Published in Front Cell Infect Microbiol on May 23, 2012
Life in the human stomach: persistence strategies of the bacterial pathogen Helicobacter pylori. Nat Rev Microbiol (2013) 2.16
The role of serine protease HtrA in acute ulcerative enterocolitis and extra-intestinal immune responses during Campylobacter jejuni infection of gnotobiotic IL-10 deficient mice. Front Cell Infect Microbiol (2014) 1.05
Helicobacter pylori virulence factor CagA promotes tumorigenesis of gastric cancer via multiple signaling pathways. Cell Commun Signal (2015) 0.92
The impact of serine protease HtrA in apoptosis, intestinal immune responses and extra-intestinal histopathology during Campylobacter jejuni infection of infant mice. Gut Pathog (2014) 0.91
Helicobacter pylori CagA: From Pathogenic Mechanisms to Its Use as an Anti-Cancer Vaccine. Front Immunol (2013) 0.91
Exploring alternative treatments for Helicobacter pylori infection. World J Gastroenterol (2014) 0.90
Signal transduction of Helicobacter pylori during interaction with host cell protein receptors of epithelial and immune cells. Gut Microbes (2013) 0.89
Helicobacter pylori and gastric cancer: Indian enigma. World J Gastroenterol (2014) 0.87
Helicobacter pylori CagL Y58/E59 mutation turns-off type IV secretion-dependent delivery of CagA into host cells. PLoS One (2014) 0.86
Systematic analysis of phosphotyrosine antibodies recognizing single phosphorylated EPIYA-motifs in CagA of Western-type Helicobacter pylori strains. PLoS One (2014) 0.81
Potential of known and short prokaryotic protein motifs as a basis for novel peptide-based antibacterial therapeutics: a computational survey. Front Microbiol (2014) 0.79
Systematic analysis of phosphotyrosine antibodies recognizing single phosphorylated EPIYA-motifs in CagA of East Asian-type Helicobacter pylori strains. BMC Microbiol (2016) 0.77
In Silico Design of a Chimeric Protein Containing Antigenic Fragments of Helicobacter pylori; A Bioinformatic Approach. Open Microbiol J (2016) 0.76
Research advances in the study of Campylobacter, Helicobacter, and related organisms. Front Cell Infect Microbiol (2012) 0.75
Differences in amino acid frequency in CagA and VacA sequences of Helicobacter pylori distinguish gastric cancer from gastric MALT lymphoma. Gut Pathog (2016) 0.75
Bacterial thiol oxidoreductases - from basic research to new antibacterial strategies. Appl Microbiol Biotechnol (2017) 0.75
A C-Terminal Coiled-Coil Region of CagL is Responsible for Helicobacter Pylori-Induced Il-8 Expression. Eur J Microbiol Immunol (Bp) (2016) 0.75
Type IV Secretion and Signal Transduction of Helicobacter pylori CagA through Interactions with Host Cell Receptors. Toxins (Basel) (2017) 0.75
Systematic site-directed mutagenesis of the Helicobacter pylori CagL protein of the Cag type IV secretion system identifies novel functional domains. Sci Rep (2016) 0.75
Overexpression of serine protease HtrA enhances disruption of adherens junctions, paracellular transmigration and type IV secretion of CagA by Helicobacter pylori. Gut Pathog (2017) 0.75
Helicobacter pylori modulates host cell responses by CagT4SS-dependent translocation of an intermediate metabolite of LPS inner core heptose biosynthesis. PLoS Pathog (2017) 0.75
DNA Transfer and Toll-like Receptor Modulation by Helicobacter pylori. Curr Top Microbiol Immunol (2017) 0.75
Integrin signaling. Science (1999) 16.44
Calculation of protein conformation from circular dichroism. Methods Enzymol (1986) 5.68
Helicobacter pylori: gastric cancer and beyond. Nat Rev Cancer (2010) 4.64
Helicobacter exploits integrin for type IV secretion and kinase activation. Nature (2007) 4.02
The SPOT-synthesis technique. Synthetic peptide arrays on membrane supports--principles and applications. J Immunol Methods (2002) 3.52
Coadaptation of Helicobacter pylori and humans: ancient history, modern implications. J Clin Invest (2009) 3.26
Host-bacterial interactions in Helicobacter pylori infection. Gastroenterology (2008) 3.25
Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse. Proc Natl Acad Sci U S A (2008) 3.17
The short amino acid sequence Pro-His-Ser-Arg-Asn in human fibronectin enhances cell-adhesive function. J Biol Chem (1994) 3.06
Structure of integrin alpha5beta1 in complex with fibronectin. EMBO J (2003) 2.99
Grb2 is a key mediator of helicobacter pylori CagA protein activities. Mol Cell (2002) 2.80
Type IV secretion systems and their effectors in bacterial pathogenesis. Curr Opin Microbiol (2006) 2.65
Computation and analysis of protein circular dichroism spectra. Methods Enzymol (2004) 2.37
Selective recognition of cyclic RGD peptides of NMR defined conformation by alpha IIb beta 3, alpha V beta 3, and alpha 5 beta 1 integrins. J Biol Chem (1994) 2.22
Role of type IV secretion in Helicobacter pylori pathogenesis. Cell Microbiol (2008) 2.18
A novel sheathed surface organelle of the Helicobacter pylori cag type IV secretion system. Mol Microbiol (2003) 2.11
Helicobacter pylori CagA induces Ras-independent morphogenetic response through SHP-2 recruitment and activation. J Biol Chem (2004) 2.01
The role of integrin binding sites in fibronectin matrix assembly in vivo. Curr Opin Cell Biol (2008) 1.89
Functional analysis of the Helicobacter pylori cag pathogenicity island reveals both VirD4-CagA-dependent and VirD4-CagA-independent mechanisms. Infect Immun (2002) 1.84
Helicobacter pylori type IV secretion apparatus exploits beta1 integrin in a novel RGD-independent manner. PLoS Pathog (2009) 1.82
The RGD motif in fibronectin is essential for development but dispensable for fibril assembly. J Cell Biol (2007) 1.81
Role of the cag-pathogenicity island encoded type IV secretion system in Helicobacter pylori pathogenesis. FEBS J (2011) 1.68
Helicobacter pylori exploits a unique repertoire of type IV secretion system components for pilus assembly at the bacteria-host cell interface. PLoS Pathog (2011) 1.67
Identification of a novel integrin binding site in fibronectin. Differential utilization by beta 3 integrins. J Biol Chem (1994) 1.60
Monoclonal antibody characterization of two distant sites required for function of the central cell-binding domain of fibronectin in cell adhesion, cell migration, and matrix assembly. J Cell Biol (1991) 1.59
Specific entry of Helicobacter pylori into cultured gastric epithelial cells via a zipper-like mechanism. Infect Immun (2002) 1.59
c-Src and c-Abl kinases control hierarchic phosphorylation and function of the CagA effector protein in Western and East Asian Helicobacter pylori strains. J Clin Invest (2012) 1.53
Structural and functional characterization of the VirB5 protein from the type IV secretion system encoded by the conjugative plasmid pKM101. Proc Natl Acad Sci U S A (2003) 1.39
Assembly and molecular mode of action of the Helicobacter pylori Cag type IV secretion apparatus. FEBS J (2011) 1.35
Conformation/activity studies of rationally designed potent anti-adhesive RGD peptides. Eur J Biochem (1992) 1.33
Molecular mechanisms of epithelial-barrier disruption by Helicobacter pylori. Trends Microbiol (2008) 1.30
VirB2 and VirB5 proteins: specialized adhesins in bacterial type-IV secretion systems? Trends Microbiol (2008) 1.27
Importance of EGF receptor, HER2/Neu and Erk1/2 kinase signalling for host cell elongation and scattering induced by the Helicobacter pylori CagA protein: antagonistic effects of the vacuolating cytotoxin VacA. Cell Microbiol (2008) 1.25
A small fibronectin-mimicking protein from bacteria induces cell spreading and focal adhesion formation. J Biol Chem (2010) 1.19
Molecular mechanisms of gastric epithelial cell adhesion and injection of CagA by Helicobacter pylori. Cell Commun Signal (2011) 1.13
Serine phosphorylation of cortactin controls focal adhesion kinase activity and cell scattering induced by Helicobacter pylori. Cell Host Microbe (2011) 1.12
Helicobacter pylori CagL activates ADAM17 to induce repression of the gastric H, K-ATPase alpha subunit. Gastroenterology (2010) 1.11
1H NMR assignment and secondary structure of the cell adhesion type III module of fibronectin. Biochemistry (1992) 1.11
Helicobacter pylori CagL dependent induction of gastrin expression via a novel αvβ5-integrin-integrin linked kinase signalling complex. Gut (2012) 1.10
Helicobacter pylori induces AGS cell motility and elongation via independent signaling pathways. Infect Immun (2004) 1.07
Cyclic RGD peptides interfere with binding of the Helicobacter pylori protein CagL to integrins αVβ3 and α5β1. Amino Acids (2011) 0.93
Helicobacter pylori type IV secretion, host cell signalling and vaccine development. Keio J Med (2002) 0.89
An improved method for the solution cyclization of peptides under pseudo-high dilution conditions. J Biotechnol (2004) 0.87
Large-scale analysis of protein-protein interactions using cellulose-bound peptide arrays. Adv Biochem Eng Biotechnol (2008) 0.84
The synergy site of fibronectin is required for strong interaction with the platelet integrin alphaIIbbeta3. Ann Biomed Eng (2006) 0.80
Helicobacter exploits integrin for type IV secretion and kinase activation. Nature (2007) 4.02
Soluble proteins produced by probiotic bacteria regulate intestinal epithelial cell survival and growth. Gastroenterology (2006) 3.96
Src is the kinase of the Helicobacter pylori CagA protein in vitro and in vivo. J Biol Chem (2002) 3.47
Public knowledge of benefits of breast and prostate cancer screening in Europe. J Natl Cancer Inst (2009) 3.45
NF-kappaB activation and potentiation of proinflammatory responses by the Helicobacter pylori CagA protein. Proc Natl Acad Sci U S A (2005) 2.52
Phosphorylation of serine 468 by GSK-3beta negatively regulates basal p65 NF-kappaB activity. J Biol Chem (2004) 2.29
Induction of TLR-2 and TLR-5 expression by Helicobacter pylori switches cagPAI-dependent signalling leading to the secretion of IL-8 and TNF-α. PLoS One (2011) 2.29
Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism. J Clin Invest (2011) 2.16
Argyrin a reveals a critical role for the tumor suppressor protein p27(kip1) in mediating antitumor activities in response to proteasome inhibition. Cancer Cell (2008) 2.12
Phylogeographic origin of Helicobacter pylori is a determinant of gastric cancer risk. Gut (2011) 2.08
ProteomeBinders: planning a European resource of affinity reagents for analysis of the human proteome. Nat Methods (2007) 2.04
Helicobacter pylori HopH (OipA) and bacterial pathogenicity: genetic and functional genomic analysis of hopH gene polymorphisms. J Infect Dis (2006) 2.02
IRSp53 links the enterohemorrhagic E. coli effectors Tir and EspFU for actin pedestal formation. Cell Host Microbe (2009) 2.01
Functional plasticity in the type IV secretion system of Helicobacter pylori. PLoS Pathog (2013) 1.84
Functional analysis of the Helicobacter pylori cag pathogenicity island reveals both VirD4-CagA-dependent and VirD4-CagA-independent mechanisms. Infect Immun (2002) 1.84
Inhibition of primary human T cell proliferation by Helicobacter pylori vacuolating toxin (VacA) is independent of VacA effects on IL-2 secretion. Proc Natl Acad Sci U S A (2004) 1.77
Molecular mechanisms and kinetics between DNA and DNA binding ligands. Biophys J (2004) 1.74
Helicobacter pylori persistence: an overview of interactions between H. pylori and host immune defenses. Clin Microbiol Rev (2006) 1.73
Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle. EMBO J (2004) 1.73
Identification of a novel plasmin(ogen)-binding motif in surface displayed alpha-enolase of Streptococcus pneumoniae. Mol Microbiol (2003) 1.72
Activation of Abl by Helicobacter pylori: a novel kinase for CagA and crucial mediator of host cell scattering. Gastroenterology (2007) 1.70
Mapping and consensus sequence identification for multiple vinculin binding sites within the talin rod. J Biol Chem (2005) 1.68
Role of the cag-pathogenicity island encoded type IV secretion system in Helicobacter pylori pathogenesis. FEBS J (2011) 1.68
Helicobacter pylori exploits a unique repertoire of type IV secretion system components for pilus assembly at the bacteria-host cell interface. PLoS Pathog (2011) 1.67
The Rho-associated protein kinase p160ROCK is required for centrosome positioning. J Cell Biol (2002) 1.65
The Helicobacter pylori CagA protein induces cortactin dephosphorylation and actin rearrangement by c-Src inactivation. EMBO J (2003) 1.60
Specific entry of Helicobacter pylori into cultured gastric epithelial cells via a zipper-like mechanism. Infect Immun (2002) 1.59
The versatility of Helicobacter pylori CagA effector protein functions: The master key hypothesis. Helicobacter (2010) 1.59
Molecular analysis of sarcoidosis tissues for mycobacterium species DNA. Emerg Infect Dis (2002) 1.59
L-arginine availability regulates inducible nitric oxide synthase-dependent host defense against Helicobacter pylori. Infect Immun (2007) 1.54
Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E-cadherin to disrupt intercellular adhesion. EMBO Rep (2010) 1.54
c-Src and c-Abl kinases control hierarchic phosphorylation and function of the CagA effector protein in Western and East Asian Helicobacter pylori strains. J Clin Invest (2012) 1.53
A fibrinogen receptor from group B Streptococcus interacts with fibrinogen by repetitive units with novel ligand binding sites. Mol Microbiol (2002) 1.52
Essential role of a GXXXG motif for membrane channel formation by Helicobacter pylori vacuolating toxin. J Biol Chem (2003) 1.50
Host response to Helicobacter pylori infection before initiation of the adaptive immune response. FEMS Immunol Med Microbiol (2007) 1.49
Human and Helicobacter pylori coevolution shapes the risk of gastric disease. Proc Natl Acad Sci U S A (2014) 1.48
Peptide-mediated interference with influenza A virus polymerase. J Virol (2007) 1.48
The oxysterol-binding protein homologue ORP1L interacts with Rab7 and alters functional properties of late endocytic compartments. Mol Biol Cell (2005) 1.46
Crystal structure of the Helicobacter pylori vacuolating toxin p55 domain. Proc Natl Acad Sci U S A (2007) 1.46
Heterogeneity among Helicobacter pylori strains in expression of the outer membrane protein BabA. Infect Immun (2004) 1.45
Iron deficiency accelerates Helicobacter pylori-induced carcinogenesis in rodents and humans. J Clin Invest (2012) 1.45
An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis. EMBO J (2006) 1.45
Genome sequence analysis of Helicobacter pylori strains associated with gastric ulceration and gastric cancer. BMC Genomics (2009) 1.42
Association of Helicobacter pylori vacuolating toxin (VacA) with lipid rafts. J Biol Chem (2002) 1.41
Regulation of Helicobacter pylori cagA expression in response to salt. Cancer Res (2007) 1.38
Antibody-drug conjugates in tumor therapy. Pharm Pat Anal (2012) 1.38
Host cell interactome of tyrosine-phosphorylated bacterial proteins. Cell Host Microbe (2009) 1.36
Distinct roles of secreted HtrA proteases from gram-negative pathogens in cleaving the junctional protein and tumor suppressor E-cadherin. J Biol Chem (2012) 1.31
Molecular mechanisms of epithelial-barrier disruption by Helicobacter pylori. Trends Microbiol (2008) 1.30
Characterization of the MHC class I cross-presentation pathway for cell-associated antigens by human dendritic cells. Blood (2003) 1.29
Epidermal growth factor receptor activation protects gastric epithelial cells from Helicobacter pylori-induced apoptosis. Gastroenterology (2009) 1.28
PI3K/Akt is required for heat shock proteins to protect hypoxia-inducible factor 1alpha from pVHL-independent degradation. J Biol Chem (2004) 1.25
Two different families of hopQ alleles in Helicobacter pylori. J Clin Microbiol (2002) 1.25
Importance of EGF receptor, HER2/Neu and Erk1/2 kinase signalling for host cell elongation and scattering induced by the Helicobacter pylori CagA protein: antagonistic effects of the vacuolating cytotoxin VacA. Cell Microbiol (2008) 1.25
Role of the small Rho GTPases Rac1 and Cdc42 in host cell invasion of Campylobacter jejuni. Cell Microbiol (2007) 1.24
Ectodomains 3 and 4 of human polymeric Immunoglobulin receptor (hpIgR) mediate invasion of Streptococcus pneumoniae into the epithelium. J Biol Chem (2003) 1.23
A small fibronectin-mimicking protein from bacteria induces cell spreading and focal adhesion formation. J Biol Chem (2010) 1.19
Biochemical and functional characterization of Helicobacter pylori vesicles. Mol Microbiol (2010) 1.18
Cellular vacuolation and mitochondrial cytochrome c release are independent outcomes of Helicobacter pylori vacuolating cytotoxin activity that are each dependent on membrane channel formation. J Biol Chem (2003) 1.18
Genome-wide transcriptional profiling in a histidine kinase mutant of Helicobacter pylori identifies members of a regulon. J Bacteriol (2002) 1.16
High dietary salt intake exacerbates Helicobacter pylori-induced gastric carcinogenesis. Infect Immun (2013) 1.16
Growth phase regulation of flaA expression in Helicobacter pylori is luxS dependent. Infect Immun (2004) 1.16
Global analysis of Helicobacter pylori gene expression in human gastric mucosa. Gastroenterology (2002) 1.14
Protein-protein interactions among Helicobacter pylori cag proteins. J Bacteriol (2006) 1.14
Antibacterial endiandric acid derivatives from Beilschmiedia anacardioides. Phytochemistry (2009) 1.14
Molecular mechanisms of gastric epithelial cell adhesion and injection of CagA by Helicobacter pylori. Cell Commun Signal (2011) 1.13
Identification of a PA-binding peptide with inhibitory activity against influenza A and B virus replication. PLoS One (2009) 1.13
Identification of hot regions of the Abeta-IAPP interaction interface as high-affinity binding sites in both cross- and self-association. Angew Chem Int Ed Engl (2010) 1.13
Serine phosphorylation of cortactin controls focal adhesion kinase activity and cell scattering induced by Helicobacter pylori. Cell Host Microbe (2011) 1.12
Multiple chromosomal loci for the babA gene in Helicobacter pylori. Infect Immun (2006) 1.12
Hepatitis C virus complete life cycle screen for identification of small molecules with pro- or antiviral activity. Antiviral Res (2010) 1.12
The functional interplay of Helicobacter pylori factors with gastric epithelial cells induces a multi-step process in pathogenesis. Cell Commun Signal (2013) 1.11
A community standard format for the representation of protein affinity reagents. Mol Cell Proteomics (2009) 1.11
Inference of genetic regulatory networks with recurrent neural network models using particle swarm optimization. IEEE/ACM Trans Comput Biol Bioinform (2007) 1.11
Helicobacter pylori CagL activates ADAM17 to induce repression of the gastric H, K-ATPase alpha subunit. Gastroenterology (2010) 1.11
The Helicobacter pylori CagA protein disrupts matrix adhesion of gastric epithelial cells by dephosphorylation of vinculin. Cell Microbiol (2007) 1.10
Minimum information about a protein affinity reagent (MIAPAR). Nat Biotechnol (2010) 1.10
Helicobacter pylori CagL dependent induction of gastrin expression via a novel αvβ5-integrin-integrin linked kinase signalling complex. Gut (2012) 1.10
Cortactin: an Achilles' heel of the actin cytoskeleton targeted by pathogens. Trends Microbiol (2005) 1.09
Helicobacter pylori vacuolating cytotoxin inhibits activation-induced proliferation of human T and B lymphocyte subsets. J Immunol (2007) 1.09
Biochemical and NMR analyses of an SF3b155-p14-U2AF-RNA interaction network involved in branch point definition during pre-mRNA splicing. RNA (2006) 1.09
β-Catenin and p120 mediate PPARδ-dependent proliferation induced by Helicobacter pylori in human and rodent epithelia. Gastroenterology (2011) 1.08
High-avidity human serum antibodies recognizing linear epitopes of Borna disease virus proteins. Biol Psychiatry (2002) 1.08
Molecular and functional characterization of clathrin- and AP-2-binding determinants within a disordered domain of auxilin. J Biol Chem (2003) 1.08
Helicobacter pylori induces AGS cell motility and elongation via independent signaling pathways. Infect Immun (2004) 1.07
The granulocyte receptor carcinoembryonic antigen-related cell adhesion molecule 3 (CEACAM3) directly associates with Vav to promote phagocytosis of human pathogens. J Immunol (2007) 1.06
Molecular evolution of the Helicobacter pylori vacuolating toxin gene vacA. J Bacteriol (2010) 1.06
Interactions between p-33 and p-55 domains of the Helicobacter pylori vacuolating cytotoxin (VacA). J Biol Chem (2003) 1.06
Correction: Induction of TLR-2 and TLR-5 Expression by Helicobacter pylori Switches cagPAI-Dependent Signalling Leading to the Secretion of IL-8 and TNF-α. PLoS One (2015) 1.06
Helicobacter pylori VacA induces programmed necrosis in gastric epithelial cells. Infect Immun (2011) 1.05
Immunization of pigs to prevent disease in humans: construction and protective efficacy of a Salmonella enterica serovar Typhimurium live negative-marker vaccine. Infect Immun (2007) 1.04