Published in Can J Psychiatry on July 01, 2012
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature (2009) 33.26
Genome-wide association study identifies five new schizophrenia loci. Nat Genet (2011) 9.07
Neuregulin 1 and susceptibility to schizophrenia. Am J Hum Genet (2002) 7.40
A polydiagnostic application of operational criteria in studies of psychotic illness. Development and reliability of the OPCRIT system. Arch Gen Psychiatry (1991) 6.74
Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. Nat Genet (2008) 6.71
Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia. Am J Hum Genet (2003) 6.63
The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria. Schizophr Bull (1991) 4.52
Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia. Am J Hum Genet (2002) 4.03
Association within a family of a balanced autosomal translocation with major mental illness. Lancet (1990) 3.94
A highly significant association between a COMT haplotype and schizophrenia. Am J Hum Genet (2002) 3.52
Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia. Proc Natl Acad Sci U S A (2002) 3.11
Neurophysiological endophenotypes of schizophrenia: the viability of selected candidate measures. Schizophr Bull (2006) 2.92
Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder. Am J Hum Genet (2004) 2.71
Association of neuregulin 1 with schizophrenia confirmed in a Scottish population. Am J Hum Genet (2002) 2.64
Operation of the schizophrenia susceptibility gene, neuregulin 1, across traditional diagnostic boundaries to increase risk for bipolar disorder. Arch Gen Psychiatry (2005) 2.58
Relationship between a high-risk haplotype in the DTNBP1 (dysbindin) gene and clinical features of schizophrenia. Am J Psychiatry (2005) 2.29
The genetic deconstruction of psychosis. Schizophr Bull (2007) 2.25
Chromosome 1 loci in Finnish schizophrenia families. Hum Mol Genet (2001) 1.95
Haplotype transmission analysis provides evidence of association for DISC1 to schizophrenia and suggests sex-dependent effects. Hum Mol Genet (2003) 1.87
G72/G30 in schizophrenia and bipolar disorder: review and meta-analysis. Biol Psychiatry (2006) 1.85
Strong inference, theory testing, and the neuroanatomy of schizophrenia. Arch Gen Psychiatry (1993) 1.78
Support for genetic variation in neuregulin 1 and susceptibility to schizophrenia. Mol Psychiatry (2003) 1.73
Most genome-wide significant susceptibility loci for schizophrenia and bipolar disorder reported to date cross-traditional diagnostic boundaries. Hum Mol Genet (2010) 1.72
Examination of G72 and D-amino-acid oxidase as genetic risk factors for schizophrenia and bipolar affective disorder. Mol Psychiatry (2004) 1.60
Genetic heterogeneity, modifier genes, and quantitative phenotypes in psychiatric illness: searching for a framework. Mol Psychiatry (2005) 1.58
The Roscommon Family Study. IV. Affective illness, anxiety disorders, and alcoholism in relatives. Arch Gen Psychiatry (1993) 1.58
Carving chaos: genetics and the classification of mood and psychotic syndromes. Harv Rev Psychiatry (2006) 1.49
Replication of 1q42 linkage in Finnish schizophrenia pedigrees. Mol Psychiatry (2004) 1.49
Genomewide linkage scan in schizoaffective disorder: significant evidence for linkage at 1q42 close to DISC1, and suggestive evidence at 22q11 and 19p13. Arch Gen Psychiatry (2005) 1.48
Linkage analysis of psychosis in bipolar pedigrees suggests novel putative loci for bipolar disorder and shared susceptibility with schizophrenia. Mol Psychiatry (2004) 1.46
The bipolar disorder phenome database: a resource for genetic studies. Am J Psychiatry (2007) 1.41
Suggestive linkage to chromosomal regions 13q31 and 22q12 in families with psychotic bipolar disorder. Am J Psychiatry (2003) 1.36
The familial aggregation of psychotic symptoms in bipolar disorder pedigrees. Am J Psychiatry (2001) 1.32
Association between the neuregulin 1 gene and schizophrenia: a systematic review. Schizophr Bull (2005) 1.30
Susceptibility loci for bipolar disorder: overlap with inherited vulnerability to schizophrenia. Biol Psychiatry (2000) 1.30
Use of a quantitative trait to map a locus associated with severity of positive symptoms in familial schizophrenia to chromosome 6p. Am J Hum Genet (1997) 1.29
Family history of psychiatric illness as a risk factor for schizoaffective disorder: a Danish register-based cohort study. Arch Gen Psychiatry (2005) 1.26
Whole genome linkage scan of recurrent depressive disorder from the depression network study. Hum Mol Genet (2005) 1.25
Variation in catechol-o-methyltransferase val158 met genotype associated with schizotypy but not cognition: a population study in 543 young men. Biol Psychiatry (2004) 1.23
Disrupted in schizophrenia 1 genotype and positive symptoms in schizophrenia. Biol Psychiatry (2006) 1.22
Clinical features of schizophrenia and linkage to chromosomes 5q, 6p, 8p, and 10p in the Irish Study of High-Density Schizophrenia Families. Am J Psychiatry (2000) 1.21
Genotype-phenotype studies in bipolar disorder showing association between the DAOA/G30 locus and persecutory delusions: a first step toward a molecular genetic classification of psychiatric phenotypes. Am J Psychiatry (2005) 1.21
Variation at the DAOA/G30 locus influences susceptibility to major mood episodes but not psychosis in schizophrenia and bipolar disorder. Arch Gen Psychiatry (2006) 1.19
Association of variants in DISC1 with psychosis-related traits in a large population cohort. Arch Gen Psychiatry (2009) 1.19
Polygenic dissection of the bipolar phenotype. Br J Psychiatry (2011) 1.17
Dysbindin genotype and negative symptoms in schizophrenia. Am J Psychiatry (2006) 1.17
COMT: a common susceptibility gene in bipolar disorder and schizophrenia. Am J Med Genet B Neuropsychiatr Genet (2004) 1.15
Association between genotype at an exonic SNP in DISC1 and normal cognitive aging. Neurosci Lett (2005) 1.15
COMT genetic variation confers risk for psychotic and affective disorders: a case control study. Behav Brain Funct (2005) 1.14
The genetics of symptom-based phenotypes: toward a molecular classification of schizophrenia. Schizophr Bull (2008) 1.11
Schizophrenia genetics: new insights from new approaches. Br Med Bull (2009) 1.11
Bipolar disorder and polymorphisms in the dysbindin gene (DTNBP1). Biol Psychiatry (2005) 1.10
Psychiatric illness in first-degree relatives of schizophrenic and surgical control patients. A family study using DSM-III criteria. Arch Gen Psychiatry (1985) 1.10
Higher scores of self reported schizotypy in healthy young males carrying the COMT high activity allele. Mol Psychiatry (2002) 1.07
Quantitative founder-effect analysis of French Canadian families identifies specific loci contributing to metabolic phenotypes of hypertension. Am J Hum Genet (2005) 1.07
Effect of schizotypy on cognitive performance and its tuning by COMT val158 met genotype variations in a large population of young men. Biol Psychiatry (2006) 1.05
Twin study of symptom dimensions in psychoses. Br J Psychiatry (2001) 1.03
Resemblance of psychotic symptoms and syndromes in affected sibling pairs from the Irish Study of High-Density Schizophrenia Families: evidence for possible etiologic heterogeneity. Am J Psychiatry (1997) 1.03
A functional serotonin transporter (5-HTT) polymorphism is associated with psychosis in neuroleptic-free schizophrenics. Mol Psychiatry (1998) 1.00
Mixture model clustering of phenotype features reveals evidence for association of DTNBP1 to a specific subtype of schizophrenia. Biol Psychiatry (2009) 1.00
Association analysis of Neuregulin 1 candidate regions in schizophrenia and bipolar disorder. Neurosci Lett (2010) 1.00
Genome scan of three quantitative traits in schizophrenia pedigrees. Biol Psychiatry (2002) 1.00
The New York High-Risk Project. Prevalence and comorbidity of axis I disorders in offspring of schizophrenic parents at 25-year follow-up. Arch Gen Psychiatry (1997) 0.99
Dimensions of psychosis in affected sibling pairs. Schizophr Bull (1999) 0.94
Association study of dysbindin gene with clinical and outcome measures in a representative cohort of Italian schizophrenic patients. Am J Med Genet B Neuropsychiatr Genet (2007) 0.93
G72 and its association with major depression and neuroticism in large population-based groups from Germany. Am J Psychiatry (2008) 0.93
Significant correlation in linkage signals from genome-wide scans of schizophrenia and schizotypy. Mol Psychiatry (2007) 0.92
Schizotypal dimensions: an intermediate phenotype associated with the COMT high activity allele. Am J Med Genet B Neuropsychiatr Genet (2007) 0.91
DRD4 exon 3 variants associated with delusional symptomatology in major psychoses: a study on 2,011 affected subjects. Am J Med Genet (2001) 0.90
Clinical features of psychotic disorders and polymorphisms in HT2A, DRD2, DRD4, SLC6A3 (DAT1), and BDNF: a family based association study. Am J Med Genet B Neuropsychiatr Genet (2004) 0.90
Heritability estimates for psychotic symptom dimensions in twins with psychotic disorders. Am J Med Genet B Neuropsychiatr Genet (2010) 0.90
Association study of NRG1, DTNBP1, RGS4, G72/G30, and PIP5K2A with schizophrenia and symptom severity in a Hungarian sample. Am J Med Genet B Neuropsychiatr Genet (2010) 0.88
Factor structure and familiality of first-rank symptoms in sibling pairs with schizophrenia and schizoaffective disorder. Br J Psychiatry (2000) 0.88
Dopamine receptor D2 Ser/Cys 311 variant is associated with delusion and disorganization symptomatology in major psychoses. Mol Psychiatry (2000) 0.87
The CCK-A receptor gene possibly associated with positive symptoms of schizophrenia. Mol Psychiatry (2000) 0.87
CAG repeat length in the hKCa3 gene and symptom dimensions in schizophrenia. Biol Psychiatry (1999) 0.86
Differential association of the COMT Val158Met polymorphism with clinical phenotypes in schizophrenia and bipolar disorder. Schizophr Res (2008) 0.85
Family-based association study of Neuregulin 1 with psychotic bipolar disorder. Am J Med Genet B Neuropsychiatr Genet (2009) 0.85
Association between the DAOA/G72 gene and bipolar disorder and meta-analyses in bipolar disorder and schizophrenia. Bipolar Disord (2011) 0.84
A dysbindin risk haplotype associated with less severe manic-type symptoms in psychosis. Neurosci Lett (2007) 0.84
Dysbindin (DTNBP1)--a role in psychotic depression? J Psychiatr Res (2010) 0.82
Associations between COMTVal158Met polymorphism and cognition: direct or indirect effects? Eur Psychiatry (2006) 0.81
Dysbindin and d-amino-acid-oxidase gene polymorphisms associated with positive and negative symptoms in schizophrenia. Neuropsychobiology (2009) 0.80
Recurrence of bipolar mania is associated with catechol-O-methyltransferase Val(108/158)Met polymorphism. J Affect Disord (2011) 0.79
D-amino acid oxidase (DAO) genotype and mood symptomatology in schizophrenia. Neurosci Lett (2007) 0.79
Evidence that the COMTVal158Met polymorphism moderates subclinical psychotic and affective symptoms in unaffected first-degree relatives of patients with schizophrenia. Eur Psychiatry (2008) 0.76
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02
Cardiometabolic risk of second-generation antipsychotic medications during first-time use in children and adolescents. JAMA (2009) 6.91
Microduplications of 16p11.2 are associated with schizophrenia. Nat Genet (2009) 6.13
Cognitive improvement after treatment with second-generation antipsychotic medications in first-episode schizophrenia: is it a practice effect? Arch Gen Psychiatry (2007) 3.26
Prefrontal white matter in pathological liars. Br J Psychiatry (2005) 3.22
High frequencies of de novo CNVs in bipolar disorder and schizophrenia. Neuron (2011) 3.08
Runs of homozygosity reveal highly penetrant recessive loci in schizophrenia. Proc Natl Acad Sci U S A (2007) 2.81
Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder. Am J Hum Genet (2004) 2.71
The schizophrenia prodrome revisited: a neurodevelopmental perspective. Schizophr Bull (2003) 2.67
Length distributions of identity by descent reveal fine-scale demographic history. Am J Hum Genet (2012) 1.91
Genetic association and brain morphology studies and the chromosome 8p22 pericentriolar material 1 (PCM1) gene in susceptibility to schizophrenia. Arch Gen Psychiatry (2006) 1.86
Clinical and neuropsychological correlates of white matter abnormalities in recent onset schizophrenia. Neuropsychopharmacology (2007) 1.70
Can antidepressants be used to treat the schizophrenia prodrome? Results of a prospective, naturalistic treatment study of adolescents. J Clin Psychiatry (2007) 1.67
Neurocognitive correlates of the COMT Val(158)Met polymorphism in chronic schizophrenia. Biol Psychiatry (2002) 1.66
Genetic variation in DTNBP1 influences general cognitive ability. Hum Mol Genet (2006) 1.61
Elucidating the relationship between DISC1, NDEL1 and NDE1 and the risk for schizophrenia: evidence of epistasis and competitive binding. Hum Mol Genet (2008) 1.60
Association of genetic variation in the MET proto-oncogene with schizophrenia and general cognitive ability. Am J Psychiatry (2010) 1.58
Interaction between FEZ1 and DISC1 in regulation of neuronal development and risk for schizophrenia. Neuron (2011) 1.57
White matter abnormalities in first-episode schizophrenia or schizoaffective disorder: a diffusion tensor imaging study. Am J Psychiatry (2005) 1.56
Cannabis use disorders in schizophrenia: effects on cognition and symptoms. Schizophr Res (2010) 1.55
Patterns of stress in schizophrenia. Psychiatry Res (2008) 1.55
Electroconvulsive therapy augmentation in clozapine-resistant schizophrenia: a prospective, randomized study. Am J Psychiatry (2014) 1.50
White matter abnormalities in obsessive-compulsive disorder: a diffusion tensor imaging study. Arch Gen Psychiatry (2005) 1.49
Early prediction of antipsychotic response in schizophrenia. Am J Psychiatry (2003) 1.47
Molecular differentiation of schizoaffective disorder from schizophrenia using BDNF haplotypes. Br J Psychiatry (2009) 1.47
Association of the DTNBP1 locus with schizophrenia in a U.S. population. Am J Hum Genet (2004) 1.45
Risk factors for psychosis: impaired social and role functioning. Schizophr Bull (2011) 1.43
Cognitive development in schizophrenia: follow-back from the first episode. J Clin Exp Neuropsychol (2006) 1.42
Clinical and cognitive correlates of suicide attempts in bipolar disorder: is suicide predictable? J Clin Psychiatry (2011) 1.42
DRD2 promoter region variation as a predictor of sustained response to antipsychotic medication in first-episode schizophrenia patients. Am J Psychiatry (2006) 1.41
Runs of homozygosity implicate autozygosity as a schizophrenia risk factor. PLoS Genet (2012) 1.40
Gray matter structural alterations in psychotropic drug-naive pediatric obsessive-compulsive disorder: an optimized voxel-based morphometry study. Am J Psychiatry (2008) 1.40
Neurocognition as a stable endophenotype in bipolar disorder and schizophrenia. J Nerv Ment Dis (2006) 1.38
Cognitive and symptomatic predictors of functional disability in schizophrenia. Schizophr Res (2010) 1.35
D2 receptor genetic variation and clinical response to antipsychotic drug treatment: a meta-analysis. Am J Psychiatry (2010) 1.33
High dose D-serine in the treatment of schizophrenia. Schizophr Res (2010) 1.33
Pharmacogenetics and antipsychotics: therapeutic efficacy and side effects prediction. Expert Opin Drug Metab Toxicol (2011) 1.31
Volume reduction in prefrontal gray matter in unsuccessful criminal psychopaths. Biol Psychiatry (2005) 1.28
Efficacy and safety of donepezil in patients with schizophrenia or schizoaffective disorder: significant placebo/practice effects in a 12-week, randomized, double-blind, placebo-controlled trial. Neuropsychopharmacology (2007) 1.27
White matter development in adolescence: diffusion tensor imaging and meta-analytic results. Schizophr Bull (2012) 1.25
Efficacy and safety of individual second-generation vs. first-generation antipsychotics in first-episode psychosis: a systematic review and meta-analysis. Int J Neuropsychopharmacol (2012) 1.25
Genome-wide association study implicates NDST3 in schizophrenia and bipolar disorder. Nat Commun (2013) 1.25
White matter abnormalities in early-onset schizophrenia: a voxel-based diffusion tensor imaging study. J Am Acad Child Adolesc Psychiatry (2005) 1.23
Sex differences in frontal lobe white matter microstructure: a DTI study. Neuroreport (2003) 1.23
Disrupted in schizophrenia 1 genotype and positive symptoms in schizophrenia. Biol Psychiatry (2006) 1.22
Antipsychotic drugs and obesity. Trends Mol Med (2010) 1.21
Effects of serotonin transporter promoter polymorphisms on serotonin function. Neuropsychopharmacology (2004) 1.21
DISC1 is associated with prefrontal cortical gray matter and positive symptoms in schizophrenia. Biol Psychol (2007) 1.21
A schizophrenia risk gene, ZNF804A, influences neuroanatomical and neurocognitive phenotypes. Neuropsychopharmacology (2010) 1.21
Association between common variants near the melanocortin 4 receptor gene and severe antipsychotic drug-induced weight gain. Arch Gen Psychiatry (2012) 1.20
DTNBP1 genotype influences cognitive decline in schizophrenia. Schizophr Res (2006) 1.20
DISC1 and neurocognitive function in schizophrenia. Neuroreport (2005) 1.19
Dysbindin genotype and negative symptoms in schizophrenia. Am J Psychiatry (2006) 1.17
Corpus callosum abnormalities in psychopathic antisocial individuals. Arch Gen Psychiatry (2003) 1.16
Abnormal temporal lobe white matter as a biomarker for genetic risk of bipolar disorder. Biol Psychiatry (2012) 1.16
Candidate gene analysis identifies a polymorphism in HLA-DQB1 associated with clozapine-induced agranulocytosis. J Clin Psychiatry (2010) 1.16
The MATRICS consensus cognitive battery in patients with bipolar I disorder. Neuropsychopharmacology (2011) 1.15
Hippocampal structural asymmetry in unsuccessful psychopaths. Biol Psychiatry (2004) 1.15
COMT genetic variation confers risk for psychotic and affective disorders: a case control study. Behav Brain Funct (2005) 1.14
Smaller anterior hippocampal formation volume in antipsychotic-naive patients with first-episode schizophrenia. Am J Psychiatry (2003) 1.14
Dopamine transporter gene variant affecting expression in human brain is associated with bipolar disorder. Neuropsychopharmacology (2011) 1.13
The genetics of symptom-based phenotypes: toward a molecular classification of schizophrenia. Schizophr Bull (2008) 1.11
Recognizing and monitoring adverse events of second-generation antipsychotics in children and adolescents. Child Adolesc Psychiatr Clin N Am (2006) 1.10
The schizophrenia prodrome: treatment and high-risk perspectives. Schizophr Res (2002) 1.10
Lower orbital frontal white matter integrity in adolescents with bipolar I disorder. J Am Acad Child Adolesc Psychiatry (2009) 1.10
Implications for health and disease in the genetic signature of the Ashkenazi Jewish population. Genome Biol (2012) 1.08
COMT genotype increases risk for bipolar I disorder and influences neurocognitive performance. Bipolar Disord (2007) 1.08
Neurocognitive profile in adolescents with early-onset schizophrenia: clinical correlates. Biol Psychiatry (2005) 1.08
Brain morphometry using diffusion-weighted magnetic resonance imaging: application to schizophrenia. Neuroreport (2005) 1.08
A voxel-based diffusion tensor imaging study of white matter in bipolar disorder. Neuropsychopharmacology (2009) 1.06
Implication of a rare deletion at distal 16p11.2 in schizophrenia. JAMA Psychiatry (2013) 1.05
Resting-state fMRI connectivity impairment in schizophrenia and bipolar disorder. Schizophr Bull (2013) 1.04
In vivo microRNA detection and quantitation in cerebrospinal fluid. J Mol Neurosci (2012) 1.02
A Randomized Comparison of Aripiprazole and Risperidone for the Acute Treatment of First-Episode Schizophrenia and Related Disorders: 3-Month Outcomes. Schizophr Bull (2015) 1.01
The role of COMT Val158Met in cognition. Biol Psychiatry (2008) 0.99
Lack of effect of stimulant combination with second-generation antipsychotics on weight gain, metabolic changes, prolactin levels, and sedation in youth with clinically relevant aggression or oppositionality. J Child Adolesc Psychopharmacol (2009) 0.98
Cognitive dysfunction in bipolar disorder: future place of pharmacotherapy. CNS Drugs (2007) 0.96