Published in Am J Respir Crit Care Med on May 31, 2012
Eosinophils: changing perspectives in health and disease. Nat Rev Immunol (2012) 2.69
Microparticle alpha-2-macroglobulin enhances pro-resolving responses and promotes survival in sepsis. EMBO Mol Med (2013) 1.05
Group 2 innate lymphoid cell production of IL-5 is regulated by NKT cells during influenza virus infection. PLoS Pathog (2013) 1.05
A robust scoring system to evaluate sepsis severity in an animal model. BMC Res Notes (2014) 1.03
Comprehensive evaluation of 11 cytokines in premature infants with surgical necrotizing enterocolitis. PLoS One (2013) 0.95
Eosinophils in infection and intestinal immunity. Curr Opin Gastroenterol (2013) 0.92
Roles and regulation of gastrointestinal eosinophils in immunity and disease. J Immunol (2014) 0.91
Microbiota-Regulated IL-25 Increases Eosinophil Number to Provide Protection during Clostridium difficile Infection. Cell Rep (2016) 0.86
Immunopathogenesis of abdominal sepsis. Langenbecks Arch Surg (2014) 0.83
Obesity alters the lung myeloid cell landscape to enhance breast cancer metastasis through IL5 and GM-CSF. Nat Cell Biol (2017) 0.82
Monocyte-derived IL-5 reduces TNF production by Mycobacterium tuberculosis-specific CD4 T cells during SIV/M. tuberculosis coinfection. J Immunol (2013) 0.82
Low eosinophil and low lymphocyte counts and the incidence of 12 cardiovascular diseases: a CALIBER cohort study. Open Heart (2016) 0.78
Severe chronic cerebral hypoperfusion induces microglial dysfunction leading to memory loss in APPswe/PS1 mice. Oncotarget (2016) 0.78
IL-33 Precedes IL-5 in Regulating Eosinophil Commitment and Is Required for Eosinophil Homeostasis. J Immunol (2016) 0.77
Non-cultured dermal-derived mesenchymal cells attenuate sepsis induced by cecal ligation and puncture in mice. Sci Rep (2015) 0.77
Human and Mouse Eosinophils Have Antiviral Activity against Parainfluenza Virus. Am J Respir Cell Mol Biol (2016) 0.76
Neonatal Meningitis: Overcoming Challenges in Diagnosis, Prognosis, and Treatment with Omics. Front Pediatr (2017) 0.75
Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med (2001) 46.58
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med (2003) 28.68
The pathophysiology and treatment of sepsis. N Engl J Med (2003) 21.67
Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: a trend analysis from 1993 to 2003. Crit Care Med (2007) 10.02
Sepsis and septic shock--a review of laboratory models and a proposal. J Surg Res (1980) 6.39
Defining a link with asthma in mice congenitally deficient in eosinophils. Science (2004) 5.20
Monocyte deactivation in septic patients: restoration by IFN-gamma treatment. Nat Med (1997) 5.19
Granulocyte-macrophage colony-stimulating factor to reverse sepsis-associated immunosuppression: a double-blind, randomized, placebo-controlled multicenter trial. Am J Respir Crit Care Med (2009) 4.98
Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense. Nat Med (2008) 4.93
Confirmatory interleukin-1 receptor antagonist trial in severe sepsis: a phase III, randomized, double-blind, placebo-controlled, multicenter trial. The Interleukin-1 Receptor Antagonist Sepsis Investigator Group. Crit Care Med (1997) 4.86
The clinical significance of positive blood cultures: a comprehensive analysis of 500 episodes of bacteremia and fungemia in adults. II. Clinical observations, with special reference to factors influencing prognosis. Rev Infect Dis (1983) 4.52
Lung natural helper cells are a critical source of Th2 cell-type cytokines in protease allergen-induced airway inflammation. Immunity (2012) 4.33
Double-blind randomised controlled trial of monoclonal antibody to human tumour necrosis factor in treatment of septic shock. NORASEPT II Study Group. Lancet (1998) 4.05
Cytokine profiles as markers of disease severity in sepsis: a multiplex analysis. Crit Care (2007) 3.80
IL-5-deficient mice have a developmental defect in CD5+ B-1 cells and lack eosinophilia but have normal antibody and cytotoxic T cell responses. Immunity (1996) 3.23
Conditional macrophage ablation in transgenic mice expressing a Fas-based suicide gene. J Leukoc Biol (2004) 2.74
Interleukin-33 attenuates sepsis by enhancing neutrophil influx to the site of infection. Nat Med (2010) 2.38
Expression of IL-5 in thymocytes/T cells leads to the development of a massive eosinophilia, extramedullary eosinophilopoiesis, and unique histopathologies. J Immunol (1997) 2.30
Depletion of dendritic cells, but not macrophages, in patients with sepsis. J Immunol (2002) 2.25
Genomic and proteomic profiling of responses to toxic metals in human lung cells. Environ Health Perspect (2003) 2.21
E5 murine monoclonal antiendotoxin antibody in gram-negative sepsis: a randomized controlled trial. E5 Study Investigators. JAMA (2000) 2.07
A randomized phase II trial of granulocyte-macrophage colony-stimulating factor therapy in severe sepsis with respiratory dysfunction. Am J Respir Crit Care Med (2002) 2.05
Safety profile, pharmacokinetics, and biologic activity of MEDI-563, an anti-IL-5 receptor alpha antibody, in a phase I study of subjects with mild asthma. J Allergy Clin Immunol (2010) 1.86
IL-5 and eosinophilia. Curr Opin Immunol (2008) 1.79
Coexpression of IL-5 and eotaxin-2 in mice creates an eosinophil-dependent model of respiratory inflammation with characteristics of severe asthma. J Immunol (2007) 1.67
Cytokine production and monocyte HLA-DR expression as predictors of outcome for patients with community-acquired severe infections. Clin Diagn Lab Immunol (2004) 1.65
Antibacterial properties of eosinophil major basic protein and eosinophil cationic protein. J Immunol (1989) 1.64
Innate immune cell populations function as initiators and effectors in Th2 cytokine responses. Trends Immunol (2010) 1.61
CD14 receptor occupancy in severe sepsis: results of a phase I clinical trial with a recombinant chimeric CD14 monoclonal antibody (IC14). Crit Care Med (2004) 1.58
Eosinopenia is a reliable marker of sepsis on admission to medical intensive care units. Crit Care (2008) 1.44
Effect of inhaled interleukin-5 on airway hyperreactivity and eosinophilia in asthmatics. Am J Respir Crit Care Med (1998) 1.37
Eosinopenia of acute infection: Production of eosinopenia by chemotactic factors of acute inflammation. J Clin Invest (1980) 1.24
Activated protein C for severe sepsis. N Engl J Med (2002) 1.17
Molecular basis of the membrane-anchored and two soluble isoforms of the human interleukin 5 receptor alpha subunit. Proc Natl Acad Sci U S A (1992) 1.16
CD40 contributes to lethality in acute sepsis: in vivo role for CD40 in innate immunity. Infect Immun (2003) 1.15
A new mechanism for IL-5-dependent helminth control: neutrophil accumulation and neutrophil-mediated worm encapsulation in murine filariasis are abolished in the absence of IL-5. Int Immunol (2000) 1.13
Deficiency of IL-5 receptor alpha-chain selectively influences the development of the common mucosal immune system independent IgA-producing B-1 cell in mucosa-associated tissues. J Immunol (1999) 1.08
The inflammatory balance in human sepsis. Intensive Care Med (2000) 1.08
Differences in innate defense mechanisms in endotoxemia and polymicrobial septic peritonitis. Infect Immun (2001) 1.08
The activation of the Jak-STAT 1 signaling pathway by IL-5 in eosinophils. J Immunol (1995) 1.03
Molgramostim (GM-CSF) associated with antibiotic treatment in nontraumatic abdominal sepsis: a randomized, double-blind, placebo-controlled clinical trial. Arch Surg (2006) 1.02
Mouse eosinophils possess potent antibacterial properties in vivo. Infect Immun (2009) 0.99
Granulocyte macrophage colony-stimulating factor improves survival in two models of gut-derived sepsis by improving gut barrier function and modulating bacterial clearance. Ann Surg (1994) 0.98
Differential expression of the common beta and specific alpha chains of the receptors for GM-CSF, IL-3, and IL-5 in endothelial cells. Exp Cell Res (1993) 0.95
Critical role of CD14 for production of proinflammatory cytokines and cytokine inhibitors during sepsis with failure to alter morbidity or mortality. Infect Immun (2001) 0.93
Mitogenic effects of interleukin-5 on microglia. Neurosci Lett (1995) 0.90
Septic plasma suppresses superoxide anion synthesis by normal homologous polymorphonuclear leukocytes. Crit Care Med (1989) 0.87
OX40 ligand regulates inflammation and mortality in the innate immune response to sepsis. J Immunol (2010) 0.87
Regulation of neutrophil superoxide production in sepsis. Arch Surg (1985) 0.86
Cyclic nucleotides regulate the morphologic alterations required for chemotaxis in monocytes. J Immunol (1982) 0.85
Priming of eosinophil and neutrophil migratory responses by interleukin 3 and interleukin 5. APMIS (1994) 0.83
Expression of interleukin (IL)-5 and IL-9 receptors on neutrophils of horses with heaves. Vet Immunol Immunopathol (2005) 0.80
Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol (2007) 37.10
PD-1 Blockade in Tumors with Mismatch-Repair Deficiency. N Engl J Med (2015) 13.08
Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense. Nat Med (2008) 4.93
Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle. Science (2009) 4.92
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet (2014) 4.13
Eosinophils are required for the maintenance of plasma cells in the bone marrow. Nat Immunol (2011) 2.83
Allergic pulmonary inflammation in mice is dependent on eosinophil-induced recruitment of effector T cells. J Exp Med (2008) 2.11
Pivotal Advance: eosinophil infiltration of solid tumors is an early and persistent inflammatory host response. J Leukoc Biol (2006) 2.06
The oesophageal string test: a novel, minimally invasive method measures mucosal inflammation in eosinophilic oesophagitis. Gut (2012) 1.98
A novel histologic scoring system to evaluate mucosal biopsies from patients with eosinophilic esophagitis. Clin Gastroenterol Hepatol (2009) 1.85
Expression of the secondary granule proteins major basic protein 1 (MBP-1) and eosinophil peroxidase (EPX) is required for eosinophilopoiesis in mice. Blood (2013) 1.72
Coexpression of IL-5 and eotaxin-2 in mice creates an eosinophil-dependent model of respiratory inflammation with characteristics of severe asthma. J Immunol (2007) 1.67
A causative relationship exists between eosinophils and the development of allergic pulmonary pathologies in the mouse. J Immunol (2003) 1.65
Immunopathogenesis of experimental ulcerative colitis is mediated by eosinophil peroxidase. J Immunol (2004) 1.62
Novel approach to inhibit asthma-mediated lung inflammation using anti-CD147 intervention. J Immunol (2006) 1.56
Eosinophils: singularly destructive effector cells or purveyors of immunoregulation? J Allergy Clin Immunol (2007) 1.55
Activated mouse eosinophils protect against lethal respiratory virus infection. Blood (2013) 1.54
Eosinophils can function as antigen-presenting cells to induce primary and secondary immune responses to Strongyloides stercoralis. Infect Immun (2006) 1.53
Phase II trial of ixabepilone, an epothilone B analog, in patients with metastatic breast cancer previously untreated with taxanes. J Clin Oncol (2007) 1.50
Eosinophilic esophagitis: epithelial mesenchymal transition contributes to esophageal remodeling and reverses with treatment. J Allergy Clin Immunol (2012) 1.50
A3 adenosine receptor signaling contributes to airway inflammation and mucus production in adenosine deaminase-deficient mice. J Immunol (2004) 1.49
Schistosoma mansoni infection in eosinophil lineage-ablated mice. Blood (2006) 1.42
Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, in metastatic and locally advanced breast cancer. J Clin Oncol (2005) 1.41
Eosinophilic granulocytes and damage-associated molecular pattern molecules (DAMPs): role in the inflammatory response within tumors. J Immunother (2007) 1.39
CD40 and CD80/86 act synergistically to regulate inflammation and mortality in polymicrobial sepsis. Am J Respir Crit Care Med (2007) 1.37
The expanding role(s) of eosinophils in health and disease. Blood (2012) 1.35
Intestinal macrophage/epithelial cell-derived CCL11/eotaxin-1 mediates eosinophil recruitment and function in pediatric ulcerative colitis. J Immunol (2008) 1.33
Eosinophil deficiency compromises parasite survival in chronic nematode infection. J Immunol (2009) 1.30
Role of eosinophils and neutrophils in innate and adaptive protective immunity to larval strongyloides stercoralis in mice. Infect Immun (2006) 1.29
Eosinophils alter colonic epithelial barrier function: role for major basic protein. Am J Physiol Gastrointest Liver Physiol (2005) 1.28
Eosinophils act as antigen-presenting cells to induce immunity to Strongyloides stercoralis in mice. J Infect Dis (2007) 1.25
Pro-oxidative diesel exhaust particle chemicals inhibit LPS-induced dendritic cell responses involved in T-helper differentiation. J Allergy Clin Immunol (2006) 1.24
In vitro assessment of chemokine receptor-ligand interactions mediating mouse eosinophil migration. J Leukoc Biol (2002) 1.23
Eosinophils regulate dendritic cells and Th2 pulmonary immune responses following allergen provocation. J Immunol (2011) 1.22
The logic of indirect speech. Proc Natl Acad Sci U S A (2008) 1.21
Ablation of eosinophils leads to a reduction of allergen-induced pulmonary pathology. Am J Physiol Lung Cell Mol Physiol (2002) 1.20
Molecular analysis of human Siglec-8 orthologs relevant to mouse eosinophils: identification of mouse orthologs of Siglec-5 (mSiglec-F) and Siglec-10 (mSiglec-G). Genomics (2003) 1.18
Galphai2-mediated signaling events in the endothelium are involved in controlling leukocyte extravasation. Proc Natl Acad Sci U S A (2007) 1.18
Differential role for CD80 and CD86 in the regulation of the innate immune response in murine polymicrobial sepsis. PLoS One (2009) 1.17
Adenomatous polyps are driven by microbe-instigated focal inflammation and are controlled by IL-10-producing T cells. Cancer Res (2013) 1.16
Major basic protein from eosinophils and myeloperoxidase from neutrophils are required for protective immunity to Strongyloides stercoralis in mice. Infect Immun (2011) 1.14
Eosinophils and asthma. Curr Allergy Asthma Rep (2007) 1.14
T(H)2-mediated pulmonary inflammation leads to the differential expression of ribonuclease genes by alveolar macrophages. Am J Respir Cell Mol Biol (2002) 1.12
The development of a sensitive and specific ELISA for mouse eosinophil peroxidase: assessment of eosinophil degranulation ex vivo and in models of human disease. J Immunol Methods (2011) 1.12
Workshop report from the National Institutes of Health Taskforce on the Research Needs of Eosinophil-Associated Diseases (TREAD). J Allergy Clin Immunol (2012) 1.12
Lack of eosinophil peroxidase or major basic protein impairs defense against murine filarial infection. Infect Immun (2006) 1.11
Prednisolone decreases cellular adhesion molecules required for inflammatory cell infiltration in dystrophin-deficient skeletal muscle. Neuromuscul Disord (2004) 1.11
Mycobacterium tuberculosis-induced CXCR4 and chemokine expression leads to preferential X4 HIV-1 replication in human macrophages. J Immunol (2004) 1.11
Homologous recombination into the eosinophil peroxidase locus generates a strain of mice expressing Cre recombinase exclusively in eosinophils. J Leukoc Biol (2013) 1.11
Diesel exhaust particles exert acute effects on airway inflammation and function in murine allergen provocation models. J Allergy Clin Immunol (2003) 1.09
General intelligence in another primate: individual differences across cognitive task performance in a New World monkey (Saguinus oedipus). PLoS One (2009) 1.09
Mechanisms of polymorphonuclear neutrophil-mediated induction of HIV-1 replication in macrophages during pulmonary tuberculosis. J Infect Dis (2007) 1.08
Validation of a new grading system for endoscopic examination of adenoid hypertrophy. Otolaryngol Head Neck Surg (2006) 1.08
Immunoglobulin E and eosinophil-dependent protective immunity to larval Onchocerca volvulus in mice immunized with irradiated larvae. Infect Immun (2004) 1.07
Androgen receptor-positive triple negative breast cancer: a unique breast cancer subtype. Ann Surg Oncol (2013) 1.07
Alcohol withdrawal syndromes in the intensive care unit. Crit Care Med (2010) 1.07
Identification of an alternative G{alpha}q-dependent chemokine receptor signal transduction pathway in dendritic cells and granulocytes. J Exp Med (2007) 1.06
Use of simulation to assess electronic health record safety in the intensive care unit: a pilot study. BMJ Open (2013) 1.04
Allergic pulmonary inflammation promotes the recruitment of circulating tumor cells to the lung. Cancer Res (2008) 1.04
Summary of the First International Gastrointestinal Eosinophil Research Symposium. J Pediatr Gastroenterol Nutr (2007) 1.03
Eosinophils preserve parasitic nematode larvae by regulating local immunity. J Immunol (2011) 1.03
Murine lung eosinophil activation and chemokine production in allergic airway inflammation. Cell Mol Immunol (2010) 1.01
Novel model of TH2-polarized chronic ileitis: the SAMP1 mouse. Inflamm Bowel Dis (2010) 1.01
Effect of proton pump inhibitor on esophageal eosinophilia. J Pediatr Gastroenterol Nutr (2013) 1.00
Mouse eosinophils possess potent antibacterial properties in vivo. Infect Immun (2009) 0.99
Gene expression profiles of bronchoalveolar cells in pulmonary TB. Tuberculosis (Edinb) (2007) 0.98
IGFBP-3 regulates esophageal tumor growth through IGF-dependent and independent mechanisms. Cancer Biol Ther (2007) 0.97
Eosinophil degranulation in the allergic lung of mice primarily occurs in the airway lumen. J Leukoc Biol (2004) 0.95
CCR3 Blockade Attenuates Eosinophilic Ileitis and Associated Remodeling. Am J Pathol (2011) 0.95
Aerosolized gamma interferon (IFN-gamma) induces expression of the genes encoding the IFN-gamma-inducible 10-kilodalton protein but not inducible nitric oxide synthase in the lung during tuberculosis. Infect Immun (2004) 0.93
Eosinophils utilize multiple chemokine receptors for chemotaxis to the parasitic nematode Strongyloides stercoralis. J Innate Immun (2009) 0.92
Immunodetection of occult eosinophils in lung tissue biopsies may help predict survival in acute lung injury. Respir Res (2011) 0.92
The construction of transgenic and gene knockout/knockin mouse models of human disease. Transgenic Res (2011) 0.91
Vascular endothelial growth factor blockade reduces plasma cytokines in a murine model of polymicrobial sepsis. Inflammation (2004) 0.91
Update on clinical and immunological features of eosinophilic gastrointestinal diseases. Curr Opin Gastroenterol (2011) 0.91
Murine cytomegalovirus interference with antigen presentation contributes to the inability of CD8 T cells to control virus in the salivary gland. J Virol (2006) 0.91
A3 adenosine receptor signaling influences pulmonary inflammation and fibrosis. Am J Respir Cell Mol Biol (2008) 0.91
High modulus nanopowder reinforced dimethacrylate matrix composites for dental cement applications. J Biomed Mater Res A (2007) 0.90
Altered eosinophil profile in mice with ST6Gal-1 deficiency: an additional role for ST6Gal-1 generated by the P1 promoter in regulating allergic inflammation. J Leukoc Biol (2009) 0.89
Eosinophils increase neuron branching in human and murine skin and in vitro. PLoS One (2011) 0.89
Post-translational tyrosine nitration of eosinophil granule toxins mediated by eosinophil peroxidase. J Biol Chem (2008) 0.88
OX40 ligand regulates inflammation and mortality in the innate immune response to sepsis. J Immunol (2010) 0.87
Muscle development and lineage-specific expression of CiMDF, the MyoD-family gene of Ciona intestinalis. Dev Biol (2002) 0.87
Why it is hard to find genes associated with social science traits: theoretical and empirical considerations. Am J Public Health (2013) 0.87
Mast cells are required for full expression of allergen/SEB-induced skin inflammation. J Invest Dermatol (2013) 0.86
Eosinophils regulate peripheral B cell numbers in both mice and humans. J Immunol (2014) 0.86
Phase II trial of ixabepilone, an epothilone B analog, given daily for three days every three weeks, in metastatic breast cancer. Invest New Drugs (2006) 0.86
Subnasale flap for correction of columellar deformity. Plast Reconstr Surg (2007) 0.85
Cys-leukotrienes promote fibrosis in a mouse model of eosinophil-mediated respiratory inflammation. Am J Respir Cell Mol Biol (2013) 0.84
Racial variations in the incidence of severe alcohol withdrawal. J Med Toxicol (2009) 0.83
Gq signaling is required for allergen-induced pulmonary eosinophilia. J Immunol (2002) 0.83
Signaling through Galphai2 protein is required for recruitment of neutrophils for antibody-mediated elimination of larval Strongyloides stercoralis in mice. J Leukoc Biol (2007) 0.83
Local proliferation and mobilization of CCR3(+) CD34(+) eosinophil-lineage-committed cells in the lung. Immunology (2010) 0.83