Published in PLoS Genet on April 21, 2011
Five years of GWAS discovery. Am J Hum Genet (2012) 12.97
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nat Genet (2012) 5.48
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet (2013) 3.25
Control of mucin-type O-glycosylation: a classification of the polypeptide GalNAc-transferase gene family. Glycobiology (2011) 2.56
Nonsense mutation in the LGR4 gene is associated with several human diseases and other traits. Nature (2013) 2.55
Genetics of osteoporosis from genome-wide association studies: advances and challenges. Nat Rev Genet (2012) 2.07
The transcriptional profile of mesenchymal stem cell populations in primary osteoporosis is distinct and shows overexpression of osteogenic inhibitors. PLoS One (2012) 1.76
Genetic determinants of trabecular and cortical volumetric bone mineral densities and bone microstructure. PLoS Genet (2013) 1.64
Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations. Am J Hum Genet (2013) 1.55
WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk. PLoS Genet (2012) 1.55
Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture. Nature (2015) 1.53
Gene-gene interaction between RBMS3 and ZNF516 influences bone mineral density. J Bone Miner Res (2013) 1.45
Congenic mice provide in vivo evidence for a genetic locus that modulates intrinsic transforming growth factor β1-mediated signaling and bone acquisition. J Bone Miner Res (2012) 1.41
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Environmental epigenetics: a role in endocrine disease? J Mol Endocrinol (2012) 1.20
Wnt signaling in bone development and disease: making stronger bone with Wnts. Cold Spring Harb Perspect Biol (2012) 1.18
Multistage genome-wide association meta-analyses identified two new loci for bone mineral density. Hum Mol Genet (2013) 1.17
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Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium. Hum Mol Genet (2014) 1.02
Multicentric carpotarsal osteolysis is caused by mutations clustering in the amino-terminal transcriptional activation domain of MAFB. Am J Hum Genet (2012) 0.98
Common variants show predicted polygenic effects on height in the tails of the distribution, except in extremely short individuals. PLoS Genet (2011) 0.94
Endocrine crosstalk between muscle and bone. Curr Osteoporos Rep (2014) 0.93
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Diabetes, diabetic complications, and fracture risk. Curr Osteoporos Rep (2015) 0.88
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Polymorphisms in the inflammatory genes CIITA, CLEC16A and IFNG influence BMD, bone loss and fracture in elderly women. PLoS One (2012) 0.87
LRP5 regulates human body fat distribution by modulating adipose progenitor biology in a dose- and depot-specific fashion. Cell Metab (2015) 0.86
Sequence variants in the PTCH1 gene associate with spine bone mineral density and osteoporotic fractures. Nat Commun (2016) 0.84
Bulked sample analysis in genetics, genomics and crop improvement. Plant Biotechnol J (2016) 0.84
Friend or foe: high bone mineral density on routine bone density scanning, a review of causes and management. Rheumatology (Oxford) (2013) 0.84
Sox4 links tumor suppression to accelerated aging in mice by modulating stem cell activation. Cell Rep (2014) 0.84
Bone mineral density-associated polymorphisms are associated with obesity-related traits in Korean adults in a sex-dependent manner. PLoS One (2012) 0.84
Genetic Risk Scores Implicated in Adult Bone Fragility Associate With Pediatric Bone Density. J Bone Miner Res (2015) 0.83
Genetic regulation of bone metabolism in the chicken: similarities and differences to Mammalian systems. PLoS Genet (2015) 0.83
The genetics of bone mass and susceptibility to bone diseases. Nat Rev Rheumatol (2016) 0.82
Does bone resorption stimulate periosteal expansion? A cross-sectional analysis of β-C-telopeptides of type I collagen (CTX), genetic markers of the RANKL pathway, and periosteal circumference as measured by pQCT. J Bone Miner Res (2014) 0.82
Metadherin regulation of vascular endothelial growth factor expression is dependent upon the PI3K/Akt pathway in squamous cell carcinoma of the head and neck. Medicine (Baltimore) (2015) 0.82
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First comprehensive in silico analysis of the functional and structural consequences of SNPs in human GalNAc-T1 gene. Comput Math Methods Med (2014) 0.81
SIBLING family genes and bone mineral density: association and allele-specific expression in humans. Bone (2014) 0.81
Genetic variants in adult bone mineral density and fracture risk genes are associated with the rate of bone mineral density acquisition in adolescence. Hum Mol Genet (2015) 0.81
Elevated circulating Sclerostin concentrations in individuals with high bone mass, with and without LRP5 mutations. J Clin Endocrinol Metab (2014) 0.80
Deconstruction of O-glycosylation-GalNAc-T isoforms direct distinct subsets of the O-glycoproteome. EMBO Rep (2015) 0.80
CER1 gene variations associated with bone mineral density, bone markers, and early menopause in postmenopausal women. Hum Genomics (2013) 0.80
A new WNT on the bone: WNT16, cortical bone thickness, porosity and fractures. Bonekey Rep (2015) 0.80
An Immunochip-based interrogation of scleroderma susceptibility variants identifies a novel association at DNASE1L3. Arthritis Res Ther (2014) 0.79
Gene-based association analysis identified novel genes associated with bone mineral density. PLoS One (2015) 0.79
Efficient identification of rare variants in large populations: deep re-sequencing the CRP locus in the CARDIA study. Nucleic Acids Res (2013) 0.78
A mouse with an N-Ethyl-N-nitrosourea (ENU) Induced Trp589Arg Galnt3 mutation represents a model for hyperphosphataemic familial tumoural calcinosis. PLoS One (2012) 0.78
Genetic analysis of high bone mass cases from the BARCOS cohort of Spanish postmenopausal women. PLoS One (2014) 0.77
Z-score discordance and contributing factors in healthy premenopausal women with low bone mineral density: the Korean National Health and Nutrition Examination Survey 2008-9. J Bone Miner Metab (2015) 0.77
A Follow-up Association Study of Genetic Variants for Bone Mineral Density in a Korean Population. Genomics Inform (2014) 0.77
Association of P2Y(2) receptor SNPs with bone mineral density and osteoporosis risk in a cohort of Dutch fracture patients. Purinergic Signal (2012) 0.76
The case for genome-wide association studies of bone acquisition in paediatric and adolescent populations. Bonekey Rep (2016) 0.76
Osteoporosis genetics: year 2011 in review. Bonekey Rep (2012) 0.76
A genome-wide association study demonstrates significant genetic variation for fracture risk in Thoroughbred racehorses. BMC Genomics (2014) 0.76
A Candidate Gene Association Study of Bone Mineral Density in an Iranian Population. Front Endocrinol (Lausanne) (2016) 0.75
Curculigoside regulates proliferation, differentiation, and pro-inflammatory cytokines levels in dexamethasone-induced rat calvarial osteoblasts. Int J Clin Exp Med (2015) 0.75
BMP7 gene polymorphisms are not associated with bone mineral density or osteoporotic fractures in postmenopausal Chinese women. Acta Pharmacol Sin (2016) 0.75
Endochondral ossification pathway genes and postmenopausal osteoporosis: Association and specific allele related serum bone sialoprotein levels in Han Chinese. Sci Rep (2015) 0.75
Identification of a Copy Number Variation on Chromosome 20q13.12 Associated with Osteoporotic Fractures in the Korean Population. Genomics Inform (2016) 0.75
Genome-wide association meta-analyses identified 1q43 and 2q32.2 for hip Ward's triangle areal bone mineral density. Bone (2016) 0.75
SOXC Genes and the Control of Skeletogenesis. Curr Osteoporos Rep (2016) 0.75
Genetic Contribution of Femoral Neck Bone Geometry to the Risk of Developing Osteoporosis: A Family-Based Study. PLoS One (2016) 0.75
Rapid phenotyping of knockout mice to identify genetic determinants of bone strength. J Endocrinol (2016) 0.75
Lysinuric Protein Intolerance Presenting with Multiple Fractures. Mol Genet Metab Rep (2014) 0.75
RSPO3-LGR4 Regulates Osteogenic Differentiation Of Human Adipose-Derived Stem Cells Via ERK/FGF Signalling. Sci Rep (2017) 0.75
Association of genetic polymorphisms of GALNT3 and VDR with osteoporosis in postmenopausal women. Exp Ther Med (2016) 0.75
How rare bone diseases have informed our knowledge of complex diseases. Bonekey Rep (2016) 0.75
Physical Activity Benefits the Skeleton of Children Genetically Predisposed to Lower Bone Density in Adulthood. J Bone Miner Res (2016) 0.75
Analysis of SNP-SNP interactions and bone quantitative ultrasound parameter in early adulthood. BMC Med Genet (2017) 0.75
Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus. Nat Commun (2017) 0.75
Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis. Nat Genet (2017) 0.75
A translational approach from an animal model identifies CD80 as a candidate gene for the study of bone phenotypes in postmenopausal women. Osteoporos Int (2017) 0.75
A genome-wide association study meta-analysis of clinical fracture in 10,012 African American women. Bone Rep (2016) 0.75
Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet (2008) 25.83
Genotype imputation. Annu Rev Genomics Hum Genet (2009) 18.64
Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits. Bioinformatics (2003) 17.92
An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int (2006) 11.05
Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature (2006) 9.40
FRAX and the assessment of fracture probability in men and women from the UK. Osteoporos Int (2008) 8.75
Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions. PLoS Genet (2009) 8.39
A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits. Nat Genet (2009) 7.65
Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study. Lancet (2008) 7.05
Multiple genetic loci for bone mineral density and fractures. N Engl J Med (2008) 6.35
Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. Nat Genet (2009) 5.32
New sequence variants associated with bone mineral density. Nat Genet (2008) 3.43
Mutations in GALNT3, encoding a protein involved in O-linked glycosylation, cause familial tumoral calcinosis. Nat Genet (2004) 3.13
Long-range LD can confound genome scans in admixed populations. Am J Hum Genet (2008) 3.06
The gene encoding R-spondin 4 (RSPO4), a secreted protein implicated in Wnt signaling, is mutated in inherited anonychia. Nat Genet (2006) 2.81
Association of JAG1 with bone mineral density and osteoporotic fractures: a genome-wide association study and follow-up replication studies. Am J Hum Genet (2010) 2.57
R-Spondin family members regulate the Wnt pathway by a common mechanism. Mol Biol Cell (2008) 2.37
Genome-wide association and follow-up replication studies identified ADAMTS18 and TGFBR3 as bone mass candidate genes in different ethnic groups. Am J Hum Genet (2009) 2.14
The heritability of bone mineral density, ultrasound of the calcaneus and hip axis length: a study of postmenopausal twins. J Bone Miner Res (1996) 1.99
Common variants in the region around Osterix are associated with bone mineral density and growth in childhood. Hum Mol Genet (2009) 1.99
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Gender specificity in the genetic determinants of peak bone mass. J Bone Miner Res (2001) 1.80
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Fibroblast growth factor-23 mutants causing familial tumoral calcinosis are differentially processed. Endocrinology (2005) 1.73
Klotho gene polymorphisms associated with bone density of aged postmenopausal women. J Bone Miner Res (2002) 1.69
R-spondin3 is required for mouse placental development. Dev Biol (2006) 1.58
Genetic analyses in a sample of individuals with high or low BMD shows association with multiple Wnt pathway genes. J Bone Miner Res (2008) 1.58
Bone sialoprotein plays a functional role in bone formation and osteoclastogenesis. J Exp Med (2008) 1.54
Identification of high-risk individuals for hip fracture: a 14-year prospective study. J Bone Miner Res (2005) 1.54
GRIMP: a web- and grid-based tool for high-speed analysis of large-scale genome-wide association using imputed data. Bioinformatics (2009) 1.53
Genetic determinants of bone mineral content at the spine and radius: a twin study. Bone (1987) 1.51
Association of polymorphisms of the androgen receptor and klotho genes with bone mineral density in Japanese women. J Mol Med (Berl) (2004) 1.50
Identification of a recurrent mutation in GALNT3 demonstrates that hyperostosis-hyperphosphatemia syndrome and familial tumoral calcinosis are allelic disorders. J Mol Med (Berl) (2004) 1.40
Common genetic variation of the low-density lipoprotein receptor-related protein 5 and 6 genes determines fracture risk in elderly white men. J Bone Miner Res (2005) 1.37
Bone abnormalities in latent TGF-[beta] binding protein (Ltbp)-3-null mice indicate a role for Ltbp-3 in modulating TGF-[beta] bioavailability. J Cell Biol (2002) 1.37
Association of klotho gene polymorphism with bone density and spondylosis of the lumbar spine in postmenopausal women. Bone (2002) 1.37
Genome-wide association study of bone mineral density in premenopausal European-American women and replication in African-American women. J Clin Endocrinol Metab (2010) 1.30
Site and gender specificity of inheritance of bone mineral density. J Bone Miner Res (2003) 1.30
Saliva-derived DNA performs well in large-scale, high-density single-nucleotide polymorphism microarray studies. Cancer Epidemiol Biomarkers Prev (2010) 1.27
Osteopenia, decreased bone formation and impaired osteoblast development in Sox4 heterozygous mice. J Cell Sci (2007) 1.20
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Comparison of BMD precision for Prodigy and Delphi spine and femur scans. Osteoporos Int (2006) 1.12
Association of the F352V variant of the Klotho gene with bone mineral density. Biogerontology (2006) 1.07
Oligodontia is caused by mutation in LTBP3, the gene encoding latent TGF-beta binding protein 3. Am J Hum Genet (2009) 1.02
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A microarray based identification of osteoporosis-related genes in primary culture of human osteoblasts. Bone (2009) 0.93
Polymorphisms of the CLCN7 gene are associated with BMD in women. J Bone Miner Res (2005) 0.85
Assessment of fracture risk: value of random population-based samples--the Geelong Osteoporosis Study. J Clin Densitom (2001) 0.83
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06
Genome-wide association study identifies novel breast cancer susceptibility loci. Nature (2007) 29.23
A high-resolution recombination map of the human genome. Nat Genet (2002) 28.66
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Genetics of gene expression and its effect on disease. Nature (2008) 21.35
Large recurrent microdeletions associated with schizophrenia. Nature (2008) 20.25
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
Association between microdeletion and microduplication at 16p11.2 and autism. N Engl J Med (2008) 19.71
Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24. Nat Genet (2007) 19.18
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet (2006) 19.03
A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science (2007) 18.96
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New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
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Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
Genome-wide association analysis identifies 20 loci that influence adult height. Nat Genet (2008) 16.92
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A common variant associated with prostate cancer in European and African populations. Nat Genet (2006) 13.47
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet (2007) 13.28
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Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 13.23
Five years of GWAS discovery. Am J Hum Genet (2012) 12.97
Many sequence variants affecting diversity of adult human height. Nat Genet (2008) 12.80
Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. Nat Genet (2007) 12.65
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Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet (2008) 12.43
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