Published in Acta Naturae on April 01, 2012
Correlation between chemosensitivity to anticancer drugs and telomerase reverse transcriptase mRNA expression in gastric cancer. Diagn Pathol (2013) 1.01
Mesenchymal stem cells-based therapy as a potential treatment in neurodegenerative disorders: is the escape from senescence an answer? Neural Regen Res (2015) 0.83
Enhancement of the in vivo persistence and antitumor efficacy of CD19 chimeric antigen receptor T cells through the delivery of modified TERT mRNA. Cell Discov (2015) 0.79
Bufalin Induces Mitochondria-Dependent Apoptosis in Pancreatic and Oral Cancer Cells by Downregulating hTERT Expression via Activation of the JNK/p38 Pathway. Evid Based Complement Alternat Med (2015) 0.78
Telomerase as a Cancer Target. Development of New Molecules. Curr Top Med Chem (2016) 0.76
Peculiarities of Yeasts and Human Telomerase RNAs Processing. Acta Naturae (2017) 0.75
Expression of functional alternative telomerase RNA component gene in mouse brain and in motor neurons cells protects from oxidative stress. Oncotarget (2016) 0.75
Expression of genes involved in DNA repair and telomere maintenance in the yeast Hansenula polymorpha DL1 under heat stress. Dokl Biochem Biophys (2015) 0.75
WAF1, a potential mediator of p53 tumor suppression. Cell (1993) 38.72
Specific association of human telomerase activity with immortal cells and cancer. Science (1994) 28.20
Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell (1985) 24.17
ATM and related protein kinases: safeguarding genome integrity. Nat Rev Cancer (2003) 16.06
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature (2005) 15.83
p21 is a universal inhibitor of cyclin kinases. Nature (1993) 15.55
Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev (2005) 15.19
Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu Rev Biochem (2004) 14.93
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature (1993) 13.68
Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization. Genes Dev (1998) 12.55
How shelterin protects mammalian telomeres. Annu Rev Genet (2008) 11.20
Origin of concatemeric T7 DNA. Nat New Biol (1972) 9.08
Structure of large fragment of Escherichia coli DNA polymerase I complexed with dTMP. Nature (1985) 8.46
Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts. Nat Cell Biol (2003) 8.42
The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity. Cell (1987) 8.32
A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. J Theor Biol (1973) 7.28
Telomerase modulates expression of growth-controlling genes and enhances cell proliferation. Nat Cell Biol (2003) 7.02
Pot1, the putative telomere end-binding protein in fission yeast and humans. Science (2001) 6.95
Telomeres and human disease: ageing, cancer and beyond. Nat Rev Genet (2005) 6.85
A tandemly repeated sequence at the termini of the extrachromosomal ribosomal RNA genes in Tetrahymena. J Mol Biol (1978) 6.45
Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends. Science (2007) 6.33
Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication. Cell (2009) 5.74
DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion. Nat Cell Biol (2005) 5.49
POT1 as a terminal transducer of TRF1 telomere length control. Nature (2003) 5.43
Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway. J Biol Chem (1996) 5.42
Protection of mammalian telomeres. Oncogene (2002) 5.38
Inhibition of telomerase by G-quartet DNA structures. Nature (1991) 5.38
The RNA world of the nucleolus: two major families of small RNAs defined by different box elements with related functions. Cell (1996) 5.14
DNA polymerases: structural diversity and common mechanisms. J Biol Chem (1999) 5.00
Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. Nat Genet (1997) 4.95
Non-coding RNAs: lessons from the small nuclear and small nucleolar RNAs. Nat Rev Mol Cell Biol (2007) 4.91
Telomeres and their control. Annu Rev Genet (2000) 4.74
Telomere end-binding proteins control the formation of G-quadruplex DNA structures in vivo. Nat Struct Mol Biol (2005) 4.61
A box H/ACA small nucleolar RNA-like domain at the human telomerase RNA 3' end. Mol Cell Biol (1999) 4.51
DNA methyltransferases control telomere length and telomere recombination in mammalian cells. Nat Cell Biol (2006) 4.38
The family of box ACA small nucleolar RNAs is defined by an evolutionarily conserved secondary structure and ubiquitous sequence elements essential for RNA accumulation. Genes Dev (1997) 4.26
TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase. Nature (2007) 4.23
A role for both RB and p53 in the regulation of human cellular senescence. Exp Cell Res (1991) 4.07
Identification of human Rap1: implications for telomere evolution. Cell (2000) 4.06
In vitro generated antibodies specific for telomeric guanine-quadruplex DNA react with Stylonychia lemnae macronuclei. Proc Natl Acad Sci U S A (2001) 3.97
Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence? Exp Cell Res (1995) 3.96
Telomerase modulates Wnt signalling by association with target gene chromatin. Nature (2009) 3.96
Reversible cellular senescence: implications for immortalization of normal human diploid fibroblasts. Mol Cell Biol (1989) 3.89
The epigenetic regulation of mammalian telomeres. Nat Rev Genet (2007) 3.82
Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection. Nat Struct Mol Biol (2004) 3.66
Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases. Nat Genet (2003) 3.64
Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks. J Cell Biol (2006) 3.63
Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types. Hum Mol Genet (1997) 3.56
Protein composition of catalytically active human telomerase from immortal cells. Science (2007) 3.53
Telomerase in yeast. Science (1995) 3.38
A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis. Science (2009) 3.34
The structure and function of telomerase reverse transcriptase. Annu Rev Biochem (2006) 3.32
POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex. Genes Dev (2004) 3.25
Cyclin D expression is controlled post-transcriptionally via a phosphatidylinositol 3-kinase/Akt-dependent pathway. J Biol Chem (1998) 3.25
Telomerase expression extends the proliferative life-span and maintains the osteogenic potential of human bone marrow stromal cells. Nat Biotechnol (2002) 3.20
Structure of the human telomerase RNA pseudoknot reveals conserved tertiary interactions essential for function. Mol Cell (2005) 3.16
Telomeres and telomerase. Philos Trans R Soc Lond B Biol Sci (2004) 3.13
An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA. Nature (2009) 3.04
Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice. Genes Dev (2009) 2.91
Nhp2p and Nop10p are essential for the function of H/ACA snoRNPs. EMBO J (1998) 2.91
Functional human telomeres are recognized as DNA damage in G2 of the cell cycle. Mol Cell (2005) 2.89
The many facets of H/ACA ribonucleoproteins. Chromosoma (2005) 2.89
Telomerase is processive. Mol Cell Biol (1991) 2.79
Human H/ACA small nucleolar RNPs and telomerase share evolutionarily conserved proteins NHP2 and NOP10. Mol Cell Biol (2000) 2.78
Tetrahymena telomerase catalyzes nucleolytic cleavage and nonprocessive elongation. Genes Dev (1993) 2.64
Telomerase activity in human development is regulated by human telomerase reverse transcriptase (hTERT) transcription and by alternate splicing of hTERT transcripts. Cancer Res (1998) 2.54
TIN2 mediates functions of TRF2 at human telomeres. J Biol Chem (2004) 2.52
Human telomerase RNA and box H/ACA scaRNAs share a common Cajal body-specific localization signal. J Cell Biol (2004) 2.49
Ras transformation results in an elevated level of cyclin D1 and acceleration of G1 progression in NIH 3T3 cells. Mol Cell Biol (1995) 2.47
Cell cycle restriction of telomere elongation. Curr Biol (2000) 2.46
A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases. Nat Struct Mol Biol (2008) 2.43
Structures of HIV-1 reverse transcriptase with pre- and post-translocation AZTMP-terminated DNA. EMBO J (2002) 2.41
Template boundary in a yeast telomerase specified by RNA structure. Science (2000) 2.39
TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres. J Biol Chem (2004) 2.36
Crystal structure of the essential N-terminal domain of telomerase reverse transcriptase. Nat Struct Mol Biol (2006) 2.32
A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins. Science (2008) 2.30
Template boundary definition in mammalian telomerase. Genes Dev (2003) 2.30
Functional links between telomeres and proteins of the DNA-damage response. Genes Dev (2004) 2.29
In vitro assembly of human H/ACA small nucleolar RNPs reveals unique features of U17 and telomerase RNAs. Mol Cell Biol (2000) 2.27
RNA binding domain of telomerase reverse transcriptase. Mol Cell Biol (2001) 2.27
Antioxidants inhibit nuclear export of telomerase reverse transcriptase and delay replicative senescence of endothelial cells. Circ Res (2004) 2.27
Cell cycle-regulated trafficking of human telomerase to telomeres. Mol Biol Cell (2005) 2.26
Suv4-20h deficiency results in telomere elongation and derepression of telomere recombination. J Cell Biol (2007) 2.24
Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signal. Science (2010) 2.23
Identification of ATPases pontin and reptin as telomerase components essential for holoenzyme assembly. Cell (2008) 2.20
TRF1 binds a bipartite telomeric site with extreme spatial flexibility. EMBO J (1999) 2.20
Mutations linked to dyskeratosis congenita cause changes in the structural equilibrium in telomerase RNA. Proc Natl Acad Sci U S A (2003) 2.18
Structure of the Tribolium castaneum telomerase catalytic subunit TERT. Nature (2008) 2.17
Telomerase RNA structure and function: implications for dyskeratosis congenita. Trends Biochem Sci (2004) 2.17
N-terminal domains of the human telomerase catalytic subunit required for enzyme activity in vivo. Mol Cell Biol (2001) 2.16
Birth of the snoRNPs: the evolution of the modification-guide snoRNAs. Trends Biochem Sci (1998) 2.14
Structure and function of telomerase RNA. Curr Opin Struct Biol (2006) 2.09
Involvement of 14-3-3 proteins in nuclear localization of telomerase. EMBO J (2000) 2.05
Architecture and assembly of mammalian H/ACA small nucleolar and telomerase ribonucleoproteins. EMBO J (2004) 2.04
The telomerase reverse transcriptase regulates chromatin state and DNA damage responses. Proc Natl Acad Sci U S A (2005) 2.01
Template boundary definition in Tetrahymena telomerase. Genes Dev (2002) 1.96
ATR: a master conductor of cellular responses to DNA replication stress. Trends Biochem Sci (2010) 1.96
Cell cycle-dependent recruitment of telomerase RNA and Cajal bodies to human telomeres. Mol Biol Cell (2005) 1.93
Spliceosomal cleavage generates the 3' end of telomerase RNA. Nature (2008) 1.93
Telomerase RNA biosynthesis and processing. Biochemistry (Mosc) (2012) 1.44
Telomerase: structure, functions, and activity regulation. Biochemistry (Mosc) (2010) 1.19
Structure and function of 5S rRNA in the ribosome. Biochem Cell Biol (1996) 1.06
Structure of 5S rRNA within the Escherichia coli ribosome: iodine-induced cleavage patterns of phosphorothioate derivatives. RNA (1998) 0.90
Saccharomyces cerevisiae telomerase subunit Est3p binds DNA and RNA and stimulates unwinding of RNA/DNA heteroduplexes. FEBS Lett (2006) 0.89
Complex of transfer-messenger RNA and elongation factor Tu. Unexpected modes of interaction. J Biol Chem (2001) 0.89
5S rRNA sugar-phosphate backbone protection in complexes with specific ribosomal proteins. FEBS Lett (1996) 0.89
[Study of ribosome structure using the biochemical methods: judgment day]. Mol Biol (Mosk) (2001) 0.85
A new technique for the characterization of long-range tertiary contacts in large RNA molecules: insertion of a photolabel at a selected position in 16S rRNA within the Escherichia coli ribosome. Nucleic Acids Res (1997) 0.84
Posttranslational Modifications of Ribosomal Proteins in Escherichia coli. Acta Naturae (2011) 0.84
[Systems biology approach to the functional role of enzymatic modification of bacterial ribosome]. Bioorg Khim (2011) 0.83
Interaction of mRNA with the Escherichia coli ribosome: accessibility of phosphorothioate-containing mRNA bound to ribosomes for iodine cleavage. Nucleic Acids Res (1996) 0.83
Telomerase from Saccharomyces cerevisiae contains several protein subunits and may have different activities depending on the protein content. FEBS Lett (1998) 0.83
[Photoaffinity modification of small ribosomal subunits of Escherichia coli with 5'-diaziryl derivatives of mRNA]. Dokl Akad Nauk SSSR (1990) 0.82
Hansenula Polymorpha TERT: A Telomerase Catalytic Subunit Isolated in Recombinant Form with Limited Reverse Transcriptase Activity. Acta Naturae (2012) 0.81
Replication protein A modulates the activity of human telomerase in vitro. Biochemistry (Mosc) (2009) 0.81
Effect of point mutations at position 89 of the E. coli 5S rRNA on the assembly and activity of the large ribosomal subunit. FEBS Lett (1998) 0.80
Telomerase from yeast Saccharomyces cerevisiae is active in vitro as a monomer. Biochemistry (Mosc) (2009) 0.80
Deamination of 5-methylcytosine residues in Mammalian cells. Acta Naturae (2009) 0.80
Identification of additional telomerase component of the yeast H. polymorpha is a step towards understanding the complex at the atomic level. Dokl Biochem Biophys (2014) 0.79
Structure of the decoding center of the ribosome. Biochemistry (Mosc) (1998) 0.79
New features of 23S ribosomal RNA folding: the long helix 41-42 makes a "U-turn" inside the ribosome. RNA (1998) 0.79
The Database of Ribosomal Cross links (DRC). Nucleic Acids Res (1998) 0.79
Yeast telosome complex: components and their functions. Biochemistry (Mosc) (2003) 0.79
Oligonucleotide inhibitors of telomerase: prospects for anticancer therapy and diagnostics. Biochemistry (Mosc) (2015) 0.78
[Interaction of 23S ribosomal RNA helices 89 and 91 of Escherichia coli contributes to the activity of IF2 but is insignificant for elongation factors functioning]. Mol Biol (Mosk) (2008) 0.78
A protonated base pair participating in rRNA tertiary structural interactions. Nucleic Acids Res (2001) 0.77
[The structural changes in the ribosome during the elongation cycle]. Mol Biol (Mosk) (2006) 0.77
Assays for detection of telomerase activity. Acta Naturae (2011) 0.77
Translational properties of mHNA, a messenger RNA containing anhydrohexitol nucleotides. Biochemistry (2001) 0.76
[Directed cleavage of the 16S rRNA molecule at a single internucleotide bond]. Biokhimiia (1995) 0.76
Telomerase is an unusual RNA-containing enzyme. A review. Biochemistry (Mosc) (1997) 0.76
[Directed introduction of photoaffinity reagents in internal segments of RNA]. Mol Biol (Mosk) (2000) 0.76
Regulation of Flagellar Gene Expression in Bacteria. Biochemistry (Mosc) (2015) 0.76
Telomerase Complex from Yeast Saccharomyces cerevisiae Contains a Biotinylated Component. Acta Naturae (2009) 0.75
Contacts of elongation factor G with the small ribosomal subunit: cross-linking approach. Dokl Biochem Biophys (2004) 0.75
Telomerase activity in peripheral blood mononuclear cells as a universal scale for quantitative measurement of telomerase activation on the example of liver diseases. Dokl Biochem Biophys (2015) 0.75
[Telomerase: structure and properties of the enzyme, characteristics of the yeast telomerase]. Mol Biol (Mosk) (2006) 0.75
[Telomerase level versus spliced hTERT-specific RNA forms in cervical carcinoma]. Vopr Onkol (2010) 0.75
Expression of genes involved in DNA repair and telomere maintenance in the yeast Hansenula polymorpha DL1 under heat stress. Dokl Biochem Biophys (2015) 0.75
Ribosomal protein TL5 of T. thermophilus is incorporated in the E. coli 50S ribosomal subunit. Dokl Biochem (2001) 0.75
[Structure and function of 5S rRNA in ribosomes]. Mol Biol (Mosk) (1996) 0.75
[Trans-translation: facts and hypothesis]. Mol Biol (Mosk) (2010) 0.75
In vitro dimerization of telomerase protein Est3p is stimulated by magnesium cations. Dokl Biochem Biophys (2010) 0.75
[High level of expression and nuclear localization of RNA, transcribed from genome region, containing repetitive elements]. Mol Biol (Mosk) (2015) 0.75
Telomerase as a potential marker for early diagnosing cervical carcinoma. Dokl Biochem Biophys (2006) 0.75
Isolation of active yeast telomerase protein Est3p and investigation of its dimerization in vitro. Biochemistry (Mosc) (2007) 0.75
[Ribosome: lessons of a molecular factory construction]. Mol Biol (Mosk) (2015) 0.75
[Synthesis in E. coli cells of short RNA encoded in plasmids]. Biokhimiia (1989) 0.75
[Structure and function of tmRNA (10Sa RNK)]. Mol Biol (Mosk) (2000) 0.75
A specific DNA-dependent DNA polymerase is associated with Saccharomyces cerevisiae telomerase. Biochemistry (Mosc) (2001) 0.75
mRNA-ribosome interactions. Biotechnol Appl Biochem (1993) 0.75
Methods of Genome Engineering: a New Era of Molecular Biology. Biochemistry (Mosc) (2016) 0.75
Does a deficiency of the signal recognition particle (SRP)-pathway affect the biosynthesis of its components in Saccharomyces cerevisiae and Escherichia coli? Biochemistry (Mosc) (2006) 0.75
Mouse chromocenters contain associated telomeric DNA and telomerase activity. Dokl Biol Sci (2002) 0.75
[Phosphate sites of RNA-ligands interacting with ribosome at different stages of translation. Thiophosphate method of analysis]. Biokhimiia (1996) 0.75
[The 5S rRNA-protein complex of Escherichia coli studied by carbodiimide modification]. Nauchnye Doki Vyss Shkoly Biol Nauki (1990) 0.75