Published in J Immunol on June 25, 2012
GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development. J Immunol (2013) 1.19
Themis sets the signal threshold for positive and negative selection in T-cell development. Nature (2013) 1.17
Themis2 is not required for B cell development, activation, and antibody responses. J Immunol (2014) 0.86
Differential function of Themis CABIT domains during T cell development. PLoS One (2014) 0.86
Fine-tuning T cell receptor signaling to control T cell development. Trends Immunol (2014) 0.85
THEMIS enhances TCR signaling and enables positive selection by selective inhibition of the phosphatase SHP-1. Nat Immunol (2017) 0.84
THEMIS is required for pathogenesis of cerebral malaria and protection against pulmonary tuberculosis. Infect Immun (2014) 0.83
Themis2 lowers the threshold for B cell activation during positive selection. Nat Immunol (2016) 0.81
In vivo functional mapping of the conserved protein domains within murine Themis1. Immunol Cell Biol (2014) 0.76
Snai2 and Snai3 transcriptionally regulate cellular fitness and functionality of T cell lineages through distinct gene programs. Immunobiology (2016) 0.75
THEMIS-tery is solved. Nat Immunol (2017) 0.75
Thymic progenitors of TCRαβ(+) CD8αα intestinal intraepithelial lymphocytes require RasGRP1 for development. J Exp Med (2017) 0.75
Proteomic analysis of regulatory T cells reveals the importance of Themis1 in the control of their suppressive function. Mol Cell Proteomics (2017) 0.75
Themis2: setting the threshold for B-cell selection. Cell Mol Immunol (2017) 0.75
LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell (1998) 6.15
T cell receptor ligation induces the formation of dynamically regulated signaling assemblies. J Cell Biol (2002) 4.89
RasGRP is essential for mouse thymocyte differentiation and TCR signaling. Nat Immunol (2000) 4.28
Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product. Nature (1997) 4.05
Essential role of LAT in T cell development. Immunity (1999) 3.94
CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity. J Exp Med (1998) 3.82
Human CD2 3'-flanking sequences confer high-level, T cell-specific, position-independent gene expression in transgenic mice. Cell (1989) 3.48
Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development. Science (1998) 3.18
Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice. Nat Rev Immunol (2008) 2.98
Dynamic molecular interactions linking the T cell antigen receptor to the actin cytoskeleton. Nat Immunol (2004) 2.94
Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76. Cell (1998) 2.62
BLNK: a central linker protein in B cell activation. Immunity (1998) 2.59
Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling. Nat Immunol (2009) 2.12
Themis, a T cell-specific protein important for late thymocyte development. Nat Immunol (2009) 2.00
Compensation between Vav-1 and Vav-2 in B cell development and antigen receptor signaling. Nat Immunol (2001) 1.93
The JNK pathway regulates the In vivo deletion of immature CD4(+)CD8(+) thymocytes. J Exp Med (1998) 1.91
Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection. Nat Immunol (2009) 1.84
Differential roles of ERK and p38 MAP kinase pathways in positive and negative selection of T lymphocytes. Immunity (1998) 1.63
LAB: a new membrane-associated adaptor molecule in B cell activation. Nat Immunol (2003) 1.58
Negative regulation of mast cell signaling and function by the adaptor LAB/NTAL. J Exp Med (2004) 1.47
T cell receptor (TCR)-induced tyrosine phosphorylation dynamics identifies THEMIS as a new TCR signalosome component. J Biol Chem (2010) 1.44
Positive and negative regulation of FcepsilonRI-mediated signaling by the adaptor protein LAB/NTAL. J Exp Med (2004) 1.44
Vav1 transduces T cell receptor signals to the activation of the Ras/ERK pathway via LAT, Sos, and RasGRP1. J Biol Chem (2004) 1.42
Gasp, a Grb2-associating protein, is critical for positive selection of thymocytes. Proc Natl Acad Sci U S A (2009) 1.37
Duration and strength of extracellular signal-regulated kinase signals are altered during positive versus negative thymocyte selection. J Immunol (2001) 1.32
A novel gene essential for the development of single positive thymocytes. Mol Cell Biol (2009) 1.32
CD28 costimulatory signal induces protein arginine methylation in T cells. J Exp Med (2005) 1.26
Binding of Vav to Grb2 through dimerization of Src homology 3 domains. Proc Natl Acad Sci U S A (1994) 1.24
Grb2 functions at the top of the T-cell antigen receptor-induced tyrosine kinase cascade to control thymic selection. Proc Natl Acad Sci U S A (2010) 1.20
LAT links the pre-BCR to calcium signaling. Immunity (2003) 1.17
SLP-76 expression is restricted to hemopoietic cells of monocyte, granulocyte, and T lymphocyte lineage and is regulated during T cell maturation and activation. J Immunol (1998) 1.16
Function of the nucleotide exchange activity of vav1 in T cell development and activation. Sci Signal (2009) 1.13
Linker for activation of B cells: a functional equivalent of a mutant linker for activation of T cells deficient in phospholipase C-gamma1 binding. J Immunol (2004) 1.12
Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav. Biochemistry (2002) 1.01
Differential effects of zeta and eta transgenes on early alpha/beta T cell development. J Exp Med (1994) 1.00
Grb2 regulates B-cell maturation, B-cell memory responses and inhibits B-cell Ca2+ signalling. EMBO J (2011) 1.00
Ligation of the T-cell antigen receptor (TCR) induces association of hSos1, ZAP-70, phospholipase C-gamma 1, and other phosphoproteins with Grb2 and the zeta-chain of the TCR. J Biol Chem (1995) 0.91
Themis2/ICB1 is a signaling scaffold that selectively regulates macrophage Toll-like receptor signaling and cytokine production. PLoS One (2010) 0.88
ZAP-70 is essential for the T cell antigen receptor-induced plasma membrane targeting of SOS and Vav in T cells. J Biol Chem (2000) 0.86
Integration with the human genome of peptide sequences obtained by high-throughput mass spectrometry. Genome Biol (2004) 4.91
T cell receptor ligation induces the formation of dynamically regulated signaling assemblies. J Cell Biol (2002) 4.89
Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation. Nat Immunol (2002) 3.60
Dynamic molecular interactions linking the T cell antigen receptor to the actin cytoskeleton. Nat Immunol (2004) 2.94
Failure to produce mitochondrial DNA results in embryonic lethality in Rnaseh1 null mice. Mol Cell (2003) 2.60
Markers for detergent-resistant lipid rafts occupy distinct and dynamic domains in native membranes. Mol Biol Cell (2004) 2.50
Studying multisite binary and ternary protein interactions by global analysis of isothermal titration calorimetry data in SEDPHAT: application to adaptor protein complexes in cell signaling. Protein Sci (2007) 2.44
A LAT mutation that inhibits T cell development yet induces lymphoproliferation. Science (2002) 2.35
A role for CCR9 in T lymphocyte development and migration. J Immunol (2002) 2.30
TCR signal strength influences alphabeta/gammadelta lineage fate. Immunity (2005) 2.15
Oligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1. Nat Struct Mol Biol (2006) 2.10
Themis, a T cell-specific protein important for late thymocyte development. Nat Immunol (2009) 2.00
Adenylyl cyclase localization regulates streaming during chemotaxis. Cell (2003) 2.00
Functional nanoscale organization of signaling molecules downstream of the T cell antigen receptor. Immunity (2011) 1.93
Selective thymus settling regulated by cytokine and chemokine receptors. J Immunol (2007) 1.92
Role of Grb2 in EGF-stimulated EGFR internalization. J Cell Sci (2002) 1.82
The LAT story: a tale of cooperativity, coordination, and choreography. Cold Spring Harb Perspect Biol (2010) 1.77
Coordination between CCR7- and CCR9-mediated chemokine signals in prevascular fetal thymus colonization. Blood (2006) 1.66
CCR6 is required for IL-23-induced psoriasis-like inflammation in mice. J Clin Invest (2009) 1.65
Dynamic movement of the calcium sensor STIM1 and the calcium channel Orai1 in activated T-cells: puncta and distal caps. Mol Biol Cell (2008) 1.63
Persistence of cooperatively stabilized signaling clusters drives T-cell activation. Mol Cell Biol (2006) 1.55
Rab35 and its GAP EPI64C in T cells regulate receptor recycling and immunological synapse formation. J Biol Chem (2008) 1.54
Binding specificity of multiprotein signaling complexes is determined by both cooperative interactions and affinity preferences. Biochemistry (2004) 1.52
Mutation of the phospholipase C-gamma1-binding site of LAT affects both positive and negative thymocyte selection. J Exp Med (2005) 1.49
Src-dependent phosphorylation of ASAP1 regulates podosomes. Mol Cell Biol (2007) 1.48
Collective cell migration requires vesicular trafficking for chemoattractant delivery at the trailing edge. J Cell Biol (2008) 1.48
Recruitment and activation of PLCgamma1 in T cells: a new insight into old domains. EMBO J (2006) 1.47
c-Cbl-mediated regulation of LAT-nucleated signaling complexes. Mol Cell Biol (2007) 1.46
Cooperative interactions at the SLP-76 complex are critical for actin polymerization. EMBO J (2010) 1.45
Nuclear adaptor Ldb1 regulates a transcriptional program essential for the maintenance of hematopoietic stem cells. Nat Immunol (2010) 1.43
CD8+ recent thymic emigrants home to and efficiently repopulate the small intestine epithelium. Nat Immunol (2006) 1.42
Retinoic acid determines the precise tissue tropism of inflammatory Th17 cells in the intestine. J Immunol (2010) 1.39
Early phosphorylation kinetics of proteins involved in proximal TCR-mediated signaling pathways. J Immunol (2005) 1.38
High-resolution multicolor imaging of dynamic signaling complexes in T cells stimulated by planar substrates. Sci STKE (2003) 1.35
Gut-tropic T cells that express integrin α4β7 and CCR9 are required for induction of oral immune tolerance in mice. Gastroenterology (2011) 1.34
A potential role for CD69 in thymocyte emigration. Int Immunol (2002) 1.34
Targeted Sos1 deletion reveals its critical role in early T-cell development. Proc Natl Acad Sci U S A (2011) 1.30
T-cell antigen receptor-induced signaling complexes: internalization via a cholesterol-dependent endocytic pathway. Traffic (2006) 1.27
Imaging techniques for assaying lymphocyte activation in action. Nat Rev Immunol (2011) 1.27
Distinct structure and signaling potential of the gamma delta TCR complex. Immunity (2002) 1.27
Clathrin adaptor AP-2 is essential for early embryonal development. Mol Cell Biol (2005) 1.26
The cytoplasmic tail of the T cell receptor CD3 epsilon subunit contains a phospholipid-binding motif that regulates T cell functions. J Immunol (2009) 1.22
Roles of the proline-rich domain in SLP-76 subcellular localization and T cell function. J Biol Chem (2004) 1.21
The four distal tyrosines are required for LAT-dependent signaling in FcepsilonRI-mediated mast cell activation. J Exp Med (2003) 1.21
Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells. Trends Immunol (2013) 1.16
LIM homeobox transcription factors integrate signaling events that control three-dimensional limb patterning and growth. Development (2009) 1.13
LAT: a T lymphocyte adapter protein that couples the antigen receptor to downstream signaling pathways. Bioessays (2004) 1.13
Deconstructing Ras signaling in the thymus. Mol Cell Biol (2012) 1.09
Expression of Dlx and Lhx family homeobox genes in fetal thymus and thymocytes. Gene Expr Patterns (2004) 1.06
Ldb1-nucleated transcription complexes function as primary mediators of global erythroid gene activation. Blood (2013) 1.05
A requirement for Lim domain binding protein 1 in erythropoiesis. J Exp Med (2010) 1.03
An architectural perspective on signaling by the pre-, alphabeta and gammadelta T cell receptors. Immunol Rev (2003) 1.02
Structural basis for differential recognition of tyrosine-phosphorylated sites in the linker for activation of T cells (LAT) by the adaptor Gads. EMBO J (2004) 1.00
Cutting edge: cell surface linker for activation of T cells is recruited to microclusters and is active in signaling. J Immunol (2013) 0.99
CD28 engagement promotes actin polymerization through the activation of the small Rho GTPase Cdc42 in human T cells. J Immunol (2003) 0.99
Enhanced T-cell signaling in cells bearing linker for activation of T-cell (LAT) molecules resistant to ubiquitylation. Proc Natl Acad Sci U S A (2011) 0.99
All roads lead to actin: the intimate relationship between TCR signaling and the cytoskeleton. Immunol Rev (2003) 0.98
Imprint control element-mediated secondary methylation imprints at the Igf2/H19 locus. J Biol Chem (2002) 0.98
Strength of signal: a fundamental mechanism for cell fate specification. Immunol Rev (2006) 0.96
Endocytic events in TCR signaling: focus on adapters in microclusters. Immunol Rev (2009) 0.96
CCR9+ macrophages are required for acute liver inflammation in mouse models of hepatitis. Gastroenterology (2011) 0.95
The multifunctional RNA-binding protein La is required for mouse development and for the establishment of embryonic stem cells. Mol Cell Biol (2006) 0.95
Cloning and characterization of a gene expressed during terminal differentiation that encodes a novel inhibitor of growth. J Biol Chem (2003) 0.95
CD5-mediated inhibition of TCR signaling during intrathymic selection and development does not require the CD5 extracellular domain. Eur J Immunol (2002) 0.95
Examining multiprotein signaling complexes from all angles. FEBS J (2005) 0.94
Genetic evidence for the role of Erk activation in a lymphoproliferative disease of mice. Proc Natl Acad Sci U S A (2009) 0.93
Super-resolution characterization of TCR-dependent signaling clusters. Immunol Rev (2013) 0.93
Bam32: a novel mediator of Erk activation in T cells. Int Immunol (2008) 0.92
LAT-independent Erk activation via Bam32-PLC-γ1-Pak1 complexes: GTPase-independent Pak1 activation. Mol Cell (2012) 0.91
Caveolin-1-LRP6 signaling module stimulates aerobic glycolysis in prostate cancer. Cancer Res (2013) 0.91
Premature expression of chemokine receptor CCR9 impairs T cell development. J Immunol (2006) 0.90
Reduced TCR signaling potential impairs negative selection but does not result in autoimmune disease. J Exp Med (2012) 0.90
The ability of Sos1 to oligomerize the adaptor protein LAT is separable from its guanine nucleotide exchange activity in vivo. Sci Signal (2013) 0.90
Inactivation of c-Cbl reverses neonatal lethality and T cell developmental arrest of SLP-76-deficient mice. J Exp Med (2004) 0.90