Published in N Engl J Med on July 03, 2008
Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association. Stroke (2011) 10.11
The worldwide epidemiology of type 2 diabetes mellitus--present and future perspectives. Nat Rev Endocrinol (2011) 5.55
Dynamic DNA methylation programs persistent adverse effects of early-life stress. Nat Neurosci (2009) 4.53
Interventions for promoting smoking cessation during pregnancy. Cochrane Database Syst Rev (2009) 4.47
Psychological stress in childhood and susceptibility to the chronic diseases of aging: moving toward a model of behavioral and biological mechanisms. Psychol Bull (2011) 4.27
DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific. Hum Mol Genet (2009) 4.25
Low early-life social class leaves a biological residue manifested by decreased glucocorticoid and increased proinflammatory signaling. Proc Natl Acad Sci U S A (2009) 4.11
Adverse childhood experiences and adult risk factors for age-related disease: depression, inflammation, and clustering of metabolic risk markers. Arch Pediatr Adolesc Med (2009) 3.41
Convergence of non-communicable and infectious diseases in low- and middle-income countries. Int J Epidemiol (2012) 3.21
Epigenetic gene promoter methylation at birth is associated with child's later adiposity. Diabetes (2011) 3.18
In utero effects. In utero undernourishment perturbs the adult sperm methylome and intergenerational metabolism. Science (2014) 3.07
First trimester fetal growth restriction and cardiovascular risk factors in school age children: population based cohort study. BMJ (2014) 2.97
The Generation R Study: design and cohort update 2012. Eur J Epidemiol (2012) 2.84
Epigenetics and environmental chemicals. Curr Opin Pediatr (2009) 2.83
Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes. J Exp Med (2008) 2.79
Cohort profile: updating the cohort profile for the MRC National Survey of Health and Development: a new clinic-based data collection for ageing research. Int J Epidemiol (2011) 2.75
Women's compliance with nutrition and lifestyle recommendations before pregnancy: general population cohort study. BMJ (2009) 2.54
Mechanisms of implantation: strategies for successful pregnancy. Nat Med (2012) 2.50
Rats exposed to isoflurane in utero during early gestation are behaviorally abnormal as adults. Anesthesiology (2011) 2.41
From stress to inflammation and major depressive disorder: a social signal transduction theory of depression. Psychol Bull (2014) 2.39
Diet-induced obesity model: abnormal oocytes and persistent growth abnormalities in the offspring. Endocrinology (2010) 2.35
Predictors of global methylation levels in blood DNA of healthy subjects: a combined analysis. Int J Epidemiol (2010) 2.34
Psychosocial interventions for supporting women to stop smoking in pregnancy. Cochrane Database Syst Rev (2013) 2.33
Childhood obesity. Circulation (2012) 2.28
Molecular signatures of major depression. Curr Biol (2015) 2.28
Periconceptional maternal folic acid use of 400 microg per day is related to increased methylation of the IGF2 gene in the very young child. PLoS One (2009) 2.23
Modulation of DNA methylation states and infant immune system by dietary supplementation with ω-3 PUFA during pregnancy in an intervention study. Am J Clin Nutr (2013) 2.20
Child health, developmental plasticity, and epigenetic programming. Endocr Rev (2010) 2.15
Type 2 diabetes in East Asians: similarities and differences with populations in Europe and the United States. Ann N Y Acad Sci (2013) 2.15
Ischemic heart disease and stroke in relation to blood DNA methylation. Epidemiology (2010) 2.10
Defining normal and abnormal fetal growth: promises and challenges. Am J Obstet Gynecol (2010) 2.05
Metformin in gestational diabetes: the offspring follow-up (MiG TOFU): body composition at 2 years of age. Diabetes Care (2011) 2.04
Developmental origins of health and disease: brief history of the approach and current focus on epigenetic mechanisms. Semin Reprod Med (2009) 2.03
Preventing obesity during infancy: a pilot study. Obesity (Silver Spring) (2010) 1.99
Integrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO type 2 diabetes and obesity susceptibility locus. PLoS One (2010) 1.93
Phthalates and other additives in plastics: human exposure and associated health outcomes. Philos Trans R Soc Lond B Biol Sci (2009) 1.87
Intergenerational transmission of glucose intolerance and obesity by in utero undernutrition in mice. Diabetes (2008) 1.86
Early developmental conditioning of later health and disease: physiology or pathophysiology? Physiol Rev (2014) 1.86
Critical need for family-based, quasi-experimental designs in integrating genetic and social science research. Am J Public Health (2013) 1.80
Preterm birth, infant weight gain, and childhood asthma risk: a meta-analysis of 147,000 European children. J Allergy Clin Immunol (2014) 1.79
Foetal hypoxia increases cardiac AT(2)R expression and subsequent vulnerability to adult ischaemic injury. Cardiovasc Res (2010) 1.74
Birth weight, head circumference, and prenatal exposure to acrylamide from maternal diet: the European prospective mother-child study (NewGeneris). Environ Health Perspect (2012) 1.74
Exposure to the Chinese famine in early life and the risk of hyperglycemia and type 2 diabetes in adulthood. Diabetes (2010) 1.74
IL-17 signaling accelerates the progression of nonalcoholic fatty liver disease in mice. Hepatology (2014) 1.69
Epigenetics and cardiovascular disease. Nat Rev Cardiol (2010) 1.68
Stress during pregnancy and offspring pediatric disease: A National Cohort Study. Environ Health Perspect (2011) 1.65
Neonatal outcomes after influenza immunization during pregnancy: a randomized controlled trial. CMAJ (2012) 1.65
The contribution of maternal stress to preterm birth: issues and considerations. Clin Perinatol (2011) 1.63
Type 2 diabetes risk alleles are associated with reduced size at birth. Diabetes (2009) 1.58
Birth weight and long-term overweight risk: systematic review and a meta-analysis including 643,902 persons from 66 studies and 26 countries globally. PLoS One (2012) 1.58
Prenatal exposure to cigarette smoke induces diet- and sex-dependent dyslipidemia and weight gain in adult murine offspring. Environ Health Perspect (2009) 1.57
Fetomaternal immune cross-talk and its consequences for maternal and offspring's health. Nat Med (2013) 1.54
Educational Differences in U.S. Adult Mortality: A Cohort Perspective. Am Sociol Rev (2012) 1.52
Early-life sodium exposure unmasks susceptibility to stroke in hyperlipidemic, hypertensive heterozygous Tg25 rats transgenic for human cholesteryl ester transfer protein. Circulation (2009) 1.51
Early origins of inflammation: microbial exposures in infancy predict lower levels of C-reactive protein in adulthood. Proc Biol Sci (2009) 1.51
Perinatal complications and aging indicators by midlife. Pediatrics (2014) 1.51
Effect of the INSIGHT Responsive Parenting Intervention on Rapid Infant Weight Gain and Overweight Status at Age 1 Year: A Randomized Clinical Trial. JAMA Pediatr (2016) 1.50
STUDIES IN FETAL BEHAVIOR: REVISITED, RENEWED, AND REIMAGINED. Monogr Soc Res Child Dev (2015) 1.49
Metabolomic markers reveal novel pathways of ageing and early development in human populations. Int J Epidemiol (2013) 1.48
Mother's education and the risk of preterm and small for gestational age birth: a DRIVERS meta-analysis of 12 European cohorts. J Epidemiol Community Health (2015) 1.47
Cord serum lipidome in prediction of islet autoimmunity and type 1 diabetes. Diabetes (2013) 1.47
The World Health Organization Fetal Growth Charts: A Multinational Longitudinal Study of Ultrasound Biometric Measurements and Estimated Fetal Weight. PLoS Med (2017) 1.47
Developmental origins of health and disease: environmental exposures. Semin Reprod Med (2009) 1.44
Impact of Maternal Exercise during Pregnancy on Offspring Chronic Disease Susceptibility. Exerc Sport Sci Rev (2015) 1.43
Maternal preeclampsia and neonatal outcomes. J Pregnancy (2011) 1.42
Genome-environment interactions that modulate aging: powerful targets for drug discovery. Pharmacol Rev (2011) 1.42
Chronic prenatal hypoxia induces epigenetic programming of PKC{epsilon} gene repression in rat hearts. Circ Res (2010) 1.41
Is Placental Mitochondrial Function a Regulator that Matches Fetal and Placental Growth to Maternal Nutrient Intake in the Mouse? PLoS One (2015) 1.40
First-trimester maternal protein intake and childhood kidney outcomes: the Generation R Study. Am J Clin Nutr (2015) 1.39
The impact of altitude on infant health in South America. Econ Hum Biol (2010) 1.38
Association of endocrine disruptors and obesity: perspectives from epidemiological studies. Int J Androl (2010) 1.36
Nutritional supplementation in girls influences the growth of their children: prospective study in Guatemala. Am J Clin Nutr (2009) 1.34
Tilting at quixotic trait loci (QTL): an evolutionary perspective on genetic causation. Genetics (2008) 1.33
DNA methylation of IGF2, GNASAS, INSIGF and LEP and being born small for gestational age. Epigenetics (2011) 1.33
Preterm birth and childhood wheezing disorders: a systematic review and meta-analysis. PLoS Med (2014) 1.33
Transcriptional modulation of the developing immune system by early life social adversity. Proc Natl Acad Sci U S A (2012) 1.31
Lifecourse health development: past, present and future. Matern Child Health J (2014) 1.30
Repetitive element hypomethylation in blood leukocyte DNA and cancer incidence, prevalence, and mortality in elderly individuals: the Normative Aging Study. Cancer Causes Control (2010) 1.30
The effect of genotype and in utero environment on interindividual variation in neonate DNA methylomes. Genome Res (2014) 1.29
The blood exposome and its role in discovering causes of disease. Environ Health Perspect (2014) 1.27
Developmental programming of cardiovascular dysfunction by prenatal hypoxia and oxidative stress. PLoS One (2012) 1.26
Accelerated postnatal growth increases lipogenic gene expression and adipocyte size in low-birth weight mice. Diabetes (2009) 1.25
Depression in pregnancy, infant birth weight and DNA methylation of imprint regulatory elements. Epigenetics (2012) 1.25
Mammalian target of rapamycin signalling modulates amino acid uptake by regulating transporter cell surface abundance in primary human trophoblast cells. J Physiol (2012) 1.23
Fragmentation and unpredictability of early-life experience in mental disorders. Am J Psychiatry (2012) 1.23
Prenatal stress exposure related to maternal bereavement and risk of childhood overweight. PLoS One (2010) 1.22
Current knowledge of obesity's effects in the pre- and periconceptional periods and avenues for future research. Am J Obstet Gynecol (2010) 1.21
Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites. Nat Commun (2015) 1.21
Offspring of mothers fed a high fat diet display hepatic cell cycle inhibition and associated changes in gene expression and DNA methylation. PLoS One (2011) 1.19
Quantification of excess risk for diabetes for those born in times of hunger, in an entire population of a nation, across a century. Proc Natl Acad Sci U S A (2013) 1.19
Long-term reduction of hippocampal brain-derived neurotrophic factor activity after fetal-neonatal iron deficiency in adult rats. Pediatr Res (2009) 1.19
Forecasting the burden of type 2 diabetes in Singapore using a demographic epidemiological model of Singapore. BMJ Open Diabetes Res Care (2014) 1.18
Progressive, transgenerational changes in offspring phenotype and epigenotype following nutritional transition. PLoS One (2011) 1.18
Colloquium paper: how grandmother effects plus individual variation in frailty shape fertility and mortality: guidance from human-chimpanzee comparisons. Proc Natl Acad Sci U S A (2010) 1.17
Developmental programming: impact of excess prenatal testosterone on intrauterine fetal endocrine milieu and growth in sheep. Biol Reprod (2010) 1.15
Vitamin D insufficiency is associated with impaired vascular endothelial and smooth muscle function and hypertension in young rats. J Physiol (2011) 1.15
Foetal nicotine exposure causes PKCε gene repression by promoter methylation in rat hearts. Cardiovasc Res (2010) 1.14
Programming of adipose tissue miR-483-3p and GDF-3 expression by maternal diet in type 2 diabetes. Cell Death Differ (2012) 1.14
Developmental origins of health and disease: reducing the burden of chronic disease in the next generation. Genome Med (2010) 1.13
Preconception care in Saudi women with diabetes mellitus. J Family Community Med (2016) 1.13
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature (2007) 144.95
Epigenetic programming by maternal behavior. Nat Neurosci (2004) 20.92
Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci U S A (2005) 15.46
Diet, nutrition and the prevention of chronic diseases. World Health Organ Tech Rep Ser (2003) 14.60
Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? Am J Hum Genet (1962) 13.72
Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia (1992) 13.20
Infant mortality, childhood nutrition, and ischaemic heart disease in England and Wales. Lancet (1986) 12.13
Relation of serial changes in childhood body-mass index to impaired glucose tolerance in young adulthood. N Engl J Med (2004) 11.09
Metabolic syndrome in childhood: association with birth weight, maternal obesity, and gestational diabetes mellitus. Pediatrics (2005) 8.99
Epigenetics: a landscape takes shape. Cell (2007) 8.29
Trajectories of growth among children who have coronary events as adults. N Engl J Med (2005) 7.29
Developmental plasticity and human health. Nature (2004) 7.13
RNA-mediated non-mendelian inheritance of an epigenetic change in the mouse. Nature (2006) 6.90
Epigenetic reprogramming in mammals. Hum Mol Genet (2005) 6.73
Developmental origins of the metabolic syndrome: prediction, plasticity, and programming. Physiol Rev (2005) 6.67
Nongenomic transmission across generations of maternal behavior and stress responses in the rat. Science (1999) 6.24
Childhood obesity and metabolic imprinting: the ongoing effects of maternal hyperglycemia. Diabetes Care (2007) 5.41
Early growth and death from cardiovascular disease in women. BMJ (1993) 5.15
Duration of breastfeeding and risk of overweight: a meta-analysis. Am J Epidemiol (2005) 5.09
Premature birth and later insulin resistance. N Engl J Med (2004) 4.75
Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring. J Nutr (2005) 4.57
Birth weight and risk of cardiovascular disease in a cohort of women followed up since 1976. BMJ (1997) 4.49
Glucose regulation in young adults with very low birth weight. N Engl J Med (2007) 4.35
Cardiovascular and diabetes mortality determined by nutrition during parents' and grandparents' slow growth period. Eur J Hum Genet (2002) 4.33
Neonatal anthropometry: the thin-fat Indian baby. The Pune Maternal Nutrition Study. Int J Obes Relat Metab Disord (2003) 4.06
In utero programming of chronic disease. Clin Sci (Lond) (1998) 4.00
Fetal origins of hyperphagia, obesity, and hypertension and postnatal amplification by hypercaloric nutrition. Am J Physiol Endocrinol Metab (2000) 3.52
Neonatal leptin treatment reverses developmental programming. Endocrinology (2005) 3.51
Early evidence of ethnic differences in cardiovascular risk: cross sectional comparison of British South Asian and white children. BMJ (2002) 3.48
The fetal insulin hypothesis: an alternative explanation of the association of low birthweight with diabetes and vascular disease. Lancet (1999) 3.48
Birthweight, body-mass index in middle age, and incident coronary heart disease. Lancet (1996) 3.37
Differential effects of culture on imprinted H19 expression in the preimplantation mouse embryo. Biol Reprod (2000) 3.33
Epigenetic modification of the renin-angiotensin system in the fetal programming of hypertension. Circ Res (2007) 3.28
DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status. Proc Natl Acad Sci U S A (2007) 3.24
Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood. Proc Natl Acad Sci U S A (2006) 3.07
Maternal protein restriction suppresses the newborn renin-angiotensin system and programs adult hypertension in rats. Pediatr Res (2001) 3.07
Vitamin B12 and folate concentrations during pregnancy and insulin resistance in the offspring: the Pune Maternal Nutrition Study. Diabetologia (2007) 2.96
Maternal nutrition in early and late pregnancy in relation to placental and fetal growth. BMJ (1996) 2.92
Predictive adaptive responses and human evolution. Trends Ecol Evol (2005) 2.90
Maternal undernutrition during the preimplantation period of rat development causes blastocyst abnormalities and programming of postnatal hypertension. Development (2000) 2.82
Size at birth and resilience to effects of poor living conditions in adult life: longitudinal study. BMJ (2001) 2.79
Glucocorticoid programming. Ann N Y Acad Sci (2004) 2.73
Dietary protein restriction of pregnant rats in the F0 generation induces altered methylation of hepatic gene promoters in the adult male offspring in the F1 and F2 generations. Br J Nutr (2007) 2.48
Impact of educational attainment on the quality of young women's diets. Eur J Clin Nutr (2004) 2.44
Environmental influences during development and their later consequences for health and disease: implications for the interpretation of empirical studies. Proc Biol Sci (2005) 2.40
Fetal exposure to a maternal low protein diet impairs nephrogenesis and promotes hypertension in the rat. Life Sci (1999) 2.39
Glucocorticoid exposure in late gestation permanently programs rat hepatic phosphoenolpyruvate carboxykinase and glucocorticoid receptor expression and causes glucose intolerance in adult offspring. J Clin Invest (1998) 2.36
Uteroplacental insufficiency increases apoptosis and alters p53 gene methylation in the full-term IUGR rat kidney. Am J Physiol Regul Integr Comp Physiol (2003) 2.31
Metabolic plasticity during mammalian development is directionally dependent on early nutritional status. Proc Natl Acad Sci U S A (2007) 2.26
Fetal programming of hypothalamo-pituitary-adrenal function: prenatal stress and glucocorticoids. J Physiol (2006) 2.18
Intergenerational consequences of fetal programming by in utero exposure to glucocorticoids in rats. Am J Physiol Regul Integr Comp Physiol (2004) 2.15
Developmental origins of disease paradigm: a mechanistic and evolutionary perspective. Pediatr Res (2004) 2.11
Association of birth weight with osteoporosis and osteoarthritis in adult twins. Rheumatology (Oxford) (2003) 2.04
The adaptive advantage of phenotypic memory in changing environments. Philos Trans R Soc Lond B Biol Sci (1995) 1.99
Prenatal programming of adult hypertension in the rat. Kidney Int (2001) 1.93
Dexamethasone in the last week of pregnancy attenuates hippocampal glucocorticoid receptor gene expression and elevates blood pressure in the adult offspring in the rat. Neuroendocrinology (1996) 1.88
Sedentary behavior during postnatal life is determined by the prenatal environment and exacerbated by postnatal hypercaloric nutrition. Am J Physiol Regul Integr Comp Physiol (2003) 1.86
Low birthweight is associated with specific changes in muscle insulin-signalling protein expression. Diabetologia (2005) 1.85
Epigenetic germline inheritance. Curr Opin Genet Dev (2004) 1.85
Growth in infancy and bone mass in later life. Ann Rheum Dis (1997) 1.84
Adult hypertension and kidney disease: the role of fetal programming. Hypertension (2006) 1.82
Congenital malformations among infants whose mothers had gestational diabetes or preexisting diabetes. Early Hum Dev (2001) 1.82
Modest maternal protein restriction fails to program adult hypertension in female rats. Am J Physiol Regul Integr Comp Physiol (2005) 1.78
Evolution, development and timing of puberty. Trends Endocrinol Metab (2005) 1.75
Dietary protein restriction in pregnancy induces hypertension and vascular defects in rat male offspring. Pediatr Res (2003) 1.73
Effect of fetal hypoxia on heart susceptibility to ischemia and reperfusion injury in the adult rat. J Soc Gynecol Investig (2003) 1.71
Maternal constraint of fetal growth and its consequences. Semin Fetal Neonatal Med (2004) 1.70
Prenatal and childhood influences on osteoporosis. Best Pract Res Clin Endocrinol Metab (2002) 1.64
Animal evidence for the transgenerational development of diabetes mellitus. Int J Biochem Cell Biol (2005) 1.62
Birthweight, vitamin D receptor genotype and the programming of osteoporosis. Paediatr Perinat Epidemiol (2001) 1.61
Prenatal glucocorticoid programming of brain corticosteroid receptors and corticotrophin-releasing hormone: possible implications for behaviour. Neuroscience (2001) 1.60
Fetal programming of body composition: relation between birth weight and body composition measured with dual-energy X-ray absorptiometry and anthropometric methods in older Englishmen. Am J Clin Nutr (2005) 1.57
Genomic imprinting, growth control and the allocation of nutritional resources: consequences for postnatal life. Curr Opin Endocrinol Diabetes Obes (2007) 1.54
Fetal origins of developmental plasticity: are fetal cues reliable predictors of future nutritional environments? Am J Hum Biol (2004) 1.48
Right ventricular systolic pressure load alters myocyte maturation in fetal sheep. Am J Physiol Regul Integr Comp Physiol (2000) 1.44
Food restriction, evolution and ageing. Mech Ageing Dev (2005) 1.38
Mismatched pre- and postnatal nutrition leads to cardiovascular dysfunction and altered renal function in adulthood. Proc Natl Acad Sci U S A (2007) 1.36
Critical differences between two low protein diet protocols in the programming of hypertension in the rat. Int J Food Sci Nutr (2000) 1.29
Maternal protein restriction in the rat impairs resistance artery but not conduit artery function in pregnant offspring. J Physiol (2002) 1.27
Exploring the thrifty genotype's food-shortage assumptions: a cross-cultural comparison of ethnographic accounts of food security among foraging and agricultural societies. Am J Phys Anthropol (2006) 1.26
Mouse embryo culture induces changes in postnatal phenotype including raised systolic blood pressure. Proc Natl Acad Sci U S A (2007) 1.25
Maternal diet during pregnancy and carotid intima-media thickness in children. Arterioscler Thromb Vasc Biol (2006) 1.23
Prenatal exposure to a maternal low protein diet shortens life span in rats. Gerontology (2001) 1.22
Is the association of birth weight with premenopausal breast cancer risk mediated through childhood growth? Br J Cancer (2004) 1.20
Nutrition, glucocorticoids and pancreas development. Horm Res (2006) 1.15
A common variant of the PAX2 gene is associated with reduced newborn kidney size. J Am Soc Nephrol (2007) 1.14
Brief undernutrition in late-gestation sheep programs the hypothalamic-pituitary-adrenal axis in adult offspring. Endocrinology (2003) 1.11
Maternal low-protein diet programs cardiac beta-adrenergic response and signaling in 3-mo-old male offspring. Am J Physiol Regul Integr Comp Physiol (2006) 1.09
Prevention of programmed hyperleptinemia and hypertension by postnatal dietary omega-3 fatty acids. Endocrinology (2005) 1.08
Programming of the endocrine pancreas by the early nutritional environment. Int J Biochem Cell Biol (2005) 1.08
Hypergonadotrophinaemia with reduced uterine and ovarian size in women born small-for-gestational-age. Hum Reprod (2003) 1.06
Combined prenatal and postnatal protein restriction influences adult kidney structure, function, and arterial pressure. Am J Physiol Regul Integr Comp Physiol (2006) 1.05
The effects of anaemia as a programming agent in the fetal heart. J Physiol (2005) 1.00
Does estrogen affect the development of abnormal vascular function in offspring of rats fed a low-protein diet in pregnancy? Pediatr Res (2006) 0.98
Fetal exposure to excess glucocorticoid is unlikely to explain the effects of periconceptional undernutrition in sheep. J Physiol (2006) 0.95
Pearl Harbor and the Emperor's physiologists. Nat Hist (1991) 0.95
Developmental origins of adult hypertension: new insights into the role of the kidney. Pediatr Nephrol (2006) 0.91
Pax-2 and N-myc regulate epithelial cell proliferation and apoptosis in a positive autocrine feedback loop. Pediatr Nephrol (2007) 0.90
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet (2010) 8.89
Living with the past: evolution, development, and patterns of disease. Science (2004) 7.14
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet (2010) 6.66
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet (2009) 5.81
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nat Genet (2012) 5.48
Osteoporosis. Lancet (2006) 5.40
Efficacy and safety of strontium ranelate in the treatment of knee osteoarthritis: results of a double-blind, randomised placebo-controlled trial. Ann Rheum Dis (2012) 4.81
Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring. J Nutr (2005) 4.57
Using natural experiments to evaluate population health interventions: new Medical Research Council guidance. J Epidemiol Community Health (2012) 4.26
Cohort profile: The Southampton Women's Survey. Int J Epidemiol (2005) 4.11
Genome-wide association study identifies five loci associated with lung function. Nat Genet (2009) 4.10
Reanalysis of two studies with contrasting results on the association between statin use and fracture risk: the General Practice Research Database. Int J Epidemiol (2006) 3.36
Grip strength, body composition, and mortality. Int J Epidemiol (2006) 3.36
A review of the measurement of grip strength in clinical and epidemiological studies: towards a standardised approach. Age Ageing (2011) 3.27
Epigenetic mechanisms that underpin metabolic and cardiovascular diseases. Nat Rev Endocrinol (2009) 3.25
Prevalence and impact of musculoskeletal disorders of the upper limb in the general population. Arthritis Rheum (2004) 3.24
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Epigenetic gene promoter methylation at birth is associated with child's later adiposity. Diabetes (2011) 3.18
Maternal high-fat feeding primes steatohepatitis in adult mice offspring, involving mitochondrial dysfunction and altered lipogenesis gene expression. Hepatology (2009) 3.11
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nat Genet (2011) 3.03
Early life events and their consequences for later disease: a life history and evolutionary perspective. Am J Hum Biol (2006) 3.02
Predictive adaptive responses and human evolution. Trends Ecol Evol (2005) 2.90
Objective measures of physical capability and subsequent health: a systematic review. Age Ageing (2010) 2.78
The cost-effectiveness of alendronate in the management of osteoporosis. Bone (2007) 2.75
Diagnosis and management of osteonecrosis of the jaw: a systematic review and international consensus. J Bone Miner Res (2015) 2.74
Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts. PLoS Med (2013) 2.73
Intelligence in childhood and chronic widespread pain in middle age: the National Child Development Survey. Pain (2012) 2.71
Does sarcopenia originate in early life? Findings from the Hertfordshire cohort study. J Gerontol A Biol Sci Med Sci (2004) 2.64
Epidemiology of hip fracture: Worldwide geographic variation. Indian J Orthop (2011) 2.60
Feeding pregnant rats a protein-restricted diet persistently alters the methylation of specific cytosines in the hepatic PPAR alpha promoter of the offspring. Br J Nutr (2008) 2.55
The developmental origins of the metabolic syndrome. Trends Endocrinol Metab (2004) 2.55
Women's compliance with nutrition and lifestyle recommendations before pregnancy: general population cohort study. BMJ (2009) 2.54
Dietary protein restriction of pregnant rats in the F0 generation induces altered methylation of hepatic gene promoters in the adult male offspring in the F1 and F2 generations. Br J Nutr (2007) 2.48
Epigenetic mechanisms and the mismatch concept of the developmental origins of health and disease. Pediatr Res (2007) 2.47
Environmental influences during development and their later consequences for health and disease: implications for the interpretation of empirical studies. Proc Biol Sci (2005) 2.40
Towards a new developmental synthesis: adaptive developmental plasticity and human disease. Lancet (2009) 2.35
Vitamin D: some perspective please. BMJ (2012) 2.35
Developmental origins of midlife physical performance: evidence from a British birth cohort. Am J Epidemiol (2006) 2.35
Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk. PLoS Genet (2011) 2.34
Metabolic plasticity during mammalian development is directionally dependent on early nutritional status. Proc Natl Acad Sci U S A (2007) 2.26
Osteoporosis: impact on health and economics. Nat Rev Rheumatol (2010) 2.25
Is grip strength a useful single marker of frailty? Age Ageing (2003) 2.22
Osteoporosis: burden, health care provision and opportunities in the EU: a report prepared in collaboration with the International Osteoporosis Foundation (IOF) and the European Federation of Pharmaceutical Industry Associations (EFPIA). Arch Osteoporos (2011) 2.14
Developmental origins of disease paradigm: a mechanistic and evolutionary perspective. Pediatr Res (2004) 2.11
Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung function. Am J Respir Crit Care Med (2011) 2.07
Non-genomic transgenerational inheritance of disease risk. Bioessays (2007) 2.07
The developmental origins of adult disease. Matern Child Nutr (2005) 2.05
Predictors of outcomes of total knee replacement surgery. Rheumatology (Oxford) (2012) 2.05
Type 2 diabetes, muscle strength, and impaired physical function: the tip of the iceberg? Diabetes Care (2005) 2.03
Gender-linked hypertension in offspring of lard-fed pregnant rats. Hypertension (2003) 2.00
Epidemiology and burden of osteoarthritis. Br Med Bull (2013) 1.97
Obesity is not protective against fracture in postmenopausal women: GLOW. Am J Med (2011) 1.95
Prediction of childhood obesity by infancy weight gain: an individual-level meta-analysis. Paediatr Perinat Epidemiol (2011) 1.93
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. Nat Genet (2012) 1.90
Risk of hip/femur fracture after stroke: a population-based case-control study. Stroke (2009) 1.88
Epigenetic regulation of transcription: a mechanism for inducing variations in phenotype (fetal programming) by differences in nutrition during early life? Br J Nutr (2007) 1.85
Monthly oral ibandronate therapy in postmenopausal osteoporosis: 1-year results from the MOBILE study. J Bone Miner Res (2005) 1.81
Low maternal vitamin D status and fetal bone development: cohort study. J Bone Miner Res (2010) 1.80
Effect of co-morbidities on fracture risk: findings from the Global Longitudinal Study of Osteoporosis in Women (GLOW). Bone (2012) 1.79
Women's dietary patterns change little from before to during pregnancy. J Nutr (2009) 1.79
Developmental origins of metabolic disease: life course and intergenerational perspectives. Trends Endocrinol Metab (2010) 1.78
Developmental origins of midlife grip strength: findings from a birth cohort study. J Gerontol A Biol Sci Med Sci (2006) 1.77
Dietary patterns in infancy: the importance of maternal and family influences on feeding practice. Br J Nutr (2007) 1.76
Evolution, development and timing of puberty. Trends Endocrinol Metab (2005) 1.75
A genome-wide association search for type 2 diabetes genes in African Americans. PLoS One (2012) 1.72
Mechanisms of disease: in utero programming in the pathogenesis of hypertension. Nat Clin Pract Nephrol (2006) 1.71
The GDF5 rs143383 polymorphism is associated with osteoarthritis of the knee with genome-wide statistical significance. Ann Rheum Dis (2010) 1.70
Maternal constraint of fetal growth and its consequences. Semin Fetal Neonatal Med (2004) 1.70
Birth weight, weight at 1 y of age, and body composition in older men: findings from the Hertfordshire Cohort Study. Am J Clin Nutr (2004) 1.68
Process evaluation in complex public health intervention studies: the need for guidance. J Epidemiol Community Health (2013) 1.68
Weight gain in pregnancy and childhood body composition: findings from the Southampton Women's Survey. Am J Clin Nutr (2010) 1.67
Epidemiological differences between back pain of sudden and gradual onset. J Rheumatol (2005) 1.67
Maternal high-fat diet disturbs uteroplacental hemodynamics and increases the frequency of stillbirth in a nonhuman primate model of excess nutrition. Endocrinology (2011) 1.66
Birth weight, childhood size, and muscle strength in adult life: evidence from a birth cohort study. Am J Epidemiol (2002) 1.66
Epidemiology of osteoporosis. Best Pract Res Clin Endocrinol Metab (2008) 1.65
Do women change their health behaviours in pregnancy? Findings from the Southampton Women's Survey. Paediatr Perinat Epidemiol (2009) 1.64
Prenatal and childhood influences on osteoporosis. Best Pract Res Clin Endocrinol Metab (2002) 1.64
Fracture risk with intermittent high-dose oral glucocorticoid therapy. Arthritis Rheum (2007) 1.63
New horizons in the pathogenesis, diagnosis and management of sarcopenia. Age Ageing (2013) 1.63
Impact of prevalent fractures on quality of life: baseline results from the global longitudinal study of osteoporosis in women. Mayo Clin Proc (2010) 1.62
Risk factors for treatment failure with antiosteoporosis medication: the global longitudinal study of osteoporosis in women (GLOW). J Bone Miner Res (2014) 1.62
Prevalence of sarcopenia in community-dwelling older people in the UK using the European Working Group on Sarcopenia in Older People (EWGSOP) definition: findings from the Hertfordshire Cohort Study (HCS). Age Ageing (2013) 1.62
Fetal anemia leads to augmented contractile response to hypoxic stress in adulthood. Am J Physiol Regul Integr Comp Physiol (2003) 1.61
Folic acid supplementation during the juvenile-pubertal period in rats modifies the phenotype and epigenotype induced by prenatal nutrition. J Nutr (2009) 1.61
The surface area of the placenta and hypertension in the offspring in later life. Int J Dev Biol (2010) 1.60
Muscle size, strength, and physical performance and their associations with bone structure in the Hertfordshire Cohort Study. J Bone Miner Res (2013) 1.60
Relationship between changes in bone mineral density and vertebral fracture risk associated with risedronate: greater increases in bone mineral density do not relate to greater decreases in fracture risk. J Clin Densitom (2004) 1.59
Is grip strength associated with health-related quality of life? Findings from the Hertfordshire Cohort Study. Age Ageing (2006) 1.56
The role of developmental plasticity and epigenetics in human health. Birth Defects Res C Embryo Today (2011) 1.55
Low birthweight and subsequent obesity in Japan. Lancet (2007) 1.54
Educating nursing home staff on fracture prevention: a cluster randomised trial. Age Ageing (2007) 1.54
Impaired glucose homeostasis and mitochondrial abnormalities in offspring of rats fed a fat-rich diet in pregnancy. Am J Physiol Regul Integr Comp Physiol (2004) 1.53
Predictors of fracture while on treatment with oral bisphosphonates: a population-based cohort study. J Bone Miner Res (2014) 1.52