Nitric oxide and geriatrics: Implications in diagnostics and treatment of the elderly.

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Published in J Geriatr Cardiol on December 01, 2011

Authors

Ashley C Torregrossa1, Mayank Aranke, Nathan S Bryan

Author Affiliations

1: Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, 1825 Pressler St. 530C, Houston, TX 77030, USA.

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Atherosclerosis--an inflammatory disease. N Engl J Med (1999) 59.28

Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev (1991) 42.38

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature (1980) 40.02

Global prevalence of dementia: a Delphi consensus study. Lancet (2005) 23.30

Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun (1984) 20.07

Diet, nutrition and the prevention of chronic diseases. World Health Organ Tech Rep Ser (2003) 14.60

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci U S A (1987) 14.22

Macrophage cytotoxicity: role for L-arginine deiminase and imino nitrogen oxidation to nitrite. Science (1987) 8.98

Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation. Nat Med (2003) 8.95

Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain. Nature (1988) 8.56

Prognostic value of coronary vascular endothelial dysfunction. Circulation (2002) 7.68

The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics. Nat Rev Drug Discov (2008) 7.58

Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide. Proc Natl Acad Sci U S A (1985) 7.36

Role of oxidative modifications in atherosclerosis. Physiol Rev (2004) 6.73

Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease. Circulation (2000) 6.13

Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. N Engl J Med (1986) 6.05

Endothelial nitric oxide synthase in vascular disease: from marvel to menace. Circulation (2006) 5.91

Systolic versus diastolic blood pressure and risk of coronary heart disease. The Framingham study. Am J Cardiol (1971) 4.90

Nitric oxide activates guanylate cyclase and increases guanosine 3':5'-cyclic monophosphate levels in various tissue preparations. Proc Natl Acad Sci U S A (1977) 4.90

Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults. Circulation (1993) 4.53

Enzyme-independent formation of nitric oxide in biological tissues. Nat Med (1995) 4.28

Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver. J Clin Invest (2005) 4.14

Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension (2008) 3.99

Endothelial function: cardiac events. Circulation (2005) 3.80

Mechanisms of increased vascular superoxide production in human diabetes mellitus: role of NAD(P)H oxidase and endothelial nitric oxide synthase. Circulation (2002) 3.71

Nitrite is a signaling molecule and regulator of gene expression in mammalian tissues. Nat Chem Biol (2005) 3.46

Age-related reduction of NO availability and oxidative stress in humans. Hypertension (2001) 3.37

Effects of dietary nitrate on blood pressure in healthy volunteers. N Engl J Med (2006) 3.29

Reduction of nitrite to nitric oxide during ischemia protects against myocardial ischemia-reperfusion damage. Proc Natl Acad Sci U S A (2004) 3.23

Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease. Circulation (1990) 3.20

Enhanced peroxynitrite formation is associated with vascular aging. J Exp Med (2000) 3.09

Arginase reciprocally regulates nitric oxide synthase activity and contributes to endothelial dysfunction in aging blood vessels. Circulation (2003) 3.01

Accelerated atherosclerosis, aortic aneurysm formation, and ischemic heart disease in apolipoprotein E/endothelial nitric oxide synthase double-knockout mice. Circulation (2001) 3.01

The emerging biology of the nitrite anion. Nat Chem Biol (2005) 2.88

S-nitrosylation in health and disease. Trends Mol Med (2003) 2.85

Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals. Free Radic Biol Med (2003) 2.83

Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO. Hypertension (2010) 2.82

Normal and abnormal biology of the beta-amyloid precursor protein. Annu Rev Neurosci (1994) 2.81

Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans. J Clin Invest (1990) 2.69

The regulation and pharmacology of endothelial nitric oxide synthase. Annu Rev Pharmacol Toxicol (2006) 2.68

Chemical generation of nitric oxide in the mouth from the enterosalivary circulation of dietary nitrate. Nat Med (1995) 2.50

Nitrite infusions to prevent delayed cerebral vasospasm in a primate model of subarachnoid hemorrhage. JAMA (2005) 2.47

Nitrate, bacteria and human health. Nat Rev Microbiol (2004) 2.44

Cellular targets and mechanisms of nitros(yl)ation: an insight into their nature and kinetics in vivo. Proc Natl Acad Sci U S A (2004) 2.33

Nitric oxide insufficiency, platelet activation, and arterial thrombosis. Circ Res (2001) 2.30

Nitrate and nitrite in biology, nutrition and therapeutics. Nat Chem Biol (2009) 2.29

L-arginine therapy in acute myocardial infarction: the Vascular Interaction With Age in Myocardial Infarction (VINTAGE MI) randomized clinical trial. JAMA (2006) 2.24

Flow-induced vasodilation of the human brachial artery is impaired in patients <40 years of age with coronary artery disease. Am J Cardiol (1996) 2.09

Inhaled nebulized nitrite is a hypoxia-sensitive NO-dependent selective pulmonary vasodilator. Nat Med (2004) 2.09

Endothelial nitric oxide modulates expression and processing of amyloid precursor protein. Circ Res (2010) 2.04

Aging progressively impairs endothelium-dependent vasodilation in forearm resistance vessels of humans. Hypertension (1996) 2.03

Dietary nitrite supplementation protects against myocardial ischemia-reperfusion injury. Proc Natl Acad Sci U S A (2007) 2.02

Dietary nitrite prevents hypercholesterolemic microvascular inflammation and reverses endothelial dysfunction. Am J Physiol Heart Circ Physiol (2009) 1.89

Plasma nitrite concentrations reflect the degree of endothelial dysfunction in humans. Free Radic Biol Med (2005) 1.85

Endothelial function predicts future development of coronary artery disease: a study of women with chest pain and normal coronary angiograms. Circulation (2004) 1.81

Methods to detect nitric oxide and its metabolites in biological samples. Free Radic Biol Med (2007) 1.81

Nitrite reductase activity is a novel function of mammalian mitochondria. FEBS Lett (1999) 1.80

Overexpression of endothelial nitric oxide synthase accelerates atherosclerotic lesion formation in apoE-deficient mice. J Clin Invest (2002) 1.80

Nutritional epidemiology in the context of nitric oxide biology: a risk-benefit evaluation for dietary nitrite and nitrate. Nitric Oxide (2009) 1.71

Atherosclerotic Vascular Disease Conference: Writing Group III: pathophysiology. Circulation (2004) 1.65

Toxicology and epidemiology: improving the science with a framework for combining toxicological and epidemiological evidence to establish causal inference. Toxicol Sci (2011) 1.64

Progression of amyloid pathology to Alzheimer's disease pathology in an amyloid precursor protein transgenic mouse model by removal of nitric oxide synthase 2. J Neurosci (2008) 1.64

Cardiovascular risk factors and incident Alzheimer disease: a systematic review of the literature. Alzheimer Dis Assoc Disord (2009) 1.64

Transdermal glyceryl trinitrate lowers blood pressure and maintains cerebral blood flow in recent stroke. Hypertension (2006) 1.61

Tissue processing of nitrite in hypoxia: an intricate interplay of nitric oxide-generating and -scavenging systems. J Biol Chem (2008) 1.61

Nitrosamine and related food intake and gastric and oesophageal cancer risk: a systematic review of the epidemiological evidence. World J Gastroenterol (2006) 1.57

N-Acetylcysteine potentiates inhibition of platelet aggregation by nitroglycerin. J Clin Invest (1985) 1.57

Characterization of the effects of oxygen on xanthine oxidase-mediated nitric oxide formation. J Biol Chem (2004) 1.48

Amyloid-beta peptide inhibits activation of the nitric oxide/cGMP/cAMP-responsive element-binding protein pathway during hippocampal synaptic plasticity. J Neurosci (2005) 1.47

Effects of age on endothelium-dependent vasodilation of resistance coronary artery by acetylcholine in humans. Circulation (1993) 1.47

Chemical synthesis of nitric oxide in the stomach from dietary nitrate in humans. Gut (1997) 1.46

Risk of colorectal and other gastro-intestinal cancers after exposure to nitrate, nitrite and N-nitroso compounds: a follow-up study. Int J Cancer (1999) 1.46

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Nitrite in saliva increases gastric mucosal blood flow and mucus thickness. J Clin Invest (2004) 1.42

Isolation and partial characterization of neurofibrillary tangles and amyloid plaque core in Alzheimer's disease: immunohistological studies. J Neuropathol Exp Neurol (1986) 1.31

Hypertension does not account for the accelerated atherosclerosis and development of aneurysms in male apolipoprotein e/endothelial nitric oxide synthase double knockout mice. Circulation (2001) 1.31

Inhibition of fibrinogen binding to human platelets by S-nitroso-N-acetylcysteine. J Biol Chem (1990) 1.28

Nitric oxide released from activated platelets inhibits platelet recruitment. J Clin Invest (1997) 1.28

S-Nitrosylation activates Cdk5 and contributes to synaptic spine loss induced by beta-amyloid peptide. Proc Natl Acad Sci U S A (2011) 1.21

Nitric oxide inhibits capacitative cation influx in human platelets by promoting sarcoplasmic/endoplasmic reticulum Ca2+-ATPase-dependent refilling of Ca2+ stores. Circ Res (1999) 1.18

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Intake of nitrate and nitrite and the risk of gastric cancer: a prospective cohort study. Br J Cancer (1998) 1.08

Myocardial aging: functional alterations and related cellular mechanisms. Am J Physiol (1982) 1.08

Emerging role of nitrite in human biology. Blood Cells Mol Dis (2004) 1.07

Dietary nitrates, nitrites, and N-nitroso compounds and cancer risk: a review of the epidemiologic evidence. Nutr Rev (1998) 1.06

Nitrite metabolism by skeletal muscle mitochondria in relation to haem pigments. Biochim Biophys Acta (1967) 1.05

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Expression of constitutive endothelial nitric oxide synthase in human blood platelets. Life Sci (1995) 1.00

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