Published in Nature on September 02, 2012
A long noncoding RNA protects the heart from pathological hypertrophy. Nature (2014) 1.96
DEAD-box helicase proteins disrupt RNA tertiary structure through helix capture. PLoS Biol (2014) 1.46
RNA helicase proteins as chaperones and remodelers. Annu Rev Biochem (2014) 1.17
Toward a molecular understanding of RNA remodeling by DEAD-box proteins. RNA Biol (2012) 1.16
DEAD-box helicases as integrators of RNA, nucleotide and protein binding. Biochim Biophys Acta (2013) 1.16
Duplex RNA activated ATPases (DRAs): platforms for RNA sensing, signaling and processing. RNA Biol (2012) 1.10
Fitting CRISPR-associated Cas3 into the helicase family tree. Curr Opin Struct Biol (2014) 1.04
Cofactor-dependent specificity of a DEAD-box protein. Proc Natl Acad Sci U S A (2013) 0.92
The DEAD-box protein Dbp2 functions with the RNA-binding protein Yra1 to promote mRNP assembly. J Mol Biol (2013) 0.92
'Black sheep' that don't leave the double-stranded RNA-binding domain fold. Trends Biochem Sci (2014) 0.90
Structural insights into RISC assembly facilitated by dsRNA-binding domains of human RNA helicase A (DHX9). Nucleic Acids Res (2013) 0.86
DDX6 regulates sequestered nuclear CUG-expanded DMPK-mRNA in dystrophia myotonica type 1. Nucleic Acids Res (2014) 0.86
P68 RNA helicase as a molecular target for cancer therapy. J Exp Clin Cancer Res (2014) 0.85
DEAD-box protein CYT-19 is activated by exposed helices in a group I intron RNA. Proc Natl Acad Sci U S A (2014) 0.85
Cancer-associated mutants of RNA helicase DDX3X are defective in RNA-stimulated ATP hydrolysis. J Mol Biol (2015) 0.84
Arabidopsis DEAD-box RNA helicase UAP56 interacts with both RNA and DNA as well as with mRNA export factors. PLoS One (2013) 0.84
DEAD-box RNA helicase domains exhibit a continuum between complete functional independence and high thermodynamic coupling in nucleotide and RNA duplex recognition. Nucleic Acids Res (2014) 0.83
Insights into mRNA export-linked molecular mechanisms of human disease through a Gle1 structure-function analysis. Adv Biol Regul (2013) 0.82
Unzippers, resolvers and sensors: a structural and functional biochemistry tale of RNA helicases. Int J Mol Sci (2015) 0.81
Autoinhibitory Interdomain Interactions and Subfamily-specific Extensions Redefine the Catalytic Core of the Human DEAD-box Protein DDX3. J Biol Chem (2015) 0.81
Molecular insights into RNA and DNA helicase evolution from the determinants of specificity for a DEAD-box RNA helicase. Elife (2014) 0.79
Division of Labor in an Oligomer of the DEAD-Box RNA Helicase Ded1p. Mol Cell (2015) 0.79
Yeast DEAD box protein Mss116p is a transcription elongation factor that modulates the activity of mitochondrial RNA polymerase. Mol Cell Biol (2014) 0.78
Synergistic effects of ATP and RNA binding to human DEAD-box protein DDX1. Nucleic Acids Res (2015) 0.77
Unwinding the mechanisms of a DEAD-box RNA helicase in cancer. J Mol Biol (2015) 0.76
A DEAD-box RNA helicase promotes thermodynamic equilibration of kinetically trapped RNA structures in vivo. RNA (2016) 0.75
DEAD box unwinding caught in the act. Structure (2014) 0.75
Sexually dimorphic expression of vasa isoforms in the tongue sole (Cynoglossus semilaevis). PLoS One (2014) 0.75
Allosteric regulation of helicase core activities of the DEAD-box helicase YxiN by RNA binding to its RNA recognition motif. Nucleic Acids Res (2017) 0.75
The DEAD-box Protein DDX43 (HAGE) Is a Dual RNA-DNA Helicase and Has a K-homology Domain Required for Full Nucleic Acid Unwinding Activity. J Biol Chem (2017) 0.75
Structure of DEAH/RHA ATPase Prp43p bound to RNA implicates a pair of hairpins and motif Va in translocation along RNA. RNA (2017) 0.75
The DEAD-box helicase Mss116 plays distinct roles in mitochondrial ribogenesis and mRNA-specific translation. Nucleic Acids Res (2017) 0.75
PHENIX: a comprehensive Python-based system for macromolecular structure solution. Acta Crystallogr D Biol Crystallogr (2010) 108.52
Phaser crystallographic software. J Appl Crystallogr (2007) 108.34
Features and development of Coot. Acta Crystallogr D Biol Crystallogr (2010) 89.46
Scaling and assessment of data quality. Acta Crystallogr D Biol Crystallogr (2005) 61.38
MolProbity: all-atom structure validation for macromolecular crystallography. Acta Crystallogr D Biol Crystallogr (2009) 53.36
Inference of macromolecular assemblies from crystalline state. J Mol Biol (2007) 44.95
The finer things in X-ray diffraction data collection. Acta Crystallogr D Biol Crystallogr (1999) 19.10
Two related superfamilies of putative helicases involved in replication, recombination, repair and expression of DNA and RNA genomes. Nucleic Acids Res (1989) 10.03
Structure and mechanism of helicases and nucleic acid translocases. Annu Rev Biochem (2007) 7.83
Protein identification and analysis tools in the ExPASy server. Methods Mol Biol (1999) 6.31
Structural basis for RNA unwinding by the DEAD-box protein Drosophila Vasa. Cell (2006) 5.70
DEAD-box proteins: the driving forces behind RNA metabolism. Nat Rev Mol Cell Biol (2004) 4.87
Structural basis for the activation of innate immune pattern-recognition receptor RIG-I by viral RNA. Cell (2011) 4.11
SF1 and SF2 helicases: family matters. Curr Opin Struct Biol (2010) 3.79
Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA. Science (2006) 3.60
Data processing and analysis with the autoPROC toolbox. Acta Crystallogr D Biol Crystallogr (2011) 3.41
From unwinding to clamping - the DEAD box RNA helicase family. Nat Rev Mol Cell Biol (2011) 3.38
Structural insights into RNA recognition by RIG-I. Cell (2011) 3.25
Structural basis of RNA recognition and activation by innate immune receptor RIG-I. Nature (2011) 3.05
ATP hydrolysis is required for DEAD-box protein recycling but not for duplex unwinding. Proc Natl Acad Sci U S A (2008) 2.14
The splicing of yeast mitochondrial group I and group II introns requires a DEAD-box protein with RNA chaperone function. Proc Natl Acad Sci U S A (2004) 2.08
Involvement of DEAD-box proteins in group I and group II intron splicing. Biochemical characterization of Mss116p, ATP hydrolysis-dependent and -independent mechanisms, and general RNA chaperone activity. J Mol Biol (2006) 1.99
Conformational influence of the ribose 2'-hydroxyl group: crystal structures of DNA-RNA chimeric duplexes. Biochemistry (1993) 1.91
DEAD-box proteins unwind duplexes by local strand separation. Mol Cell (2007) 1.85
DEAD-box proteins can completely separate an RNA duplex using a single ATP. Proc Natl Acad Sci U S A (2008) 1.72
Structure of the Yeast DEAD box protein Mss116p reveals two wedges that crimp RNA. Mol Cell (2009) 1.44
DEAD-box proteins as RNA helicases and chaperones. Wiley Interdiscip Rev RNA (2011) 1.37
Unwinding by local strand separation is critical for the function of DEAD-box proteins as RNA chaperones. J Mol Biol (2009) 1.30
Pathway of ATP utilization and duplex rRNA unwinding by the DEAD-box helicase, DbpA. Proc Natl Acad Sci U S A (2010) 1.28
Comparative structural analysis of human DEAD-box RNA helicases. PLoS One (2010) 1.21
Mechanism of Mss116 ATPase reveals functional diversity of DEAD-Box proteins. J Mol Biol (2011) 1.17
B-form to A-form conversion by a 3'-terminal ribose: crystal structure of the chimera d(CCACTAGTG)r(G). Nucleic Acids Res (2000) 1.13
Crystal structure and nucleotide binding of the Thermus thermophilus RNA helicase Hera N-terminal domain. J Mol Biol (2006) 1.12
Extended upstream A-T sequence increases T7 promoter strength. J Biol Chem (2005) 1.08
Solution structures of DEAD-box RNA chaperones reveal conformational changes and nucleic acid tethering by a basic tail. Proc Natl Acad Sci U S A (2011) 1.06
Time-resolved measurements of intracellular ATP in the yeast Saccharomyces cerevisiae using a new type of nanobiosensor. J Biol Chem (2010) 1.06
Roles of DEAD-box proteins in RNA and RNP Folding. RNA Biol (2010) 0.99
The Bacillus subtilis RNA helicase YxiN is distended in solution. Biophys J (2007) 0.94
ATP-dependent roles of the DEAD-box protein Mss116p in group II intron splicing in vitro and in vivo. J Mol Biol (2011) 0.90
High-throughput genetic identification of functionally important regions of the yeast DEAD-box protein Mss116p. J Mol Biol (2011) 0.82
Use of computer-designed group II introns to disrupt Escherichia coli DExH/D-box protein and DNA helicase genes. J Mol Biol (2004) 2.18
A DEAD-box protein functions as an ATP-dependent RNA chaperone in group I intron splicing. Cell (2002) 2.09
The splicing of yeast mitochondrial group I and group II introns requires a DEAD-box protein with RNA chaperone function. Proc Natl Acad Sci U S A (2004) 2.08
Targeted and random bacterial gene disruption using a group II intron (targetron) vector containing a retrotransposition-activated selectable marker. Nucleic Acids Res (2003) 2.00
Involvement of DEAD-box proteins in group I and group II intron splicing. Biochemical characterization of Mss116p, ATP hydrolysis-dependent and -independent mechanisms, and general RNA chaperone activity. J Mol Biol (2006) 1.99
XPB, a subunit of TFIIH, is a target of the natural product triptolide. Nat Chem Biol (2011) 1.89
DEAD-box proteins unwind duplexes by local strand separation. Mol Cell (2007) 1.85
DEAD-box proteins can completely separate an RNA duplex using a single ATP. Proc Natl Acad Sci U S A (2008) 1.72
RNA polymerase II acts as an RNA-dependent RNA polymerase to extend and destabilize a non-coding RNA. EMBO J (2013) 1.68
Characterization of the C-terminal DNA-binding/DNA endonuclease region of a group II intron-encoded protein. J Mol Biol (2002) 1.64
Mechanisms used for genomic proliferation by thermophilic group II introns. PLoS Biol (2010) 1.62
A DEAD-box protein alone promotes group II intron splicing and reverse splicing by acting as an RNA chaperone. Proc Natl Acad Sci U S A (2006) 1.55
Do DEAD-box proteins promote group II intron splicing without unwinding RNA? Mol Cell (2007) 1.50
Structure of the Yeast DEAD box protein Mss116p reveals two wedges that crimp RNA. Mol Cell (2009) 1.44
Recruitment of host functions suggests a repair pathway for late steps in group II intron retrohoming. Genes Dev (2005) 1.41
Genetic manipulation of Lactococcus lactis by using targeted group II introns: generation of stable insertions without selection. Appl Environ Microbiol (2003) 1.36
Structure of a tyrosyl-tRNA synthetase splicing factor bound to a group I intron RNA. Nature (2008) 1.36
Group II intron mobility using nascent strands at DNA replication forks to prime reverse transcription. EMBO J (2003) 1.35
Effects of maturase binding and Mg2+ concentration on group II intron RNA folding investigated by UV cross-linking. Biochemistry (2003) 1.30
Unwinding by local strand separation is critical for the function of DEAD-box proteins as RNA chaperones. J Mol Biol (2009) 1.30
Thermostable group II intron reverse transcriptase fusion proteins and their use in cDNA synthesis and next-generation RNA sequencing. RNA (2013) 1.29
Function of the C-terminal domain of the DEAD-box protein Mss116p analyzed in vivo and in vitro. J Mol Biol (2007) 1.29
Probing the mechanisms of DEAD-box proteins as general RNA chaperones: the C-terminal domain of CYT-19 mediates general recognition of RNA. Biochemistry (2007) 1.27
A group II intron-encoded maturase functions preferentially in cis and requires both the reverse transcriptase and X domains to promote RNA splicing. J Mol Biol (2004) 1.27
Domain structure and three-dimensional model of a group II intron-encoded reverse transcriptase. RNA (2004) 1.25
A three-dimensional model of a group II intron RNA and its interaction with the intron-encoded reverse transcriptase. Mol Cell (2008) 1.23
Binding of a group II intron-encoded reverse transcriptase/maturase to its high affinity intron RNA binding site involves sequence-specific recognition and autoregulates translation. J Mol Biol (2002) 1.21
Gene targeting in gram-negative bacteria by use of a mobile group II intron ("Targetron") expressed from a broad-host-range vector. Appl Environ Microbiol (2007) 1.20
Retrotransposition strategies of the Lactococcus lactis Ll.LtrB group II intron are dictated by host identity and cellular environment. Mol Microbiol (2005) 1.19
Toward a molecular understanding of RNA remodeling by DEAD-box proteins. RNA Biol (2012) 1.16
Mobility of the Sinorhizobium meliloti group II intron RmInt1 occurs by reverse splicing into DNA, but requires an unknown reverse transcriptase priming mechanism. J Mol Biol (2003) 1.15
The pathway for DNA recognition and RNA integration by a group II intron retrotransposon. Mol Cell (2003) 1.10
A tyrosyl-tRNA synthetase adapted to function in group I intron splicing by acquiring a new RNA binding surface. Mol Cell (2005) 1.09
Solution structures of DEAD-box RNA chaperones reveal conformational changes and nucleic acid tethering by a basic tail. Proc Natl Acad Sci U S A (2011) 1.06
tRNA-like recognition of group I introns by a tyrosyl-tRNA synthetase. Proc Natl Acad Sci U S A (2002) 1.02
The DIVa maturase binding site in the yeast group II intron aI2 is essential for intron homing but not for in vivo splicing. Mol Cell Biol (2003) 1.02
Identification of proteins associated with the yeast mitochondrial RNA polymerase by tandem affinity purification. Yeast (2009) 1.02
Toward predicting self-splicing and protein-facilitated splicing of group I introns. RNA (2008) 1.00
Mobile Bacterial Group II Introns at the Crux of Eukaryotic Evolution. Microbiol Spectr (2015) 1.00
Group II intron-based gene targeting reactions in eukaryotes. PLoS One (2008) 0.98
Molecular basis of antibiotic multiresistance transfer in Staphylococcus aureus. Proc Natl Acad Sci U S A (2013) 0.98
EcI5, a group IIB intron with high retrohoming frequency: DNA target site recognition and use in gene targeting. RNA (2009) 0.98
Putative proteins related to group II intron reverse transcriptase/maturases are encoded by nuclear genes in higher plants. Nucleic Acids Res (2003) 0.97
Group II intron protein localization and insertion sites are affected by polyphosphate. PLoS Biol (2008) 0.96
Identification and evolution of fungal mitochondrial tyrosyl-tRNA synthetases with group I intron splicing activity. Proc Natl Acad Sci U S A (2008) 0.96
Structural basis of SUFU-GLI interaction in human Hedgehog signalling regulation. Acta Crystallogr D Biol Crystallogr (2013) 0.95
Gene targeting using randomly inserted group II introns (targetrons) recovered from an Escherichia coli gene disruption library. Nucleic Acids Res (2005) 0.94
Crystal structure of TruD, a novel pseudouridine synthase with a new protein fold. J Biol Chem (2004) 0.93
A bacterial group II intron-encoded reverse transcriptase localizes to cellular poles. Proc Natl Acad Sci U S A (2005) 0.92
Generalized bacterial genome editing using mobile group II introns and Cre-lox. Mol Syst Biol (2013) 0.90
A targetron system for gene targeting in thermophiles and its application in Clostridium thermocellum. PLoS One (2013) 0.90
ATP-dependent roles of the DEAD-box protein Mss116p in group II intron splicing in vitro and in vivo. J Mol Biol (2011) 0.90
The retrohoming of linear group II intron RNAs in Drosophila melanogaster occurs by both DNA ligase 4-dependent and -independent mechanisms. PLoS Genet (2012) 0.89
Enhanced group II intron retrohoming in magnesium-deficient Escherichia coli via selection of mutations in the ribozyme core. Proc Natl Acad Sci U S A (2013) 0.88
RNA polymerase II and TAFs undergo a slow isomerization after the polymerase is recruited to promoter-bound TFIID. J Mol Biol (2010) 0.88
High-affinity binding site for a group II intron-encoded reverse transcriptase/maturase within a stem-loop structure in the intron RNA. RNA (2004) 0.87
Genetic identification of potential RNA-binding regions in a group II intron-encoded reverse transcriptase. RNA (2010) 0.87
Atomic force microscopy reveals DNA bending during group II intron ribonucleoprotein particle integration into double-stranded DNA. Biochemistry (2006) 0.86
Retargeting mobile group II introns to repair mutant genes. Mol Ther (2005) 0.86
Linear group II intron RNAs can retrohome in eukaryotes and may use nonhomologous end-joining for cDNA ligation. Proc Natl Acad Sci U S A (2009) 0.85
Identification of a hydrophobic cleft in the LytTR domain of AgrA as a locus for small molecule interactions that inhibit DNA binding. Biochemistry (2012) 0.85
Genetic and biochemical assays reveal a key role for replication restart proteins in group II intron retrohoming. PLoS Genet (2013) 0.84
The Neurospora crassa CYT-18 protein C-terminal RNA-binding domain helps stabilize interdomain tertiary interactions in group I introns. RNA (2004) 0.82
High-throughput genetic identification of functionally important regions of the yeast DEAD-box protein Mss116p. J Mol Biol (2011) 0.82
Crystallization and preliminary X-ray diffraction of the DEAD-box protein Mss116p complexed with an RNA oligonucleotide and AMP-PNP. Acta Crystallogr Sect F Struct Biol Cryst Commun (2009) 0.79
Modified Nucleosides of Escherichia coli Ribosomal RNA. Ecosal Plus (2004) 0.76
NMR Structure of the C-terminal domain of a tyrosyl-tRNA synthetase that functions in group I intron splicing. Biochemistry (2011) 0.76
Rapid targeted gene disruption in Bacillus anthracis. BMC Biotechnol (2013) 0.75
High-grade ovarian cancer associated H/ACA snoRNAs promote cancer cell proliferation and survival. NAR Cancer (2022) 0.75