Published in EMBO J on February 05, 2009
How telomeres solve the end-protection problem. Science (2009) 4.54
Alternative lengthening of telomeres: models, mechanisms and implications. Nat Rev Genet (2010) 4.26
Telomeres: protecting chromosomes against genome instability. Nat Rev Mol Cell Biol (2010) 4.23
Super-resolution fluorescence imaging of telomeres reveals TRF2-dependent T-loop formation. Cell (2013) 1.79
Conservation of telomere protein complexes: shuffling through evolution. Crit Rev Biochem Mol Biol (2009) 1.29
Cruciform structures are a common DNA feature important for regulating biological processes. BMC Mol Biol (2011) 1.23
Telomeres: structures in need of unwinding. FEBS Lett (2010) 1.21
FEN1 ensures telomere stability by facilitating replication fork re-initiation. J Biol Chem (2010) 1.14
The role of double-strand break repair pathways at functional and dysfunctional telomeres. Cold Spring Harb Perspect Biol (2014) 1.12
Telomeric circles: universal players in telomere maintenance? Nat Struct Mol Biol (2009) 1.10
The N-terminal domains of TRF1 and TRF2 regulate their ability to condense telomeric DNA. Nucleic Acids Res (2011) 1.04
A three-state model of telomere control over human proliferative boundaries. Curr Opin Cell Biol (2012) 1.04
TRF2 recruits RTEL1 to telomeres in S phase to promote t-loop unwinding. Mol Cell (2015) 1.03
TRF2-Mediated Control of Telomere DNA Topology as a Mechanism for Chromosome-End Protection. Mol Cell (2016) 1.02
Alternative lengthening of telomeres: remodeling the telomere architecture. Front Oncol (2013) 1.00
Telomeric protein TRF2 protects Holliday junctions with telomeric arms from displacement by the Werner syndrome helicase. Nucleic Acids Res (2010) 0.97
Telomeric armor: the layers of end protection. J Cell Sci (2009) 0.95
One identity or more for telomeres? Front Oncol (2013) 0.91
Shelterin Protects Chromosome Ends by Compacting Telomeric Chromatin. Cell (2016) 0.90
The basic N-terminal domain of TRF2 limits recombination endonuclease action at human telomeres. Cell Cycle (2014) 0.89
Ku80 facilitates chromatin binding of the telomere binding protein, TRF2. Cell Cycle (2010) 0.89
SMARCAL1 Resolves Replication Stress at ALT Telomeres. Cell Rep (2016) 0.85
SLX4 contributes to telomere preservation and regulated processing of telomeric joint molecule intermediates. Nucleic Acids Res (2015) 0.85
The telomere binding protein TRF2 induces chromatin compaction. PLoS One (2011) 0.84
Human Rap1 modulates TRF2 attraction to telomeric DNA. Nucleic Acids Res (2015) 0.83
Chromatin structure in telomere dynamics. Front Oncol (2013) 0.82
Control of structure-specific endonucleases to maintain genome stability. Nat Rev Mol Cell Biol (2017) 0.81
TRF1 and TRF2 differentially modulate Rad51-mediated telomeric and nontelomeric displacement loop formation in vitro. Biochemistry (2014) 0.81
How homologous recombination maintains telomere integrity. Chromosoma (2014) 0.81
TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions. Nat Commun (2016) 0.80
Potential Risks in the Paradigm of Basic to Translational Research: A Critical Evaluation of qPCR Telomere Size Techniques. J Cancer Epidemiol Treat (2015) 0.80
Role of STN1 and DNA polymerase α in telomere stability and genome-wide replication in Arabidopsis. PLoS Genet (2014) 0.80
Ku's essential role in keeping telomeres intact. Proc Natl Acad Sci U S A (2009) 0.80
A higher-order entity formed by the flexible assembly of RAP1 with TRF2. Nucleic Acids Res (2016) 0.79
Strand exchange of telomeric DNA catalyzed by the Werner syndrome protein (WRN) is specifically stimulated by TRF2. Nucleic Acids Res (2014) 0.79
Enhanced electrostatic force microscopy reveals higher-order DNA looping mediated by the telomeric protein TRF2. Sci Rep (2016) 0.79
Targeting the telomere and shelterin complex for cancer therapy: current views and future perspectives. J Cell Mol Med (2011) 0.79
To fuse or not to fuse: how do checkpoint and DNA repair proteins maintain telomeres? Front Biosci (Landmark Ed) (2010) 0.78
The DDR at telomeres lacking intact shelterin does not require substantial chromatin decompaction. Genes Dev (2017) 0.77
TRF1 and TRF2 binding to telomeres is modulated by nucleosomal organization. Nucleic Acids Res (2015) 0.77
TRF2 Protein Interacts with Core Histones to Stabilize Chromosome Ends. J Biol Chem (2016) 0.76
SIRT6 interacts with TRF2 and promotes its degradation in response to DNA damage. Nucleic Acids Res (2016) 0.75
How do telomeres and NHEJ coexist? Mol Cell Oncol (2014) 0.75
DSE-FRET: A new anticancer drug screening assay for DNA binding proteins. Cancer Sci (2014) 0.75
The long and the short of TRF2 in neurogenesis. Cell Cycle (2016) 0.75
Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev (2005) 15.19
Mammalian telomeres end in a large duplex loop. Cell (1999) 12.12
TRF2 protects human telomeres from end-to-end fusions. Cell (1998) 10.13
Telomere maintenance by recombination in human cells. Nat Genet (2000) 5.14
Homologous recombination generates T-loop-sized deletions at human telomeres. Cell (2004) 4.85
Senescence induced by altered telomere state, not telomere loss. Science (2002) 4.17
Replication and protection of telomeres. Nature (2007) 3.98
The DNA damage machinery and homologous recombination pathway act consecutively to protect human telomeres. Cell (2006) 3.45
Identification of Holliday junction resolvases from humans and yeast. Nature (2008) 3.33
T-loop assembly in vitro involves binding of TRF2 near the 3' telomeric overhang. EMBO J (2001) 3.28
How telomeres are replicated. Nat Rev Mol Cell Biol (2007) 3.27
RAD51C is required for Holliday junction processing in mammalian cells. Science (2004) 3.05
ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes. Mol Cell (2003) 3.01
Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest. EMBO Rep (2000) 2.88
Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins. J Biol Chem (2004) 2.76
A RAP1/TRF2 complex inhibits nonhomologous end-joining at human telomeric DNA ends. Mol Cell (2007) 2.67
Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases. J Biol Chem (2002) 2.53
The kinetics of spontaneous DNA branch migration. Proc Natl Acad Sci U S A (1994) 2.41
Targeting assay to study the cis functions of human telomeric proteins: evidence for inhibition of telomerase by TRF1 and for activation of telomere degradation by TRF2. Mol Cell Biol (2002) 2.25
Rad54 protein promotes branch migration of Holliday junctions. Nature (2006) 2.08
Topoisomerase IIIalpha and Bloom's helicase can resolve a mobile double Holliday junction substrate through convergent branch migration. Proc Natl Acad Sci U S A (2006) 1.83
TRF1 promotes parallel pairing of telomeric tracts in vitro. J Mol Biol (1998) 1.73
TRF2 is required for repair of nontelomeric DNA double-strand breaks by homologous recombination. Proc Natl Acad Sci U S A (2007) 1.67
A topological mechanism for TRF2-enhanced strand invasion. Nat Struct Mol Biol (2007) 1.65
Observing spontaneous branch migration of Holliday junctions one step at a time. Proc Natl Acad Sci U S A (2005) 1.60
Crystal structure of T4 endonuclease VII resolving a Holliday junction. Nature (2007) 1.59
The structure-selectivity and sequence-preference of the junction-resolving enzyme CCE1 of Saccharomyces cerevisiae. J Mol Biol (1996) 1.49
The basic domain of TRF2 directs binding to DNA junctions irrespective of the presence of TTAGGG repeats. J Biol Chem (2006) 1.45
WRN controls formation of extrachromosomal telomeric circles and is required for TRF2DeltaB-mediated telomere shortening. Mol Cell Biol (2008) 1.39
Cleavage specificity of bacteriophage T4 endonuclease VII and bacteriophage T7 endonuclease I on synthetic branch migratable Holliday junctions. J Mol Biol (1990) 1.38
Replication fork regression in repetitive DNAs. Nucleic Acids Res (2006) 1.35
New insight into the recognition of branched DNA structure by junction-resolving enzymes. Curr Opin Struct Biol (2007) 1.30
Topoisomerase IIIalpha is required for normal proliferation and telomere stability in alternative lengthening of telomeres. EMBO J (2008) 1.15
Structural recognition and distortion by the DNA junction-resolving enzyme RusA. J Mol Biol (1998) 1.15
Role of mammalian Rad54 in telomere length maintenance. Mol Cell Biol (2003) 0.99
Differential scanning calorimetry. Methods Cell Biol (2008) 0.99
The structure of Escherichia coli RusA endonuclease reveals a new Holliday junction DNA binding fold. Structure (2003) 0.90
Structural recognition between a four-way DNA junction and a resolving enzyme. J Mol Biol (2006) 0.89
Kinetic studies on promoter-RNA polymerase complexes. Methods Enzymol (1991) 0.87
DNA interstrand crosslink repair and cancer. Nat Rev Cancer (2011) 4.29
Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM. Mol Cell (2007) 4.28
Structural dynamics of individual Holliday junctions. Nat Struct Biol (2003) 4.00
Folding of the adenine riboswitch. Chem Biol (2006) 3.95
CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair. Nature (2005) 3.90
RTEL1 maintains genomic stability by suppressing homologous recombination. Cell (2008) 3.84
Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1. Science (2009) 3.68
Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins. Nature (2008) 3.67
Stabilization of RAD51 nucleoprotein filaments by the C-terminal region of BRCA2. Nat Struct Mol Biol (2007) 3.45
Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2. Cell (2010) 3.43
Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair. Mol Cell (2009) 3.38
Identification of Holliday junction resolvases from humans and yeast. Nature (2008) 3.33
Structural and functional relationships of the XPF/MUS81 family of proteins. Annu Rev Biochem (2008) 3.32
Human DNA polymerase eta promotes DNA synthesis from strand invasion intermediates of homologous recombination. Mol Cell (2005) 3.16
Nuclear architecture and spatial positioning help establish transcriptional states of telomeres in yeast. Nat Cell Biol (2002) 3.16
A role for small RNAs in DNA double-strand break repair. Cell (2012) 3.15
RAD51C is required for Holliday junction processing in mammalian cells. Science (2004) 3.05
The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates. Nature (2006) 2.86
A four-way junction accelerates hairpin ribozyme folding via a discrete intermediate. Proc Natl Acad Sci U S A (2003) 2.65
Defective DNA repair and neurodegenerative disease. Cell (2007) 2.57
Fluorescence-force spectroscopy maps two-dimensional reaction landscape of the holliday junction. Science (2007) 2.49
Identification and characterization of the human mus81-eme1 endonuclease. J Biol Chem (2003) 2.43
Can one predict DNA transcription start sites by studying bubbles? Phys Rev Lett (2005) 2.39
Vesicle encapsulation studies reveal that single molecule ribozyme heterogeneities are intrinsic. Biophys J (2004) 2.37
Human RECQ5beta, a protein with DNA helicase and strand-annealing activities in a single polypeptide. EMBO J (2004) 2.33
FANCM connects the genome instability disorders Bloom's Syndrome and Fanconi Anemia. Mol Cell (2009) 2.29
Targeting assay to study the cis functions of human telomeric proteins: evidence for inhibition of telomerase by TRF1 and for activation of telomere degradation by TRF2. Mol Cell Biol (2002) 2.25
Structure of the single-strand annealing domain of human RAD52 protein. Proc Natl Acad Sci U S A (2002) 2.24
Orientation dependence in fluorescent energy transfer between Cy3 and Cy5 terminally attached to double-stranded nucleic acids. Proc Natl Acad Sci U S A (2008) 2.24
FANCM and FAAP24 function in ATR-mediated checkpoint signaling independently of the Fanconi anemia core complex. Mol Cell (2008) 2.14
Single-stranded DNA-binding protein hSSB1 is critical for genomic stability. Nature (2008) 2.12
Interplay between human DNA repair proteins at a unique double-strand break in vivo. EMBO J (2006) 2.09
Holliday junction resolution in human cells: two junction endonucleases with distinct substrate specificities. EMBO J (2002) 2.09
The kink-turn motif in RNA is dimorphic, and metal ion-dependent. RNA (2004) 2.08
Regulatory control of the resolution of DNA recombination intermediates during meiosis and mitosis. Cell (2011) 2.08
BRCA2-dependent and independent formation of RAD51 nuclear foci. Oncogene (2003) 2.03
Folding of the natural hammerhead ribozyme is enhanced by interaction of auxiliary elements. RNA (2004) 1.99
Aberrant chromosome morphology in human cells defective for Holliday junction resolution. Nature (2011) 1.97
The Apollo 5' exonuclease functions together with TRF2 to protect telomeres from DNA repair. Curr Biol (2006) 1.95
XRCC3 and Rad51 modulate replication fork progression on damaged vertebrate chromosomes. Mol Cell (2003) 1.94
Involvement of human polynucleotide kinase in double-strand break repair by non-homologous end joining. EMBO J (2002) 1.93
Natural and pharmacological regulation of telomerase. Nucleic Acids Res (2002) 1.92
Telomere maintenance requires the RAD51D recombination/repair protein. Cell (2004) 1.89
The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA. Nat Struct Mol Biol (2010) 1.85
RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling. Proc Natl Acad Sci U S A (2007) 1.79
Human telomeric position effect is determined by chromosomal context and telomeric chromatin integrity. EMBO Rep (2002) 1.79
Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways. Hum Mol Genet (2004) 1.73
RTEL-1 enforces meiotic crossover interference and homeostasis. Science (2010) 1.70
Eme1 is involved in DNA damage processing and maintenance of genomic stability in mammalian cells. EMBO J (2003) 1.68
BRCA2 BRC motifs bind RAD51-DNA filaments. Proc Natl Acad Sci U S A (2005) 1.68
Coordinated actions of SLX1-SLX4 and MUS81-EME1 for Holliday junction resolution in human cells. Mol Cell (2013) 1.67
A topological mechanism for TRF2-enhanced strand invasion. Nat Struct Mol Biol (2007) 1.65
RPA regulates telomerase action by providing Est1p access to chromosome ends. Nat Genet (2003) 1.65
CST meets shelterin to keep telomeres in check. Mol Cell (2010) 1.63
RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females. J Cell Biol (2007) 1.62
The G-quadruplex ligand telomestatin inhibits POT1 binding to telomeric sequences in vitro and induces GFP-POT1 dissociation from telomeres in human cells. Cancer Res (2006) 1.62
Observing spontaneous branch migration of Holliday junctions one step at a time. Proc Natl Acad Sci U S A (2005) 1.60
Observation of internal cleavage and ligation reactions of a ribozyme. Nat Struct Mol Biol (2004) 1.58
Induced fit of RNA on binding the L7Ae protein to the kink-turn motif. RNA (2005) 1.58
Telomeric position effect: from the yeast paradigm to human pathologies? Biochimie (2007) 1.57
Cooperative control of holliday junction resolution and DNA repair by the SLX1 and MUS81-EME1 nucleases. Mol Cell (2013) 1.57
Role of RAD51C and XRCC3 in genetic recombination and DNA repair. J Biol Chem (2006) 1.56
Mechanism of Holliday junction resolution by the human GEN1 protein. Genes Dev (2010) 1.54
A two-step model for senescence triggered by a single critically short telomere. Nat Cell Biol (2009) 1.51
TRF2 and apollo cooperate with topoisomerase 2alpha to protect human telomeres from replicative damage. Cell (2010) 1.50
Exploring rare conformational species and ionic effects in DNA Holliday junctions using single-molecule spectroscopy. J Mol Biol (2004) 1.50
Positioning of nuclei in Arabidopsis root hairs: an actin-regulated process of tip growth. Plant Cell (2002) 1.48
Functional overlap between the structure-specific nucleases Yen1 and Mus81-Mms4 for DNA-damage repair in S. cerevisiae. DNA Repair (Amst) (2010) 1.48
InTERTpreting telomerase structure and function. Nucleic Acids Res (2010) 1.47
Happy Hollidays: 40th anniversary of the Holliday junction. Nat Rev Mol Cell Biol (2004) 1.47
Solution structure of the E.coli TolA C-terminal domain reveals conformational changes upon binding to the phage g3p N-terminal domain. J Mol Biol (2005) 1.46
Cisplatin is a DNA-damaging antitumour compound triggering multifactorial biochemical responses in cancer cells: importance of apoptotic pathways. Curr Med Chem Anticancer Agents (2005) 1.42
DNA repair synthesis facilitates RAD52-mediated second-end capture during DSB repair. Mol Cell (2008) 1.41
Role of mammalian RAD51L2 (RAD51C) in recombination and genetic stability. J Biol Chem (2002) 1.41
General regulatory factors (GRFs) as genome partitioners. J Biol Chem (2002) 1.39
Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect. J Clin Invest (2007) 1.39
The human enhancer blocker CTC-binding factor interacts with the transcription factor Kaiso. J Biol Chem (2005) 1.37
The D4Z4 macrosatellite repeat acts as a CTCF and A-type lamins-dependent insulator in facio-scapulo-humeral dystrophy. PLoS Genet (2009) 1.37
In vivo analysis of local wall stiffness at the shoot apical meristem in Arabidopsis using atomic force microscopy. Plant J (2011) 1.37
Repeated early hemofiltration filters clotting and heparin-induced thrombocytopenia in ICU. J Clin Monit Comput (2014) 1.36
The DNA damage response at eroded telomeres and tethering to the nuclear pore complex. Nat Cell Biol (2009) 1.36
Unlinking chromosome catenanes in vivo by site-specific recombination. EMBO J (2007) 1.35
Folding and activity of the hammerhead ribozyme. Chembiochem (2002) 1.34
The complete VS ribozyme in solution studied by small-angle X-ray scattering. Structure (2008) 1.34
The global structure of the VS ribozyme. EMBO J (2002) 1.34
Protein protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein. Proc Natl Acad Sci U S A (2007) 1.34
Interactions between human BRCA2 protein and the meiosis-specific recombinase DMC1. EMBO J (2007) 1.33