Published in Proc Natl Acad Sci U S A on March 07, 2014
Genetics of autoimmune diseases: perspectives from genome-wide association studies. Int Immunol (2016) 0.93
A pilot study showing associations between frequency of CD4(+) memory cell subsets at diagnosis and duration of partial remission in type 1 diabetes. Clin Immunol (2016) 0.92
Genomic modulators of gene expression in human neutrophils. Nat Commun (2015) 0.91
Type 1 diabetes vaccine candidates promote human Foxp3(+)Treg induction in humanized mice. Nat Commun (2016) 0.89
Autoimmune diseases - connecting risk alleles with molecular traits of the immune system. Nat Rev Genet (2016) 0.88
High Graft CD8 Cell Dose Predicts Improved Survival and Enables Better Donor Selection in Allogeneic Stem-Cell Transplantation With Reduced-Intensity Conditioning. J Clin Oncol (2015) 0.87
Genetics of gene expression in immunity to infection. Curr Opin Immunol (2014) 0.84
Expression of CD39 on Activated T Cells Impairs their Survival in Older Individuals. Cell Rep (2016) 0.84
Divergent Phenotypes of Human Regulatory T Cells Expressing the Receptors TIGIT and CD226. J Immunol (2015) 0.83
Variation and genetic control of gene expression in primary immunocytes across inbred mouse strains. J Immunol (2014) 0.83
Pathogenic implications for autoimmune mechanisms derived by comparative eQTL analysis of CD4+ versus CD8+ T cells. PLoS Genet (2017) 0.82
The role of regulatory T cells in cancer immunology. Immunotargets Ther (2015) 0.82
Different molecular complexes that mediate transcriptional induction and repression by FoxP3. Nat Immunol (2017) 0.80
Transcriptome profiling of human FoxP3(+) regulatory T cells. Hum Immunol (2015) 0.80
Unstable FoxP3+ T regulatory cells in NZW mice. Proc Natl Acad Sci U S A (2016) 0.79
Deep phenotyping of Tregs identifies an immune signature for idiopathic aplastic anemia and predicts response to treatment. Blood (2016) 0.78
Genetic and epigenetic variation in the lineage specification of regulatory T cells. Elife (2015) 0.78
Genetics and immunity in the era of single-cell genomics. Hum Mol Genet (2016) 0.78
Network pharmacology of JAK inhibitors. Proc Natl Acad Sci U S A (2016) 0.77
Dual-Specificity Phosphatase 4 Regulates STAT5 Protein Stability and Helper T Cell Polarization. PLoS One (2015) 0.76
Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity. J Vis Exp (2016) 0.75
Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements. Nat Genet (2017) 0.75
PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet (2007) 209.92
Empirical threshold values for quantitative trait mapping. Genetics (1994) 46.95
Control of regulatory T cell development by the transcription factor Foxp3. Science (2003) 40.32
Population genomics of human gene expression. Nat Genet (2007) 24.49
Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity (2005) 23.00
Regulatory T cells and immune tolerance. Cell (2008) 18.77
B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity (2000) 15.44
Module networks: identifying regulatory modules and their condition-specific regulators from gene expression data. Nat Genet (2003) 14.56
How regulatory T cells work. Nat Rev Immunol (2008) 11.66
Common regulatory variation impacts gene expression in a cell type-dependent manner. Science (2009) 11.28
Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J Exp Med (2007) 10.00
Foxp3-dependent programme of regulatory T-cell differentiation. Nature (2007) 9.48
Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios. Science (2003) 9.20
The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation. Nat Immunol (2009) 8.32
In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes. J Exp Med (2004) 8.00
FOXP3: of mice and men. Annu Rev Immunol (2006) 6.89
Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses. Nature (2009) 6.65
Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor? Immunity (2009) 6.11
Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction. Immunity (2008) 6.08
Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression. Blood (2007) 6.03
Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature. Immunity (2007) 5.67
Regulatory T cell development in the absence of functional Foxp3. Nat Immunol (2007) 5.44
Coordination of early protective immunity to viral infection by regulatory T cells. Science (2008) 5.33
CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes. J Exp Med (2004) 4.35
Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes. Diabetes (2005) 4.34
PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells. Nature (2012) 4.31
Foxp3+ regulatory T cells: differentiation, specification, subphenotypes. Nat Immunol (2009) 4.07
Mechanisms of impaired regulation by CD4(+)CD25(+)FOXP3(+) regulatory T cells in human autoimmune diseases. Nat Rev Immunol (2010) 3.69
From evolutionary genetics to human immunology: how selection shapes host defence genes. Nat Rev Genet (2009) 2.98
Foxp3-dependent and -independent molecules specific for CD25+CD4+ natural regulatory T cells revealed by DNA microarray analysis. Int Immunol (2006) 2.93
Foxp3 exploits a pre-existent enhancer landscape for regulatory T cell lineage specification. Cell (2012) 2.79
Functional defects and the influence of age on the frequency of CD4+ CD25+ T-cells in type 1 diabetes. Diabetes (2005) 2.63
Where CD4+CD25+ T reg cells impinge on autoimmune diabetes. J Exp Med (2005) 2.61
Defective regulatory and effector T cell functions in patients with FOXP3 mutations. J Clin Invest (2006) 2.58
The effector T cells of diabetic subjects are resistant to regulation via CD4+ FOXP3+ regulatory T cells. J Immunol (2008) 2.39
Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes. J Immunol (2011) 2.39
The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. Nat Immunol (2008) 2.34
CD4+CD25high regulatory T cells in human autoimmune diabetes. J Autoimmun (2005) 1.96
A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells. Nat Immunol (2012) 1.93
Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjects. Diabetes (2009) 1.88
Regulatory T cells increase the avidity of primary CD8+ T cell responses and promote memory. Science (2012) 1.88
Genetics of type 1 diabetes: what's next? Diabetes (2010) 1.80
The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity. Proc Natl Acad Sci U S A (2009) 1.77
Loss of epigenetic modification driven by the Foxp3 transcription factor leads to regulatory T cell insufficiency. Immunity (2012) 1.61
Enhanced thymic selection of FoxP3+ regulatory T cells in the NOD mouse model of autoimmune diabetes. Proc Natl Acad Sci U S A (2007) 1.51
An N-terminal mutation of the Foxp3 transcription factor alleviates arthritis but exacerbates diabetes. Immunity (2012) 1.50
Increased resistance to CD4+CD25hi regulatory T cell-mediated suppression in patients with type 1 diabetes. Clin Exp Immunol (2008) 1.44
Expansion of Th17 cells and functional defects in T regulatory cells are key features of the pancreatic lymph nodes in patients with type 1 diabetes. Diabetes (2011) 1.39
Homeostasis and function of regulatory T cells in aging. Curr Opin Immunol (2012) 1.30
Signatures of human regulatory T cells: an encounter with old friends and new players. Genome Biol (2006) 1.27
CCR8 expression identifies CD4 memory T cells enriched for FOXP3+ regulatory and Th2 effector lymphocytes. J Immunol (2006) 1.25
The contribution of RNA decay quantitative trait loci to inter-individual variation in steady-state gene expression levels. PLoS Genet (2012) 1.25
Treg cells, life history, and diversity. Cold Spring Harb Perspect Biol (2012) 1.19
Next-generation insights into regulatory T cells: expression profiling and FoxP3 occupancy in Human. Nucleic Acids Res (2011) 1.14
Chronic inflammation and aging: DNA damage tips the balance. Curr Opin Immunol (2012) 1.13
Common risk alleles for inflammatory diseases are targets of recent positive selection. Am J Hum Genet (2013) 1.09
CD101 surface expression discriminates potency among murine FoxP3+ regulatory T cells. J Immunol (2007) 1.02
Uncoupling of proliferation and cytokines from suppression within the CD4+CD25+Foxp3+ T-cell compartment in the 1st year of human type 1 diabetes. Diabetes (2011) 0.86
Frequency and gene expression profile of regulatory T cells in renal cell carcinoma. Tumour Biol (2009) 0.82
Coordinating GWAS results with gene expression in a systems immunologic paradigm in autoimmunity. Curr Opin Immunol (2012) 0.80
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09
Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27
Continuous glucose monitoring and intensive treatment of type 1 diabetes. N Engl J Med (2008) 17.19
Risk alleles for multiple sclerosis identified by a genomewide study. N Engl J Med (2007) 17.06
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 13.23
Projection of an immunological self shadow within the thymus by the aire protein. Science (2002) 12.15
Common regulatory variation impacts gene expression in a cell type-dependent manner. Science (2009) 11.28
A high-density admixture map for disease gene discovery in african americans. Am J Hum Genet (2004) 10.87
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet (2011) 10.07
Care of children and adolescents with type 1 diabetes: a statement of the American Diabetes Association. Diabetes Care (2005) 9.97
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. Nat Genet (2010) 9.90
Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med (2009) 9.71
FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell (2006) 9.24
Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity (2010) 8.90
The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells. J Exp Med (2008) 6.07
Gut immune maturation depends on colonization with a host-specific microbiota. Cell (2012) 5.91
Mast cells: a cellular link between autoantibodies and inflammatory arthritis. Science (2002) 5.82
Charting a dynamic DNA methylation landscape of the human genome. Nature (2013) 5.80
Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature. Immunity (2007) 5.67
Arthritis critically dependent on innate immune system players. Immunity (2002) 5.31
Patterns of cis regulatory variation in diverse human populations. PLoS Genet (2012) 5.28
Cytokine requirements for acute and Basal homeostatic proliferation of naive and memory CD8+ T cells. J Exp Med (2002) 5.09
Genetic analysis of human traits in vitro: drug response and gene expression in lymphoblastoid cell lines. PLoS Genet (2008) 5.08
A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility. Nat Genet (2005) 5.02
Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations. PLoS Genet (2010) 4.95
The effect of continuous glucose monitoring in well-controlled type 1 diabetes. Diabetes Care (2009) 4.93
Automated high-dimensional flow cytometric data analysis. Proc Natl Acad Sci U S A (2009) 4.91
Stability of the regulatory T cell lineage in vivo. Science (2010) 4.89
The cellular mechanism of Aire control of T cell tolerance. Immunity (2005) 4.74
GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. Science (2013) 4.71
Genevar: a database and Java application for the analysis and visualization of SNP-gene associations in eQTL studies. Bioinformatics (2010) 4.56
Aire. Annu Rev Immunol (2009) 4.43
Pervasive sharing of genetic effects in autoimmune disease. PLoS Genet (2011) 4.42
PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells. Nature (2012) 4.31
Foxp3+ regulatory T cells: differentiation, specification, subphenotypes. Nat Immunol (2009) 4.07
De novo copy number variants identify new genes and loci in isolated sporadic tetralogy of Fallot. Nat Genet (2009) 3.86
Genome-wide chromatin state transitions associated with developmental and environmental cues. Cell (2013) 3.83
Progress and promise of genome-wide association studies for human complex trait genetics. Genetics (2010) 3.81
Chromatin marks identify critical cell types for fine mapping complex trait variants. Nat Genet (2012) 3.67
CD4+CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion. J Exp Med (2004) 3.57
Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic mice. Proc Natl Acad Sci U S A (2011) 3.55
Defining the role of the MHC in autoimmunity: a review and pooled analysis. PLoS Genet (2008) 3.54
Breaking the waves: improved detection of copy number variation from microarray-based comparative genomic hybridization. Genome Biol (2007) 3.54
Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. Ann Neurol (2011) 3.52
Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine. J Cell Biol (2010) 3.50
Adaptation of TCR repertoires to self-peptides in regulatory and nonregulatory CD4+ T cells. J Immunol (2007) 3.47
Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells. Immunity (2008) 3.25
How antibodies to a ubiquitous cytoplasmic enzyme may provoke joint-specific autoimmune disease. Nat Immunol (2002) 3.20
Antigen persistence is required throughout the expansion phase of a CD4(+) T cell response. J Exp Med (2005) 3.14
A special population of regulatory T cells potentiates muscle repair. Cell (2013) 3.09
A comprehensive review of interventions in the NOD mouse and implications for translation. Immunity (2005) 3.07
Critical roles for interleukin 1 and tumor necrosis factor alpha in antibody-induced arthritis. J Exp Med (2002) 2.98
Physiological beta cell death triggers priming of self-reactive T cells by dendritic cells in a type-1 diabetes model. J Exp Med (2003) 2.94
Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells. J Exp Med (2004) 2.92
Admixture mapping of an allele affecting interleukin 6 soluble receptor and interleukin 6 levels. Am J Hum Genet (2007) 2.91
Cre-mediated cell ablation contests mast cell contribution in models of antibody- and T cell-mediated autoimmunity. Immunity (2011) 2.87
Factors predictive of use and of benefit from continuous glucose monitoring in type 1 diabetes. Diabetes Care (2009) 2.85
Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire. J Exp Med (2007) 2.84
Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells. Proc Natl Acad Sci U S A (2006) 2.83
Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes. Science (2014) 2.77
Aire's partners in the molecular control of immunological tolerance. Cell (2010) 2.68
Self-reactivity in thymic double-positive cells commits cells to a CD8 alpha alpha lineage with characteristics of innate immune cells. Nat Immunol (2004) 2.68
Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein. Nat Med (2007) 2.64
Common genetic variants modulate pathogen-sensing responses in human dendritic cells. Science (2014) 2.63