Published in Nat Struct Mol Biol on November 21, 2004
Quadruplex DNA: sequence, topology and structure. Nucleic Acids Res (2006) 6.42
Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics. Nucleic Acids Res (2007) 3.49
TPP1 OB-fold domain controls telomere maintenance by recruiting telomerase to chromosome ends. Cell (2012) 2.74
POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end. EMBO J (2005) 2.69
Extreme conformational diversity in human telomeric DNA. Proc Natl Acad Sci U S A (2005) 2.63
Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro. Proc Natl Acad Sci U S A (2005) 2.63
POT1 mutations cause telomere dysfunction in chronic lymphocytic leukemia. Nat Genet (2013) 2.62
Conserved telomere maintenance component 1 interacts with STN1 and maintains chromosome ends in higher eukaryotes. Mol Cell (2009) 2.62
POT1 loss-of-function variants predispose to familial melanoma. Nat Genet (2014) 2.40
TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo. Mol Cell Biol (2010) 2.39
The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity. Nature (2012) 2.33
TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA. Nature (2011) 2.17
Telomere length homeostasis. Chromosoma (2006) 2.12
Rare missense variants in POT1 predispose to familial cutaneous malignant melanoma. Nat Genet (2014) 2.08
A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly. Proc Natl Acad Sci U S A (2006) 2.04
Polymorphism of human telomeric quadruplex structures. Biochimie (2008) 1.89
Functional dissection of human and mouse POT1 proteins. Mol Cell Biol (2008) 1.87
Evolution of CST function in telomere maintenance. Cell Cycle (2010) 1.81
POT1-TPP1 enhances telomerase processivity by slowing primer dissociation and aiding translocation. EMBO J (2010) 1.80
DNA damage response at functional and dysfunctional telomeres. Genes Dev (2008) 1.75
Finding the end: recruitment of telomerase to telomeres. Nat Rev Mol Cell Biol (2013) 1.73
Protection of telomeres by a conserved Stn1-Ten1 complex. Proc Natl Acad Sci U S A (2007) 1.71
POT1b protects telomeres from end-to-end chromosomal fusions and aberrant homologous recombination. EMBO J (2006) 1.66
Telomere protection by TPP1/POT1 requires tethering to TIN2. Mol Cell (2011) 1.62
Functional interaction between telomere protein TPP1 and telomerase. Genes Dev (2010) 1.60
The telosome/shelterin complex and its functions. Genome Biol (2008) 1.57
Cdc13 OB2 dimerization required for productive Stn1 binding and efficient telomere maintenance. Structure (2012) 1.56
Telomeric overhang length determines structural dynamics and accessibility to telomerase and ALT-associated proteins. Structure (2014) 1.54
OB fold-containing protein 1 (OBFC1), a human homolog of yeast Stn1, associates with TPP1 and is implicated in telomere length regulation. J Biol Chem (2009) 1.53
The Arabidopsis Pot1 and Pot2 proteins function in telomere length homeostasis and chromosome end protection. Mol Cell Biol (2005) 1.52
Telomere maintenance through spatial control of telomeric proteins. Mol Cell Biol (2007) 1.51
Stn1-Ten1 is an Rpa2-Rpa3-like complex at telomeres. Genes Dev (2009) 1.51
Nucleobase recognition in ssDNA at the central constriction of the alpha-hemolysin pore. Nano Lett (2010) 1.51
Nonspecific recognition is achieved in Pot1pC through the use of multiple binding modes. Structure (2012) 1.47
Structural insights into G-quadruplexes: towards new anticancer drugs. Future Med Chem (2010) 1.44
Multiple base-recognition sites in a biological nanopore: two heads are better than one. Angew Chem Int Ed Engl (2010) 1.41
Arabidopsis POT1 associates with the telomerase RNP and is required for telomere maintenance. EMBO J (2007) 1.38
Single-molecule analysis reveals differential effect of ssDNA-binding proteins on DNA translocation by XPD helicase. Mol Cell (2009) 1.32
Oligonucleotide/oligosaccharide-binding fold proteins: a growing family of genome guardians. Crit Rev Biochem Mol Biol (2010) 1.30
Conservation of telomere protein complexes: shuffling through evolution. Crit Rev Biochem Mol Biol (2009) 1.29
Genetic and molecular identification of three human TPP1 functions in telomerase action: recruitment, activation, and homeostasis set point regulation. Genes Dev (2014) 1.26
DNA damage responses in neural cells: Focus on the telomere. Neuroscience (2007) 1.23
Vertebrate POT1 restricts G-overhang length and prevents activation of a telomeric DNA damage checkpoint but is dispensable for overhang protection. Mol Cell Biol (2006) 1.23
Structural bases of dimerization of yeast telomere protein Cdc13 and its interaction with the catalytic subunit of DNA polymerase α. Cell Res (2010) 1.23
Mechanisms and regulation of DNA end resection. EMBO J (2010) 1.22
Two RNA subunits and POT1a are components of Arabidopsis telomerase. Proc Natl Acad Sci U S A (2010) 1.20
Telomere capping proteins are structurally related to RPA with an additional telomere-specific domain. Proc Natl Acad Sci U S A (2009) 1.19
Pot1 and telomere maintenance. FEBS Lett (2010) 1.18
Distinct functions of POT1 at telomeres. Mol Cell Biol (2008) 1.18
POT1-TPP1 regulates telomeric overhang structural dynamics. Structure (2012) 1.17
Telomeres-structure, function, and regulation. Exp Cell Res (2012) 1.11
Single molecule studies of physiologically relevant telomeric tails reveal POT1 mechanism for promoting G-quadruplex unfolding. J Biol Chem (2010) 1.09
How telomeric protein POT1 avoids RNA to achieve specificity for single-stranded DNA. Proc Natl Acad Sci U S A (2009) 1.09
Structural polymorphism of intramolecular quadruplex of human telomeric DNA: effect of cations, quadruplex-binding drugs and flanking sequences. Nucleic Acids Res (2008) 1.07
Distinct requirements for Pot1 in limiting telomere length and maintaining chromosome stability. Mol Cell Biol (2005) 1.07
Hoyeraal-Hreidarsson syndrome caused by a germline mutation in the TEL patch of the telomere protein TPP1. Genes Dev (2014) 1.07
Telomeres in evolution and evolution of telomeres. Chromosome Res (2005) 1.06
A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms. Nat Struct Mol Biol (2011) 1.06
Human POT1 is required for efficient telomere C-rich strand replication in the absence of WRN. Genes Dev (2009) 1.05
The N-terminus of hTERT contains a DNA-binding domain and is required for telomerase activity and cellular immortalization. Nucleic Acids Res (2009) 1.05
Telomerase and telomere-associated proteins: structural insights into mechanism and evolution. Structure (2012) 1.05
Identification of human TERT elements necessary for telomerase recruitment to telomeres. Elife (2014) 1.05
G-quadruplex formation in telomeres enhances POT1/TPP1 protection against RPA binding. Proc Natl Acad Sci U S A (2014) 1.05
A mutation in the POT1 gene is responsible for cardiac angiosarcoma in TP53-negative Li-Fraumeni-like families. Nat Commun (2015) 1.04
Divergent evolution within protein superfolds inferred from profile-based phylogenetics. J Mol Biol (2005) 1.04
Many disease-associated variants of hTERT retain high telomerase enzymatic activity. Nucleic Acids Res (2013) 1.04
Telomeric D-loops containing 8-oxo-2'-deoxyguanosine are preferred substrates for Werner and Bloom syndrome helicases and are bound by POT1. J Biol Chem (2009) 1.04
RECQL4, the protein mutated in Rothmund-Thomson syndrome, functions in telomere maintenance. J Biol Chem (2011) 1.04
Shelterin complex and associated factors at human telomeres. Nucleus (2011) 1.04
Mechanism and substrate specificity of telomeric protein POT1 stimulation of the Werner syndrome helicase. Nucleic Acids Res (2008) 1.02
Direct binding of glyceraldehyde 3-phosphate dehydrogenase to telomeric DNA protects telomeres against chemotherapy-induced rapid degradation. J Mol Biol (2009) 1.01
POT1 association with TRF2 regulates telomere length. Mol Cell Biol (2009) 1.01
POT1 proteins in green algae and land plants: DNA-binding properties and evidence of co-evolution with telomeric DNA. Nucleic Acids Res (2009) 1.00
Structural basis for Tetrahymena telomerase processivity factor Teb1 binding to single-stranded telomeric-repeat DNA. Proc Natl Acad Sci U S A (2011) 1.00
A prospective study of leukocyte telomere length and risk of type 2 diabetes in postmenopausal women. Diabetes (2012) 0.98
Single-stranded DNA-binding proteins: multiple domains for multiple functions. Structure (2013) 0.97
Chromosome end protection by blunt-ended telomeres. Genes Dev (2012) 0.97
Telomere maintenance and the etiology of adult glioma. Neuro Oncol (2015) 0.97
Alterations of DNA and chromatin structures at telomeres and genetic instability in mouse cells defective in DNA polymerase alpha. Mol Cell Biol (2005) 0.97
Telomeric armor: the layers of end protection. J Cell Sci (2009) 0.95
Probing the mechanism of recognition of ssDNA by the Cdc13-DBD. Nucleic Acids Res (2008) 0.95
LIM-domain proteins TRIP6 and LPP associate with shelterin to mediate telomere protection. Aging (Albany NY) (2010) 0.95
Ku must load directly onto the chromosome end in order to mediate its telomeric functions. PLoS Genet (2011) 0.94
Identification of the determinants for the specific recognition of single-strand telomeric DNA by Cdc13. Biochemistry (2006) 0.94
Cdc13 N-terminal dimerization, DNA binding, and telomere length regulation. Mol Cell Biol (2010) 0.94
The MRT-1 nuclease is required for DNA crosslink repair and telomerase activity in vivo in Caenorhabditis elegans. EMBO J (2009) 0.93
Protection of Telomeres 1 is required for telomere integrity in the moss Physcomitrella patens. Plant Cell (2010) 0.93
Telomere lengthening and other functions of telomerase. Acta Naturae (2012) 0.92
Schizosaccharomyces pombe protection of telomeres 1 utilizes alternate binding modes to accommodate different telomeric sequences. Biochemistry (2011) 0.92
A self-regulating template in human telomerase. Proc Natl Acad Sci U S A (2014) 0.91
Human single-stranded DNA binding proteins are essential for maintaining genomic stability. BMC Mol Biol (2013) 0.91
Replication protein A stimulates the Werner syndrome protein branch migration activity. J Biol Chem (2009) 0.90
Human RECQL1 participates in telomere maintenance. Nucleic Acids Res (2014) 0.90
The long-term impact of adverse caregiving environments on epigenetic modifications and telomeres. Front Behav Neurosci (2015) 0.89
Nonadditivity in the recognition of single-stranded DNA by the schizosaccharomyces pombe protection of telomeres 1 DNA-binding domain, Pot1-DBD. Biochemistry (2009) 0.89
Targeting the OB-Folds of Replication Protein A with Small Molecules. J Nucleic Acids (2010) 0.88
Single strand DNA binding proteins 1 and 2 protect newly replicated telomeres. Cell Res (2013) 0.88
Multiple POT1-TPP1 proteins coat and compact long telomeric single-stranded DNA. J Mol Biol (2011) 0.88
Thermodynamic characterization of binding Oxytricha nova single strand telomere DNA with the alpha protein N-terminal domain. J Mol Biol (2006) 0.88
Solution structure of the DNA-binding domain of RPA from Saccharomyces cerevisiae and its interaction with single-stranded DNA and SV40 T antigen. Nucleic Acids Res (2005) 0.87
The POT1-TPP1 telomere complex is a telomerase processivity factor. Nature (2007) 5.08
The chemical repertoire of natural ribozymes. Nature (2002) 3.77
Promiscuous RNA binding by Polycomb repressive complex 2. Nat Struct Mol Biol (2013) 2.91
Structure of the Tetrahymena ribozyme: base triple sandwich and metal ion at the active site. Mol Cell (2004) 2.68
Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro. Proc Natl Acad Sci U S A (2005) 2.63
Rebalancing teaching and research. Science (2003) 2.54
Yeast telomerase RNA: a flexible scaffold for protein subunits. Proc Natl Acad Sci U S A (2004) 2.52
The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity. Nature (2012) 2.33
Crystal structure of the essential N-terminal domain of telomerase reverse transcriptase. Nat Struct Mol Biol (2006) 2.32
DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA. Nature (2003) 2.08
Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells. Nature (2011) 2.03
A bulged stem tethers Est1p to telomerase RNA in budding yeast. Genes Dev (2002) 1.95
Essential regions of Saccharomyces cerevisiae telomerase RNA: separate elements for Est1p and Est2p interaction. Mol Cell Biol (2002) 1.89
Switching human telomerase on and off with hPOT1 protein in vitro. J Biol Chem (2005) 1.83
Atomic level architecture of group I introns revealed. Trends Biochem Sci (2005) 1.82
POT1-TPP1 enhances telomerase processivity by slowing primer dissociation and aiding translocation. EMBO J (2010) 1.80
Low abundance of telomerase in yeast: implications for telomerase haploinsufficiency. RNA (2006) 1.74
Finding the end: recruitment of telomerase to telomeres. Nat Rev Mol Cell Biol (2013) 1.73
Human Pot1 (protection of telomeres) protein: cytolocalization, gene structure, and alternative splicing. Mol Cell Biol (2002) 1.69
Evolution of Tetrahymena ribozyme mutants with increased structural stability. Nat Struct Biol (2002) 1.68
Human POT1 facilitates telomere elongation by telomerase. Curr Biol (2003) 1.64
POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates. J Biol Chem (2005) 1.64
Triple-helix structure in telomerase RNA contributes to catalysis. Nat Struct Mol Biol (2008) 1.62
Functional interaction between telomere protein TPP1 and telomerase. Genes Dev (2010) 1.60
Local RNA structural changes induced by crystallization are revealed by SHAPE. RNA (2007) 1.55
Managing your own lab. Science (2004) 1.44
FUS binds the CTD of RNA polymerase II and regulates its phosphorylation at Ser2. Genes Dev (2012) 1.39
Cooperative binding of single-stranded telomeric DNA by the Pot1 protein of Schizosaccharomyces pombe. Biochemistry (2002) 1.38
A miniature yeast telomerase RNA functions in vivo and reconstitutes activity in vitro. Nat Struct Mol Biol (2005) 1.37
N-terminal domain of yeast telomerase reverse transcriptase: recruitment of Est3p to the telomerase complex. Mol Biol Cell (2003) 1.26
Mutation in TERT separates processivity from anchor-site function. Nat Struct Mol Biol (2008) 1.24
A template-proximal RNA paired element contributes to Saccharomyces cerevisiae telomerase activity. RNA (2003) 1.24
The Euplotes La motif protein p43 has properties of a telomerase-specific subunit. Biochemistry (2003) 1.24
Soluble domains of telomerase reverse transcriptase identified by high-throughput screening. Protein Sci (2005) 1.14
The RNA accordion model for template positioning by telomerase RNA during telomeric DNA synthesis. Nat Struct Mol Biol (2011) 1.14
A new model for Schizosaccharomyces pombe telomere recognition: the telomeric single-stranded DNA-binding activity of Pot11-389. J Mol Biol (2006) 1.12
Tetrahymena telomerase is active as a monomer. Mol Biol Cell (2003) 1.10
How telomeric protein POT1 avoids RNA to achieve specificity for single-stranded DNA. Proc Natl Acad Sci U S A (2009) 1.09
Mutually exclusive binding of telomerase RNA and DNA by Ku alters telomerase recruitment model. Cell (2012) 1.08
Tetrahymena telomerase protein p65 induces conformational changes throughout telomerase RNA (TER) and rescues telomerase reverse transcriptase and TER assembly mutants. Mol Cell Biol (2010) 1.06
Many disease-associated variants of hTERT retain high telomerase enzymatic activity. Nucleic Acids Res (2013) 1.04
Toward predicting self-splicing and protein-facilitated splicing of group I introns. RNA (2008) 1.00
Multiple yeast genes, including Paf1 complex genes, affect telomere length via telomerase RNA abundance. Mol Cell Biol (2008) 0.96
Global expression changes resulting from loss of telomeric DNA in fission yeast. Genome Biol (2004) 0.95
Inhibition of telomerase recruitment and cancer cell death. J Biol Chem (2013) 0.94
Expression of a RecQ helicase homolog affects progression through crisis in fission yeast lacking telomerase. J Biol Chem (2004) 0.94
Inhibition of yeast telomerase action by the telomeric ssDNA-binding protein, Cdc13p. Nucleic Acids Res (2008) 0.94
3' terminal diversity of MRP RNA and other human noncoding RNAs revealed by deep sequencing. BMC Mol Biol (2013) 0.94
A natural ribozyme with 3',5' RNA ligase activity. Nat Chem Biol (2009) 0.93
Yeast telomerase is specialized for C/A-rich RNA templates. Nucleic Acids Res (2003) 0.93
In vivo selection of better self-splicing introns in Escherichia coli: the role of the P1 extension helix of the Tetrahymena intron. RNA (2002) 0.92
The Euplotes telomerase subunit p43 stimulates enzymatic activity and processivity in vitro. RNA (2004) 0.92
Biochemical Properties and Biological Functions of FET Proteins. Annu Rev Biochem (2014) 0.91
RNase P branches out from RNP to protein: organelle-triggered diversification? Genes Dev (2012) 0.90
Comparison of crystal structure interactions and thermodynamics for stabilizing mutations in the Tetrahymena ribozyme. RNA (2006) 0.88
Multiple POT1-TPP1 proteins coat and compact long telomeric single-stranded DNA. J Mol Biol (2011) 0.88
Effects of nucleotide analogues on Euplotes aediculatus telomerase processivity: evidence for product-assisted translocation. Biochemistry (2002) 0.86
DNA-induced dimerization of the single-stranded DNA binding telomeric protein Pot1 from Schizosaccharomyces pombe. Nucleic Acids Res (2011) 0.86
Sequence-specific and 3'-end selective single-strand DNA binding by the Oxytricha nova telomere end binding protein alpha subunit. Biochemistry (2003) 0.86
Ku can contribute to telomere lengthening in yeast at multiple positions in the telomerase RNP. RNA (2010) 0.86
Engineering cis-telomerase RNAs that add telomeric repeats to themselves. Proc Natl Acad Sci U S A (2010) 0.85
RNA finds a simpler way. Nature (2004) 0.83
RNA recognition by the DNA end-binding Ku heterodimer. RNA (2013) 0.83
SnapShot: telomeres and telomerase. Cell (2012) 0.78
HHMI's attention to Wiley's lab staff. Science (2002) 0.75