1
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Examination of oral absorption and lymphatic transport of halofantrine in a triple-cannulated canine model after administration in self-microemulsifying drug delivery systems (SMEDDS) containing structured triglycerides.
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Eur J Pharm Sci
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2003
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1.21
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2
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Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories.
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Eur J Pharm Sci
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2008
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1.16
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3
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Meeting report: applied biopharmaceutics and quality by design for dissolution/release specification setting: product quality for patient benefit.
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AAPS J
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2010
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1.11
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4
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Bioavailability of cinnarizine in dogs: effect of SNEDDS loading level and correlation with cinnarizine solubilization during in vitro lipolysis.
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Pharm Res
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2013
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1.10
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5
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Bioavailability of seocalcitol II: development and characterisation of self-microemulsifying drug delivery systems (SMEDDS) for oral administration containing medium and long chain triglycerides.
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Eur J Pharm Sci
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2006
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0.99
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6
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Bioavailability of seocalcitol I: Relating solubility in biorelevant media with oral bioavailability in rats--effect of medium and long chain triglycerides.
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J Pharm Sci
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2005
|
0.99
|
7
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In vivo in vitro correlations for a poorly soluble drug, danazol, using the flow-through dissolution method with biorelevant dissolution media.
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Eur J Pharm Sci
|
2005
|
0.99
|
8
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Lipid-based formulations for oral administration of poorly water-soluble drugs.
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Int J Pharm
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2013
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0.95
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9
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Bioavailability of probucol from lipid and surfactant based formulations in minipigs: influence of droplet size and dietary state.
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Eur J Pharm Biopharm
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2008
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0.92
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10
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Toward the establishment of standardized in vitro tests for lipid-based formulations, part 1: method parameterization and comparison of in vitro digestion profiles across a range of representative formulations.
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J Pharm Sci
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2012
|
0.91
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11
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Effect of liquid volume and food intake on the absolute bioavailability of danazol, a poorly soluble drug.
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Eur J Pharm Sci
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2005
|
0.91
|
12
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In vitro lipolysis models as a tool for the characterization of oral lipid and surfactant based drug delivery systems.
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Int J Pharm
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2011
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0.89
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13
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Lipid-based formulations for danazol containing a digestible surfactant, Labrafil M2125CS: in vivo bioavailability and dynamic in vitro lipolysis.
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Pharm Res
|
2008
|
0.88
|
14
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Adsorption of pharmaceutical excipients onto microcrystals of siramesine hydrochloride: effects on physicochemical properties.
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Eur J Pharm Biopharm
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2008
|
0.87
|
15
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Characterization of prototype self-nanoemulsifying formulations of lipophilic compounds.
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J Pharm Sci
|
2007
|
0.87
|
16
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Influence of the type of surfactant and the degree of dispersion on the lymphatic transport of halofantrine in conscious rats.
|
Pharm Res
|
2004
|
0.85
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17
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Supersaturated self-nanoemulsifying drug delivery systems (Super-SNEDDS) enhance the bioavailability of the poorly water-soluble drug simvastatin in dogs.
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AAPS J
|
2012
|
0.85
|
18
|
Oral bioavailability of cinnarizine in dogs: relation to SNEDDS droplet size, drug solubility and in vitro precipitation.
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Eur J Pharm Sci
|
2012
|
0.85
|
19
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Precipitation of a poorly soluble model drug during in vitro lipolysis: characterization and dissolution of the precipitate.
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J Pharm Sci
|
2010
|
0.85
|
20
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Toward the establishment of standardized in vitro tests for lipid-based formulations, part 3: understanding supersaturation versus precipitation potential during the in vitro digestion of type I, II, IIIA, IIIB and IV lipid-based formulations.
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Pharm Res
|
2013
|
0.84
|
21
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Toward the establishment of standardized in vitro tests for lipid-based formulations. 2. The effect of bile salt concentration and drug loading on the performance of type I, II, IIIA, IIIB, and IV formulations during in vitro digestion.
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Mol Pharm
|
2012
|
0.84
|
22
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Characterising the behaviour of poorly water soluble drugs in the intestine: application of biorelevant media for solubility, dissolution and transport studies.
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J Pharm Pharmacol
|
2010
|
0.84
|
23
|
Influence of bile on the absorption of halofantrine from lipid-based formulations.
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Eur J Pharm Biopharm
|
2012
|
0.83
|
24
|
Influence of lipid composition and drug load on the In Vitro performance of self-nanoemulsifying drug delivery systems.
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J Pharm Sci
|
2012
|
0.83
|
25
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Structured triglyceride vehicles for oral delivery of halofantrine: examination of intestinal lymphatic transport and bioavailability in conscious rats.
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Pharm Res
|
2002
|
0.83
|
26
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Phase transformations of amlodipine besylate solid forms.
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J Pharm Sci
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2011
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0.82
|
27
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Bile salts and their importance for drug absorption.
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Int J Pharm
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2013
|
0.82
|
28
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Intestinal lymphatic transport of halofantrine in rats assessed using a chylomicron flow blocking approach: the influence of polysorbate 60 and 80.
|
Eur J Pharm Sci
|
2008
|
0.82
|
29
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Enzymatic characterization of lipid-based drug delivery systems.
|
Int J Pharm
|
2005
|
0.81
|
30
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Characterising lipid lipolysis and its implication in lipid-based formulation development.
|
AAPS J
|
2012
|
0.81
|
31
|
Using biorelevant dissolution to obtain IVIVC of solid dosage forms containing a poorly-soluble model compound.
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Eur J Pharm Biopharm
|
2007
|
0.81
|
32
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Colloidal structures in media simulating intestinal fed state conditions with and without lipolysis products.
|
Pharm Res
|
2008
|
0.81
|
33
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Bioavailability of seocalcitol III. Administration of lipid-based formulations to minipigs in the fasted and fed state.
|
Eur J Pharm Sci
|
2007
|
0.80
|
34
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The biopharmaceutics risk assessment roadmap for optimizing clinical drug product performance.
|
J Pharm Sci
|
2014
|
0.80
|
35
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In vitro lipolysis data does not adequately predict the in vivo performance of lipid-based drug delivery systems containing fenofibrate.
|
AAPS J
|
2014
|
0.80
|
36
|
Feasibility of capsule endoscopy for direct imaging of drug delivery systems in the fasted upper-gastrointestinal tract.
|
Pharm Res
|
2014
|
0.80
|
37
|
Biorelevant media simulating fed state intestinal fluids: colloid phase characterization and impact on solubilization capacity.
|
J Pharm Sci
|
2010
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0.80
|
38
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Solid lipid particles for oral delivery of peptide and protein drugs II--the digestion of trilaurin protects desmopressin from proteolytic degradation.
|
Pharm Res
|
2014
|
0.80
|
39
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Solid lipid particles for oral delivery of peptide and protein drugs III - the effect of fed state conditions on the in vitro release and degradation of desmopressin.
|
AAPS J
|
2014
|
0.79
|
40
|
Investigating the correlation between in vivo absorption and in vitro release of fenofibrate from lipid matrix particles in biorelevant medium.
|
Eur J Pharm Sci
|
2013
|
0.79
|
41
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Biorelevant dissolution media: aggregation of amphiphiles and solubility of estradiol.
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J Pharm Sci
|
2006
|
0.79
|
42
|
Oral delivery of peptides and proteins using lipid-based drug delivery systems.
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Expert Opin Drug Deliv
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2012
|
0.79
|
43
|
Characterization of fasted human gastric fluid for relevant rheological parameters and gastric lipase activities.
|
Eur J Pharm Biopharm
|
2013
|
0.78
|
44
|
Exploring the fate of liposomes in the intestine by dynamic in vitro lipolysis.
|
Int J Pharm
|
2012
|
0.78
|
45
|
Toward the establishment of standardized in vitro tests for lipid-based formulations, part 6: effects of varying pancreatin and calcium levels.
|
AAPS J
|
2014
|
0.78
|
46
|
Optimization of self nanoemulsifying drug delivery system for poorly water-soluble drug using response surface methodology.
|
Drug Dev Ind Pharm
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2012
|
0.78
|
47
|
The Effect of Digestion and Drug Load on Halofantrine Absorption from Self-nanoemulsifying Drug Delivery System (SNEDDS).
|
AAPS J
|
2016
|
0.77
|
48
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Preparation of an amorphous sodium furosemide salt improves solubility and dissolution rate and leads to a faster Tmax after oral dosing to rats.
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Eur J Pharm Biopharm
|
2013
|
0.77
|
49
|
Effect of different surfactants in biorelevant medium on the secretion of a lipophilic compound in lipoproteins using Caco-2 cell culture.
|
J Pharm Sci
|
2006
|
0.77
|
50
|
Effect of bile on the oral absorption of halofantrine in polyethylene glycol 400 and polysorbate 80 formulations dosed to bile duct cannulated rats.
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J Pharm Pharmacol
|
2011
|
0.77
|
51
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SNEDDS Containing Poorly Water Soluble Cinnarizine; Development and in Vitro Characterization of Dispersion, Digestion and Solubilization.
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Pharmaceutics
|
2012
|
0.76
|
52
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Insights into the early dissolution events of amlodipine using UV imaging and Raman spectroscopy.
|
Mol Pharm
|
2011
|
0.76
|
53
|
Bioavailability of seocalcitol IV: evaluation of lymphatic transport in conscious rats.
|
Pharm Res
|
2006
|
0.76
|
54
|
pH-triggered drug release from biodegradable microwells for oral drug delivery.
|
Biomed Microdevices
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2015
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0.75
|
55
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Toward the establishment of standardized in vitro tests for lipid-based formulations, part 4: proposing a new lipid formulation performance classification system.
|
J Pharm Sci
|
2014
|
0.75
|
56
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Real-time dissolution behavior of furosemide in biorelevant media as determined by UV imaging.
|
Pharm Dev Technol
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2012
|
0.75
|
57
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Toward the establishment of standardized in vitro tests for lipid-based formulations. 5. Lipolysis of representative formulations by gastric lipase.
|
Pharm Res
|
2014
|
0.75
|
58
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Miniaturized approach for excipient selection during the development of oral solid dosage form.
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J Pharm Sci
|
2014
|
0.75
|
59
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In vitro and in vivo evaluations of the performance of an indirubin derivative, formulated in four different self-emulsifying drug delivery systems.
|
J Pharm Pharmacol
|
2014
|
0.75
|
60
|
Determination of surface-adsorbed excipients of various types on drug particles prepared by antisolvent precipitation using HPLC with evaporative light scattering detection.
|
J Pharm Biomed Anal
|
2007
|
0.75
|
61
|
A novel excipient, 1-perfluorohexyloctane shows limited utility for the oral delivery of poorly water-soluble drugs.
|
Eur J Pharm Sci
|
2011
|
0.75
|
62
|
Azone® decreases the buccal mucosal permeation of diazepam in a concentration-dependent manner via a reservoir effect.
|
J Pharm Sci
|
2014
|
0.75
|
63
|
Spatial confinement can lead to increased stability of amorphous indomethacin.
|
Eur J Pharm Biopharm
|
2012
|
0.75
|
64
|
Biorelevant characterisation of amorphous furosemide salt exhibits conversion to a furosemide hydrate during dissolution.
|
Int J Pharm
|
2013
|
0.75
|
65
|
Using resin to generate a non-invasive intestinal bile-depleted rat model was unsuccessful.
|
Eur J Pharm Sci
|
2012
|
0.75
|
66
|
Development of simulated intestinal fluids containing nutrients as transport media in the Caco-2 cell culture model: assessment of cell viability, monolayer integrity and transport of a poorly aqueous soluble drug and a substrate of efflux mechanisms.
|
Eur J Pharm Sci
|
2007
|
0.75
|
67
|
A new approach to dissolution testing by UV imaging and finite element simulations.
|
Pharm Res
|
2013
|
0.75
|
68
|
Preparation and characterization of insulin-surfactant complexes for loading into lipid-based drug delivery systems.
|
J Pharm Sci
|
2013
|
0.75
|
69
|
Ex vivo correlation of the permeability of metoprolol across human and porcine buccal mucosa.
|
J Pharm Sci
|
2014
|
0.75
|
70
|
Investigation of the intra- and inter-laboratory reproducibility of a small scale standardized supersaturation and precipitation method.
|
Mol Pharm
|
2017
|
0.75
|
71
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Evaluation of the use of Göttingen minipigs to predict food effects on the oral absorption of drugs in humans.
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J Pharm Sci
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2014
|
0.75
|
72
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A slow cooling rate of indomethacin melt spatially confined in microcontainers increases the physical stability of the amorphous drug without influencing its biorelevant dissolution behaviour.
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Drug Deliv Transl Res
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2014
|
0.75
|
73
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Effects of polysorbate 80 on the in-vitro precipitation and oral bioavailability of halofantrine from polyethylene glycol 400 formulations in rats.
|
J Pharm Pharmacol
|
2010
|
0.75
|
74
|
Influence of the solid form of siramesine hydrochloride on its behavior in aqueous environments.
|
Pharm Res
|
2008
|
0.75
|