PubRank

Joseph A Trapani

Author PubWeight™ 104.49‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 A common fold mediates vertebrate defense and bacterial attack. Science 2007 3.43
2 The immunostimulatory effect of lenalidomide on NK-cell function is profoundly inhibited by concurrent dexamethasone therapy. Blood 2010 3.23
3 Perforin-mediated target-cell death and immune homeostasis. Nat Rev Immunol 2006 3.04
4 The structural basis for membrane binding and pore formation by lymphocyte perforin. Nature 2010 2.23
5 The MACPF/CDC family of pore-forming toxins. Cell Microbiol 2008 2.15
6 The molecular basis for perforin oligomerization and transmembrane pore assembly. Immunity 2009 1.98
7 Suppression of lymphoma and epithelial malignancies effected by interferon gamma. J Exp Med 2002 1.85
8 Single-chain antigen recognition receptors that costimulate potent rejection of established experimental tumors. Blood 2002 1.83
9 Novel mechanisms of apoptosis induced by histone deacetylase inhibitors. Cancer Res 2003 1.73
10 Protection from endogenous perforin: glycans and the C terminus regulate exocytic trafficking in cytotoxic lymphocytes. Immunity 2011 1.73
11 Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack. Blood 2013 1.53
12 The major human and mouse granzymes are structurally and functionally divergent. J Cell Biol 2006 1.48
13 Functional crosstalk between type I and II interferon through the regulated expression of STAT1. PLoS Biol 2010 1.40
14 Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation. Immunity 2002 1.39
15 Extracellular matrix remodeling by human granzyme B via cleavage of vitronectin, fibronectin, and laminin. J Biol Chem 2005 1.39
16 Persistence and efficacy of second generation CAR T cell against the LeY antigen in acute myeloid leukemia. Mol Ther 2013 1.33
17 Biochemical and growth regulatory activities of the HIN-200 family member and putative tumor suppressor protein, AIM2. Biochem Biophys Res Commun 2005 1.32
18 Rejection of syngeneic colon carcinoma by CTLs expressing single-chain antibody receptors codelivering CD28 costimulation. J Immunol 2002 1.31
19 Calcium-dependent plasma membrane binding and cell lysis by perforin are mediated through its C2 domain: A critical role for aspartate residues 429, 435, 483, and 485 but not 491. J Biol Chem 2004 1.31
20 Perforin: structure, function, and role in human immunopathology. Immunol Rev 2010 1.30
21 Apoptosis induced by the lymphocyte effector molecule perforin. Curr Opin Immunol 2007 1.29
22 Gene-engineered T cells as a superior adjuvant therapy for metastatic cancer. J Immunol 2004 1.24
23 Caspase activation by granzyme B is indirect, and caspase autoprocessing requires the release of proapoptotic mitochondrial factors. Immunity 2003 1.23
24 Perforin and granzymes: function, dysfunction and human pathology. Nat Rev Immunol 2015 1.23
25 A functional analysis of the putative polymorphisms A91V and N252S and 22 missense perforin mutations associated with familial hemophagocytic lymphohistiocytosis. Blood 2005 1.22
26 The battlefield of perforin/granzyme cell death pathways. J Leukoc Biol 2009 1.18
27 hScrib is a functional homologue of the Drosophila tumour suppressor Scribble. Oncogene 2003 1.15
28 Adoptive transfer of T cells modified with a humanized chimeric receptor gene inhibits growth of Lewis-Y-expressing tumors in mice. Proc Natl Acad Sci U S A 2005 1.14
29 Temperature sensitivity of human perforin mutants unmasks subtotal loss of cytotoxicity, delayed FHL, and a predisposition to cancer. Proc Natl Acad Sci U S A 2009 1.14
30 Cytotoxic T lymphocytes from cathepsin B-deficient mice survive normally in vitro and in vivo after encountering and killing target cells. J Biol Chem 2006 1.13
31 A role for granzyme M in TLR4-driven inflammation and endotoxicosis. J Immunol 2010 1.13
32 Functional dissection of the granzyme family: cell death and inflammation. Immunol Rev 2010 1.12
33 Cytotoxic T-cells from T-cell receptor transgenic NOD8.3 mice destroy beta-cells via the perforin and Fas pathways. Diabetes 2006 1.12
34 Adoptive transfer of gene-engineered CD4+ helper T cells induces potent primary and secondary tumor rejection. Blood 2005 1.10
35 Perforin activity and immune homeostasis: the common A91V polymorphism in perforin results in both presynaptic and postsynaptic defects in function. Blood 2007 1.10
36 A central role for Bid in granzyme B-induced apoptosis. J Biol Chem 2004 1.10
37 Endolysosomal proteases and their inhibitors in immunity. Nat Rev Immunol 2009 1.10
38 Protecting a serial killer: pathways for perforin trafficking and self-defence ensure sequential target cell death. Trends Immunol 2012 1.09
39 Rapid and unidirectional perforin pore delivery at the cytotoxic immune synapse. J Immunol 2013 1.08
40 Perforin and Fas induced by IFNgamma and TNFalpha mediate beta cell death by OT-I CTL. Int Immunol 2006 1.08
41 Granzyme B encoded by the commonly occurring human RAH allele retains pro-apoptotic activity. J Biol Chem 2004 1.07
42 Sustained antigen-specific antitumor recall response mediated by gene-modified CD4+ T helper-1 and CD8+ T cells. Cancer Res 2007 1.06
43 The functional basis for hemophagocytic lymphohistiocytosis in a patient with co-inherited missense mutations in the perforin (PFN1) gene. J Exp Med 2004 1.05
44 Assaying cytochrome C translocation during apoptosis. Methods Mol Biol 2004 1.05
45 Cationic sites on granzyme B contribute to cytotoxicity by promoting its uptake into target cells. Mol Cell Biol 2005 1.04
46 Tumor ablation by gene-modified T cells in the absence of autoimmunity. Cancer Res 2010 1.04
47 A functional role for CD28 costimulation in tumor recognition by single-chain receptor-modified T cells. Cancer Gene Ther 2004 1.03
48 Discordant regulation of granzyme H and granzyme B expression in human lymphocytes. J Biol Chem 2004 1.03
49 Granzyme M mediates a novel form of perforin-dependent cell death. J Biol Chem 2004 1.01
50 Cathepsin H is an additional convertase of pro-granzyme B. J Biol Chem 2010 0.99
51 Ligation of the cell surface receptor, CD46, alters T cell polarity and response to antigen presentation. Proc Natl Acad Sci U S A 2006 0.99
52 Cutting edge: rapid and efficient in vivo cytotoxicity by cytotoxic T cells is independent of granzymes A and B. J Immunol 2009 0.98
53 Residual active granzyme B in cathepsin C-null lymphocytes is sufficient for perforin-dependent target cell apoptosis. J Cell Biol 2007 0.97
54 Granzyme B-mediated death of pancreatic beta-cells requires the proapoptotic BH3-only molecule bid. Diabetes 2006 0.96
55 Cytotoxic T lymphocyte-induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis. J Cell Biol 2006 0.95
56 Purification of natural killer cell cytotoxic granules for assaying target cell apoptosis. J Immunol Methods 2003 0.95
57 Granzyme K expressing cytotoxic T lymphocytes protects against influenza virus in granzyme AB-/- mice. Viral Immunol 2008 0.94
58 Perforin-mediated suppression of B-cell lymphoma. Proc Natl Acad Sci U S A 2009 0.94
59 A novel c-Jun-dependent signal transduction pathway necessary for the transcriptional activation of interferon gamma response genes. J Biol Chem 2006 0.94
60 Cutting edge: granzymes A and B are not essential for perforin-mediated tumor rejection. J Immunol 2003 0.94
61 Cytotoxic activity of the lymphocyte toxin granzyme B. Microbes Infect 2004 0.94
62 A critical role for granzymes in antigen cross-presentation through regulating phagocytosis of killed tumor cells. J Immunol 2011 0.92
63 Expression of IFI 16 in epithelial cells and lymphoid tissues. Histochem Cell Biol 2002 0.91
64 Perforin evolved from a gene duplication of MPEG1, followed by a complex pattern of gene gain and loss within Euteleostomi. BMC Evol Biol 2012 0.91
65 The Lewis-Y carbohydrate antigen is expressed by many human tumors and can serve as a target for genetically redirected T cells despite the presence of soluble antigen in serum. J Immunother 2009 0.90
66 Exploration of a series of 5-arylidene-2-thioxoimidazolidin-4-ones as inhibitors of the cytolytic protein perforin. J Med Chem 2013 0.90
67 Inhibition of the pore-forming protein perforin by a series of aryl-substituted isobenzofuran-1(3H)-ones. Bioorg Med Chem 2011 0.90
68 Homeostatic defects in interleukin 18-deficient mice contribute to protection against the lethal effects of endotoxin. Immunol Cell Biol 2011 0.88
69 Addressing the mysteries of perforin function. Immunol Cell Biol 2006 0.87
70 Role of Bid-induced mitochondrial outer membrane permeabilization in granzyme B-induced apoptosis. Immunol Cell Biol 2006 0.87
71 A critical role for granzyme B, in addition to perforin and TNFalpha, in alloreactive CTL-induced mouse pancreatic beta cell death. Transplantation 2006 0.86
72 Cytotoxic lymphocytes; instigators of dramatic target cell death. Biochem Pharmacol 2004 0.86
73 Defining the interaction of perforin with calcium and the phospholipid membrane. Biochem J 2013 0.85
74 Human and mouse perforin are processed in part through cleavage by the lysosomal cysteine proteinase cathepsin L. Immunology 2010 0.85
75 Inhibition of the cellular function of perforin by 1-amino-2,4-dicyanopyrido[1,2-a]benzimidazoles. Bioorg Med Chem 2011 0.83
76 Measuring cell death mediated by cytotoxic lymphocytes or their granule effector molecules. Methods 2008 0.83
77 Granzyme B is dispensable in the development of diabetes in non-obese diabetic mice. PLoS One 2012 0.82
78 Activated mouse B cells lack expression of granzyme B. J Immunol 2012 0.82
79 Dihydrofuro[3,4-c]pyridinones as inhibitors of the cytolytic effects of the pore-forming glycoprotein perforin. J Med Chem 2008 0.81
80 Interaction of the nuclear localizing cytolytic granule serine protease granzyme B with importin alpha or beta: modulation by the serpin inhibitor PI-9. J Cell Biochem 2005 0.81
81 Proteolytic activation of the cytotoxic phenotype during human NK cell development. J Immunol 2009 0.81
82 The role of p202 in regulating hematopoietic cell proliferation and differentiation. J Interferon Cytokine Res 2008 0.80
83 The perforin pore facilitates the delivery of cationic cargos. J Biol Chem 2014 0.79
84 The granzyme B gene is highly polymorphic in wild mice but essentially invariant in common inbred laboratory strains. Tissue Antigens 2007 0.79
85 Cloning and characterisation of Ifi206: a new murine HIN-200 family member. J Cell Biochem 2008 0.78
86 Fatal immune dysregulation due to a gain of glycosylation mutation in lymphocyte perforin. Blood 2011 0.78
87 H is for helper: granzyme H helps granzyme B kill adenovirus-infected cells. Trends Immunol 2007 0.77
88 Functional role of phosphatidylinositol 3-kinase in direct tumor lysis by human natural killer cells. Immunobiology 2002 0.76
89 Cathepsin C limits acute viral infection independently of NK cell and CD8+ T-cell cytolytic function. Immunol Cell Biol 2010 0.76
90 Targeting the adenosine 2A receptor enhances chimeric antigen receptor T cell efficacy. J Clin Invest 2017 0.76
91 Incentives: encouraging adventurous ideas. Science 2010 0.75
92 A novel role for granzymes in anti-tumor immunity. Oncoimmunology 2012 0.75
93 Granzyme H is a novel protease expressed by human mast cells. Int Arch Allergy Immunol 2014 0.75
94 Cloning and characterising an unusual perforin from chicken (Gallus gallus). Dev Comp Immunol 2013 0.75
95 Immunotherapy of cancer. Aust Fam Physician 2017 0.75
96 Proteases in lymphocyte killer function: redundancy, polymorphism and questions remaining. Biol Chem 2010 0.75