randomized, double-blind, placebo-controlled, Phase 2b study to evaluate the safety and efficacy of recombinant human soluble thrombomodulin, ART-123, in patients with sepsis and suspected disseminated intravascular coagulation. Crit Care Med (2013) 2.68
Significance of arterial hypotension after resuscitation from cardiac arrest. Crit Care Med (2009) 2.68
Urban land teleconnections and sustainability. Proc Natl Acad Sci U S A (2012) 2.66
Relationship between supranormal oxygen tension and outcome after resuscitation from cardiac arrest. Circulation (2011) 2.65
Clinician predictions of intensive care unit mortality. Crit Care Med (2004) 2.65
Dissecting the heterogeneity of triple-negative breast cancer. J Clin Oncol (2012) 2.64
Risk factors for extubation failure in patients following a successful spontaneous breathing trial. Chest (2006) 2.60
Multicenter study of early lactate clearance as a determinant of survival in patients with presumed sepsis. Shock (2009) 2.59
Awake anaesthesia for major thoracic surgical procedures: an observational study. Eur J Cardiothorac Surg (2007) 2.40
Activated protein C and septic shock: a propensity-matched cohort study*. Crit Care Med (2012) 2.39
Pulmonary artery occlusion pressure and central venous pressure fail to predict ventricular filling volume, cardiac performance, or the response to volume infusion in normal subjects. Crit Care Med (2004) 2.35
Utility of history, physical examination, electrocardiogram, and chest radiograph for differentiating normal from decreased systolic function in patients with heart failure. Am J Med (2002) 2.34
Randomized phase IIB trial of BLP25 liposome vaccine in stage IIIB and IV non-small-cell lung cancer. J Clin Oncol (2005) 2.25
Thrombocytopenia in critically ill patients receiving thromboprophylaxis: frequency, risk factors, and outcomes. Chest (2013) 2.24
A matched cohort study of postoperative outcomes in obstructive sleep apnea: could preoperative diagnosis and treatment prevent complications? Anesthesiology (2014) 2.24
Comprehensive evidence-based clinical practice guidelines for ventilator-associated pneumonia: prevention. J Crit Care (2008) 2.23
Twenty-four-hour intensivist presence: a pilot study of effects on intensive care unit patients, families, doctors, and nurses. Am J Respir Crit Care Med (2012) 2.22
Failure of anticoagulant thromboprophylaxis: risk factors in medical-surgical critically ill patients*. Crit Care Med (2015) 2.16
Characteristics and outcomes of ventilated patients according to time to liberation from mechanical ventilation. Am J Respir Crit Care Med (2011) 2.15
Associations of multiple metals with kidney outcomes in lead workers. Occup Environ Med (2012) 2.14
Frequent users of emergency departments: developing standard definitions and defining prominent risk factors. Ann Emerg Med (2012) 2.09
Association between source of infection and hospital mortality in patients who have septic shock. Am J Respir Crit Care Med (2014) 2.05
Breast carcinoma during pregnancy. International recommendations from an expert meeting. Cancer (2006) 2.04
Outcomes of patients ventilated with synchronized intermittent mandatory ventilation with pressure support: a comparative propensity score study. Chest (2009) 2.03
Randomized trial of combination versus monotherapy for the empiric treatment of suspected ventilator-associated pneumonia. Crit Care Med (2008) 1.94
Acute kidney injury in septic shock: clinical outcomes and impact of duration of hypotension prior to initiation of antimicrobial therapy. Intensive Care Med (2008) 1.93
Survey of interventions for the prevention and treatment of acute respiratory distress syndrome. Crit Care Med (2004) 1.90
Serum lactate as a predictor of mortality in patients with infection. Intensive Care Med (2007) 1.88
Clinical review: Myocardial depression in sepsis and septic shock. Crit Care (2002) 1.74
Intensive care unit admission has minimal impact on long-term mortality. Crit Care Med (2002) 1.73
Interaction between fluids and vasoactive agents on mortality in septic shock: a multicenter, observational study. Crit Care Med (2014) 1.72
Management and outcome of mechanically ventilated neurologic patients. Crit Care Med (2011) 1.71
Implementation of clinical practice guidelines for ventilator-associated pneumonia: a multicenter prospective study. Crit Care Med (2013) 1.68
Associations of low-level urine cadmium with kidney function in lead workers. Occup Environ Med (2010) 1.67
Outcomes of chronic dialysis patients admitted to the intensive care unit. J Am Soc Nephrol (2009) 1.64
Resuscitating the microcirculation in sepsis: the central role of nitric oxide, emerging concepts for novel therapies, and challenges for clinical trials. Acad Emerg Med (2008) 1.61
Effect of large volume infusion on left ventricular volumes, performance and contractility parameters in normal volunteers. Intensive Care Med (2004) 1.59
Screening and prevention of venous thromboembolism in critically ill patients: a decision analysis and economic evaluation. Am J Respir Crit Care Med (2011) 1.58
Prevalence, risk factors, and outcomes of delirium in mechanically ventilated adults. Crit Care Med (2015) 1.58
Early and small changes in serum creatinine concentrations are associated with mortality in mechanically ventilated patients. Shock (2010) 1.54
Understanding cardiopulmonary resuscitation decision making: perspectives of seriously ill hospitalized patients and family members. Chest (2006) 1.53
Knowledge translation interventions for critically ill patients: a systematic review*. Crit Care Med (2013) 1.53
Qualitative analysis of an intensive care unit family satisfaction survey. Crit Care Med (2011) 1.52
Low-dose corticosteroid treatment in septic shock: a propensity-matching study. Crit Care Med (2014) 1.50