Published in Int J Cell Biol on July 19, 2012
Single-molecule analysis of combinatorial epigenomic states in normal and tumor cells. Proc Natl Acad Sci U S A (2013) 1.21
Bridging epigenetics and metabolism: role of non-essential amino acids. Epigenetics (2013) 0.95
MUC1: a novel metabolic master regulator. Biochim Biophys Acta (2014) 0.92
Imaging heterogeneity in the mitochondrial redox state of premalignant pancreas in the pancreas-specific PTEN-null transgenic mouse model. Biomark Res (2013) 0.92
Glutaminase regulation in cancer cells: a druggable chain of events. Drug Discov Today (2013) 0.89
Succinate dehydrogenase expression in breast cancer. Springerplus (2013) 0.86
Resistance to Dasatinib in primary chronic lymphocytic leukemia lymphocytes involves AMPK-mediated energetic re-programming. Oncotarget (2013) 0.86
Nuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer. EMBO J (2014) 0.85
Mechanism for enhanced 5-aminolevulinic acid fluorescence in isocitrate dehydrogenase 1 mutant malignant gliomas. Oncotarget (2015) 0.83
Intermittent hypoxia selects for genotypes and phenotypes that increase survival, invasion, and therapy resistance. PLoS One (2015) 0.82
Cancer metabolism and oxidative stress: Insights into carcinogenesis and chemotherapy via the non-dihydrofolate reductase effects of methotrexate. BBA Clin (2015) 0.81
Unraveling biochemical pathways affected by mitochondrial dysfunctions using metabolomic approaches. Metabolites (2014) 0.80
Hyperpolarized [1,4-(13)C]-diethylsuccinate: a potential DNP substrate for in vivo metabolic imaging. NMR Biomed (2014) 0.79
Metabolic and protein interaction sub-networks controlling the proliferation rate of cancer cells and their impact on patient survival. Sci Rep (2013) 0.79
Oncogene-directed alterations in cancer cell metabolism. Trends Cancer (2016) 0.78
Mitochondrial Ca(2+) Remodeling is a Prime Factor in Oncogenic Behavior. Front Oncol (2015) 0.78
Post-translational modifications in mitochondria: protein signaling in the powerhouse. Cell Mol Life Sci (2016) 0.77
Tumor microenvironment promotes dicarboxylic acid carrier-mediated transport of succinate to fuel prostate cancer mitochondria. Am J Cancer Res (2015) 0.77
Metabolic Reprogramming in Glioma. Front Cell Dev Biol (2017) 0.77
Role of metabolism during viral infections, and crosstalk with the innate immune system. Intractable Rare Dis Res (2016) 0.76
Genetic variations in genes of metabolic enzymes predict postoperational prognosis of patients with colorectal cancer. Mol Cancer (2015) 0.75
Mutant IDH: a targetable driver of leukemic phenotypes linking metabolism, epigenetics and transcriptional regulation. Epigenomics (2016) 0.75
The opposite prognostic effect of NDUFS1 and NDUFS8 in lung cancer reflects the oncojanus role of mitochondrial complex I. Sci Rep (2016) 0.75
Altered oxidative stress and carbohydrate metabolism in canine mammary tumors. Vet World (2016) 0.75
Two isoforms of TALDO1 generated by alternative translational initiation show differential nucleocytoplasmic distribution to regulate the global metabolic network. Sci Rep (2016) 0.75
Expression of ERβ gene in breast carcinoma and the relevance in neoadjuvant therapy. Oncol Lett (2017) 0.75
Polymorphisms in Genes of Tricarboxylic Acid Cycle Key Enzymes Are Associated with Early Recurrence of Hepatocellular Carcinoma. PLoS One (2015) 0.75
Towards Real-time Metabolic Profiling of Cancer with Hyperpolarized Succinate. J Mol Imaging Dyn (2016) 0.75
Protective effect and mechanism of estrogen receptor β on myocardial infarction in mice. Exp Ther Med (2017) 0.75
Evaluation of mitochondrial respiratory function in highly glycolytic glioma cells reveals low ADP phosphorylation in relation to oxidative capacity. J Neurooncol (2017) 0.75
An integrated genomic analysis of human glioblastoma multiforme. Science (2008) 51.36
On the origin of cancer cells. Science (1956) 49.55
IDH1 and IDH2 mutations in gliomas. N Engl J Med (2009) 32.41
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature (2009) 19.65
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell (2010) 15.20
The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. Cancer Cell (2010) 13.13
Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. Free Radic Biol Med (2001) 11.92
Tumor cell metabolism: cancer's Achilles' heel. Cancer Cell (2008) 11.18
Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha. Science (2009) 10.78
Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature (2009) 10.31
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature (2011) 9.70
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase. Cancer Cell (2005) 9.33
Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma. Science (2000) 8.64
Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer. Nat Genet (2002) 8.19
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. Nature (2011) 7.94
Production of large amounts of hydrogen peroxide by human tumor cells. Cancer Res (1991) 6.99
Mitochondrial reactive oxygen species trigger hypoxia-induced transcription. Proc Natl Acad Sci U S A (1998) 6.90
Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing. J Biol Chem (2000) 6.71
Reductive carboxylation supports growth in tumour cells with defective mitochondria. Nature (2011) 6.57
Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers. Nat Rev Cancer (2010) 6.27
HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability. Cancer Cell (2005) 5.47
Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability. Proc Natl Acad Sci U S A (2011) 5.24
Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function. Proc Natl Acad Sci U S A (2010) 4.99
The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases. EMBO Rep (2011) 4.89
IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication. J Clin Oncol (2010) 4.72
Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma. Am J Hum Genet (2001) 4.71
Mutations in SDHC cause autosomal dominant paraganglioma, type 3. Nat Genet (2000) 4.55
NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer. Trends Biochem Sci (2009) 4.50
Mutational analysis of IDH1 codon 132 in glioblastomas and other common cancers. Int J Cancer (2009) 4.45
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation. Nature (2012) 4.37
Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase. Nature (2011) 4.32
A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes. Nature (1998) 4.06
Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer. Oncogene (2006) 4.05
Mitochondrial tumour suppressors: a genetic and biochemical update. Nat Rev Cancer (2005) 3.85
Persistent oxidative stress in cancer. FEBS Lett (1995) 3.85
SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma. Science (2009) 3.72
Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome. Proc Natl Acad Sci U S A (2011) 3.66
Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer. Cancer Cell (2005) 3.51
Dual roles of Nrf2 in cancer. Pharmacol Res (2008) 3.41
Inherited susceptibility to uterine leiomyomas and renal cell cancer. Proc Natl Acad Sci U S A (2001) 3.31
Mitochondrial energetics and therapeutics. Annu Rev Pathol (2010) 3.07
SDHA is a tumor suppressor gene causing paraganglioma. Hum Mol Genet (2010) 3.07
Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling. Cancer Cell (2011) 3.00
A HIF1alpha regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas. PLoS Genet (2005) 2.85
IDH mutations in glioma and acute myeloid leukemia. Trends Mol Med (2010) 2.83
An antioxidant response phenotype shared between hereditary and sporadic type 2 papillary renal cell carcinoma. Cancer Cell (2011) 2.78
Cancer-associated IDH mutations: biomarker and therapeutic opportunities. Oncogene (2010) 2.76
Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells. J Cell Biol (2011) 2.64
D-2-hydroxyglutaric acid induces oxidative stress in cerebral cortex of young rats. Eur J Neurosci (2003) 2.62
NMDA receptor activation and respiratory chain complex V inhibition contribute to neurodegeneration in d-2-hydroxyglutaric aciduria. Eur J Neurosci (2002) 2.54
Non-heme dioxygenases: cellular sensors and regulators jelly rolled into one? Nat Chem Biol (2007) 2.47
Loss of the SdhB, but Not the SdhA, subunit of complex II triggers reactive oxygen species-dependent hypoxia-inducible factor activation and tumorigenesis. Mol Cell Biol (2007) 2.45
Histone onco-modifications. Oncogene (2011) 2.44
SDHAF2 mutations in familial and sporadic paraganglioma and phaeochromocytoma. Lancet Oncol (2010) 2.42
Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value. Blood (2010) 2.40
Prevalence of SDHB, SDHC, and SDHD germline mutations in clinic patients with head and neck paragangliomas. J Med Genet (2002) 2.33
The R22X mutation of the SDHD gene in hereditary paraganglioma abolishes the enzymatic activity of complex II in the mitochondrial respiratory chain and activates the hypoxia pathway. Am J Hum Genet (2001) 2.28
Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1alpha stabilization by glucose-dependent generation of reactive oxygen species. Mol Cell Biol (2009) 2.27
IDH2 mutations are frequent in angioimmunoblastic T-cell lymphoma. Blood (2012) 2.23
Oxidative and nitrative DNA damage in animals and patients with inflammatory diseases in relation to inflammation-related carcinogenesis. Biol Chem (2006) 2.07
The kinesin KIF1Bbeta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor. Genes Dev (2008) 1.93
SDH mutations in cancer. Biochim Biophys Acta (2011) 1.92
Regulation of the Nrf2-Keap1 antioxidant response by the ubiquitin proteasome system: an insight into cullin-ring ubiquitin ligases. Antioxid Redox Signal (2010) 1.85
A defect in the cytochrome b large subunit in complex II causes both superoxide anion overproduction and abnormal energy metabolism in Caenorhabditis elegans. J Biol Chem (2001) 1.84
A mutation in the SDHC gene of complex II increases oxidative stress, resulting in apoptosis and tumorigenesis. Cancer Res (2005) 1.69
Succinate inhibition of alpha-ketoglutarate-dependent enzymes in a yeast model of paraganglioma. Hum Mol Genet (2007) 1.67
Inhibition of succinate dehydrogenase dysregulates histone modification in mammalian cells. Mol Cancer (2009) 1.62
Increased risk of cancer in patients with fumarate hydratase germline mutation. J Med Genet (2005) 1.61
Structural insights into histone lysine demethylation. Curr Opin Struct Biol (2010) 1.44
Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism. Hum Mol Genet (2010) 1.33
Distinct expression profile in fumarate-hydratase-deficient uterine fibroids. Hum Mol Genet (2005) 1.26
Glutamine homeostasis and mitochondrial dynamics. Int J Biochem Cell Biol (2009) 1.24
Disulfide relays and phosphorylative cascades: partners in redox-mediated signaling pathways. Cell Death Differ (2005) 1.17
Adult leydig cell tumors of the testis caused by germline fumarate hydratase mutations. J Clin Endocrinol Metab (2006) 1.12
Epigenetic regulation in cancer development. Front Biosci (Landmark Ed) (2011) 1.01
Fumarase deficiency: a new cause of mitochondrial encephalomyopathy. N Engl J Med (1986) 0.97
Genetic basis for kidney cancer: opportunity for disease-specific approaches to therapy. Expert Opin Biol Ther (2008) 0.96
Cellular epigenetic stability and cancer. Trends Genet (2012) 0.86
Differential metabolic consequences of fumarate hydratase and respiratory chain defects. Biochim Biophys Acta (2008) 0.86
Antigen-presenting dendritic cells provide the reducing extracellular microenvironment required for T lymphocyte activation. Proc Natl Acad Sci U S A (2002) 2.35
Peroxisome proliferator-activated receptor gamma co-activator 1alpha (PGC-1alpha) and sirtuin 1 (SIRT1) reside in mitochondria: possible direct function in mitochondrial biogenesis. J Biol Chem (2010) 1.71
Cell signalling and the glutathione redox system. Biochem Pharmacol (2002) 1.68
Glutathione limits Ero1-dependent oxidation in the endoplasmic reticulum. J Biol Chem (2004) 1.58
Redox implications of AMPK-mediated signal transduction beyond energetic clues. J Cell Sci (2012) 1.28
Pathogen-induced interleukin-1beta processing and secretion is regulated by a biphasic redox response. J Immunol (2009) 1.25
Glutathione disulfide induces apoptosis in U937 cells by a redox-mediated p38 MAP kinase pathway. FASEB J (2002) 1.23
Role of nitric oxide synthases in Parkinson's disease: a review on the antioxidant and anti-inflammatory activity of polyphenols. Neurochem Res (2008) 1.20
Proapoptotic activity of new glutathione S-transferase inhibitors. Cancer Res (2005) 1.10
Targeting aerobic glycolysis: 3-bromopyruvate as a promising anticancer drug. J Bioenerg Biomembr (2012) 1.08
Isatin-Schiff base copper(II) complexes and their influence on cellular viability. J Inorg Biochem (2005) 1.06
Under the ROS…thiol network is the principal suspect for autophagy commitment. Autophagy (2010) 1.04
Modulation of intracellular glutathione affects adipogenesis in 3T3-L1 cells. J Cell Physiol (2011) 1.00
Mitochondrial damage due to SOD1 deficiency in SH-SY5Y neuroblastoma cells: a rationale for the redundancy of SOD1. FASEB J (2006) 1.00
Nitric oxide is the primary mediator of cytotoxicity induced by GSH depletion in neuronal cells. J Cell Sci (2011) 1.00
Double-strand DNA cleavage induced by oxindole-Schiff base copper(II) complexes with potential antitumor activity. J Inorg Biochem (2008) 0.92
Glutamine deprivation enhances antitumor activity of 3-bromopyruvate through the stabilization of monocarboxylate transporter-1. Cancer Res (2012) 0.92
Glutathione participates in the modulation of starvation-induced autophagy in carcinoma cells. Autophagy (2012) 0.89
Influenza virus replication in lung epithelial cells depends on redox-sensitive pathways activated by NOX4-derived ROS. Cell Microbiol (2014) 0.87
The cystine/cysteine cycle and GSH are independent and crucial antioxidant systems in malignant melanoma cells and represent druggable targets. Antioxid Redox Signal (2011) 0.86
Proteasome activation and nNOS down-regulation in neuroblastoma cells expressing a Cu,Zn superoxide dismutase mutant involved in familial ALS. J Neurochem (2003) 0.86
Glutathione influences c-Myc-induced apoptosis in M14 human melanoma cells. J Biol Chem (2002) 0.85
Caloric Restriction and the Nutrient-Sensing PGC-1α in Mitochondrial Homeostasis: New Perspectives in Neurodegeneration. Int J Cell Biol (2012) 0.85
Interplay of Cu,Zn superoxide dismutase and nitric oxide synthase in neurodegenerative processes. IUBMB Life (2004) 0.84
trans-Resveratrol inhibits H2O2-induced adenocarcinoma gastric cells proliferation via inactivation of MEK1/2-ERK1/2-c-Jun signalling axis. Biochem Pharmacol (2008) 0.84
Glutathione is a crucial guardian of protein integrity in the brain upon nitric oxide imbalance. Commun Integr Biol (2011) 0.83
Deprive to kill: glutamine closes the gate to anticancer monocarboxylic drugs. Autophagy (2012) 0.81
Selenium- and zinc-deficient cardiomyopathy in human intestinal malabsorption: preliminary results of selenium/zinc infusion. Eur J Heart Fail (2011) 0.81
Rescue of cells from apoptosis by antioxidants occurs downstream from GSH extrusion. Ann N Y Acad Sci (2003) 0.81
Neuronal nitric oxide synthase protects neuroblastoma cells from oxidative stress mediated by garlic derivatives. J Neurochem (2007) 0.80
Redox control of apoptosis. Antioxid Redox Signal (2005) 0.78
6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol, a specific glutathione S-transferase inhibitor, overcomes the multidrug resistance (MDR)-associated protein 1-mediated MDR in small cell lung cancer. Mol Cancer Ther (2008) 0.78
Effect of Cu,Zn superoxide dismutase on cholesterol metabolism in human hepatocarcinoma (HepG2) cells. Biochem Biophys Res Commun (2002) 0.77
Intracellular redox state as target for anti-influenza therapy: are antioxidants always effective? Curr Top Med Chem (2014) 0.77
PYRROLO[1,2-b][1,2,5]BENZOTHIADIAZEPINES (PBTDs) induce apoptosis in K562 cells. BMC Cancer (2007) 0.75
The interference of rosmarinic acid in the DNA fragmentation induced by osmotic shock. Front Biosci (2007) 0.75