Published in Cancer Res on June 01, 2012
EMT and tumor metastasis. Clin Transl Med (2015) 1.29
E-cadherin loss alters cytoskeletal organization and adhesion in non-malignant breast cells but is insufficient to induce an epithelial-mesenchymal transition. BMC Cancer (2014) 1.01
MMP-9 expression varies according to molecular subtypes of breast cancer. BMC Cancer (2014) 1.00
Secreted Hsp90 is a novel regulator of the epithelial to mesenchymal transition (EMT) in prostate cancer. J Biol Chem (2012) 0.99
E-cadherin and gastric cancer: cause, consequence, and applications. Biomed Res Int (2014) 0.92
Nuclear signaling from cadherin adhesion complexes. Curr Top Dev Biol (2015) 0.90
ERRβ signalling through FST and BCAS2 inhibits cellular proliferation in breast cancer cells. Br J Cancer (2014) 0.88
Protein arginine methyltransferase 7 promotes breast cancer cell invasion through the induction of MMP9 expression. Oncotarget (2015) 0.86
Moonlighting proteins in cancer. Cancer Lett (2015) 0.82
Diagnostic impact of promoter methylation and E-cadherin gene and protein expression levels in laryngeal carcinoma. Contemp Oncol (Pozn) (2013) 0.81
Development and characterization of two human triple-negative breast cancer cell lines with highly tumorigenic and metastatic capabilities. Cancer Med (2016) 0.81
Novel regulatory program for norepinephrine-induced epithelial-mesenchymal transition in gastric adenocarcinoma cell lines. Cancer Sci (2014) 0.81
Inflammation and the Intestinal Barrier: Leukocyte-Epithelial Cell Interactions, Cell Junction Remodeling, and Mucosal Repair. Gastroenterology (2016) 0.79
Cyclin b1 suppresses colorectal cancer invasion and metastasis by regulating e-cadherin. PLoS One (2015) 0.79
sE-cadherin serves as a diagnostic and predictive parameter in prostate cancer patients. J Exp Clin Cancer Res (2015) 0.78
Characterization of ascites-derived ovarian tumor cells from spontaneously occurring ovarian tumors of the chicken: evidence for E-cadherin upregulation. PLoS One (2013) 0.78
Inflammation-induced desmoglein-2 ectodomain shedding compromises the mucosal barrier. Mol Biol Cell (2015) 0.78
Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue. Cell Rep (2015) 0.77
Carcinoma cells induce lumen filling and EMT in epithelial cells through soluble E-cadherin-mediated activation of EGFR. J Cell Sci (2015) 0.77
RUNX2 and TAZ-dependent signaling pathways regulate soluble E-Cadherin levels and tumorsphere formation in breast cancer cells. Oncotarget (2015) 0.77
Novel therapeutic strategy targeting the Hedgehog signalling and mTOR pathways in biliary tract cancer. Br J Cancer (2015) 0.76
A protease storm cleaves a cell-cell adhesion molecule in cancer: multiple proteases converge to regulate PTPmu in glioma cells. J Cell Biochem (2014) 0.76
The Dysregulation of Polyamine Metabolism in Colorectal Cancer Is Associated with Overexpression of c-Myc and C/EBPβ rather than Enterotoxigenic Bacteroides fragilis Infection. Oxid Med Cell Longev (2016) 0.76
Evidence for cadherin-11 cleavage in the synovium and partial characterization of its mechanism. Arthritis Res Ther (2015) 0.76
Cytoskeletal changes induced by allosteric modulators of calcium-sensing receptor in esophageal epithelial cells. Physiol Rep (2015) 0.76
The effects of 1,4-dimethylpyridine in metastatic prostate cancer in mice. BMC Cancer (2017) 0.75
Fine Tuning Cell Migration by a Disintegrin and Metalloproteinases. Mediators Inflamm (2017) 0.75
RARγ-induced E-cadherin downregulation promotes hepatocellular carcinoma invasion and metastasis. J Exp Clin Cancer Res (2016) 0.75
Proteolysis in Helicobacter pylori-Induced Gastric Cancer. Toxins (Basel) (2017) 0.75
Epithelial-to-mesenchymal transition in pancreatic ductal adenocarcinoma: Characterization in a 3D-cell culture model. World J Gastroenterol (2016) 0.75
Activation of cell-surface proteases promotes necroptosis, inflammation and cell migration. Cell Res (2016) 0.75
Interleukin-32α induces migration of human melanoma cells through downregulation of E-cadherin. Oncotarget (2016) 0.75
Cadherin-6B proteolysis promotes the neural crest cell epithelial-to-mesenchymal transition through transcriptional regulation. J Cell Biol (2016) 0.75
Suppression of AGR2 in a TGF-β-induced Smad regulatory pathway mediates epithelial-mesenchymal transition. BMC Cancer (2017) 0.75
Role of caspase-3/E-cadherin in helicobacter pylori-induced apoptosis of gastric epithelial cells. Oncotarget (2017) 0.75
The extracellular domain of E cadherin linked to invasiveness in colorectal cancer: a new resistance and relapses monitoring serum-bio marker? J Cancer Res Clin Oncol (2017) 0.75
Wnt signalling in stem cells and cancer. Nature (2005) 19.26
Regulation of cadherin-mediated adhesion in morphogenesis. Nat Rev Mol Cell Biol (2005) 9.27
A causal role for E-cadherin in the transition from adenoma to carcinoma. Nature (1998) 8.48
Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis. Cancer Res (2006) 5.90
Identification and purification of a cell surface glycoprotein mediating intercellular adhesion in embryonic and adult tissue. Cell (1983) 4.81
N-cadherin promotes motility in human breast cancer cells regardless of their E-cadherin expression. J Cell Biol (1999) 4.20
A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions. EMBO J (2002) 3.87
Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting. FEBS J (2010) 3.68
ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation. Proc Natl Acad Sci U S A (2005) 3.57
E-cadherin binding prevents beta-catenin nuclear localization and beta-catenin/LEF-1-mediated transactivation. J Cell Sci (1999) 3.55
Release of an invasion promoter E-cadherin fragment by matrilysin and stromelysin-1. J Cell Sci (2001) 3.51
beta-catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer. Am J Pathol (1999) 3.47
Ovarian cancer metastasis: integrating insights from disparate model organisms. Nat Rev Cancer (2005) 3.20
Soluble 80-kd fragment of cell-CAM 120/80 disrupts cell-cell adhesion. J Cell Biochem (1987) 3.17
Mechanisms of motility in metastasizing cells. Mol Cancer Res (2010) 2.42
E-cadherin-mediated adhesion inhibits ligand-dependent activation of diverse receptor tyrosine kinases. EMBO J (2004) 2.38
Signaling from E-cadherins to the MAPK pathway by the recruitment and activation of epidermal growth factor receptors upon cell-cell contact formation. J Biol Chem (2000) 2.12
Activation of the protein kinase Akt/PKB by the formation of E-cadherin-mediated cell-cell junctions. Evidence for the association of phosphatidylinositol 3-kinase with the E-cadherin adhesion complex. J Biol Chem (1999) 2.06
E-cadherin is crucial for embryonic stem cell pluripotency and can replace OCT4 during somatic cell reprogramming. EMBO Rep (2011) 1.93
Cleavage and shedding of E-cadherin after induction of apoptosis. J Biol Chem (2000) 1.90
Engagement of collagen-binding integrins promotes matrix metalloproteinase-9-dependent E-cadherin ectodomain shedding in ovarian carcinoma cells. Cancer Res (2007) 1.90
Na,K-ATPase beta-subunit is required for epithelial polarization, suppression of invasion, and cell motility. Mol Biol Cell (2001) 1.68
An intact overexpressed E-cadherin/alpha,beta-catenin axis characterizes the lymphovascular emboli of inflammatory breast carcinoma. Cancer Res (2001) 1.65
Effect of celecoxib on E-cadherin, VEGF, Microvessel density and apoptosis in gastric cancer. Cancer Biol Ther (2007) 1.59
Calcium influx triggers the sequential proteolysis of extracellular and cytoplasmic domains of E-cadherin, leading to loss of beta-catenin from cell-cell contacts. Oncogene (1999) 1.55
The ectodomain shedding of E-cadherin by ADAM15 supports ErbB receptor activation. J Biol Chem (2008) 1.53
The catenin p120ctn inhibits Kaiso-mediated transcriptional repression of the beta-catenin/TCF target gene matrilysin. Exp Cell Res (2005) 1.53
Activation of EGFR promotes squamous carcinoma SCC10A cell migration and invasion via inducing EMT-like phenotype change and MMP-9-mediated degradation of E-cadherin. J Cell Biochem (2011) 1.52
Misregulated E-cadherin expression associated with an aggressive brain tumor phenotype. PLoS One (2010) 1.44
Metastatic progression of prostate cancer and e-cadherin regulation by zeb1 and SRC family kinases. Am J Pathol (2011) 1.33
A role for the cleaved cytoplasmic domain of E-cadherin in the nucleus. J Biol Chem (2008) 1.32
Tumor response to combination celecoxib and erlotinib therapy in non-small cell lung cancer is associated with a low baseline matrix metalloproteinase-9 and a decline in serum-soluble E-cadherin. J Thorac Oncol (2008) 1.28
Formation of E-cadherin-mediated cell-cell adhesion activates AKT and mitogen activated protein kinase via phosphatidylinositol 3 kinase and ligand-independent activation of epidermal growth factor receptor in ovarian cancer cells. Mol Endocrinol (2005) 1.25
Upregulation of MMPs by soluble E-cadherin in human lung tumor cells. Int J Cancer (2003) 1.21
Soluble cadherins as cancer biomarkers. Clin Exp Metastasis (2007) 1.20
E-cadherin binding modulates EGF receptor activation. Cell Commun Adhes (2003) 1.10
Dual roles of E-cadherin in prostate cancer invasion. J Cell Biochem (2004) 1.00
Soluble E-cadherin promotes cell survival by activating epidermal growth factor receptor. Exp Cell Res (2011) 0.98
ErbB receptors and epithelial-cadherin-catenin complex in human carcinomas. Future Oncol (2006) 0.90
EGF promotes the shedding of soluble E-cadherin in an ADAM10-dependent manner in prostate epithelial cells. Cell Signal (2011) 0.89
Dominant-negative E-cadherin inhibits the invasiveness of inflammatory breast cancer cells in vitro. J Cancer Res Clin Oncol (2006) 0.88
Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis. Cancer Res (2006) 5.90
A novel cytoplasmic tail MXXXL motif mediates the internalization of prostate-specific membrane antigen. Mol Biol Cell (2003) 1.60
Estrogen receptor-alpha binds p53 tumor suppressor protein directly and represses its function. J Biol Chem (2006) 1.44
Clinical trials of cancer therapies targeting prostate-specific membrane antigen. Rev Recent Clin Trials (2007) 1.43
Novel role for Na,K-ATPase in phosphatidylinositol 3-kinase signaling and suppression of cell motility. Mol Biol Cell (2004) 1.33
Upregulation of tissue inhibitor of metalloproteinases (TIMP)-2 promotes matrix metalloproteinase (MMP)-2 activation and cell invasion in a human glioblastoma cell line. Lab Invest (2004) 1.30
Prostate-specific membrane antigen association with filamin A modulates its internalization and NAALADase activity. Cancer Res (2003) 1.22
Repression of Na,K-ATPase beta1-subunit by the transcription factor snail in carcinoma. Mol Biol Cell (2003) 1.22
Na-K-ATPase regulates tight junction permeability through occludin phosphorylation in pancreatic epithelial cells. Am J Physiol Gastrointest Liver Physiol (2006) 1.19
Na,K-ATPase subunits as markers for epithelial-mesenchymal transition in cancer and fibrosis. Mol Cancer Ther (2010) 1.13
Analysis of the Na,K-ATPase alpha- and beta-subunit expression profiles of bladder cancer using tissue microarrays. Cancer (2003) 1.10
Na,K-ATPase inhibition alters tight junction structure and permeability in human retinal pigment epithelial cells. Am J Physiol Cell Physiol (2003) 1.09
Ligation of HLA class I molecules on endothelial cells induces phosphorylation of Src, paxillin, and focal adhesion kinase in an actin-dependent manner. J Immunol (2002) 1.07
Na,K-ATPase and epithelial tight junctions. Front Biosci (Landmark Ed) (2009) 1.07
Interactions of tight junctions with membrane channels and transporters. Biochim Biophys Acta (2007) 1.06
Janus model of the Na,K-ATPase beta-subunit transmembrane domain: distinct faces mediate alpha/beta assembly and beta-beta homo-oligomerization. J Mol Biol (2006) 1.05
Biological impediments to monoclonal antibody-based cancer immunotherapy. Mol Cancer Ther (2004) 1.02
Multiple functions of Na,K-ATPase in epithelial cells. Semin Nephrol (2005) 1.00
HPAF-II, a cell culture model to study pancreatic epithelial cell structure and function. Pancreas (2004) 0.99
Soluble E-cadherin promotes cell survival by activating epidermal growth factor receptor. Exp Cell Res (2011) 0.98
alpha-Catenin overrides Src-dependent activation of beta-catenin oncogenic signaling. Mol Cancer Ther (2008) 0.97
Na,K-adenosine triphosphatase alpha1-subunit predicts survival of renal clear cell carcinoma. J Urol (2007) 0.97
N-glycosylation and microtubule integrity are involved in apical targeting of prostate-specific membrane antigen: implications for immunotherapy. Mol Cancer Ther (2005) 0.94
Na,K-ATPase beta1-subunit increases the translation efficiency of the alpha1-subunit in MSV-MDCK cells. Mol Biol Cell (2004) 0.93
Dexamethasone-loaded block copolymer nanoparticles induce leukemia cell death and enhance therapeutic efficacy: a novel application in pediatric nanomedicine. Mol Pharm (2012) 0.91
Protein expression based multimarker analysis of breast cancer samples. BMC Cancer (2011) 0.88
Prostate-specific membrane antigen associates with anaphase-promoting complex and induces chromosomal instability. Mol Cancer Ther (2008) 0.88
Dysfunction of ouabain-induced cardiac contractility in mice with heart-specific ablation of Na,K-ATPase beta1-subunit. J Mol Cell Cardiol (2009) 0.85
Association of prostate-specific membrane antigen with caveolin-1 and its caveolae-dependent internalization in microvascular endothelial cells: implications for targeting to tumor vasculature. Microvasc Res (2006) 0.85
Preferential association of prostate cancer cells expressing prostate specific membrane antigen to bone marrow matrix. Int J Oncol (2007) 0.85
Polarity of prostate specific membrane antigen, prostate stem cell antigen, and prostate specific antigen in prostate tissue and in a cultured epithelial cell line. Prostate (2003) 0.85
Na,K-ATPase β-subunit cis homo-oligomerization is necessary for epithelial lumen formation in mammalian cells. J Cell Sci (2012) 0.82
Expression of Na,K-ATPase-beta(1) subunit increases uptake and sensitizes carcinoma cells to oxaliplatin. Cancer Chemother Pharmacol (2009) 0.81
Expression of Na,K-ATPase beta-subunit in transformed MDCK cells increases the translation of the Na,K-ATPase alpha-subunit. Ann N Y Acad Sci (2003) 0.81
Na,K-ATPase is a target of cigarette smoke and reduced expression predicts poor patient outcome of smokers with lung cancer. Am J Physiol Lung Cell Mol Physiol (2012) 0.79
Differing effects of microtubule depolymerizing and stabilizing chemotherapeutic agents on t-SNARE-mediated apical targeting of prostate-specific membrane antigen. Mol Cancer Ther (2006) 0.79
Gramicidin A induces metabolic dysfunction and energy depletion leading to cell death in renal cell carcinoma cells. Mol Cancer Ther (2013) 0.79
Interaction of prostate specific membrane antigen with clathrin and the adaptor protein complex-2. Int J Oncol (2007) 0.78
Gramicidin A blocks tumor growth and angiogenesis through inhibition of hypoxia-inducible factor in renal cell carcinoma. Mol Cancer Ther (2014) 0.75