Published in Cell Cycle on August 23, 2012
The Down syndrome-related protein kinase DYRK1A phosphorylates p27(Kip1) and Cyclin D1 and induces cell cycle exit and neuronal differentiation. Cell Cycle (2014) 1.08
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Dosage of Dyrk1a shifts cells within a p21-cyclin D1 signaling map to control the decision to enter the cell cycle. Mol Cell (2013) 0.95
Site-specific proteasome phosphorylation controls cell proliferation and tumorigenesis. Nat Cell Biol (2015) 0.92
An ID2-dependent mechanism for VHL inactivation in cancer. Nature (2016) 0.88
Smoking dysregulates the human airway basal cell transcriptome at COPD risk locus 19q13.2. PLoS One (2014) 0.87
Mirk/dyrk1B Kinase in Ovarian Cancer. Int J Mol Sci (2013) 0.83
Role of non-genomic androgen signalling in suppressing proliferation of fibroblasts and fibrosarcoma cells. Cell Death Dis (2014) 0.82
Algal dual-specificity tyrosine phosphorylation-regulated kinase, triacylglycerol accumulation regulator1, regulates accumulation of triacylglycerol in nitrogen or sulfur deficiency. Plant Physiol (2015) 0.82
DYRK1A: the double-edged kinase as a protagonist in cell growth and tumorigenesis. Mol Cell Oncol (2015) 0.79
Oncosuppressive functions of decorin. Mol Cell Oncol (2015) 0.78
Drosophila Dyrk2 plays a role in the development of the visual system. PLoS One (2013) 0.77
Design and synthesis of a library of lead-like 2,4-bisheterocyclic substituted thiophenes as selective Dyrk/Clk inhibitors. PLoS One (2014) 0.77
DYRK1B as therapeutic target in Hedgehog/GLI-dependent cancer cells with Smoothened inhibitor resistance. Oncotarget (2016) 0.77
Selectivity Profiling and Biological Activity of Novel β-Carbolines as Potent and Selective DYRK1 Kinase Inhibitors. PLoS One (2015) 0.76
DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3. J Exp Med (2015) 0.76
The Tumor Suppressor NKX3.1 Is Targeted for Degradation by DYRK1B Kinase. Mol Cancer Res (2015) 0.76
Chronological Lifespan in Yeast Is Dependent on the Accumulation of Storage Carbohydrates Mediated by Yak1, Mck1 and Rim15 Kinases. PLoS Genet (2016) 0.75
The adaptor protein DCAF7 mediates the interaction of the adenovirus E1A oncoprotein with the protein kinases DYRK1A and HIPK2. Sci Rep (2016) 0.75
Effect of dietary restriction and subsequent re-alimentation on the transcriptional profile of hepatic tissue in cattle. BMC Genomics (2016) 0.75
Reversible phosphorylation of the 26S proteasome. Protein Cell (2017) 0.75
Dual-specificity tyrosine-regulated kinase 2 is a suppressor and potential prognostic marker for liver metastasis of colorectal cancer. Cancer Sci (2017) 0.75
DYRK1B mutations associated with metabolic syndrome impair the chaperone-dependent maturation of the kinase domain. Sci Rep (2017) 0.75
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DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage. Mol Cell (2007) 2.18
Non-canonical activation of GLI transcription factors: implications for targeted anti-cancer therapy. Cell Cycle (2007) 2.16
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Identification of mutations that disrupt phosphorylation-dependent nuclear export of cyclin D1. Oncogene (2006) 1.69
Post-translational regulation of the tumor suppressor p27(KIP1). Cell Mol Life Sci (2008) 1.68
The cyclin-dependent kinase inhibitor p27Kip1 is stabilized in G(0) by Mirk/dyrk1B kinase. J Biol Chem (2004) 1.61
A human homologue of Drosophila minibrain (MNB) is expressed in the neuronal regions affected in Down syndrome and maps to the critical region. Hum Mol Genet (1996) 1.60
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DYRK1A-dosage imbalance perturbs NRSF/REST levels, deregulating pluripotency and embryonic stem cell fate in Down syndrome. Am J Hum Genet (2008) 1.45
Function and regulation of Dyrk1A: towards understanding Down syndrome. Cell Mol Life Sci (2009) 1.44
Mirk/dyrk1B kinase destabilizes cyclin D1 by phosphorylation at threonine 288. J Biol Chem (2004) 1.44
The C. elegans DYRK Kinase MBK-2 Marks Oocyte Proteins for Degradation in Response to Meiotic Maturation. Curr Biol (2005) 1.44
Dyrk1A overexpression inhibits proliferation and induces premature neuronal differentiation of neural progenitor cells. J Neurosci (2010) 1.37
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MNB/DYRK1A as a multiple regulator of neuronal development. FEBS J (2010) 1.36
Homeodomain-interacting protein kinase-2 mediates CtBP phosphorylation and degradation in UV-triggered apoptosis. Proc Natl Acad Sci U S A (2005) 1.35
Phosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinases. J Biol Chem (2003) 1.32
The Conserved Kinases CDK-1, GSK-3, KIN-19, and MBK-2 Promote OMA-1 Destruction to Regulate the Oocyte-to-Embryo Transition in C. elegans. Curr Biol (2005) 1.32
A kinase shRNA screen links LATS2 and the pRB tumor suppressor. Genes Dev (2011) 1.30
DYRK1A and glycogen synthase kinase 3beta, a dual-kinase mechanism directing proteasomal degradation of CRY2 for circadian timekeeping. Mol Cell Biol (2010) 1.28
Mirk/Dyrk1B in cancer. J Cell Biochem (2007) 1.25
The MNB/DYRK1A protein kinase: neurobiological functions and Down syndrome implications. J Neural Transm Suppl (2003) 1.25
Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factors. J Biol Chem (2003) 1.23
DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells. J Clin Invest (2012) 1.18
DYRK2 and GSK-3 phosphorylate and promote the timely degradation of OMA-1, a key regulator of the oocyte-to-embryo transition in C. elegans. Dev Biol (2005) 1.17
Glycogen synthase kinase-3beta and p38 phosphorylate cyclin D2 on Thr280 to trigger its ubiquitin/proteasome-dependent degradation in hematopoietic cells. Oncogene (2007) 1.17
Mirk/Dyrk1B: a multifunctional dual-specificity kinase involved in growth arrest, differentiation, and cell survival. Cell Biochem Biophys (2006) 1.17
Role for DYRK family kinases on regulation of apoptosis. Biochem Pharmacol (2008) 1.14
REST regulates DYRK1A transcription in a negative feedback loop. J Biol Chem (2011) 1.14
cAMP-induced degradation of cyclin D3 through association with GSK-3beta. J Cell Sci (2004) 1.10
P38SAPK2 phosphorylates cyclin D3 at Thr-283 and targets it for proteasomal degradation. Oncogene (2004) 1.09
Transient expression of Mnb/Dyrk1a couples cell cycle exit and differentiation of neuronal precursors by inducing p27KIP1 expression and suppressing NOTCH signaling. Development (2011) 1.08
The C. elegans anaphase promoting complex and MBK-2/DYRK kinase act redundantly with CUL-3/MEL-26 ubiquitin ligase to degrade MEI-1 microtubule-severing activity after meiosis. Dev Biol (2006) 1.05
The WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functions. EMBO J (2010) 1.02
Phylogenetic, structural and functional relationships between WD- and Kelch-repeat proteins. Subcell Biochem (2008) 1.02
Involvement of GSK-3beta and DYRK1B in differentiation-inducing factor-3-induced phosphorylation of cyclin D1 in HeLa cells. J Biol Chem (2006) 1.02
Multiple mechanisms for p27(Kip1) translocation and degradation. Cell Cycle (2007) 1.01
Cytoplasmic CUL9/PARC ubiquitin ligase is a tumor suppressor and promotes p53-dependent apoptosis. Cancer Res (2011) 1.00
Regulation of SCF(SKP2) ubiquitin E3 ligase assembly and p27(KIP1) proteolysis by the PTEN pathway and cyclin D1. Cell Cycle (2007) 0.98
HIPK2 phosphorylates ΔNp63α and promotes its degradation in response to DNA damage. Oncogene (2011) 0.97
SCF(Fbx4/alphaB-crystallin) E3 ligase: when one is not enough. Cell Cycle (2008) 0.94
Regulation of RCAN1 protein activity by Dyrk1A protein-mediated phosphorylation. J Biol Chem (2011) 0.94
Homeodomain-interacting protein kinase 2 (HIPK2) targets beta-catenin for phosphorylation and proteasomal degradation. Biochem Biophys Res Commun (2010) 0.93
The human protein kinase HIPK2 phosphorylates and downregulates the methyl-binding transcription factor ZBTB4. Oncogene (2009) 0.90
Dyrk1A-mediated phosphorylation of Presenilin 1: a functional link between Down syndrome and Alzheimer's disease. J Neurochem (2010) 0.89
DYRK1A binds to an evolutionarily conserved WD40-repeat protein WDR68 and induces its nuclear translocation. Biochim Biophys Acta (2011) 0.89
From top to bottom: the two faces of HIPK2 for regulation of the hypoxic response. Cell Cycle (2009) 0.89
The zebrafish dyrk1b gene is important for endoderm formation. Genesis (2010) 0.87
The deubiquitylase USP37 links REST to the control of p27 stability and cell proliferation. Oncogene (2012) 0.85
DYRK1A stabilizes HPV16E7 oncoprotein through phosphorylation of the threonine 5 and threonine 7 residues. Int J Biochem Cell Biol (2008) 0.82
Homeodomain-interacting protein kinase-2 stabilizes p27(kip1) by its phosphorylation at serine 10 and contributes to cell motility. J Biol Chem (2011) 0.81
Activation, regulation, and inhibition of DYRK1A. FEBS J (2010) 1.18