PubRank

Leonid Kruglyak

Author PubWeight™ 306.40‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Finding the missing heritability of complex diseases. Nature 2009 67.95
2 Genetic dissection of transcriptional regulation in budding yeast. Science 2002 25.01
3 Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium. Am J Hum Genet 2003 21.52
4 Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors. Nat Genet 2003 11.84
5 The landscape of genetic complexity across 5,700 gene expression traits in yeast. Proc Natl Acad Sci U S A 2005 9.66
6 Mapping complex disease loci in whole-genome association studies. Nature 2004 7.31
7 Population history and natural selection shape patterns of genetic variation in 132 genes. PLoS Biol 2004 7.11
8 Patterns of linkage disequilibrium in the human genome. Nat Rev Genet 2002 7.09
9 Genetics of global gene expression. Nat Rev Genet 2006 6.80
10 Genetic interactions between polymorphisms that affect gene expression in yeast. Nature 2005 6.42
11 Measuring differential gene expression by short read sequencing: quantitative comparison to 2-channel gene expression microarrays. BMC Genomics 2009 6.41
12 Genetic structure of the purebred domestic dog. Science 2004 6.39
13 Integrating large-scale functional genomic data to dissect the complexity of yeast regulatory networks. Nat Genet 2008 5.80
14 Multiple locus linkage analysis of genomewide expression in yeast. PLoS Biol 2005 5.61
15 A 3.9-centimorgan-resolution human single-nucleotide polymorphism linkage map and screening set. Am J Hum Genet 2003 5.34
16 Additional SNPs and linkage-disequilibrium analyses are necessary for whole-genome association studies in humans. Nat Genet 2003 5.30
17 Gene-environment interaction in yeast gene expression. PLoS Biol 2008 4.48
18 Natural malaria infection in Anopheles gambiae is regulated by a single genomic control region. Science 2006 4.38
19 Dissection of genetically complex traits with extremely large pools of yeast segregants. Nature 2010 4.32
20 Haplotype diversity across 100 candidate genes for inflammation, lipid metabolism, and blood pressure regulation in two populations. Am J Hum Genet 2004 3.91
21 Comprehensive polymorphism survey elucidates population structure of Saccharomyces cerevisiae. Nature 2009 3.67
22 Finding the sources of missing heritability in a yeast cross. Nature 2013 3.43
23 Genome-wide detection of polymorphisms at nucleotide resolution with a single DNA microarray. Science 2006 3.32
24 Local regulatory variation in Saccharomyces cerevisiae. PLoS Genet 2005 3.23
25 Recombinational landscape and population genomics of Caenorhabditis elegans. PLoS Genet 2009 3.14
26 Genetic basis of proteome variation in yeast. Nat Genet 2007 3.04
27 Extensive and breed-specific linkage disequilibrium in Canis familiaris. Genome Res 2004 2.85
28 Chromosome-scale selective sweeps shape Caenorhabditis elegans genomic diversity. Nat Genet 2012 2.85
29 Widespread genetic incompatibility in C. elegans maintained by balancing selection. Science 2008 2.84
30 Selection at linked sites shapes heritable phenotypic variation in C. elegans. Science 2010 2.84
31 Simultaneous genotyping, gene-expression measurement, and detection of allele-specific expression with oligonucleotide arrays. Genome Res 2005 2.66
32 Population genomic analysis of outcrossing and recombination in yeast. Nat Genet 2006 2.50
33 Quantitative mapping of a digenic behavioral trait implicates globin variation in C. elegans sensory behaviors. Neuron 2009 2.44
34 Telomere length as a quantitative trait: genome-wide survey and genetic mapping of telomere length-control genes in yeast. PLoS Genet 2006 2.36
35 Catecholamine receptor polymorphisms affect decision-making in C. elegans. Nature 2011 2.32
36 Genetic basis of individual differences in the response to small-molecule drugs in yeast. Nat Genet 2007 2.18
37 Genetic loci affecting resistance to human malaria parasites in a West African mosquito vector population. Science 2002 2.11
38 Genetic variation shapes protein networks mainly through non-transcriptional mechanisms. PLoS Biol 2011 2.08
39 Absence of detectable arsenate in DNA from arsenate-grown GFAJ-1 cells. Science 2012 2.03
40 A polymorphism in npr-1 is a behavioral determinant of pathogen susceptibility in C. elegans. Science 2009 1.98
41 Revealing complex traits with small molecules and naturally recombinant yeast strains. Chem Biol 2006 1.87
42 A novel sperm-delivered toxin causes late-stage embryo lethality and transmission ratio distortion in C. elegans. PLoS Biol 2011 1.84
43 Genome-wide analysis of nucleotide-level variation in commonly used Saccharomyces cerevisiae strains. PLoS One 2007 1.80
44 Natural variation in a chloride channel subunit confers avermectin resistance in C. elegans. Science 2012 1.77
45 Molecular basis of the copulatory plug polymorphism in Caenorhabditis elegans. Nature 2008 1.61
46 Identification and dissection of a complex DNA repair sensitivity phenotype in Baker's yeast. PLoS Genet 2008 1.45
47 Breeding designs for recombinant inbred advanced intercross lines. Genetics 2008 1.40
48 Polymorphisms in multiple genes contribute to the spontaneous mitochondrial genome instability of Saccharomyces cerevisiae S288C strains. Genetics 2009 1.38
49 Allele frequency matching between SNPs reveals an excess of linkage disequilibrium in genic regions of the human genome. PLoS Genet 2006 1.27
50 A new susceptibility locus for autosomal dominant pancreatic cancer maps to chromosome 4q32-34. Am J Hum Genet 2002 1.21
51 A practical algorithm for finding maximal exact matches in large sequence datasets using sparse suffix arrays. Bioinformatics 2009 1.16
52 More than the sum of its parts: a complex epistatic network underlies natural variation in thermal preference behavior in Caenorhabditis elegans. Genetics 2012 1.14
53 Genetic architecture of highly complex chemical resistance traits across four yeast strains. PLoS Genet 2012 1.13
54 Power tools for human genetics. Nat Genet 2005 1.12
55 Protein quantification across hundreds of experimental conditions. Proc Natl Acad Sci U S A 2009 1.10
56 Multiparameter behavioral profiling reveals distinct thermal response regimes in Caenorhabditis elegans. BMC Biol 2012 1.09
57 Comparative developmental expression profiling of two C. elegans isolates. PLoS One 2008 1.08
58 Optimized detection of sequence variation in heterozygous genomes using DNA microarrays with isothermal-melting probes. Proc Natl Acad Sci U S A 2010 1.08
59 Rise of the machines. PLoS Genet 2008 1.04
60 A natural polymorphism in rDNA replication origins links origin activation with calorie restriction and lifespan. PLoS Genet 2013 1.02
61 Using expression and genotype to predict drug response in yeast. PLoS One 2009 0.95
62 Quantitative measurement of allele-specific protein expression in a diploid yeast hybrid by LC-MS. Mol Syst Biol 2012 0.93
63 Molecular genetics: DNA analysis of a putative dog clone. Nature 2006 0.93
64 Long-range regulatory polymorphisms affecting a GABA receptor constitute a quantitative trait locus (QTL) for social behavior in Caenorhabditis elegans. PLoS Genet 2012 0.90
65 Accurate proteome-wide protein quantification from high-resolution 15N mass spectra. Genome Biol 2011 0.87
66 Natural polymorphism in BUL2 links cellular amino acid availability with chronological aging and telomere maintenance in yeast. PLoS Genet 2011 0.86
67 Variants in SUP45 and TRM10 underlie natural variation in translation termination efficiency in Saccharomyces cerevisiae. PLoS Genet 2011 0.84
68 Genetic basis of hidden phenotypic variation revealed by increased translational readthrough in yeast. PLoS Genet 2012 0.83
69 Genetics. It's the sequence, stupid! Science 2008 0.81
70 Comment on 'Discrepancies in dbSNP confirmations rates and allele frequency distributions from varying genotyping error rates and patterns'. Bioinformatics 2004 0.79
71 Sequence-based linkage analysis. Am J Hum Genet 2004 0.78
72 No bias in linkage analysis. Am J Hum Genet 2004 0.77
73 Cause and express. Nat Biotechnol 2009 0.75