Published in Clin Epigenetics on May 08, 2010
MicroRNAs: genomics, biogenesis, mechanism, and function. Cell (2004) 198.59
Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell (2005) 96.87
Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature (2007) 21.53
A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. Cell (2006) 11.01
miR-21-mediated tumor growth. Oncogene (2006) 9.90
Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells. Cancer Cell (2006) 8.46
microRNAs exhibit high frequency genomic alterations in human cancer. Proc Natl Acad Sci U S A (2006) 8.24
A microRNA DNA methylation signature for human cancer metastasis. Proc Natl Acad Sci U S A (2008) 7.14
Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell lines. Gastroenterology (2006) 7.06
Arabidopsis micro-RNA biogenesis through Dicer-like 1 protein functions. Proc Natl Acad Sci U S A (2004) 6.61
Epigenetic inactivation of microRNA gene hsa-mir-9-1 in human breast cancer. J Pathol (2008) 3.18
MicroRNA expression profiles for the NCI-60 cancer cell panel. Mol Cancer Ther (2007) 2.53
MicroRNAs as novel regulators of angiogenesis. Circ Res (2009) 2.33
miRNA expression profiling in melanocytes and melanoma cell lines reveals miRNAs associated with formation and progression of malignant melanoma. J Invest Dermatol (2009) 2.06
MicroRNAs in tumorigenesis: a primer. Am J Pathol (2007) 1.83
Integrative analysis of epigenetic modulation in melanoma cell response to decitabine: clinical implications. PLoS One (2009) 1.80
Malignant melanoma: prevention, early detection, and treatment in the 21st century. CA Cancer J Clin (2000) 1.79
Palliative therapy of disseminated malignant melanoma: a systematic review of 41 randomised clinical trials. Lancet Oncol (2003) 1.78
Epigenetic therapy upregulates the tumor suppressor microRNA-126 and its host gene EGFL7 in human cancer cells. Biochem Biophys Res Commun (2008) 1.74
Breast cancer metastasis: a microRNA story. Breast Cancer Res (2008) 1.70
MicroRNA-15b represents an independent prognostic parameter and is correlated with tumor cell proliferation and apoptosis in malignant melanoma. Int J Cancer (2010) 1.62
Molecular therapy in the microRNA era. Pharmacogenomics J (2006) 1.52
Peroxisome proliferator-activated receptor alpha activation decreases metastatic potential of melanoma cells in vitro via down-regulation of Akt. Clin Cancer Res (2006) 1.49
MicroRNA: An emerging therapeutic target and intervention tool. Int J Mol Sci (2008) 1.41
Design and delivery of antisense oligonucleotides to block microRNA function in cultured Drosophila and human cells. Nat Protoc (2008) 1.38
MicroRNA therapeutics: a new niche for antisense nucleic acids. Trends Mol Med (2006) 1.29
Epigenetic events in malignant melanoma. Pigment Cell Res (2007) 1.10
MicroRNA-dependent regulation of cKit in cutaneous melanoma. Biochem Biophys Res Commun (2009) 1.09
Profiling and discovery of novel miRNAs from formalin-fixed, paraffin-embedded melanoma and nodal specimens. J Mol Diagn (2009) 1.05
Changes in miRNA expression in solid tumors: an miRNA profiling in melanomas. Semin Cancer Biol (2008) 0.99
On the Oregon trail: rationing health care. BMJ (1991) 20.63
Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety. Nat Genet (1999) 11.79
An international classification and grading system for age-related maculopathy and age-related macular degeneration. The International ARM Epidemiological Study Group. Surv Ophthalmol (1995) 10.05
The Wisconsin epidemiologic study of diabetic retinopathy. II. Prevalence and risk of diabetic retinopathy when age at diagnosis is less than 30 years. Arch Ophthalmol (1984) 9.28
Role of brain insulin receptor in control of body weight and reproduction. Science (2000) 8.14
Onset of NIDDM occurs at least 4-7 yr before clinical diagnosis. Diabetes Care (1992) 7.69
The Wisconsin epidemiologic study of diabetic retinopathy. III. Prevalence and risk of diabetic retinopathy when age at diagnosis is 30 or more years. Arch Ophthalmol (1984) 7.68
Milburn's vision of a new NHS. Adopting the missionary position. BMJ (2001) 7.31
Two views on the Griffiths report. The mobilisation of consent versus the management of conflict: decoding the Griffiths report. Br Med J (Clin Res Ed) (1983) 6.16
Methods for evaluation of retinal microvascular abnormalities associated with hypertension/sclerosis in the Atherosclerosis Risk in Communities Study. Ophthalmology (1999) 6.07
Prevalence of hearing loss in older adults in Beaver Dam, Wisconsin. The Epidemiology of Hearing Loss Study. Am J Epidemiol (1998) 6.04
The Wisconsin epidemiologic study of diabetic retinopathy. IV. Diabetic macular edema. Ophthalmology (1984) 5.91
Explaining outputs of primary health care: population and practice factors. BMJ (1991) 5.61
Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor. Nature (1995) 5.51
Prevalence of glaucoma. The Beaver Dam Eye Study. Ophthalmology (1992) 5.35
Risk factors for age-related macular degeneration: Pooled findings from three continents. Ophthalmology (2001) 5.06
Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis. Genes Dev (1999) 4.75
Variations in budgets of fundholding practices. BMJ (1991) 4.71
Beta1-class integrins regulate the development of laminae and folia in the cerebral and cerebellar cortex. Neuron (2001) 4.62
The Beaver Dam Health Outcomes Study: initial catalog of health-state quality factors. Med Decis Making (1993) 4.46
Essential role for TrkB receptors in hippocampus-mediated learning. Neuron (1999) 4.20
The prevalence by staged severity of various types of diabetic neuropathy, retinopathy, and nephropathy in a population-based cohort: the Rochester Diabetic Neuropathy Study. Neurology (1993) 4.18
The 14-year incidence of visual loss in a diabetic population. Ophthalmology (1998) 4.08
Prevalence of and risk factors for dry eye syndrome. Arch Ophthalmol (2000) 3.94
Cigarette smoking and hearing loss: the epidemiology of hearing loss study. JAMA (1998) 3.86
Identifying the content area for the 51-item National Eye Institute Visual Function Questionnaire: results from focus groups with visually impaired persons. Arch Ophthalmol (1998) 3.75
Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene. Nature (1994) 3.73
Equity and the NHS: self-reported morbidity, access, and primary care. Br Med J (1980) 3.72
Assessment of cataracts from photographs in the Beaver Dam Eye Study. Ophthalmology (1990) 3.66
Visual impairment in diabetes. Ophthalmology (1984) 3.64
Warning signals from Oregon. BMJ (1992) 3.58
Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development. Mol Cell (2000) 3.54
Towards a new pluralism. Health Policy (1987) 3.47
Diabetic retinopathy. Diabetes Care (1998) 3.39
Chlorination of taurine by human neutrophils. Evidence for hypochlorous acid generation. J Clin Invest (1982) 3.33
The prevalence of glaucoma in a population-based study of Hispanic subjects: Proyecto VER. Arch Ophthalmol (2001) 3.31
Retinal microvascular abnormalities and incident stroke: the Atherosclerosis Risk in Communities Study. Lancet (2001) 3.28
Diabetic retinopathy as detected using ophthalmoscopy, a nonmydriatic camera and a standard fundus camera. Ophthalmology (1985) 3.20
Rationing in practice: the case of in vitro fertilisation. BMJ (1993) 3.20
Nuk controls pathfinding of commissural axons in the mammalian central nervous system. Cell (1996) 3.19
Priorities and rationing: pragmatism or principles? BMJ (1995) 3.09
An alternative method of grading diabetic retinopathy. Ophthalmology (1986) 3.05
Apoptosis of CD8+ T cells is mediated by macrophages through interaction of HIV gp120 with chemokine receptor CXCR4. Nature (1998) 3.02
trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3. Cell (1991) 2.97
Is the risk of diabetic retinopathy greater in non-Hispanic blacks and Mexican Americans than in non-Hispanic whites with type 2 diabetes? A U.S. population study. Diabetes Care (1998) 2.97
Ten-year incidence of visual loss in a diabetic population. Ophthalmology (1994) 2.91
Cause-specific mortality in a population-based study of diabetes. Am J Public Health (1991) 2.89
Low prevalence of hearing aid use among older adults with hearing loss: the Epidemiology of Hearing Loss Study. J Am Geriatr Soc (1998) 2.88
Tyro-3 family receptors are essential regulators of mammalian spermatogenesis. Nature (1999) 2.80
The politics of change. BMJ (1991) 2.70
Prevalence of age-related lens opacities in a population. The Beaver Dam Eye Study. Ophthalmology (1992) 2.68
Puzzling out priorities. Why we must acknowledge that rationing is a political process. BMJ (1998) 2.65
Intraocular pressure in an American community. The Beaver Dam Eye Study. Invest Ophthalmol Vis Sci (1992) 2.55
Retinal microvascular abnormalities and their relationship with hypertension, cardiovascular disease, and mortality. Surv Ophthalmol (2001) 2.51
Performance-based and self-assessed measures of visual function as related to history of falls, hip fractures, and measured gait time. The Beaver Dam Eye Study. Ophthalmology (1998) 2.50
Is the English NHS underfunded? BMJ (1999) 2.47
Association of NIDDM and hearing loss. Diabetes Care (1998) 2.45
The GlideScope Video Laryngoscope: randomized clinical trial in 200 patients. Br J Anaesth (2004) 2.41
Tyrosine phosphorylation of transmembrane ligands for Eph receptors. Science (1997) 2.40
Sibling correlations and segregation analysis of age-related maculopathy: the Beaver Dam Eye Study. Genet Epidemiol (1994) 2.39
Controlling the gatekeepers: the accountability of general practitioners. J R Coll Gen Pract (1986) 2.39
From evidence-based medicine to evidence-based policy? J Health Serv Res Policy (2000) 2.36
Refractive status in the Beaver Dam Eye Study. Invest Ophthalmol Vis Sci (1994) 2.36
Alcohol intake and the risk of coronary heart disease mortality in persons with older-onset diabetes mellitus. JAMA (1999) 2.35
The Wisconsin Epidemiologic Study of Diabetic Retinopathy. XIII. Relationship of serum cholesterol to retinopathy and hard exudate. Ophthalmology (1991) 2.34
The 14-year incidence of lower-extremity amputations in a diabetic population. The Wisconsin Epidemiologic Study of Diabetic Retinopathy. Diabetes Care (1999) 2.33
On the way to Calvary. Ministers should realise the command and control model the white paper entails. BMJ (1998) 2.30
Methodology for retinal photography and assessment of diabetic retinopathy: the EURODIAB IDDM complications study. Diabetologia (1995) 2.27
Sek4 and Nuk receptors cooperate in guidance of commissural axons and in palate formation. EMBO J (1996) 2.26
Production and characterization of monoclonal antibodies against the Epstein-Barr virus membrane antigen. J Virol (1982) 2.26
Comparison between ophthalmoscopy and fundus photography in determining severity of diabetic retinopathy. Ophthalmology (1985) 2.26
Why Britain is reorganizing its national health service--yet again. Health Aff (Millwood) (1998) 2.25
Is there evidence of an estrogen effect on age-related lens opacities? The Beaver Dam Eye Study. Arch Ophthalmol (1994) 2.23
Diabetes and diabetic retinopathy in a Mexican-American population: Proyecto VER. Diabetes Care (2001) 2.16
A role for the Ras signalling pathway in synaptic transmission and long-term memory. Nature (1997) 2.16
The validity of self-reported and surrogate-reported cataract and age-related macular degeneration in the Beaver Dam Eye Study. Am J Epidemiol (1991) 2.14
Uncoupling of Grb2 from the Met receptor in vivo reveals complex roles in muscle development. Cell (1996) 2.14
Dietary fat and age-related maculopathy. Arch Ophthalmol (1995) 2.11
A diet history questionnaire ranks nutrient intakes in middle-aged and older men and women similarly to multiple food records. J Nutr (1993) 2.06
Kinase-independent requirement of EphB2 receptors in hippocampal synaptic plasticity. Neuron (2001) 2.06
Incomes: vive la différence. Br Med J (1976) 2.03
Retinal arteriolar diameters and elevated blood pressure: the Atherosclerosis Risk in Communities Study. Am J Epidemiol (1999) 2.01
Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells. Neuron (1993) 2.01
Adrenocortical function in acquired immunodeficiency syndrome. J Clin Endocrinol Metab (1987) 1.99
The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3. Cell (1991) 1.97
The cytoplasmic domain of the ligand ephrinB2 is required for vascular morphogenesis but not cranial neural crest migration. Cell (2001) 1.88
Association of dietary and life-style factors with sex hormones in postmenopausal women. Epidemiology (1995) 1.86
The risk of cardiovascular disease mortality associated with microalbuminuria and gross proteinuria in persons with older-onset diabetes mellitus. Arch Intern Med (2000) 1.86
Ephrin-B3 is the midline barrier that prevents corticospinal tract axons from recrossing, allowing for unilateral motor control. Genes Dev (2001) 1.83
Challenge and promise: roles for clusterin in pathogenesis, progression and therapy of cancer. Cell Death Differ (2006) 1.83
Sunlight and age-related macular degeneration. The Beaver Dam Eye Study. Arch Ophthalmol (1993) 1.81
EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains. Neuron (1999) 1.81
A multi-site study using high-resolution HLA genotyping by next generation sequencing. Tissue Antigens (2011) 1.81
Cigarette smoking and lens opacities: the Beaver Dam Eye Study. Am J Prev Med (1993) 1.80
The Onchocerciasis Elimination Program for the Americas: a history of partnership. Rev Panam Salud Publica (1998) 1.79
Accuracy of self-reported hearing loss. Audiology (1998) 1.77
Lessons from the financial scandals in Wessex and the West Midlands. BMJ (1994) 1.76
The collagen receptor DDR2 regulates proliferation and its elimination leads to dwarfism. EMBO Rep (2001) 1.76
Kinase-dependent and kinase-independent functions of EphA4 receptors in major axon tract formation in vivo. Neuron (2001) 1.75
Diagnostic x-ray exposure and lens opacities: the Beaver Dam Eye Study. Am J Public Health (1993) 1.75