Published in Blood on April 22, 2013
Role of LDB1 in the transition from chromatin looping to transcription activation. Genes Dev (2014) 1.71
An Overview of Genome Organization and How We Got There: from FISH to Hi-C. Microbiol Mol Biol Rev (2015) 1.10
β-thalassemias: paradigmatic diseases for scientific discoveries and development of innovative therapies. Haematologica (2015) 1.06
Ldb1 complexes: the new master regulators of erythroid gene transcription. Trends Genet (2013) 0.96
TMEM14C is required for erythroid mitochondrial heme metabolism. J Clin Invest (2014) 0.96
The hematopoietic regulator TAL1 is required for chromatin looping between the β-globin LCR and human γ-globin genes to activate transcription. Nucleic Acids Res (2014) 0.92
Distinct, strict requirements for Gfi-1b in adult bone marrow red cell and platelet generation. J Exp Med (2014) 0.91
Mechanism governing a stem cell-generating cis-regulatory element. Proc Natl Acad Sci U S A (2014) 0.90
LIM domain-binding 1 maintains the terminally differentiated state of pancreatic β cells. J Clin Invest (2016) 0.87
Insight into GATA1 transcriptional activity through interrogation of cis elements disrupted in human erythroid disorders. Proc Natl Acad Sci U S A (2016) 0.84
Hematopoietic transcriptional mechanisms: from locus-specific to genome-wide vantage points. Exp Hematol (2014) 0.84
A Systems Approach Identifies Essential FOXO3 Functions at Key Steps of Terminal Erythropoiesis. PLoS Genet (2015) 0.81
Extrinsic and intrinsic control by EKLF (KLF1) within a specialized erythroid niche. Development (2014) 0.81
Control of developmentally primed erythroid genes by combinatorial co-repressor actions. Nat Commun (2015) 0.80
Defining the Minimal Factors Required for Erythropoiesis through Direct Lineage Conversion. Cell Rep (2016) 0.80
Chromatin looping as a target for altering erythroid gene expression. Ann N Y Acad Sci (2016) 0.79
LMO2 induces T-cell leukemia with epigenetic deregulation of CD4. Exp Hematol (2014) 0.79
GFI1B, EVI5, MYB--additional genes that cooperate with the human BCL6 gene to promote the development of lymphomas. Blood Cells Mol Dis (2013) 0.79
Five transcription factors and FGF pathway inhibition efficiently induce erythroid differentiation in the epiblast. Stem Cell Reports (2014) 0.77
Genome-Wide Organization of GATA1 and TAL1 Determined at High Resolution. Mol Cell Biol (2015) 0.77
Requirement for ssbp2 in hematopoietic stem cell maintenance and stress response. J Immunol (2014) 0.77
The DEK Oncoprotein Is a Critical Component of the EKLF/KLF1 Enhancer in Erythroid Cells. Mol Cell Biol (2015) 0.76
Intron 1 GATA site enhances ALAS2 expression indispensably during erythroid differentiation. Nucleic Acids Res (2016) 0.75
LMO2 Oncoprotein Stability in T-Cell Leukemia Requires Direct LDB1 Binding. Mol Cell Biol (2015) 0.75
Fitting a mixture model by expectation maximization to discover motifs in biopolymers. Proc Int Conf Intell Syst Mol Biol (1994) 37.96
Combining evidence using p-values: application to sequence homology searches. Bioinformatics (1998) 16.51
Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1. Nature (1991) 10.30
Genome-wide identification of in vivo protein-DNA binding sites from ChIP-Seq data. Nucleic Acids Res (2008) 8.89
Preferential associations between co-regulated genes reveal a transcriptional interactome in erythroid cells. Nat Genet (2009) 6.39
The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins. EMBO J (1997) 6.36
An erythrocyte-specific DNA-binding factor recognizes a regulatory sequence common to all chicken globin genes. Proc Natl Acad Sci U S A (1988) 5.29
The oncogenic cysteine-rich LIM domain protein rbtn2 is essential for erythroid development. Cell (1994) 4.58
Global regulation of erythroid gene expression by transcription factor GATA-1. Blood (2004) 4.22
Hematopoietic fingerprints: an expression database of stem cells and their progeny. Cell Stem Cell (2007) 4.06
Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy. Mol Cell (2009) 3.96
Functional synergy and physical interactions of the erythroid transcription factor GATA-1 with the Krüppel family proteins Sp1 and EKLF. Mol Cell Biol (1995) 3.39
A common set of gene regulatory networks links metabolism and growth inhibition. Mol Cell (2004) 3.37
GATA-1-dependent transcriptional repression of GATA-2 via disruption of positive autoregulation and domain-wide chromatin remodeling. Proc Natl Acad Sci U S A (2003) 3.32
Insights into GATA-1-mediated gene activation versus repression via genome-wide chromatin occupancy analysis. Mol Cell (2009) 3.05
Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor. Cell (2012) 2.87
Use of altered specificity mutants to probe a specific protein-protein interaction in differentiation: the GATA-1:FOG complex. Mol Cell (1999) 2.66
Erythroid GATA1 function revealed by genome-wide analysis of transcription factor occupancy, histone modifications, and mRNA expression. Genome Res (2009) 2.64
Genome-wide identification of TAL1's functional targets: insights into its mechanisms of action in primary erythroid cells. Genome Res (2010) 2.64
GATA-1 forms distinct activating and repressive complexes in erythroid cells. EMBO J (2005) 2.56
FOG-1 recruits the NuRD repressor complex to mediate transcriptional repression by GATA-1. EMBO J (2005) 2.53
The genome-wide dynamics of the binding of Ldb1 complexes during erythroid differentiation. Genes Dev (2010) 2.47
A positive role for NLI/Ldb1 in long-range beta-globin locus control region function. Mol Cell (2007) 2.43
A global role for EKLF in definitive and primitive erythropoiesis. Blood (2005) 2.24
SCL and associated proteins distinguish active from repressive GATA transcription factor complexes. Blood (2008) 2.19
A global role for KLF1 in erythropoiesis revealed by ChIP-seq in primary erythroid cells. Genome Res (2010) 2.02
The multifunctional role of EKLF/KLF1 during erythropoiesis. Blood (2011) 1.93
Identification of a TAL1 target gene reveals a positive role for the LIM domain-binding protein Ldb1 in erythroid gene expression and differentiation. Mol Cell Biol (2003) 1.92
SCL assembles a multifactorial complex that determines glycophorin A expression. Mol Cell Biol (2004) 1.89
Unrestrained erythroblast development in Nix-/- mice reveals a mechanism for apoptotic modulation of erythropoiesis. Proc Natl Acad Sci U S A (2007) 1.86
Genome-wide ChIP-Seq reveals a dramatic shift in the binding of the transcription factor erythroid Kruppel-like factor during erythrocyte differentiation. Blood (2011) 1.50
Functional interaction of GATA1 with erythroid Krüppel-like factor and Sp1 at defined erythroid promoters. Blood (1996) 1.45
Tie2Cre-mediated gene ablation defines the stem-cell leukemia gene (SCL/tal1)-dependent window during hematopoietic stem-cell development. Blood (2005) 1.44
Nuclear adaptor Ldb1 regulates a transcriptional program essential for the maintenance of hematopoietic stem cells. Nat Immunol (2010) 1.43
Dynamic long-range chromatin interactions control Myb proto-oncogene transcription during erythroid development. EMBO J (2011) 1.41
CLEAN: CLustering Enrichment ANalysis. BMC Bioinformatics (2009) 1.29
Formation of mammalian erythrocytes: chromatin condensation and enucleation. Trends Cell Biol (2011) 1.28
A genome scale location analysis of human Staf/ZNF143-binding sites suggests a widespread role for human Staf/ZNF143 in mammalian promoters. J Biol Chem (2006) 1.17
EKLF/KLF1 controls cell cycle entry via direct regulation of E2f2. J Biol Chem (2009) 1.13
Novel roles for KLF1 in erythropoiesis revealed by mRNA-seq. Genome Res (2012) 1.13
Autophagy driven by a master regulator of hematopoiesis. Mol Cell Biol (2011) 1.13
A core erythroid transcriptional network is repressed by a master regulator of myelo-lymphoid differentiation. Proc Natl Acad Sci U S A (2012) 1.12
A large gene network in immature erythroid cells is controlled by the myeloid and B cell transcriptional regulator PU.1. PLoS Genet (2011) 1.09
Mitochondrial clearance by autophagy in developing erythrocytes: clearly important, but just how much so? Cell Cycle (2010) 1.07
A requirement for Lim domain binding protein 1 in erythropoiesis. J Exp Med (2010) 1.03
Recruitment of the SWI/SNF protein Brg1 by a multiprotein complex effects transcriptional repression in murine erythroid progenitors. Biochem J (2006) 1.03
KLF1 directly coordinates almost all aspects of terminal erythroid differentiation. IUBMB Life (2010) 1.03
The GATA-E box-GATA motif in the EKLF promoter is required for in vivo expression. Blood (2000) 1.03
Identification of distal cis-regulatory elements at mouse mitoferrin loci using zebrafish transgenesis. Mol Cell Biol (2011) 0.97
High-resolution profiling of histone methylations in the human genome. Cell (2007) 85.74
Combinatorial patterns of histone acetylations and methylations in the human genome. Nat Genet (2008) 18.28
Dynamic regulation of nucleosome positioning in the human genome. Cell (2008) 15.60
Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells. Immunity (2009) 9.73
Genome-wide identification of in vivo protein-DNA binding sites from ChIP-Seq data. Nucleic Acids Res (2008) 8.89
Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes. Cell (2009) 8.69
Chromatin signatures in multipotent human hematopoietic stem cells indicate the fate of bivalent genes during differentiation. Cell Stem Cell (2009) 8.62
A clustering approach for identification of enriched domains from histone modification ChIP-Seq data. Bioinformatics (2009) 8.33
Global analysis of the insulator binding protein CTCF in chromatin barrier regions reveals demarcation of active and repressive domains. Genome Res (2008) 7.41
Active chromatin domains are defined by acetylation islands revealed by genome-wide mapping. Genes Dev (2005) 7.21
c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells. Cell (2012) 6.49
Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells. Nature (2011) 6.48
The genomic landscape of histone modifications in human T cells. Proc Natl Acad Sci U S A (2006) 6.09
Nucleosome dynamics define transcriptional enhancers. Nat Genet (2010) 5.94
H3.3/H2A.Z double variant-containing nucleosomes mark 'nucleosome-free regions' of active promoters and other regulatory regions. Nat Genet (2009) 5.82
Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells. Genes Dev (2011) 4.45
Experimental comparison and cross-validation of the Affymetrix and Illumina gene expression analysis platforms. Nucleic Acids Res (2005) 4.41
Genome-wide approaches to studying chromatin modifications. Nat Rev Genet (2008) 4.28
An embryonic stem cell chromatin remodeling complex, esBAF, is an essential component of the core pluripotency transcriptional network. Proc Natl Acad Sci U S A (2009) 4.07
Identification of genetic elements that autonomously determine DNA methylation states. Nat Genet (2011) 4.04
Hybrid DNA virus in Chinese patients with seronegative hepatitis discovered by deep sequencing. Proc Natl Acad Sci U S A (2013) 3.35
Cell type specificity of chromatin organization mediated by CTCF and cohesin. Proc Natl Acad Sci U S A (2010) 3.03
Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor. Cell (2012) 2.87
IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells. Proc Natl Acad Sci U S A (2009) 2.83
Novel Foxo1-dependent transcriptional programs control T(reg) cell function. Nature (2012) 2.77
PBAF chromatin-remodeling complex requires a novel specificity subunit, BAF200, to regulate expression of selective interferon-responsive genes. Genes Dev (2005) 2.70
Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer. Genome Biol (2007) 2.70
High-resolution genome-wide mapping of histone modifications. Nat Biotechnol (2004) 2.69
Distinctive signatures of histone methylation in transcribed coding and noncoding human beta-globin sequences. Mol Cell Biol (2006) 2.68
Genome-wide prediction of conserved and nonconserved enhancers by histone acetylation patterns. Genome Res (2006) 2.67
Detection of single nucleotide variations in expressed exons of the human genome using RNA-Seq. Nucleic Acids Res (2009) 2.61
Failure to produce mitochondrial DNA results in embryonic lethality in Rnaseh1 null mice. Mol Cell (2003) 2.60
Genome-wide analyses of transcription factor GATA3-mediated gene regulation in distinct T cell types. Immunity (2011) 2.53
Genomic location analysis by ChIP-Seq. J Cell Biochem (2009) 2.44
A positive role for NLI/Ldb1 in long-range beta-globin locus control region function. Mol Cell (2007) 2.43
GATA3 controls Foxp3⁺ regulatory T cell fate during inflammation in mice. J Clin Invest (2011) 2.43
Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes. Nature (2002) 2.41
The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma. Immunity (2010) 2.38
A LAT mutation that inhibits T cell development yet induces lymphoproliferation. Science (2002) 2.35
Priming for T helper type 2 differentiation by interleukin 2-mediated induction of interleukin 4 receptor alpha-chain expression. Nat Immunol (2008) 2.31
A role for CCR9 in T lymphocyte development and migration. J Immunol (2002) 2.30
esBAF facilitates pluripotency by conditioning the genome for LIF/STAT3 signalling and by regulating polycomb function. Nat Cell Biol (2011) 2.29
Chromatin poises miRNA- and protein-coding genes for expression. Genome Res (2009) 2.28
H2A.Z facilitates access of active and repressive complexes to chromatin in embryonic stem cell self-renewal and differentiation. Cell Stem Cell (2012) 2.20
Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development. Nature (2010) 2.20
Characterization of human epigenomes. Curr Opin Genet Dev (2009) 2.17
Critical Role of STAT5 transcription factor tetramerization for cytokine responses and normal immune function. Immunity (2012) 2.16
TCR signal strength influences alphabeta/gammadelta lineage fate. Immunity (2005) 2.15
An insulator blocks spreading of histone acetylation and interferes with RNA polymerase II transfer between an enhancer and gene. Nucleic Acids Res (2004) 2.11
Genome-wide analysis of histone methylation reveals chromatin state-based regulation of gene transcription and function of memory CD8+ T cells. Immunity (2009) 2.11
Characterization of genome-wide enhancer-promoter interactions reveals co-expression of interacting genes and modes of higher order chromatin organization. Cell Res (2012) 2.09
Intragenic DNA methylation modulates alternative splicing by recruiting MeCP2 to promote exon recognition. Cell Res (2013) 2.07
PTIP promotes chromatin changes critical for immunoglobulin class switch recombination. Science (2010) 2.05
Themis, a T cell-specific protein important for late thymocyte development. Nat Immunol (2009) 2.00
Regulation of nucleosome landscape and transcription factor targeting at tissue-specific enhancers by BRG1. Genome Res (2011) 2.00
Pol II and its associated epigenetic marks are present at Pol III-transcribed noncoding RNA genes. Nat Struct Mol Biol (2010) 1.93
Selective thymus settling regulated by cytokine and chemokine receptors. J Immunol (2007) 1.92
CTCF-dependent enhancer-blocking by alternative chromatin loop formation. Proc Natl Acad Sci U S A (2008) 1.90
Enhancer and promoter interactions-long distance calls. Curr Opin Genet Dev (2011) 1.88
The transcription factor T-bet is induced by multiple pathways and prevents an endogenous Th2 cell program during Th1 cell responses. Immunity (2012) 1.84
Determination of enriched histone modifications in non-genic portions of the human genome. BMC Genomics (2009) 1.80
Genome-wide incorporation dynamics reveal distinct categories of turnover for the histone variant H3.3. Genome Biol (2013) 1.77
Regulation of pluripotency and self- renewal of ESCs through epigenetic-threshold modulation and mRNA pruning. Cell (2012) 1.76
Maximal induction of a subset of interferon target genes requires the chromatin-remodeling activity of the BAF complex. Mol Cell Biol (2002) 1.73
The FUSE/FBP/FIR/TFIIH system is a molecular machine programming a pulse of c-myc expression. EMBO J (2006) 1.73
Expression and regulation of intergenic long noncoding RNAs during T cell development and differentiation. Nat Immunol (2013) 1.71
ChIP-Seq: technical considerations for obtaining high-quality data. Nat Immunol (2011) 1.69
Integrated expression profiling and ChIP-seq analyses of the growth inhibition response program of the androgen receptor. PLoS One (2009) 1.68
CCR6 is required for IL-23-induced psoriasis-like inflammation in mice. J Clin Invest (2009) 1.65
BRG1 requirement for long-range interaction of a locus control region with a downstream promoter. Proc Natl Acad Sci U S A (2009) 1.65