Published in Nat Immunol on September 09, 2012
The plasticity and stability of regulatory T cells. Nat Rev Immunol (2013) 2.15
Aryl hydrocarbon receptor control of adaptive immunity. Pharmacol Rev (2013) 1.38
Immunological Genome Project and systems immunology. Trends Immunol (2013) 1.34
Regulatory T-cell therapy in transplantation: moving to the clinic. Cold Spring Harb Perspect Med (2013) 1.29
Once a Treg, always a Treg? Immunol Rev (2014) 1.27
Inflammation-induced repression of chromatin bound by the transcription factor Foxp3 in regulatory T cells. Nat Immunol (2014) 1.21
Treg and CTLA-4: two intertwining pathways to immune tolerance. J Autoimmun (2013) 1.18
Harnessing the plasticity of CD4(+) T cells to treat immune-mediated disease. Nat Rev Immunol (2016) 1.15
Differential roles of epigenetic changes and Foxp3 expression in regulatory T cell-specific transcriptional regulation. Proc Natl Acad Sci U S A (2014) 1.12
Helios induces epigenetic silencing of IL2 gene expression in regulatory T cells. J Immunol (2012) 1.06
Helios Controls a Limited Subset of Regulatory T Cell Functions. J Immunol (2015) 1.03
Interindividual variation in human T regulatory cells. Proc Natl Acad Sci U S A (2014) 1.01
Treg functional stability and its responsiveness to the microenvironment. Immunol Rev (2014) 1.01
Overlapping gene coexpression patterns in human medullary thymic epithelial cells generate self-antigen diversity. Proc Natl Acad Sci U S A (2013) 0.98
Molecular determinants of regulatory T cell development: the essential roles of epigenetic changes. Front Immunol (2013) 0.98
Transcriptional and epigenetic regulation of T-helper lineage specification. Immunol Rev (2014) 0.97
Adipose tissue-resident regulatory T cells: phenotypic specialization, functions and therapeutic potential. Immunology (2014) 0.95
Transcriptional and epigenetic networks of helper T and innate lymphoid cells. Immunol Rev (2014) 0.93
Transcription factors and CD4 T cells seeking identity: masters, minions, setters and spikers. Immunology (2013) 0.93
Transcription factor interplay in T helper cell differentiation. Brief Funct Genomics (2013) 0.92
Differential control of Helios(+/-) Treg development by monocyte subsets through disparate inflammatory cytokines. Blood (2013) 0.92
Regulatory T cell identity: formation and maintenance. Trends Immunol (2015) 0.91
Epigenetic modulation of type-1 diabetes via a dual effect on pancreatic macrophages and β cells. Elife (2014) 0.91
PLAU inferred from a correlation network is critical for suppressor function of regulatory T cells. Mol Syst Biol (2012) 0.89
Bach2 regulates homeostasis of Foxp3+ regulatory T cells and protects against fatal lung disease in mice. J Immunol (2013) 0.88
Regulators of chromatin state and transcription in CD4 T-cell polarization. Immunology (2013) 0.87
Protein phosphatase 2A enables expression of interleukin 17 (IL-17) through chromatin remodeling. J Biol Chem (2013) 0.85
Aire's plant homeodomain(PHD)-2 is critical for induction of immunological tolerance. Proc Natl Acad Sci U S A (2013) 0.84
Transcription Factor Repertoire of Homeostatic Eosinophilopoiesis. J Immunol (2015) 0.84
HIV-1 infection impairs regulatory T-cell suppressive capacity on a per-cell basis. J Infect Dis (2014) 0.83
Plasticity within the αβ⁺CD4⁺ T-cell lineage: when, how and what for? Open Biol (2013) 0.83
SOCS1 and regulation of regulatory T cells plasticity. J Immunol Res (2014) 0.82
Ubiquitin-specific Protease-7 Inhibition Impairs Tip60-dependent Foxp3+ T-regulatory Cell Function and Promotes Antitumor Immunity. EBioMedicine (2016) 0.82
TNF-α trips up Treg cells in rheumatoid arthritis. Nat Med (2013) 0.82
Transcription factor IRF8 controls Th1-like regulatory T-cell function. Cell Mol Immunol (2015) 0.81
Different molecular complexes that mediate transcriptional induction and repression by FoxP3. Nat Immunol (2017) 0.80
Helper T cell plasticity: impact of extrinsic and intrinsic signals on transcriptomes and epigenomes. Curr Top Microbiol Immunol (2014) 0.80
The Foxp3 interactome: a network perspective of T(reg) cells. Nat Immunol (2012) 0.80
Inflammation negatively regulates FOXP3 and regulatory T-cell function via DBC1. Proc Natl Acad Sci U S A (2015) 0.80
Transcriptome profiling of human FoxP3(+) regulatory T cells. Hum Immunol (2015) 0.80
T-cell tolerance in cancer. Immunotherapy (2013) 0.79
Searching for the Achilles Heel of FOXP3. Front Oncol (2013) 0.79
Regulation of central nervous system autoimmunity by the aryl hydrocarbon receptor. Semin Immunopathol (2013) 0.79
Unstable FoxP3+ T regulatory cells in NZW mice. Proc Natl Acad Sci U S A (2016) 0.79
In vitro induced regulatory T cells are unique from endogenous regulatory T cells and effective at suppressing late stages of ongoing autoimmunity. PLoS One (2014) 0.78
Epigenetic enzymes are the therapeutic targets for CD4(+)CD25(+/high)Foxp3(+) regulatory T cells. Transl Res (2014) 0.78
Ubiquitin-dependent regulation of Foxp3 and Treg function. Immunol Rev (2015) 0.78
In vivo induction of regulatory T cells for immune tolerance in hemophilia. Cell Immunol (2015) 0.78
LAG3 limits regulatory T cell proliferation and function in autoimmune diabetes. Sci Immunol (2017) 0.78
Regulatory T-Cell Therapy for Graft-versus-host Disease. J Immunol Res Ther (2016) 0.77
Human macrophages induce CD4(+)Foxp3(+) regulatory T cells via binding and re-release of TGF-β. Immunol Cell Biol (2016) 0.77
Comparative Analysis of Protocols to Induce Human CD4+Foxp3+ Regulatory T Cells by Combinations of IL-2, TGF-beta, Retinoic Acid, Rapamycin and Butyrate. PLoS One (2016) 0.77
Immuno-Navigator, a batch-corrected coexpression database, reveals cell type-specific gene networks in the immune system. Proc Natl Acad Sci U S A (2016) 0.77
Identity crisis: it's not just Foxp3 anymore. Immunity (2012) 0.77
PKC-Theta in Regulatory and Effector T-cell Functions. Front Immunol (2015) 0.77
The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells. Elife (2015) 0.77
Eos Is Redundant for Regulatory T Cell Function but Plays an Important Role in IL-2 and Th17 Production by CD4+ Conventional T Cells. J Immunol (2015) 0.76
Ubiquitous points of control over regulatory T cells. J Mol Med (Berl) (2014) 0.76
Functional Mechanisms of Treg in the Context of HIV Infection and the Janus Face of Immune Suppression. Front Immunol (2016) 0.76
Writ large: Genomic dissection of the effect of cellular environment on immune response. Science (2016) 0.76
CD8(+) Tregs promote GVHD prevention and overcome the impaired GVL effect mediated by CD4(+) Tregs in mice. Oncoimmunology (2016) 0.76
MicroRNA-17 Modulates Regulatory T Cell Function by Targeting Co-regulators of the Foxp3 Transcription Factor. Immunity (2016) 0.76
The regulation of immune tolerance by FOXP3. Nat Rev Immunol (2017) 0.76
Stabilization of Foxp3 expression by CRISPR-dCas9-based epigenome editing in mouse primary T cells. Epigenetics Chromatin (2017) 0.75
Humoral Immunodeficiency with Hypotonia, Feeding Difficulties, Enteropathy, and Mild Eczema Caused by a Classical FOXP3 Mutation. Front Pediatr (2017) 0.75
Regulatory T Cells: Central Concepts from Ontogeny to Therapy. Transfus Med Rev (2016) 0.75
Flicr, a long noncoding RNA, modulates Foxp3 expression and autoimmunity. Proc Natl Acad Sci U S A (2017) 0.75
One way to pathogenesis, many ways to homeostasis. Cell Mol Immunol (2012) 0.75
Mixed Integer Linear Programming based machine learning approach identifies regulators of telomerase in yeast. Nucleic Acids Res (2016) 0.75
Antigenic Stimulation of Kv1.3-Deficient Th Cells Gives Rise to a Population of Foxp3-Independent T Cells with Suppressive Properties. J Immunol (2015) 0.75
Human lung tumor FOXP+ Tregs upregulate four "Treg-locking" transcription factors. JCI Insight (2017) 0.75
A tissue-specific promoter derived from a SINE retrotransposon drives biallelic expression of PLAGL1 in human lymphocytes. PLoS One (2017) 0.75
Molecular mechanisms underlying Th1-like Treg generation and function. Cell Mol Life Sci (2017) 0.75
Control of Regulatory T Cell Differentiation by the Transcription Factors Thpok and LRF. J Immunol (2017) 0.75
Control of regulatory T cell development by the transcription factor Foxp3. Science (2003) 40.32
GenePattern 2.0. Nat Genet (2006) 29.07
Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity (2005) 23.00
Regulatory T cells and immune tolerance. Cell (2008) 18.77
TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature (2008) 14.26
Reverse engineering of regulatory networks in human B cells. Nat Genet (2005) 13.16
How regulatory T cells work. Nat Rev Immunol (2008) 11.66
c-Myc regulates transcriptional pause release. Cell (2010) 11.64
Large-scale mapping and validation of Escherichia coli transcriptional regulation from a compendium of expression profiles. PLoS Biol (2007) 10.46
An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation. Cell (2009) 10.09
Regulatory T cells: mechanisms of differentiation and function. Annu Rev Immunol (2012) 9.75
Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells. J Immunol (2010) 9.72
Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med (2009) 9.71
Foxp3-dependent programme of regulatory T-cell differentiation. Nature (2007) 9.48
FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell (2006) 9.24
Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo. Nat Immunol (2009) 8.65
The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation. Nat Immunol (2009) 8.32
FOXP3: of mice and men. Annu Rev Immunol (2006) 6.89
Control of the embryonic stem cell state. Cell (2011) 6.89
Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses. Nature (2009) 6.65
CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner. Science (2009) 6.14
Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor? Immunity (2009) 6.11
Regulation of hepatic lipogenesis by the transcription factor XBP1. Science (2008) 6.02
HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells. J Exp Med (2011) 5.99
Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature. Immunity (2007) 5.67
Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1. Cell (2011) 5.63
Regulatory T cell development in the absence of functional Foxp3. Nat Immunol (2007) 5.44
Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1. Nature (2007) 5.14
Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivo. J Exp Med (2002) 5.07
Stability of the regulatory T cell lineage in vivo. Science (2010) 4.89
Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches. Science (2009) 4.80
Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis. Nat Immunol (2009) 4.76
lambda Repressor and cro--components of an efficient molecular switch. Nature (1981) 4.52
A two-step process for thymic regulatory T cell development. Immunity (2008) 4.29
Heterogeneity of natural Foxp3+ T cells: a committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity. Proc Natl Acad Sci U S A (2009) 4.25
Foxp3+ regulatory T cells: differentiation, specification, subphenotypes. Nat Immunol (2009) 4.07
Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire. Immunity (2008) 3.56
Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells. Immunity (2008) 3.25
Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage? Nat Rev Immunol (2009) 3.23
Foxp3-dependent and -independent molecules specific for CD25+CD4+ natural regulatory T cells revealed by DNA microarray analysis. Int Immunol (2006) 2.93
Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells. Science (2009) 2.76
Reverse-engineering transcription control networks. Phys Life Rev (2005) 2.59
Natural Treg cells spontaneously differentiate into pathogenic helper cells in lymphopenic conditions. Eur J Immunol (2009) 2.21
Identification of FOXP3-negative regulatory T-like (CD4(+)CD25(+)CD127(low)) cells in patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome. Clin Immunol (2011) 1.57
Helios deficiency has minimal impact on T cell development and function. J Immunol (2009) 1.50
Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation. Nat Immunol (2011) 1.49
Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells. Proc Natl Acad Sci U S A (2011) 1.38
An intrinsic mechanism predisposes Foxp3-expressing regulatory T cells to Th2 conversion in vivo. J Immunol (2010) 1.24
A genetic switch for long-term memory. C R Acad Sci III (1998) 0.96
Probabilistic discovery of overlapping cellular processes and their regulation. J Comput Biol (2005) 0.90
Stochasticity in gene expression: from theories to phenotypes. Nat Rev Genet (2005) 14.39
Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell (2010) 14.18
A common mechanism of cellular death induced by bactericidal antibiotics. Cell (2007) 12.92
Projection of an immunological self shadow within the thymus by the aire protein. Science (2002) 12.15
Large-scale mapping and validation of Escherichia coli transcriptional regulation from a compendium of expression profiles. PLoS Biol (2007) 10.46
Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med (2009) 9.71
FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell (2006) 9.24
Inferring genetic networks and identifying compound mode of action via expression profiling. Science (2003) 9.10
Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity (2010) 8.90
Synthetic biology: applications come of age. Nat Rev Genet (2010) 6.96
Wisdom of crowds for robust gene network inference. Nat Methods (2012) 6.91
Decidual NK cells regulate key developmental processes at the human fetal-maternal interface. Nat Med (2006) 6.54
The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells. J Exp Med (2008) 6.07
Gut immune maturation depends on colonization with a host-specific microbiota. Cell (2012) 5.91
Mast cells: a cellular link between autoantibodies and inflammatory arthritis. Science (2002) 5.82
Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature. Immunity (2007) 5.67
Sublethal antibiotic treatment leads to multidrug resistance via radical-induced mutagenesis. Mol Cell (2010) 5.33
Arthritis critically dependent on innate immune system players. Immunity (2002) 5.31
Reverse engineering gene networks using singular value decomposition and robust regression. Proc Natl Acad Sci U S A (2002) 5.29
Cytokine requirements for acute and Basal homeostatic proliferation of naive and memory CD8+ T cells. J Exp Med (2002) 5.09
Engineered riboregulators enable post-transcriptional control of gene expression. Nat Biotechnol (2004) 5.07
Phenotypic consequences of promoter-mediated transcriptional noise. Mol Cell (2006) 4.93
Stability of the regulatory T cell lineage in vivo. Science (2010) 4.89
Reverse engineering gene networks: integrating genetic perturbations with dynamical modeling. Proc Natl Acad Sci U S A (2003) 4.89
The cellular mechanism of Aire control of T cell tolerance. Immunity (2005) 4.74
Programmable cells: interfacing natural and engineered gene networks. Proc Natl Acad Sci U S A (2004) 4.72
How antibiotics kill bacteria: from targets to networks. Nat Rev Microbiol (2010) 4.65
Synthetic gene networks that count. Science (2009) 4.54
Mistranslation of membrane proteins and two-component system activation trigger antibiotic-mediated cell death. Cell (2008) 4.47
Cellular decision making and biological noise: from microbes to mammals. Cell (2011) 4.44
Aire. Annu Rev Immunol (2009) 4.43
PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells. Nature (2012) 4.31
Foxp3+ regulatory T cells: differentiation, specification, subphenotypes. Nat Immunol (2009) 4.07
Metabolite-enabled eradication of bacterial persisters by aminoglycosides. Nature (2011) 4.06
Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer. Nature (2010) 4.01
Gyrase inhibitors induce an oxidative damage cellular death pathway in Escherichia coli. Mol Syst Biol (2007) 3.98
Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling. Genome Biol (2008) 3.93
Chemogenomic profiling on a genome-wide scale using reverse-engineered gene networks. Nat Biotechnol (2005) 3.89
Diversity-based, model-guided construction of synthetic gene networks with predicted functions. Nat Biotechnol (2009) 3.86
CD4+CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion. J Exp Med (2004) 3.57
Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic mice. Proc Natl Acad Sci U S A (2011) 3.55
Bacterial charity work leads to population-wide resistance. Nature (2010) 3.50
Programmable bacteria detect and record an environmental signal in the mammalian gut. Proc Natl Acad Sci U S A (2014) 3.50
Vibrating insoles and balance control in elderly people. Lancet (2003) 3.48
Adaptation of TCR repertoires to self-peptides in regulatory and nonregulatory CD4+ T cells. J Immunol (2007) 3.47
RNA synthetic biology. Nat Biotechnol (2006) 3.37
Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth. Proc Natl Acad Sci U S A (2008) 3.27
Donor cell type can influence the epigenome and differentiation potential of human induced pluripotent stem cells. Nat Biotechnol (2011) 3.25
Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells. Immunity (2008) 3.25
How antibodies to a ubiquitous cytoplasmic enzyme may provoke joint-specific autoimmune disease. Nat Immunol (2002) 3.20
Antigen persistence is required throughout the expansion phase of a CD4(+) T cell response. J Exp Med (2005) 3.14
Next-generation synthetic gene networks. Nat Biotechnol (2009) 3.12
A special population of regulatory T cells potentiates muscle repair. Cell (2013) 3.09
A comprehensive review of interventions in the NOD mouse and implications for translation. Immunity (2005) 3.07
Antibiotic treatment expands the resistance reservoir and ecological network of the phage metagenome. Nature (2013) 3.02
Engineered bacteriophage targeting gene networks as adjuvants for antibiotic therapy. Proc Natl Acad Sci U S A (2009) 3.01
Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice. Nat Rev Immunol (2008) 2.98
Critical roles for interleukin 1 and tumor necrosis factor alpha in antibody-induced arthritis. J Exp Med (2002) 2.98
Signaling-mediated bacterial persister formation. Nat Chem Biol (2012) 2.96
Physiological beta cell death triggers priming of self-reactive T cells by dendritic cells in a type-1 diabetes model. J Exp Med (2003) 2.94
Reprogramming of T cells from human peripheral blood. Cell Stem Cell (2010) 2.93
Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells. J Exp Med (2004) 2.92
Dispersing biofilms with engineered enzymatic bacteriophage. Proc Natl Acad Sci U S A (2007) 2.87
Cre-mediated cell ablation contests mast cell contribution in models of antibody- and T cell-mediated autoimmunity. Immunity (2011) 2.87
Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire. J Exp Med (2007) 2.84
A tunable genetic switch based on RNAi and repressor proteins for regulating gene expression in mammalian cells. Cell (2007) 2.83
Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells. Proc Natl Acad Sci U S A (2006) 2.83
'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR. Nat Immunol (2007) 2.80